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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao q.H.Cao X.Cao Z.Cao q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.q.Hao J.B.He S.q.He X.G.He y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang q.y.Huang W.q.Huang X.T.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.q.Li X.H.Li y.Li y.y.Li Z.J.Li H.Liang J.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.y.Liu K.Liu L.Liu q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu J.X.Lu N.Lu q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi y.q.qi W.B.qian y.qian C.F.qiao J.J.qin J.J.qin L.q.qin X.S.qin T.L.qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

The secretory function of adipose tissues in metabolic regulation

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Life Metabolism 2024年第2期3卷 9-23页

作者： yang Liu Shu-Wen qian yan tang qi-qun tang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan HospitalFudan UniversityShanghai 200032China

In addition to their pivotal roles in energy storage and expenditure,adipose tissues play a crucial part in the secretion of bioactive molecules,including peptides,lipids,metabolites,and extracellular vesicles,in response to physiological stimulation and met-abolic *** secretory factors,through autocrine and paracrine mechanisms,regulate various processes within adipose *** processes include adipogenesis,glucose and lipid metabolism,inflammation,and adaptive thermogenesis,all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment.A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite,cognitive function,energy expenditure,insulin secretion and sensitivity,gluconeogenesis,cardiovascular remodeling,and exercise *** this review,we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating meta-bolic ***,we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions,shedding light on potential pharmacological treatment strategies for related diseases.

关键词： adipokines autocrine paracrine endocrine metabolic regulation

公元241~1912年中国河西走廊地区年际干湿变化与游牧战争的关系

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中国科学：地球科学 2024年第6期54卷 1950-1959页

作者：唐飞史志林田沁花杜小刚张永中国科学院地理科学与资源研究所陆地表层格局与模拟院重点实验室北京100101 兰州大学敦煌学研究所兰州730020 中国气象局国家气候中心北京100081 甘肃祁连山国家级自然保护区管护中心隆畅河自然保护站张掖734400 中国科学院大学北京100049

长期以来,气候与战争之间的关系一直是一个备受关注的科学和社会问题.在本研究中,探讨了公元241年以来中国河西走廊地区气候与战争爆发的可能关联.基于河西走廊地区树轮资料以及历史时期游牧战争数据,利用时序叠加分析方法,我们发现河... 详细信息

长期以来,气候与战争之间的关系一直是一个备受关注的科学和社会问题.在本研究中,探讨了公元241年以来中国河西走廊地区气候与战争爆发的可能关联.基于河西走廊地区树轮资料以及历史时期游牧战争数据,利用时序叠加分析方法,我们发现河西走廊地区年际干湿变化与游牧民族发动的战争之间存在明显的相关性,但是这种关系是动态的,并与该地区的政权格局有关.在河西走廊存在多个地方政权统治的时期,战争往往随着干旱的气候条件而发生,这可能是由于这些时期的异常干旱加剧了对资源和土地的争夺.相反,在统一王朝管理时期,气候湿润时更容易发生战争,因为牧场的扩大和资源的积累有助于游牧民族的对外征服.这些发现凸显了战争与气候变化之间关系的复杂性.为了更加全面地分析二者之间的关系,需要在更多地区建立覆盖范围更广、分布更均匀且连续的高分辨率历史温湿数据集.此外,对于具有独特特征的区域,需要收集更多的历史战争数据,进行分类讨论研究.

关键词：干旱年际干湿变化战争河西走廊树轮游牧民族

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen y.B.Chen y.q.Chen Z.J.Chen Z.y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang y.Fang y.q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.q.Feng J.H.Feng y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu y.W.Fu H.Gao y.N.Gao yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding y.Ding y.Ding J.Dong L.y.Dong M.y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.q.Guo L.B.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou B.y.Hu H.M.Hu J.F.Hu T.Hu y.Hu G.S.Huang K.X.Huang L.q.Huang X.T.Huang y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong q.Ji q.P.Ji W.Ji X.B.Ji X.L.Ji y.y.Ji X.q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin y.Jin M.q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li q.M.Li q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.y.Li y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

Complement C1q induces the M2-polarization of tumor-associated macrophages in lung adenocarcinoma

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Genes & Diseases 2024年第4期11卷 145-148页

作者： yuxiao Song yang Fu Jun Wang Jiazhuo tang Jiaxin yin Zhimin Zhang qibin Song Bicheng Zhang Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430061China Department of Oncology Xiangyang HospitalHubei University of Chinese MedicineXiangyangHubei 441100China Department of Oncology The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250000China

Complement C1q was proved to be able to regulate the polarization of macrophages to the anti-inflammatory phenotype(M2 polarized),acting as an anti-inflammation molecule independent of the classical complement pathway.A high level of C1q expression has been detected in the tumor microenvironment(TME)of diverse tumors,including non-small cell lung cancer,in which C1q could be considered a predictor of poor prognosis.

关键词： C1q lung inflammation

An inducible CRISPR activation tool for accelerating plant regeneration

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Plant Communications 2024年第5期5卷 109-122页

作者： Cuimei Zhang yajun tang Shanjie tang Lei Chen Tong Li Haidi yuan yujun Xu yangyan Zhou Shuaibin Zhang Jianli Wang Hongyu Wen Wenbo Jiang yongzhen Pang Xian Deng Xiaofeng Cao Junhui Zhou Xianwei Song qikun Liu State Key Laboratory of Protein and Plant Gene Research School of Advanced Agricultural SciencesPeking UniversityBeijing 100871China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences at WeifangShandong 261000China National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Grass and Science Institute of Heilongjiang Academy of Agricultural Sciences Heilongjiang 150086China Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Seed Innovation and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

The inducible CRISPR activation(CRISPR-a)system offers unparalleled precision and versatility for regu-lating endogenous genes,making it highly sought after in plant *** this study,we developed a chem-ically inducible CRISPR-a tool for plants called ER-Tag by combining the LexA-VP16-ER inducible system with the SunTag CRISPR-a *** systematically compared different induction strategies and achieved high efficiency in target gene *** demonstrated that guide RNAs can be multiplexed and pooled for large-scale screening of effective morphogenic genes and gene pairs involved in plant *** experiments showed that induced activation of these morphogenic genes can accelerate regenera-tion and improve regeneration efficiency in both eudicot and monocot plants,including alfalfa,woodland strawberry,and *** study expands the CRISPR toolset in plants and provides a powerful new strategy for studying gene function when constitutive expression is not feasible or ideal.

关键词： inducible CRISPR activation morphogenic gene genetic transformation plant regeneration

青藏高原及其周边前成冰纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 915-935页

作者：胡培远翟庆国赵国春 Peter A.CAWOOD 唐跃刘一鸣中国地质科学院地质研究所北京100037 香港大学地球科学系中国香港999077 大陆动力学国家重点实验室西北大学地质学系西安710069 School of Earth Atmosphere&EnvironmentMonash UniversityMelbourneVIC 3800Australia

青藏高原及邻区前成冰纪物质组成及其地质演化过程,在地球早期超大陆形成演化过程的研究中扮演了重要角色.本文系统梳理和总结了青藏高原及邻区前成冰纪沉积岩、古生物、岩浆和变质作用特征.根据现有资料,青藏高原及邻区前成冰纪沉积岩... 详细信息

青藏高原及邻区前成冰纪物质组成及其地质演化过程,在地球早期超大陆形成演化过程的研究中扮演了重要角色.本文系统梳理和总结了青藏高原及邻区前成冰纪沉积岩、古生物、岩浆和变质作用特征.根据现有资料,青藏高原及邻区前成冰纪沉积岩和古生物记录主要集中于中~新元古代,古元古代及更早的记录相对较少,最古老的地质记录为喜马拉雅和昌都地区前寒武纪变质沉积岩中的冥古宙碎屑锆石(约4.0Ga).青藏高原及邻区保存了凯诺兰超级克拉通以及哥伦比亚、罗迪尼亚和冈瓦纳超大陆形成演化过程的记录,其前成冰纪基底可划分为3种类型:塔里木型、扬子型和拉萨型.塔里木型基底与澳大利亚和印度大陆北缘具有古地理亲缘性,且不发育罗迪尼亚超大陆聚合相关的碎屑锆石年龄峰值和岩浆-变质记录(约1.3~0.9Ga);扬子型基底发育与前成冰纪最晚期全球变冷密切相关的火山活动记录,可见中~新元古代叠层石和微古植物化石,以及约1.1~1.0Ga与罗迪尼亚超大陆聚合相关的岩浆-变质作用记录;拉萨型基底发育新元古代早期大陆裂谷沉积记录(约900Ma)和晚期高压变质事件(约650Ma),具有明显的1.2~1.1Ga碎屑锆石年龄峰值,它很可能与非洲大陆具有古地理亲缘性.

关键词：青藏高原前成冰纪沉积地层古生物群古地理演化

Boosting genome editing in plants with single transcript unit surrogate reporter systems

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Plant Communications 2024年第6期5卷 32-43页

作者： Xu tang qiurong Ren Xiaodan yan Rui Zhang Li Liu qinqin Han Xuelian Zheng yiping qi Hongyuan Song yong Zhang Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science CitySchool of Life SciencesSouthwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper yangtze River Ministry of EducationChongqing 400715China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China School of Synbiology School of Life ScienceShanxi UniversityTaiyuan 030006China Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

CRISPR-Cas-based genome editing holds immense promise for advancing plant genomics and crop ***,the challenge of low editing activity complicates the identification of editing *** this study,we introduce multiple single transcript unit surrogate reporter(STU-SR)systems to enhance the selection of genome-edited *** systems use the same single guide RNAs designed for endogenous genes to edit reporter genes,establishing a direct link between reporter gene editing activity and that of endogenous *** strategies are used to restore functional reporter genes after genome editing,including efficient single-strand annealing(SSA)for homologous recombination in STUSR-SSA ***-SR-base editor systems leverage base editing to reinstate the start codon,enriching C-to-T and A-to-G base editing *** results showcase the effectiveness of these STU-SR systems in enhancing genome editing events in the monocot rice,encompassing Cas9 nuclease-based targeted mutagenesis,cytosine base editing,and adenine base *** systems exhibit compatibility with Cas9 variants,such as the PAM-less SpRy,and are shown to boost genome editing in Brassica oleracea,a dicot vegetable *** summary,we have developed highly efficient and versatile STU-SR systems for enrichment of genome-edited plants.

关键词： CRISPR-Cas9 single transcript unit STU surrogate reporter SR single strand annealing SSA cyto-sine base editing adenine base editing

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-yu Liu Ruizhi yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster