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建筑技术及设计 2005年第10期 26-27页

作者： sherry yang(翻译) wendy ng(校译)

保存过去是可持续发展的一部分，保存古建筑，促发人们思考未来的问题。在今年七月，由香港珠海学院（Chu Hai College of Higher Education）建筑系主办的一场题为“文化传承：可持续发展及美学”的研讨会，来自香港、新加坡、台湾和... 详细信息

保存过去是可持续发展的一部分，保存古建筑，促发人们思考未来的问题。在今年七月，由香港珠海学院（Chu Hai College of Higher Education）建筑系主办的一场题为“文化传承：可持续发展及美学”的研讨会，来自香港、新加坡、台湾和内地的政府官员、专家学者及民间古迹保护人士就一系话题进行探讨：新加坡政府如保透过规划（MASTER PLAN 2003）保存其城市的独特身份？香港市民近期侃谈集体回忆的可贵，究竟与城市发展和古迹保护有何关系？极速发展中的北京，传统胡同和四合院尚余多少？香港市区重建背后的理念是什么？台湾的传统民居今天面貌如何等。

关键词：大学建筑古建筑保存香港概念化可持续发展教授中文工具

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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Cytogenetic and molecular aberrations of multiple myeloma patients： a single-center study in Singapore

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Chinese Medical Journal 2013年第10期126卷 1872-1877页

作者： LIM Alvin Soon Tiong LIM Tse Hui SEE Karen Hsu Shien ng Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung Cytogenetics Laboratory Department of Pathology SingaporeGeneral Hospital Singapore School of Biological Sciences Nanyang Technological UniversitySingapore Temasek Applied Science School Temasek Polytechnic Singapore Department of Haematology Singapore General HospitalSingapore

Background Much is known about the cytogenetic lesions that characterize multiple myeloma （MM） patients from the USA, Europe, and East Asia. However, little has been published about the disease among Southeast Asians. The aim of this study was to determine the chromosomal abnormalities of MM patients in our Singapore population. Methods Forty-five newly-diagnosed, morphologically confirmed patients comprising 18 males and 27 females, aged 46-84 years （median 65 years） were investigated by karyotyping and fluorescence in situ hybridization （FISH）. FISH employing standard panel probes and lp36/lq21 and 6q21/15q22 probes was performed on diagnostic bone marrow samples. Results Thirty-four cases （75.6%） had karyotypic abnormalities. Including FISH, a total detection rate of 91.1% was at- tained. Numerical and complex structural aberrations were common to both hyperdiploid and non-hyperdiploid patients. Numerical gains of several recurring chromosomes were frequent among hyperdiploid patients while structural rear- rangements of several chromosomes including 8q24.1 and 14q32 characterized non-hyperdiploid patients. With FISH, immunoglobulin heavy chain （IGH） gene rearrangements, especially fibroblast growth factor receptor 3 （FGFR3）/IGH and RB1 deletion/monosomy 13 were the most common abnormalities （43.4%）. Amplification lq21 was 10 times more frequent （42.5%） than del（1p36） and del（6q21）. Conclusions We have successfully reported the comprehensive cytogenetic profiling of a cohort of newly-diagnosed myeloma patients in our population. This study indicates that the genetic and cytogenetic abnormalities, and their frequencies, in our study group are generally similar to other populations.

关键词： amp(l q21), del(13q) fluorescence in situ hybridization, immunoglobulin heavy chain, Southeast Asia

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Umbilical Cord Blood Mononuclear Cell Treatment for Neonatal Rats with Hypoxic Ischemia

Umbilical Cord Blood Mononuclear Cell Treatment for Neonatal...

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第十六届中国医师协会神经外科医师年会

作者： Hao LYU Dong Ming SUN Chi Ping ng wendy S CHEng Jun Fan CHEN Yu Zhong HE Sin Yu LAM Zhi Yuan ZHEng Guo Dong HUAng Chi Chiu WAng Wise Young Wai Sang POON Division of Neurosurgery Department of SurgeryFaculty of MedicineThe Chinese University of Hong Kong Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgerythe Shenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen University W.M.Keck Center for Collaborative Neuroscience RutgersState University of New Jersey Department of Neurosurgery Hainan Hospital of People's Liberation Army General Hospital Department of Obstetrics and Gynecology The Chinese University of Hong Kong

Background:Hypoxic-Ischemic Encephalopathy(HIE) occurs when an infant’s brain has not received adequate oxygen and blood supply,resulting in ischemic and hypoxic ***,supportive care and hypothermia therapy have been the standard treatment for ***,there are still over 20% of treated infants died and 19-30% survived with significant *** animal model was first established by Vannucci et al,involving the ligation of one common carotid artery followed by *** this study,we investigated human umbilical cord blood(HUCB) and its two components mononuclear cell(MNC) and red cell fraction(RCF) in both short and long term study using a modified HIE rat ***:In this modified HIE model,both common carotid arteries were occluded,breathing 8% oxygen in a hypoxic chamber for 60-minute,followed by the release of the common carotid arteries ligature,mimicking reperfusion *** cell therapeutic study,cells were intravenously injected to HIE rat pups,and both behavioral and histological changes were assessed at selected time ***:Statistically significant behavioral improvements were demonstrated on Day 7 and 1 month between saline treated HIE rats and UCB/MNC treated ***,at 3 months,the therapeutic improvements were only showed between saline treated HIE animals and MNC treated HIE *** histological analysis one month after cell injection,the number of functional neurons were statistically increased between saline treated HIE and UCB/MNC/RCF treated HIE *** 3 months,the significant increase in functional neurons was only present in MNC treated HIE ***:We have used a bilateral temporary occlusion of 60 minutes,a moderately brain damaged model,for cell therapeutic *** umbilical cord blood(HUCB) mononuclear cell(MNC) therapy showed benefits in neonatal HIE rats in both short and long term behavioral and histological assessments.

关键词： Hypoxic Ischemic Encephalopathy animal model cell therapeutic

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Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma

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Journal of Biomedical Science and Engineering 2014年第11期7卷 857-865页

作者： Ka-Wai Wong Dora Lai-Wan Kwong Pek-Lan Khong Victor Ho-Fun Lee sherry Chor-Yi ng Martin Wai-Ming Law The Department of Clinical Oncology Queen Elizabeth Hospital Hong Kong China The Department of Clinical Oncology Queen Mary Hospital Hong Kong China The Department of Clinical Oncology The University of Hong Kong Hong Kong China The Department of Diagnostic Radiology Queen Mary Hospital Hong Kong China The Department of Diagnostic Radiology The University of Hong Kong Hong Kong China

Objective: To develop an auto-segmentation method for delineating the biological tumor volume of nasopharyngeal carcinoma from positron emission tomography images. Methods: A phantom consisting of a water tank with fixed background fluorodeoxyglucose [18F-FDG] activity and spheres with diameters ranging from 2.1 to 5 cm with varying activities of FDG were used to simulate tumors of different sizes and FDG uptake. The phantom was scanned with a PET/CT scan at different sphere to background intensity ratios. An optimum fixed percentage threshold (FT) approach and a signal-to-background ratio (SBR) approach were developed to estimate the true size of the spheres from the PET images. Both approaches were further evaluated in patient images for validation. Twenty-two patients with NPC from stage T1 to T4 were included. The PET based biological tumor volumes (BTV) were delineated with both FT (BTVFT) and SBR (BTVSBR) approaches and compared with the gross tumor volume localized from MRI (GTVMR). The mean volumes of BTVFT and BTVSBR were compared and the degree of overlap between GTVMR and both BTVs was evaluated. Paired t-tests were used for statistical analysis. Results: The optimal FT value was 36.5% of maximal intensity, and SBR approach was represented by an inverse linear regression model. The estimated volume of spheres segmented by both approaches shows no significant difference from the true volume of spheres (p > 0.05), but the average absolute errors were smaller from SBR approach than FT approach (p = 0.008). GTVMR was larger than both BTVFT (p = 0.003) and BTVSBR (p SBR with GTVMR is significantly larger than with BTVFT (0.52 and 0.42 respectively, p MR for radiotherapy planning purpose.

关键词： Segmentation Approach SBR Fixed Threshold NPC PET

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Unconsciously Implanted Visuoauditory Memory in the Presence of Cholecystokinin Retrieved in a Behaviorally Relevant Context

Unconsciously Implanted Visuoauditory Memory in the Presence...

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中国神经科学学会第十二届全国学术会议

作者： Zicong Zhang Christine Xuejiao Zheng Yujie Peng Xi Chen Yiping Guo Danyi Lu Xiao Li Wenjian Sun Peng Tang sherry Ling He Min Li Qing Liu Fuqiang Xu Gabriel ng Jufang He Departments of Biomedical Sciences and Biology and Chemistry City University of Hong Kong Department of Rehabilitation Sciences The Hong Kong Polytechnic University City University of Hong Kong Shenzhen Research Institute Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences

We investigated whether an associative memory can be artificially implanted under anesthesia and then retrieved in a behaviorally relevant context. Rats with bilateral electrodes in the auditory cortex were trained to approach the left or the right hole of a behavioral apparatus to retrieve a reward depending on whether the right or left auditory cortex was electrically stimulated. Next, under anesthesia, a previously irrelevant visual stimulus（VS） was repeatedly paired with electrical stimulation of the auditory cortex（EAC） in the presence of cholecystokinin（CCK）, after which auditory cortex neurons started to respond to the light stimulus in both anesthetized and awake states. In subsequent behavioral testing, in response to the VS, rats approached the hole that was "engineered" to be associated with reward availability. High-frequency（HF） activation of the terminals of the entorhinal CCK neurons in the auditory cortex, which was followed by the pairing of the VS and EAC, enhanced neuronal responses to the VS in the auditory cortex of anesthetized mice. When the mice were pre-conditioned EAC with footshock, mice showed significantly increased freezing responses to the VS after the pairings. Application of CCK antagonist blocked the establishment of visuoauditory association in the behavioral experiment. CCK-/-mice have deficit in forming the visuoauditory association, but systemic administration of tetropeptide CCK rescued the formation of associative memory in CCK-/-mice. Our finding that an artificial memory formed under anesthesia could be translated into behavioral action provides a scientific foundation for "memory implantation" and CCK is the switching chemical for the formation of visuoauditory associative memory.

关键词： auditory cortex neural plasticity operant conditioning entorhinal cortex memory encoding cholecystokinin

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来谈谈那些ng掉的性爱

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优雅 2014年第2期 122-123页

作者： Miche leKary wendy

他的装备不听使唤'第一次与男友做爱时,他就不给力,'31岁的吕婷说道,'我们都喝醉了,他的身体一直罢工.第二天清晨我们再次尝试,依然失败.我简直都想放弃了.'勃起问题在男性间普遍存在,但我们的文化却认为男人们都是性爱永动机.因此当你... 详细信息

他的装备不听使唤'第一次与男友做爱时,他就不给力,'31岁的吕婷说道,'我们都喝醉了,他的身体一直罢工.第二天清晨我们再次尝试,依然失败.我简直都想放弃了.'勃起问题在男性间普遍存在,但我们的文化却认为男人们都是性爱永动机.因此当你遇上一个装备无法工作的家伙,你会很自然地做出最坏的假设:你对他没有足够的吸引力、他在欺骗你、你在床上的表现很糟糕……另一种做法更是错误:事后回避它!虽然重提这蹩脚的性爱令人尴尬,但当鸵鸟装作一切都没有发生更不可取,你会无意识地回想当时的场景.在事后的一两天内,你可以在卧房外轻轻地旧事重提,消除不安.安抚他,减轻他的压力,告诉他即便没他的装备,你们也可以享受性爱.但无论你怎么做,都不要在网上购买药品来私自治疗,如果运气差,你可能得不偿失.

关键词：装备性爱网上购买永动机吸引力无意识治疗运气药品压力文化鸵鸟身体男性男人场景罢工

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北京延庆创意园区总体规划

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城市环境设计 2010年第1期 32-35页

作者： Ben van Berkel Caroline Bos Markus van Aalderen Mieneke Dijkema Ren Yee Clarissa Alfrink Megan ng Maud van Hees wendy van der Knijff Jae Young Lee UNStudio

北京延庆创意园区的设计是绿化带与城市结构的双重压缩。城市结构的压缩创造了一个紧密强化的城市环境。城市结构的边缘由相互交织基础创意产业带和配套设施带组成,从而创造了一系列开放空间。

关键词：总体规划整体规划规划论创意园区绿化带北京延庆

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北京创意园区整体规划

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建筑技艺 2011年第6期17卷 94-99页

作者： Ben van Berkel Caroline Bos Markus van Aalderen Yi Cheng Pan Mieneke Dijkema Ren Yee Clarissa Alfrink Megan ng Maudvan Hees wendy van der Knijff Jae Young Lee 吴春花 UNStudio

客户北京市延庆区人民政府规划与建筑设计UNStudio:Ben van Berkel,Caroline Bos with Markus van Aalderen,Yi Cheng Pan and Mieneke Dijkema,Ren Yee,Clarissa Alfrink,Megan ng,Maud van Hees,wendy van der Knijff,Jae Young Lee 基地面积210 152m2建筑面积145 119m2城市发展顾问dcu,Pablo Vaggione可持续设计顾问Arup工程顾问(上海)有限公司'于自然中的都市'这一主题旨在保护延庆当地的自然特征,同时容纳一定的城市生活,整个设计将绿带与城市肌理两个尺度结合起来.通过对城市肌理的浓缩,创造出一个高度编织和紧密的城市环境,从而在城市与自然之间既形成清晰的界限又具有紧凑性.两个不同但相互联系的创意产业带和基础设施带相互编织成边缘地带的城市组织,同时营造了从街道到庭院到公共广场的一系列连续的开放空间.浓缩景观最大限度地扩展了绿带,增加的绿带和公园为创意人士工作、组织活动以及画室和亭、阁的娱乐活动提供了绿色环境.

关键词：城市肌理创意园区公园园林广场绿带设计者 Nature

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The dosimetric and clinical advantage of intensity - modulated radiotherapy （IMRT） in the primary radical treatment of nasopharyngeal carcinoma - is chemo - IMRT the state - of - the - art in 2004?

The dosimetric and clinical advantage of intensity - modulat...

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第三届中国肿瘤学术大会

作者： Peter M. L. Teo , Anthony T. C. Chan, sherry C. Y. ng Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territo-ries, Hong Kong, China. Oncology Centre, Hong Kong Sanatorium & Hospital Happy Valley, Hong Kong. Department of Radiotherapy, Hong Kong Sanatorium & Hospital Happy Valley, Hong Kong.

＜正＞ This review described the clinical background that underlies the gradual establishment of intensity modulated （IMRT） as the radiation technique of choice in the primary radical treatment of nasopharyngeal cancer （ NPC）. We have critically examined the positive impact of 3D methods - with emphasis on intensity -modulated radiotherapy （IMRT） - on the dosimetric end-point of adequate target - dose coverage, and dose - sparing of normal organs and the clinical endpoint of overall and relapse -free survival and local - and distant - failure - free rates. Potential problems related to the widespread practice of IMRT such as quality assurance, utilization of medical resources and the risk of developing radiation -induced secondary cancers were stud-ied. Application of IMRT within the context of altered fractionation, dose escalation and concurrent chemotherapy were dis-cussed. The article concluded with a suggested treatment approach and research direction for different stages of NPC.

关键词： NPC 3DCRT IMRT SRS local control xerostomia dose - escalation fractionation chemotherapy

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