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Metabolic-associated fatty liver disease and sarcopenia:A double whammy

World Journal of Hepatology 2024年第2期16卷 152-163页

作者： Aditya Viswanath sherouk fouda Cornelius James Fernandez Joseph M Pappachan School of Medicine Leicester UniversityLeicester LE17RHUnited Kingdom School of Health and Biomedical Sciences Rmit UniversityMelbourne VICAustralia Department of Endocrinology and Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

The prevalence of metabolic-associated fatty liver disease(MAFLD)has increased substantially in recent years because of the global obesity ***,now recognized as the number one cause of chronic liver disease in the world,not only increases liver-related morbidity and mortality among sufferers but also worsens the complications associated with other comorbid conditions such as cardiovascular disease,type 2 diabetes mellitus,obstructive sleep apnoea,lipid disorders and *** the interplay between MAFLD and these comorbidities is important to design optimal therapeutic *** can be either part of the disease process that results in MAFLD(e.g.,obesity or adiposity)or a consequence of MAFLD,especially in the advanced stages such as fibrosis and *** can also worsen MAFLD by reducing exercise capacity and by the production of various muscle-related chemical ***,it is crucial to thoroughly understand how we deal with these diseases,especially when they *** explore the pathobiological interlinks between MAFLD and sarcopenia in this comprehensive clinical update review article and propose evidence-based therapeutic strategies to enhance patient care.

关键词： Metabolic-associated fatty liver disease Sarcopenia Sarcopenic obesity Lean metabolic-associated fatty liver disease Cardiovascular disease Liver-muscle axis

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Clinical implications of COVID-19 in patients with metabolicassociated fatty liver disease

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World Journal of Gastroenterology 2023年第3期29卷 487-502页

作者： Mohammad Sadiq Jeeyavudeen Rahul Chaudhari Joseph M Pappachan sherouk fouda Department of Endocrinology and Metabolism University Hospitals of EdinburghEdinburgh EH42XUUnited Kingdom Department of Gastroenterology Hepatology and NutritionVirginia Commonwealth UniversityRichmondVA 23298United States Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom School of Health and Biomedical Sciences RMIT UniversityMelbourne VICAustralia

People across the world are affected by the"coronavirus disease 2019(COVID-19)",brought on by the"SARS-CoV type-2 coronavirus".Due to its high incidence in individuals with diabetes,metabolic syndrome,and metabolic-associated fatty liver disease(MAFLD),COVID-19 has gained much *** metabolic syndrome's hepatic manifestation,MAFLD,carries a significant risk of *** link between the above two conditions has also drawn increasing consideration since MAFLD is intricately linked to the obesity *** of the metabolic syndrome,MAFLD may impact the severity of the viral infections,including COVID-19 or may even be a risk *** important question is whether the present COVID-19 pandemic has been fueled by the obesity and MAFLD *** liver markers are seen elevated in *** patients with associated comorbid conditions like obesity,cardiovascular disease,renal disease,malignancy,hypertension,and old age are prone to develop severe *** is an urgent need for more studies to determine the link between the two conditions and whether it might account for racial differences in the mortality and morbidity rates linked to *** role of innate and adaptive immunity alterations in MAFLD patients may influence the severity of *** review investigates the implications of COVID-19 on liver injury and disease severity and *** also addressed the severity of COVID-19 in patients with prior MAFLD and its potential implications and therapeutic administration in the clinical setting.

关键词： Metabolic-associated fatty liver disease COVID-19 Metabolic syndrome Non-alcoholic steatohepatitis Angiotensin converting enzyme 2

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Management of metabolic-associated fatty liver disease: The diabetology perspective

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World Journal of Gastroenterology 2023年第1期29卷 126-143页

作者： Mohammad Sadiq Jeeyavudeen Shahanas K A Khan sherouk fouda Joseph M Pappachan Department of Endocrinology and Metabolism University Hospitals of EdinburghEdinburgh EH42XUUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom School of Health and Biomedical Sciences RMIT UniversityMelbourneVIC 3046Australia Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology University of ManchesterManchester M139PLUnited Kingdom

The metabolic syndrome as a consequence of the obesity pandemic resulted in a substantial increase in the prevalence of metabolic-associated fatty live disease(MAFLD)and type 2 diabetes mellitus(T2DM).Because of the similarity in pathobiology shared between T2DM and MAFLD,both disorders coexist in many patients and may potentiate the disease-related outcomes with rapid progression and increased complications of the individual *** fact,awareness about this coexistence and the risk of complications are often overlooked by both hepatologists and *** of these individual disorders in a patient should be addressed wholistically using an appropriate multidisciplinary team approach involving both the specialists and,when necessary,liaising with dieticians and *** comprehensive review is to compile the current evidence from a diabetologist's perspective on MAFLD and T2DM and to suggest optimal management strategies.

关键词： Metabolic syndrome Metabolic-associated fatty liver disease Type 2 diabetes mellitus Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Diabetology perspective Obesity

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Pregnancy and Metabolic-associated Fatty Liver Disease:A Clinical Update

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 947-954页

作者： sherouk fouda Madhu Mathew Vennikandam Joseph M.Pappachan Cornelius J.Fernandez School of Health and Biomedical Sciences RMIT UniversityMelbourneVICAustralia Department of Gastroenterology and Hepatology Sparrow HospitalMichigan State University College of Human MedicineLansingMIUSA Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPrestonUK Faculty of Science Manchester Metropolitan UniversityManchesterUK Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Department of Endocrinology&Metabolism Pilgrim HospitalBostonUK

The intricate relationship between metabolic-associated fatty liver disease(MAFLD)and maternal complications has rapidly become a significant health threat in pregnant *** presence of MAFLD in pregnancy increases the maternal risk of metabolic complications and comorbidities for both mother and *** preexistence or development of MAFLD in pregnancy is a complex multifactorial disorder that can lead to further complications for mother and ***,as pregnant women are severely underrepresented in clinical research,there is a great need for a fair inclusion of this group in clinical *** review aims to explore the effects of MAFLD during pregnancy in the context of maternal complications and outcomes and explore the effects of pregnancy on the development and progression of MAFLD within the context of maternal obesity,altered metabolic profiles,gestational diabetes and altered hormonal *** also addressed potential implications for the presence of MAFLD during pregnancy and its management in the clinical setting.

关键词： Metabolic-associated fatty liver disease Pregnancy Maternal complications Fatty liver

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Metabolic complications of hepatitis C virus infection

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World Journal of Gastroenterology 2021年第13期27卷 1267-1282页

作者： Rahul Chaudhari sherouk fouda Ashik Sainu Joseph M Pappachan Department of Medicine Pennsylvania Hospital of the University of PennsylvaniaPennsylvaniaPA 19104United States School of Health and Biomedical Sciences RMIT UniversityMelbourne VIC 3000Australia Department of Gastroenterology and Hepatology Aster Oman HospitalAl GhubraMuscat OM 133Oman Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Hepatitis C virus(HCV) infection is a systemic disease that is implicated in multiple extrahepatic organ dysfunction contributing to its protean manifestations. HCV is associated with diverse extrahepatic disorders including atherosclerosis, glucose and lipid metabolic disturbances, alterations in the iron metabolic pathways, and lymphoproliferative diseases over and above the traditional liver manifestations of cirrhosis and hepatocellular carcinoma. The orchestration between HCV major proteins and the liver-muscle-adipose axis, poses a major burden on the global health of human body organs, if not adequately addressed. The close and inseparable associations between chronic HCV infection, metabolic disease, and cardiovascular disorders are specifically important considering the increasing prevalence of obesity and metabolic syndrome, and their economic burden to patients, the healthcare systems, and society. Cellular and molecular mechanisms governing the interplay of these organs and tissues in health and disease are therefore of significant interest. The coexistence of metabolic disorders and chronic hepatitis C infection also enhances the progression to liver fibrosis and hepatocellular carcinoma. The presence of metabolic disorders is believed to influence the chronicity and virulence of HCV leading to liver disease progression. This comprehensive review highlights current knowledge on the metabolic manifestations of hepatitis C and the potential pathways in which these metabolic changes can influence the natural history of the disease.

关键词： Chronic hepatitis C infection Insulin resistance Metabolic syndrome Cardiovascular diseases Fatty liver Diabetes mellitus

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