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Beta-endorphin in serum and seminal plasma in infertile men

Asian Journal of Andrology 2006年第6期8卷 709-712页

作者： Shawky El-Haggar Salah El-Ashmawy Ahmed Attia Taymour Mostafa M.M.Farid Roaiah Ashraf Fayez sherif ghazi Wael Zohdy Nagwa Roshdy Andrology Department Clinical Pathology Department Medical Biochemistry Department Faculty of MedicineCairo UniversityCairo 12311Egypt

Aim： To access beta-endorphin levels in serum as well as seminal plasma in different infertile male groups. Methods： Beta-endorphin was estimated in the serum and seminal plasma by enzyme-linked immunosorbent assay （ELISA） method in 80 infertile men equally divided into four groups： non-obstructive azoospermia （NOA）, obstructive azoospermia （OA）, congenital bilateral absent vas deferens （CBVAD） and asthenozoospermia. The results were compared to those of 20 normozoospermic proven fertile men. Results： There was a decrease in the mean levels of betaendorphin in the seminal plasma of all successive infertile groups （mean ± SD： NOA 51.30 ± 27.37, OA 51.88 ± 9.47, CBAVD 20.36 ± 13.39, asthenozoospermia 49.26 ± 12.49 pg/mL, respectively） compared to the normozoospermic fertile control （87.23 ± 29.55 pg/mL）. This relation was not present in mean serum level of beta-endorphin between four infertile groups （51.09 ± 14.71, 49.76 ± 12.4, 33.96 ± 7.2, 69.1 ± 16.57 pg/mL, respectively） and the fertile control group （49.26 ± 31.32 pg/mL）. The CBVAD group showed the lowest seminal plasma mean level of beta-endorphin. Testicular contribution of seminal beta-endorphin was estimated to be approximately 40%. Seminal beta-endorphin showed significant correlation with the sperm concentration （r = 0.699, P = 0.0188） and nonsignificant correlation with its serum level （r = 0.375, P = 0.185） or with the sperm motility percentage （r = 0.470, P = 0.899）. Conclusion： The estimation of beta-endorphin alone is not conclusive to evaluate male reproduction as there are many other opiates acting at the hypothalamic pituitary gonadal axis.

关键词： azoospermia beta-endorphin male infertility opioid peptides semen seminal plasma

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Efficient Relational Techniques for Processing Graph Queries

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Journal of Computer Science & Technology 2010年第6期25卷 1237-1255页

作者： sherif Sakr ghazi Al-Naymat School of Computer Science and Engineering University of New South Wales Managing Complexity Group National ICT Australia (NICTA)

Graphs are widely used for modeling complicated data such as social networks,chemical compounds,protein interactions and semantic *** effiectively understand and utilize any collection of graphs,a graph database that efficiently supports elementary querying mechanisms is crucially *** example,Subgraph and Supergraph queries are important types of graph queries which have many applications in practice.A primary challenge in computing the answers of graph queries is that pair-wise comparisons of graphs are usually hard *** database management systems（RDBMSs） have repeatedly been shown to be able to efficiently host different types of data such as complex objects and XML *** derive much of their performance from sophisticated optimizer components which make use of physical properties that are specific to the relational model such as sortedness,proper join ordering and powerful indexing *** this article,we study the problem of indexing and querying graph databases using the relational *** present a purely relational framework for processing graph *** framework relies on building a layer of graph features knowledge which capture metadata and summary features of the underlying graph *** describe different querying mechanisms which make use of the layer of graph features knowledge to achieve scalable performance for processing graph ***,we conduct an extensive set of experiments on real and synthetic datasets to demonstrate the efficiency and the scalability of our techniques.

关键词： graph database graph query subgraph query supergraph query

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