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Preparation of Polyfunctionally Substituted Pyridine-2(1<i>h</i>)-Thione Derivatives as Precursors to Bicycles and Polycycles

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International Journal of Organic Chemistry 2014年第5期4卷 319-330页

作者： Fathi A. Abu-Shanab Sayed A. S. Mousa sherif M. sherif Mohamed I. hassan Department of Chemistry Faculty of Science Al-Azhar University Assiut Egypt Department of Chemistry Faculty of Science Gazan University Gazan KSA Department of Chemistry Faculty of Science Cairo University Giza Egypt

Reaction of acetylacetone with 1 mole of dimethylformamide dimethyl acetal (DMFDMA) affords enamine 2a which reacts with cyanothioacetamide to give pyridinethione 3a. Pyridinethione 3a reacts with methyl iodide, halogenated compounds, aromatic aldehyde and malononitrile/elemental sulfur to yiled compounds 7-10 respectively. Reactions of thioether 7 in ethanolic K2CO3, 1 mole DMFDMA and 4-(dimethylamino)benzaldehyde give compounds 11, 13, 14 respectively. Enaminone 12 can be prepared by reaction of compound 11 with DMFDMA. We have demonstrated some reactions in order to show the potential usefulness of the prepared compounds for the preparation of new bipyridyl compounds 15, 16, 18, bicyclic compounds 17 and uncommon tricyclic compounds 20, 21, 22 and 23 respectively using DMFDMA.

关键词： Acetyl Acetone DMFDMA Malononitrile Dimmer Bipyridyl 5-Acetylpyridinethione

Radioactivity Measurements for Some Building Materials in Yemen and Simulation of the Annual Effective Dose Rate

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Radioactivity Measurements for Some Building Materials in Ye...

Integrated Control of Meloidogyne Incognita Infesting Tomato Plants Using Callus Powders Derived from Certain Plants Either Alone or in Combination with Oxamyl under Out-Door Conditions

2012 International Conference on Environment,Energy and Biotechnology（ICEEB 2012）

作者： M.M.sherif S.harb h.Diab Safa.Y.Abdo Department of Physics Faculty of scienceCairo UniversityGiza 12613Egypt. Department of Physics Faculty of scienceSouth Valley University. Egyptian atomic energy authority.

Fifty three samples were collected from two governorates in Yemen (Taiz and hodeida) which covered the most citizens' use of these *** have been measured for gamma radiation using hpGe *** experimentally results for the activity concentrations have been used in the developed model of a Yemeni room to calculate the indoor exposure dose *** annual effective dose rate were ranged between [294.250-329.452],[1029.829] and[929.497] μSvy-1 for a habitant in a room built of concrete,granite and cement brick respectively.

关键词： Radioactive contamination,MCNPcode,Annual effective dose and Yemen

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Journal of Agricultural Science and Technology(A) 2011年第2X期1卷 225-230页

作者： Ahmed h. Nour El-Deen A. G. EI-sherif Fatma A. M. Mostafa A. R. Refaei Nematology Research Unit Agricultural Zoology Dept. Fac. of Agric. Mansoura Univ. El-Mansoura DK. 35516 Egypt

The effect of four dried callus powders derived from certain plants, i.e. tomato, Lycopersicon esculentum; periwinkle, Catharanthus roseus; thorne apple, Datura stramonium and oleander, Nerium oleander applied separately or concomitantly with oxamyl at a half of the recommended dose each on tomato seedlings grown in soil naturally heavy infested with M. incognita under field conditions, indicated that dried callus powder derived from N. oleander either alone or mixed with oxamyl significantly surpassed the other tested treatments in improving percentages of increase in whole plant fresh and shoot dry weights as well as increasing numbers and weights of fruits. Concerning other treatments including oxamyl at a half of recommended dose with each tested callus powder, similar results were evident regarding tomato plant growth parameters. C. roseus plus oxamyl achieved the highest percentage of increase in whole plant fresh weight （141.4%） and shoot dry weight （189.7%） and ranked second to N. oleander ＋ oxamyl in this respect over the untreated plants, respectively. One the other hand, among all tested materials single application of either L. esculentum or oxamyl gave the least values of such criteria which averaged 34.4% and 61.7% or 39.5% and 11.2%, respectively. All tested treatments significantly reduced the total number of galls, egg-masses and eggs in egg-masses especially, dried callus powder of N. oleander which applied singly or combined with oxamyl. The least values of reduction percentages of galls and eggs in egg-masses among all treatments were recorded from tomato plant received dried callus powders of L. esculentum applied alone or concomitant with oxamyl.

关键词： Tomato Meloidogyne incognita MS medium callus powders.

Measurement of Gamma Emitting Radionuclides for Assessment, Environmental hazards of Radiation in Rock and Soil Samples of Shabwah and hadramout Regions, Yemen

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Journal of Geoscience and Environment Protection 2017年第5期5卷 66-75页

作者： sherif S. Nafee Dheya Al-Othmany Safia h.Q. hamidalddin J.h. Al-Zahrani W.R. Alharbi hanan M. Barashed Physics Department Faculty of Science King Abdulaziz University Jeddah Saudi Arabia Physics Department Faculty of Science Alexandria University Alexandria Egypt Nuclear Engineering Department Faculty of Engineering King Abdulaziz University Jeddah Saudi Arabia Physics Department Girls Faculty of Science King Abdulaziz University Jeddah Saudi Arabia

The natural radioactivity of 226Ra, 232Th and 40K and the fallout of 137Cs in soils and granite rocks of two regions in Yemen (Shabwah and hadramout) were measured by using gamma-ray spectrometry (hPGe) detector. The average values of the radionuclides 226Ra, 232Th and 40K in the soil samples are 14.34, 25.78 and 566.05 Bq/kg respectively. For rock samples, the average activity concentration for 226Ra, 232Th and 40K are 45, 106 and 1235 Bq/kg respectively. Low concentration values of 137Cs in soil and rock samples under investigation, are not radiologically important. The radium equivalent activity (Raeq) and external hazard index (hex) of all samples are less than the limits of 370 Bq·kg-1 and unity, respectively. The average values of total absorbed dose rate due to three primordial radionuclides in soil and rock samples are 46.5 nGy/h and 138.36 nGy/h, respectively, where the absorbed average value of the granite is higher than the permitted limit. So, the local people must avoid using these granite samples as the interior decorative materials of dwelling without radioactivity control.

关键词： Gamma Spectrometry Annual Effective Dose External hazard Index

A Single Institutional Phase II Randomized Trial of Whole Brain Radiation Therapy with or without Irinotecan for the Treatment of Brain Metastases from Solid Tumours

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Journal of Cancer Therapy 2015年第10期6卷 859-870页

作者： Soheir S. Ismail Soheir h. Mahmoud Dina A. Salem Ahmed E. Essa Diaa El-Din M. sherif Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Ain-Shams University Cairo Egypt

Background: The relatively suboptimal results of whole brain radiation therapy (WBRT) alone in eradication of brain metastases and an attempt to improve outcomes with WBRT have led to studies combining radiotherapy with chemotherapy drugs that could act as radiosensitizers with a rationale of improving local tumor control. Materials and Methods: This randomized phase II study evaluated the use of Irinotecan concomitant with 37.5 Gray (Gy) of WBRT in 2.5 Gy daily fractions × 5 days each week for 3 weeks versus Whole WBRT alone in patients with brain metastasis (BM) from solid tumors. Fifty patients were randomized to receive either WBRT alone or concomitant with three irinotecan IV infusions 80 mg/m2, 2 hrs before RT on days 1, 8, and 15. Results: The objective response rate (ORR) was significantly improved in patients receiving Irinotecan with radiotherapy versus radiotherapy alone (48% vs. 28%;p = 0.048). The median time to progression of brain metastasis was significantly longer in the irinotecan and WBRT arm as compared to the WBRT arm (8 vs. 5 months;p here was no significant difference in survival between treatment arms (p = 0.361). Irinotecan with radiotherapy was generally well tolerated and did not interfere with the delivery of WBRT. Conclusions: Irinotecan concomitant with WBRT was well tolerated and significantly improved local control of BM compared with WBRT alone. These findings require confirmation in a phase III trial with addition of quality of life assessment.

关键词： Brain Metastasis Irinotecan Whole Cranial Irradiation Concomitant Treatment

Association between IL-37 and VEGF Gene Expression in Psoriasis Pathogenesis in Egyptian Population

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Journal of Biosciences and Medicines 2022年第5期10卷 136-149页

作者： sherif M. El-Sherbini Ahmed Kh. S. Salama Laila A. Rashed Mohamed h. Nafady Samir A. M. El-Masry Genetic Engineering and Biotechnology Research Institute Al-Sadat University Al-Sadat Egypt Faculty of Applied Medical science Misr University for Science and Technology Giza Egypt Faculty of Medicine Cairo University Cairo Egypt

Background: Psoriasis is considered a common skin disease, marked by the production and elevation of inflammatory plaques that regularly shed scales resulting from extensive skin epithelial cell proliferation. T lymphocytes, neutrophils, and other leukocytes enter the irritated skin, resulting in epidermal keratinocyte hyperplasia, vascular hyperplasia, ectasia, and T lymphocyte, neutrophil other forms of leukocyte infiltration. Aim of the Work: the study aimed to investigate the role of IL-37 and VEGF gene expression in the pathogenesis of psoriasis in Egyptian patients. Methodology: Polymerase chain reaction techniques (PCR) were applied to detect VEGF in the skin homogenates of psoriasis patients. In addition, the ELIZA technique was applied to investigate IL-37 in skin homogenates. One hundred cases have been divided into two groups: 50 healthy volunteers as the group I healthy control;50 psoriasis patients as group II. PCR real-time technology was assessed through extracted DNA samples for VEGF amplification in skin homogenate. Result: Our results revealed that psoriasis patients significantly had a substantial reduction in IL-37 compared to the control group (p Conclusion: There is a significant inverse association between IL-37 and VEGF in psoriasis patients. Study findings revealed that IL-37 gene expression decreases while VEGF gene expression increases in psoriatic individuals. Such a measurement may be beneficial in determining the severity of the condition, as well as taking into consideration of the disease’s diagnosis.

关键词： IL-37 VEGF Gene Expression Psoriasis PCR

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基于土壤-环境关系的更新传统土壤图研究

土壤学报 2010年第6期47卷 1039-1049页

作者：杨琳 Fahmy sherif Jiao You hann Sheldon 朱阿兴秦承志徐志刚中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 Potato Research Centre Agriculture and Agri-Food Canada E3B4Z7 Canada Agrifoods Development Branch Department of Natural Resources A2H6JS Canada 中国科学院遥感应用研究所北京100101

传统土壤图是流域管理、生态水文模型所需土壤空间分布信息的主要数据源。然而,受传统制图技术和基础数据质量所限,传统土壤图的空间详细度和属性精确度并不高。随着地理信息技术的发展,如何利用可获取的高质量空间数据和现代空间分析... 详细信息

传统土壤图是流域管理、生态水文模型所需土壤空间分布信息的主要数据源。然而,受传统制图技术和基础数据质量所限,传统土壤图的空间详细度和属性精确度并不高。随着地理信息技术的发展,如何利用可获取的高质量空间数据和现代空间分析技术来更新传统土壤图显得十分必要。基于传统土壤图中的土壤多边形与通过模糊聚类所得环境因子组合之间存在着对应关系这一假设,本文提出了一种从传统土壤图中提取土壤-环境关系知识并利用该知识更新传统土壤图的方法。该方法包括四个步骤:对环境数据进行模糊c均值聚类获取环境因子组合;利用传统土壤图建立环境因子组合与土壤类型间的对应关系;提取土壤-环境关系知识;进行土壤推理制图。将该方法应用于加拿大New B runsw ick省的W akefield研究区,以更新该区现有的1∶20 000的传统土壤图。应用结果表明:更新后的数字土壤图显示了更详细的空间分布信息;经野外独立验证点验证,所得土壤图(制图单元为土壤组合-排水等级)精度高出原土壤图约20%。因此,该方法是一种有效的更新传统土壤图的方法,可增加土壤图的空间详细度、提高土壤图的属性精确度。

关键词：传统土壤图土壤-环境关系知识模糊c均值聚类环境因子组合土壤-环境推理模型(SoLIM)

Gastric polyps: Association with helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study

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World Journal of Gastrointestinal Endoscopy 2015年第10期7卷 995-1002页

作者： sherif Elhanafi Mohammed Saadi Wynee Lou Indika Mallawaarachchi Alok Dwivedi Marc Zuckerman Mohamed O Othman Division of Gastroenterology Department of Internal Medicine Paul L.Foster School of Medicine Texas Tech University Health Sciences Center Division of Biostatistics and Epidemiology Department of Biomedical Sciences Paul L.Foster School of Medicine Texas Tech University Health Sciences Center Gastroenterology and hepatology Section Department of Internal Medicine Baylor College of Medicine

aim:To assess the endoscopic characteristics of gastric polyps and their association with helicobacter pylori(***)status in a predominantly hispanic population.m EThODS:We conducted a retrospective study of all esophagogastroduodenoscopies performed at our ***,endoscopic and histopathological data were *** of patients into hispanic and Non-hispanic was based on *** without resection/biopsy were not included in the *** of polyps type was based on histological *** way analysis of variance was used to compare continuousvariables among different polyp types and Fisher’s exact test was used compare categorical variables among polyp *** and adjusted comparisons of demographic and clinical characteristics were performed according to the *** status and polyp type using logistic ***:Of 7090 patients who had upper endoscopy,335 patients had gastric polyps(4.7%).Resection or biopsy of gastric polyps was performed in 296 patients(88.4%)with a total of 442 polyps removed or *** 296 patients,87(29%)had hyperplastic polyps,82(28%)had fundic gland polyps and 5(1.7%)had adenomatous *** polyps were significantly associated with positive *** status compared with fundic gland polyps(OR=4.621;95%CI:1.92-11.13,P=0.001).hyperplastic polyps were also found to be significantly associated with portal hypertensive gastropathy compared with fundic gland polyps(OR=6.903;95%CI:1.41-33.93,P=0.0174).Out of 296 patients,30(10.1%)had a followup endoscopy with a mean duration of 26±16.3 *** development of cancer was not noted in any of the patients during follow up *** ON:Gastric hyperplastic polyps were significantly associated with positive *** status and portal hypertensive gastropathy as compared with fundic gland polyps.

关键词： Gastric polyps Fundic gland polyp hyperplasticpolyp Adenomatous polyps Chronic gastritis helicobacter pylori

Effect of Ketamine Instillation on Acute and Chronic Post Mastectomy Pain, a Dose Finding Clinical Study

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Open Journal of Anesthesiology 2022年第4期12卷 146-159页

作者： Fatma El sherif hany Elmorabaa Khaled Mohamed Fares Sahar Abdel-Baky Mohamed Nourhan M. Elgalaly Khalid Rezk Moaaz Tohamy Department of Anesthesia ICU and Pain Management South Egypt Cancer Institute Assiut University Assiut Egypt Department of Anesthesia ICU and Pain Management Faculty of Medicine Assuit University Assiut Egypt

Background: Uncontrolled acute postoperative pain is considered a risk factor for the development of chronic pain afterward. Objectives: To explore the most effective dose of ketamine instillation (1 of 3 doses: 1, 2, or 3 mg/kg) for acute and chronic post mastectomy pain (PMP). Methods: Ninety female patients with cancer breast, aged (18 - 60 yrs), weighted (50 - 90 kg), scheduled for modified radical mastectomy, randomly allocated into 3 groups to receive ketamine instillation after surgical homeostasis before wound closure (1 of 3 doses;1, 2, or 3 mg/kg as A, B or C groups respectively) patients were followed up for 48 h for acute pain (total morphine consumption, the first request of analgesia and visual analog scale at rest and movement (VASR/M), chronic pain by Leeds assessment of neuropathic signs and symptoms (LANSS) for six-months, hemodynamics, and side effects. Results: Median total dose of morphine consumption was 8 mg (5 - 10) versus 6 mg (6 - 7) in A and B groups respectively in the first 48 h postoperatively. Lowest VASR/M was recorded in C then B and lastly A group (P = 0.037). No patients in the C group requested analgesia versus thirty (100%) and nine (30%) patients in the A and B groups respectively with the first request of analgesia was 12 h (5 - 36) in the A group versus 30 h (12 - 36) in the B group respectively (P Conclusion: Ketamine instillation effectively controlled acute post mastectomy pain (PMP) in a dose-dependent manner and reduced the incidence and severity of chronic pain in patients who undergoing a modified radical mastectomy.

关键词： Acute Pain Breast Cancer Chronic Pain Ketamine Instillation Modified Radical Mastectomy