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Delineation of Biological Tumor Volume from Positron Emission Tomography Images in Nasopharyngeal Carcinoma

Journal of Biomedical Science and Engineering 2014年第11期7卷 857-865页

作者： Ka-Wai Wong Dora Lai-Wan Kwong Pek-Lan Khong Victor Ho-Fun Lee sherry chor-yi ng Martin Wai-Ming Law The Department of Clinical Oncology Queen Elizabeth Hospital Hong Kong China The Department of Clinical Oncology Queen Mary Hospital Hong Kong China The Department of Clinical Oncology The University of Hong Kong Hong Kong China The Department of Diagnostic Radiology Queen Mary Hospital Hong Kong China The Department of Diagnostic Radiology The University of Hong Kong Hong Kong China

Objective: To develop an auto-segmentation method for delineating the biological tumor volume of nasopharyngeal carcinoma from positron emission tomography images. Methods: A phantom consisting of a water tank with fixed background fluorodeoxyglucose [18F-FDG] activity and spheres with diameters ranging from 2.1 to 5 cm with varying activities of FDG were used to simulate tumors of different sizes and FDG uptake. The phantom was scanned with a PET/CT scan at different sphere to background intensity ratios. An optimum fixed percentage threshold (FT) approach and a signal-to-background ratio (SBR) approach were developed to estimate the true size of the spheres from the PET images. Both approaches were further evaluated in patient images for validation. Twenty-two patients with NPC from stage T1 to T4 were included. The PET based biological tumor volumes (BTV) were delineated with both FT (BTVFT) and SBR (BTVSBR) approaches and compared with the gross tumor volume localized from MRI (GTVMR). The mean volumes of BTVFT and BTVSBR were compared and the degree of overlap between GTVMR and both BTVs was evaluated. Paired t-tests were used for statistical analysis. Results: The optimal FT value was 36.5% of maximal intensity, and SBR approach was represented by an inverse linear regression model. The estimated volume of spheres segmented by both approaches shows no significant difference from the true volume of spheres (p > 0.05), but the average absolute errors were smaller from SBR approach than FT approach (p = 0.008). GTVMR was larger than both BTVFT (p = 0.003) and BTVSBR (p SBR with GTVMR is significantly larger than with BTVFT (0.52 and 0.42 respectively, p MR for radiotherapy planning purpose.

关键词： Segmentation Approach SBR Fixed Threshold NPC PET

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4D imaging of void nucleation,growth,and coalescence from large and small inclusions in steel under tensile deformation

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Journal of Materials Science & Technology 2022年第28期123卷 168-176页

作者： yi Guo Timothy L.Burnett Samuel A.McDonald Michael Daly Andrew H.sherry Philip J.Withers Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Henry Royce Institute Department of MaterialsUniversity of ManchesterM139PLUK European Synchrotron Radiation Facility(ESRF) 6 rue J Horowitz38000 GrenobleFrance National Nuclear Laboratory Chadwick HouseBirchwood ParkWarringtonWA36AEUK

Samples of SA508 grade 3 nuclear pressure vessel ferritic steel were subjected to tensile straining whilst being simultaneously imaged in 3D in real time using high resolution,high frame rate time-lapse synchrotron computed tomography(CT).This enabled direct observation of void development from nucleation,through growth to coalescence and final failure validating many inferences made post-mortem or by theoretical models,as well as raising new *** sparse,large inclusions were found to nucleate voids at essentially zero plastic strain(consistent with zero interfacial strength);these became increasingly elongated with *** contrast,a high density of small spherical voids were found to nucleate from the sub-micron cementite particles at larger strains(>200%)only in the centre of the necked(high triaxiality)*** interfacial strength approaching 2100 MPa was inferred and soon after their nucleation,these small voids coalesce to form internal microcracks that lead to the final failure of the *** surprisingly,under these conditions of generally low triaxial constraint the large voids are simply cut across and appear to play no significant role in determining the final *** implications of these results are discussed in terms of ductile fracture behaviour and the Gurson model for ductile fracture.

关键词： Void growth Ductile fracture Synchrotron X-ray tomography 4D imaging Bainitic steel

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Two fully automated data-driven 3D whole-breast segmentation strategies in MRI for MR-based breast density using image registration and U-Net with a focus on reproducibility

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 303-314页

作者： Jia ying Renee Cattell Tianyun Zhao Lan Lei Zhao Jiang Shahid M.Hussain yi Gao H‑H.sherry Chow Alison T.Stopeck Patricia A.Thompson Chuan Huang Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Radiation Oncology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Medicine Northside Hospital GwinnettLawrencevilleGA 30046USA Program of Public Health Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Radiology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Biomedical Informatics Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060China University of Arizona Cancer Center TucsonAZ 85719USA Department of Medicine Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Stony Brook Cancer Center Stony Brook UniversityStony BrookNY 11794USA Department of Medicine Cedar Sinai CancerCedars Sinai Medical CenterLos AngelesCA 90048USA

Presence of higher breast density(BD)and persistence over time are risk factors for breast cancer.A quantitatively accurate and highly reproducible BD measure that relies on precise and reproducible whole-breast segmentation is *** this study,we aimed to develop a highly reproducible and accurate whole-breast segmentation algorithm for the generation of reproducible BD *** datasets of volunteers from two clinical trials were *** MR images were acquired on 3T Siemens Biograph mMR,Prisma,and Skyra using 3D Cartesian six-echo GRE sequences with a fat-water separation *** whole-breast segmentation strategies,utiliz-ing image registration and 3D U-Net,were *** segmentation was performed.A task-based analysis was performed:a previously developed MR-based BD measure,MagDensity,was calculated and assessed using automated and manual *** mean squared error(MSE)and intraclass correlation coefficient(ICC)between MagDensity were evaluated using the manual segmentation as a *** test-retest reproducibility of MagDensity derived from different breast segmentation methods was assessed using the difference between the test and retest measures(Δ_(2-1)),MSE,and *** results showed that MagDensity derived by the registration and deep learning segmentation methods exhibited high concordance with manual segmentation,with ICCs of 0.986(95%CI:0.974-0.993)and 0.983(95%CI:0.961-0.992),*** test-retest analysis,MagDensity derived using the regis-tration algorithm achieved the smallest MSE of 0.370 and highest ICC of 0.993(95%CI:0.982-0.997)when compared to other segmentation *** conclusion,the proposed registration and deep learning whole-breast segmentation methods are accurate and reliable for estimating *** methods outperformed a previously developed algorithm and manual segmentation in the test-retest assessment,with the registration exhibiting superior performance for highly reproducibl

关键词： Breast cancer Breast density Breast segmentation Image registration Deep learning

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α-Vitamin E derivative, RRR-α-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells

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Asian Journal of Andrology 2007年第1期9卷 31-39页

作者： Eugene Chang Jing Ni yi yin Chiu-Chun Lin Philip Chang Nadine S. James sherry R. Chemler Shuyuan Yeh Departments of Urology and Pathology University of Rochester Rochester NY 14642 USA Department of Chemistry The State University of New York at Buffalo Buffalo NY 14260 USA

Aim： To investigate the activity of RRR-α-tocopheryloxybutyric acid （TOB）, an ether analog of RRR-α-tocopheryl succinate （VES）, in prostate cancer cells. Methods： VES and TOB were used to treat prostate cancer LNCaP, PC3, and 22Rvl cells and primary-cultured prostate fibroblasts. The proliferation rates were determined by MTT assay, the cell viabilities were determined by trypan blue exclusion assay, and the cell deaths were evaluated by using Cell Death Detection ELISA kit. The protein expression levels were determined by Western blot analysis. Results： The MTT growth assay demonstrated that TOB could effectively suppress the proliferation of prostate cancer cells, but not normal prostate fibroblasts. Mechanism dissections revealed that TOB reduced cell viability and induced apoptosis in prostate cancer cells similar to VES. In addition, both TOB and VES suppressed prostate-specific antigen （PSA） at the transcriptional level leading to reduced PSA protein expression. Furthermore, vitamin D receptor （VDR） expression increased after the addition of TOB. Conclusion： Our data suggests that the VES derivative, TOB, is effective in inhibiting prostate cancer cell proliferation, suggesting that TOB could be used for both chemopreventive and chemotherapeutic purposes in the future.

关键词： α-tocopheryloxybutyric acid α-vitamin E succinate prostate cancer prostate-specific antigen vitamin D receptor LNCaP PC3, 22Rvl

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儿童危重症液体复苏及相关问题

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中国循证儿科杂志 2007年第1期2卷 1-6页

作者： David Jaimovich sherry Zombik 曾其毅美国芝加哥Hope儿童医院广州市儿童医院

曾其毅教授:有幸参加美国芝加哥Hope儿童医院和复旦大学附属儿科医院联合举办的'上海国际儿科危重病研讨会',在会上我们就儿科危重症很多方面的问题进行了很有意义的研讨.《中国循证儿科杂志》专家对谈录栏目邀请您两位和我就儿童危重... 详细信息

曾其毅教授:有幸参加美国芝加哥Hope儿童医院和复旦大学附属儿科医院联合举办的'上海国际儿科危重病研讨会',在会上我们就儿科危重症很多方面的问题进行了很有意义的研讨.《中国循证儿科杂志》专家对谈录栏目邀请您两位和我就儿童危重症液体复苏及相关问题再次进行更深入的讨论,这是一个自由的讨论,各抒己见,不需要达成共识.

关键词：儿科危重症儿童医院液体复苏医院联合复旦大学 Hope 危重病芝加哥

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基于机器学习标准化积分面积算法的脊柱侧弯度量方法

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临床放射学杂志 2024年第3期43卷 414-419页

作者：张屹韩殊曼杨晨韩晓楠吴慧钊曹磊于宝海吴文娟河北科技大学石家庄050051 河北医科大学第三医院放射科

目的基于机器学习算法搜索全脊柱X线影像的行最大像素和像素局部极值,开发一种自动度量脊柱侧弯程度的计算机视觉评估方法。方法搜集129例特发性脊柱侧弯患者全脊柱正位X线影像,行直方图均衡后使用对称叠加阈值算法凸显出非对称像素,... 详细信息

目的基于机器学习算法搜索全脊柱X线影像的行最大像素和像素局部极值,开发一种自动度量脊柱侧弯程度的计算机视觉评估方法。方法搜集129例特发性脊柱侧弯患者全脊柱正位X线影像,行直方图均衡后使用对称叠加阈值算法凸显出非对称像素,搜寻每行中最大亮度的像素点作为全局最大像素点,搜寻每行像素中比两侧3~5个像素点高的局部极值点,以两种点的交集作为候选锚点。从最上面的候选锚点开始向第二行的候选锚点连直线,如连线斜率绝对值>1则第二行的点即作为精细锚点。所有精细锚点用3次样条算法进行拟合得到脊柱的近似曲线,以曲线与脊柱首尾相连的直线之间的标准化积分面积对脊柱侧弯程度进行度量。以人工测量Cobb角值为标准,评价人工测量Cobb角与积分面积算法度量的相关性,使用受试者工作特征曲线分析积分面积算法度量的曲线下面积。结果人工测量Cobb角与积分面积算法度量呈正相关(r=0.658,P<0.001),积分面积算法度量中度、重度侧弯的受试者工作特征曲线下面积分别为0.889、0.862。结论本方法快速、高效地从全局角度评估脊柱侧弯的程度,适合于大面积脊柱侧弯程度评估的筛查,可作为脊柱侧弯角度精细测量的有益补充。

关键词：脊柱侧弯度量 X线影像机器学习穷尽搜索算法锚点标准化面积

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根键式基桩竖向承载力自平衡法试验研究

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世界桥梁 2013年第3期41卷 52-56页

作者：刘彦峰严艺薰中铁大桥局集团桥科院有限公司湖北武汉430034 桥梁结构安全与健康湖北省重点实验室湖北武汉430034 中国地质大学工程学院湖北武汉430074

根键式桩基础是一种新型的基础形式,其通过固结的根键来增加结构与土体的共同作用,以提高基础的承载力。为检验自平衡法在根键式基桩承载力测试中的适用性,以及进一步了解根键式基桩承载能力的性能,以某长江大桥试桩为背景,对1根根键式... 详细信息

根键式桩基础是一种新型的基础形式,其通过固结的根键来增加结构与土体的共同作用,以提高基础的承载力。为检验自平衡法在根键式基桩承载力测试中的适用性,以及进一步了解根键式基桩承载能力的性能,以某长江大桥试桩为背景,对1根根键式试桩和1根普通试桩竖向承载能力进行自平衡试验。试验结果显示:自平衡试桩法可用于检验根键式桩基础的施工工艺和成桩后的承载力;根键能提高基桩承载力和减小桩顶沉降。结合计算结果对根键式桩基础的设计和施工提出了建议。

关键词：桥梁工程根式基础根键式桩基础承载力自平衡法试验研究

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建筑管道支吊架耐火性能试验研究

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消防科学与技术 2023年第11期42卷 1512-1517页

作者：廖曙江董朋朋黎小涛刘义中机中联工程有限公司重庆400012 招商局检测认证有限公司重庆401121 重庆尔安机电设备工程有限公司重庆400015 中煤科工重庆设计研究院有限公司重庆400016

通过对建筑管道支吊架安装方式的调研,对支吊架的典型锚固形式开展常温和火灾状态下的拉拔力对比试验,验证支吊架的不同锚固方式在火灾情况下的耐火稳定性。结果表明,支吊架不同锚固构件在受火状态下的抗拉能力衰减最大可达到80%,其结... 详细信息

通过对建筑管道支吊架安装方式的调研,对支吊架的典型锚固形式开展常温和火灾状态下的拉拔力对比试验,验证支吊架的不同锚固方式在火灾情况下的耐火稳定性。结果表明,支吊架不同锚固构件在受火状态下的抗拉能力衰减最大可达到80%,其结构稳定性存在薄弱环节,锚固点和吊杆存在耐火稳定性降低乃至丧失的情况,不同锚固构件之间耐火性能也存在较大差异,螺杆式锚栓的耐火稳定性最好,化学锚栓的耐火稳定性最弱,需要在实际工程中采取相应的防火保护措施。

关键词：支吊架锚固方式吊杆耐火稳定性

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镜下肩袖损伤修复两种肱二头肌长头腱处理比较

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中国矫形外科杂志 2023年第20期31卷 1831-1835页

作者：桑鹏刘毅杨继滨孙鹏鹏邹刚金瑛遵义医科大学附属医院骨科贵州遵义563000

[目的]比较肩袖损伤修复术中两种肱二头肌长头腱(long head of biceps tendons,LHBT)断裂和处理方式的临床效果。[方法]回顾性分析2015年1月—2020年3月本院收治的肩袖损伤合并LHBT断裂72例患者的临床资料,完成肩袖修复后,37例患者采用... 详细信息

[目的]比较肩袖损伤修复术中两种肱二头肌长头腱(long head of biceps tendons,LHBT)断裂和处理方式的临床效果。[方法]回顾性分析2015年1月—2020年3月本院收治的肩袖损伤合并LHBT断裂72例患者的临床资料,完成肩袖修复后,37例患者采用挤压钉固定LHBT,35例采用带线锚钉缝合套扎固定LHBT。比较两组的围手术期、随访和影像学资料。[结果]两组患者均顺利完成手术,未发生严重并发症。挤压固定组的手术时间明显少于套扎固定组[(61.4±2.5)min vs(70.2±2.6)min,P0.05)。两组恢复完全负重时间的差异无统计学意义(P>0.05)。影像方面,术后随时间推移,两组患者的CHD均显著增加(P0.05)。[结论]对肩袖损伤合并LHBT断裂,采用界面螺钉挤压固定LHBT,可以缩短手术时间,减少术后引流量,有利于功能恢复。

关键词：肩袖损伤关节镜肱二头肌长头腱固定

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骶骨外脊柱少见部位脊索瘤的临床病理特征分析

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临床肿瘤学杂志 2015年第7期20卷 646-650页

作者：杨勇昆牛晓辉李兰丁宜北京积水潭医院骨肿瘤科北京100035 北京积水潭医院病理科 100035

目的探讨发生于脊柱少见部位的脊索瘤的临床特点及诊断和治疗方法。方法收集2001年12月至2013年10月发生于颈、胸、腰椎的6例脊索瘤患者的临床资料,包括临床表现、影像学和病理学特点以及接受外科治疗的情况。结果 6例脊索瘤的发生部位... 详细信息

目的探讨发生于脊柱少见部位的脊索瘤的临床特点及诊断和治疗方法。方法收集2001年12月至2013年10月发生于颈、胸、腰椎的6例脊索瘤患者的临床资料,包括临床表现、影像学和病理学特点以及接受外科治疗的情况。结果 6例脊索瘤的发生部位：腰椎3例,颈椎2例,胸椎1例。6例均接受手术治疗,术后随访时间平均38.7个月（12~45个月）。术后复发2例,均为囊内切除边界。1例全身多发转移,术后5个月死亡。病理组织学检查均表现为脊索瘤经典型形态：肿瘤细胞片状分布或呈条索状和散在分布于丰富的黏液性间质中,肿瘤细胞主要由含空泡的液滴样细胞和嗜酸性星形细胞构成。结论颈、胸、腰椎脊索瘤罕见,临床症状多不典型,容易漏诊或误诊,需结合影像学和病理学表现诊断,囊内切除后复发率高。

关键词：脊索瘤脊柱临床特点诊断与治疗

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