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The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： mENNA AL-ADL mAGDY mYOUSSEF AHmED el-SEBAIE sherif REFAAT AFAF el-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including chemotherapeutics.The gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used drugs.This research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide chemotherapy.DNA was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy individuals.The presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed up.The CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,pminant(GT+TT vs.GG,OR=5.4,pmodels.Following cyclophosphamide chemotherapy,we found that the patients with variant genotypes(GT+TT)were less likely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian patients.This variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

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Comparative study between three carbonaceous nanoblades and nanodarts for antimicrobial applications

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Journal of Environmental Sciences 2024年第2期136卷 594-605页

作者： mohamed S.Selim Ahmed m.Azzam mohamed A.Shenashen Shimaa A.Higazy Bayaumy B.mostafa sherif A.el-Safty National Institute for materials Science(NImS) 1-2-1 SengenTsukuba-ShiIbaraki-Ken 305-0047Japan Petroleum Application Department Egyptian Petroleum Research InstituteNasr City 11727Egypt Department of Environmental Research Theodor Bilharz Research InstituteGizaEgypt

The design of nanostructured materials occupies a privileged position in the development and management of affordable and effective technology in the antibacterial sector.Here,we discuss the antimicrobial properties of three carbonaceous nanoblades and nanodarts materials of graphene oxide(GO),reduced graphene oxide(RGO),and single-wall carbon nanotubes(SWCNTs)that have a mechano-bactericidal effect,and the ability to piercing or slicing bacterial membranes.To demonstrate the significance of size,morphology and composition on the antibacterial activity mechanism,the designed nanomaterials have been characterized.The minimum inhibitory concentration(mIC),standard agar well diffusion,and transmission electron microscopy were utilized to evaluate the antibacterial activity of GO,RGO,and SWCNTs.Based on the evidence obtained,the three carbonaceous materials exhibit activity against all microbial strains tested by completely encapsulating bacterial cells and causing morphological disruption by degrading the microbial cell membrane in the order of RGO>GO>SWCNTs.Because of the external cell wall structure and outer membrane proteins,the synthesized carbonaceous nanomaterials exhibited higher antibacterial activity against Gram-positive bacterial strains than Gram-negative and fungal microorganisms.RGO had the lowest mIC values(0.062,0.125,and 0.25 mg/mL against B.subtilis,S.aureus,and E.coli,respectively),as well as minimum fungal concentrations(0.5 mg/mL for both A.fumigatus and C.albicans).At 12 hr,the cell viability values against tested microbial strains were completely suppressed.Cell lysis and death occurred as a result of severe membrane damage caused by microorganisms perched on RGO nanoblades.Our work gives an insight into the design of effective graphene-based antimicrobial materials for water treatment and remediation.

关键词： Antimicrobial properties Nanoblades mechano-bactericidal effect RGO nanosheets Gram-positive bacteria Cell viability

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Predicting resilient modulus of recycled concrete and clay masonry blends for pavement applications using soft computing techniques

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Frontiers of Structural and Civil Engineering 2019年第6期13卷 1379-1392页

作者： mosbeh R.KALOOP Alaa R.GABR sherif m.el-badawy Ali ARISHA Sayed SHWALLY Jong Wan HU Department of Civil and Environmental Engineering Incheon National UniversityIncheon 22012South Korea Incheon Disaster Prevention Research Center Incheon National UniversityIncheon 22012South Korea Department of Public Works and Civil Engineering Mansoura UniversityMansoura 35516Egypt

To date,very few researchers employed the Least Square Support Vector machine(LSSVm)in predicting the resilient modulus(mr)of Unbound Granular materials(UGms).This paper focused on the development of a LSSVm model to predict the mT of recycled materials for pavement applications and comparison with other different models such as Regression,and Artificial Neural Network(ANN).Blends of Recycled Concrete Aggregate(RCA)with Recycled Clay masonry(RCm)with proportions of 100/0,90/10,80/20,70/30,55/45,40/60,20/80,and 0/100 by the total aggregate mass were evaluated for use as UGms.RCA/RCm materials were collected from dumps on the sides of roads around mansoura city,Egypt.The investigated blends were evaluated experimentally by routine and advanced tests and the mr values were detennined by Repeated Load Triaxial Test(RLTT).Regression,ANN,and LSSVm models were utilized and compared in predicting the mr of the investigated blends optimizing the best design model.Results showed that the mx values of the investigated RCA/RCm blends were generally increased with the decrease in RCm proportion.Statistical analyses were utilized for evaluating the performance of the developed models and the inputs sensitivity parameters.Eventually,the results approved that the LSSVm model can be used as a novel tool to estimate the mx of the investigated RCA/RCm blends.

关键词： Least Square Support Vector machine Artificial Neural Network resilient modulus Recycled Concrete Aggregate Recycled Clay masonry

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Strain engineering in electrocatalysis:Strategies,characterization,and insights

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Nano Research 2024年第5期17卷 3603-3621页

作者： Qibo Deng Peng Xu Hassanien Gomaa mohamed A.Shenashen sherif A.el-Safty Cuihua An Li-Hua Shao Ning Hu School of mechanical Engineering Hebei University of TechnologyTianjin 300401China Department of Chemistry Faculty of ScienceAl-Azhar University71524AssiutEgypt Department of Petrochemical Egyptian Petroleum Research Institute(EPRI)Nasr City11727CairoEgypt Center for Functional materials National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki-ken305-0047Japan State Key Laboratory of Reliability and Intelligence electrical Equipment Key Laboratory of Advanced Intelligent Protective Equipment TechnologyMinistry of Educationand School of Mechanical EngineeringHebei University of TechnologyTianjin 300401China National Key Laboratory of Strength and Structural Integrity Institute of Solid MechanicsSchool of Aeronautic Science and EngineeringBeihang UniversityBeijing100191China Advanced Equipment Research Institute Co. Ltd.of HEBUTTianjin 300401China

Strain engineering,as a cutting-edge method for modulating the electronic structure of catalysts,plays a crucial role in regulating the interaction between the catalytic surface and the adsorbed molecules.The electrocatalytic performance is influenced by the electronic structure,which can be achieved by introducing the external forces or stresses to adjust interatomic spacing between surface atoms.The challenges in strain engineering research lie in accurately understanding the mechanical impact of strain on performance.This paper first introduces the basic strategy for generating the strain,summarizes the different strain generation forms and their advantages and disadvantages.The progress in researching the characterization means for the lattice strains and their applications in the field of electrocatalysis is also emphasized.Finally,the challenges of strain engineering are introduced,and an outlook on the future research directions is provided.

关键词： strain electrocatalysis characterization chemical reaction kinetics lattice mismatch

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Intelligent Fractional-Order Controller for SmES Systems in Renewable Energy-Based microgrid

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Computer modeling in Engineering & Sciences 2024年第8期140卷 1807-1830页

作者： Aadel m.Alatwi Abualkasim Bakeer sherif A.Zaid Ibrahem E.Atawi Hani Albalawi Ahmed m.Kassem electrical Engineering Department Faculty of EngineeringUniversity of TabukTabuk47913Saudi Arabia Industrial Innovation and Robotic Center(IIRC) University of TabukTabuk47731Saudi Arabia Department of electrical Engineering Faculty of EngineeringAswan UniversityAswan81542Egypt Renewable Energy and Environmental Technology Centre University of TabukTabuk47913Saudi Arabia electrical Engineering Department Faculty of EngineeringSohag UniversitySohag82524Egypt

An autonomous microgrid that runs on renewable energy sources is presented in this article.It has a supercon-ducting magnetic energy storage(SmES)device,wind energy-producing devices,and an energy storage battery.However,because such microgrids are nonlinear and the energy they create varies with time,controlling and managing the energy inside them is a difficult issue.Fractional-order proportional integral(FOPI)controller is recommended for the current research to enhance a standalone microgrid’s energy management and performance.The suggested dedicated control for the SmES comprises two loops:the outer loop,which uses the FOPI to regulate the DC-link voltage,and the inner loop,responsible for regulating the SmES current,is constructed using the intelligent FOPI(iFOPI).The FOPI+iFOPI parameters are best developed using the dandelion optimizer(DO)approach to achieve the optimum performance.The suggested FOPI+iFOPI controller’s performance is contrasted with a conventional PI controller for variations in wind speed and microgrid load.The optimal FOPI+iFOPI controller manages the voltage and frequency of the load.The behavior of the microgrid as a reaction to step changes in load and wind speed was measured using the proposed controller.mATLAB simulations were used to evaluate the recommended system’s performance.The results of the simulations showed that throughout all interruptions,the recommended microgrid provided the load with AC power with a constant amplitude and frequency.In addition,the required load demand was accurately reduced.Furthermore,the microgrid functioned incredibly well despite SmES and varying wind speeds.Results obtained under identical conditions were compared with and without the best FOPI+iFOPI controller.When utilizing the optimal FOPI+iFOPI controller with SmES,it was found that the microgrid performed better than the microgrid without SmES.

关键词： Fractional-order proportional integral(FOPI) intelligent controller renewable energy resources superconducting magnetic energy storage optimization

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Double Deep Q-Network method for Energy Efficiency and Throughput in a UAV-Assisted Terrestrial Network

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Computer Systems Science & Engineering 2023年第7期46卷 73-92页

作者： mohamed Amine Ouamri Reem Alkanhel Daljeet Singh el-sayed m.el-kenaway sherif S.m.Ghoneim University Grenoble Alpes CNRSGrenoble INPLIGDRAKKAR Teams38000GrenobleFrance Laboratoire d’informatique médical Universitéde BejaiaTarga OuzemourQ22R+475Algeria Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Research and Development Centre for Space ResearchSchool of Electronics and Electrical EngineeringLovely Professional UniversityPhagwara144411India Department of Communication and electronics Delta Higher Institute of Engineering and TechnologyMansouraEgypt electrical Engineering Department College of EngineeringTaif UniversityP.O.BOX 11099Taif21944Saudi Arabia

Increasing the coverage and capacity of cellular networks by deploying additional base stations is one of the fundamental objectives of fifth-generation(5G)networks.However,it leads to performance degradation and huge spectral consumption due to the massive densification of connected devices and simultaneous access demand.To meet these access conditions and improve Quality of Service,resource allocation(RA)should be carefully optimized.Traditionally,RA problems are nonconvex optimizations,which are performed using heuristic methods,such as genetic algorithm,particle swarm optimization,and simulated annealing.However,the application of these approaches remains computationally expensive and unattractive for dense cellular networks.Therefore,artificial intelligence algorithms are used to improve traditional RA mechanisms.Deep learning is a promising tool for addressing resource management problems in wireless communication.In this study,we investigate a double deep Q-network-based RA framework that maximizes energy efficiency(EE)and total network throughput in unmanned aerial vehicle(UAV)-assisted terrestrial networks.Specifically,the system is studied under the constraints of interference.However,the optimization problem is formulated as a mixed integer nonlinear program.Within this framework,we evaluated the effect of height and the number of UAVs on EE and throughput.Then,in accordance with the experimental results,we compare the proposed algorithm with several artificial intelligence methods.Simulation results indicate that the proposed approach can increase EE with a considerable throughput.

关键词： UAV terrestrial network reinforcement learning mmWave resource allocation

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氮掺杂对环境空气中TiO_(2)纳米催化剂抗甲醛光催化矿化的影响

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Chinese Journal of Catalysis 2024年第4期59卷 303-323页

作者： Dae-Hwan Lim Aadil Bathla Hassan Anwer sherif AYounis Danil WBoukhvalov Ki-Hyun Kim 汉阳大学土木与环境工程系首尔韩国国立科技大学环境工程系伊斯兰堡巴基斯坦埃及石油研究所分析与评估部开罗埃及南京林业大学材料物理与化学研究所理学院江苏南京乌拉尔联邦大学物理与技术研究所叶卡捷琳堡俄罗斯

通过氮掺杂TiO_(2)(N-TiO_(2))浸渍蜂窝过滤器构建了一系列原型光催化空气净化器(AP(N_(x)-C_(y)))系统,并用于在UV-LED光(1 W)照射条件下光催化分解0.5-5 ppm甲醛(CH_(2)O)蒸汽.在上述催化过滤器系统中,Nx和Cy分别代表N/Ti摩尔比(0-20)... 详细信息

通过氮掺杂TiO_(2)(N-TiO_(2))浸渍蜂窝过滤器构建了一系列原型光催化空气净化器(AP(N_(x)-C_(y)))系统,并用于在UV-LED光(1 W)照射条件下光催化分解0.5-5 ppm甲醛(CH_(2)O)蒸汽.在上述催化过滤器系统中,Nx和Cy分别代表N/Ti摩尔比(0-20)和N-TiO_(2)浓度(2-20 mg mL^(-1)).光催化分解实验结果表明,AP(N_(10)-C_(10))的性能最好,其催化CH2O转化为CO_(2)的转化率最高,循环反应10次后CO_(2)产率仍达到89.2%,在干燥空气中的清洁空气输送速率为9.45 L min^(-1).N10-C10的电荷载流子寿命(τa:1.70 ns)优于其他样品(如纯TiO_(2)的电荷载流子寿命为1.37 ns),这表明N缺陷(No)有助于降低带隙(3.10 eV)和产生氧空位OVs-Ti^(3+),这与密度泛函理论(DFT)模拟结果一致.采用原位漫反射红外傅里叶变换、电子顺磁共振和DFT分析等多种方法研究了CH_(2)O的光催化氧化途径.结果表明,氧化过程涉及多个能量有利的中间步骤(例如CH2O以CH_(2)O_(2)的形式在TiO_(2)-OV{110}表面的桥连O/OH基团上发生放热共价吸附,随后通过催化脱氢/氧化反应直接生成CO_(2):CH_(2)O_(2)/HCOO^(-)+•OH→H_(2)O+CO_(2)).这些步骤与具有N杂质的{101}表面上化学活性Ti原子的态密度计算结果一致.预计No缺陷和OVs的存在将通过降低活化能垒来影响反应能量和中间产物,从而在加湿条件下实现有效的矿化.综上,本文为设计和构建先进的光催化系统,并用于环境空气中醛类挥发性有机物(VOCs)的有效矿化提供了新思路.

关键词：光催化蜂窝过滤器甲醛氮掺杂TiO_(2) 密度泛函理论计算催化反应途径空气净化

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Preparation of solar-enhanced AlZnO@carbon nano-substrates for remediation of textile wastewaters

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Journal of Environmental Sciences 2020年第6期32卷 52-68页

作者： Esraa m.el-Fawal sherif A.Younis Yasser m.moustafa Philippe Serp Central Laboratories Analysis and Evaluation DepartmentEgyptian Petroleum Research InstituteNasr CityCairo 11727Egypt Laboratoire de Chimie de Coordination(LCC) Unite Propre de Recherche(UPR)Du Centre National de La Recherche Scientifique(CNRS)8241Composante de L’Ecole Nationale D’Ingenieurs en Arts Chimiques et Technologiques(ENSIACET)Universite de ToulouseUniversite Paul Sabatier(UPS)Institut National Polytechnique(INP)-LCC4 Allee Emile Monso31030Toulouse Cedex 4France

Photoactive aluminum doped ZnO(AlZnO)was synthesized by sol-gel method.After that,AlZnO photocatalyst was deposited on five carbon-based materials(CBms)using ultrasonic route followed by solid-state mixing using ball mill.The CBms used were poly aniline(PANI),carbon nitride(CN),carbon nanotubes(CNT),graphene(G),and carbon nanofibers(CNF).The crystal phases,elemental compositions,morphological,and optical properties of the AlZnO@CBms composites were investigated.Experimental results revealed that two of AlZnO@CBms composites exhibited superior bleaching efficiency(100%removal)and photocatalytic stability(three cycles)for 50μmol/L methylene Blue(mB)contaminated water after 60 min irradiation in visible light at pH 6.5,0.7%H2O2,and 5 g/L inorganic salts.Under optimum conditions,AlZnO@CBms nanocomposites were employed for the treatment of mixed dyestuffs composed of mB,methyl Orange(mO),Astrazone Blue FRR(BB 69),and Rhodamine B(RhB)dyes under dark,ultraviolet,visible,and direct sunlight.For mixed dyestuffs,the AlZnO@G achieved the highest dye sorption capacity(60.91μmol dye stuffs/g)with kinetic rate 8.22×10^-3 min^-1 in 90 min via multi-layer physisorption(Freundlich isotherm)on graphene sheet.In additions,AlZnO@CN offered the highest photo-kinetic rate(Kphoto)of^54.1×10^-3 min^-1(93.8%after 60 min)under direct sunlight.Furthermore,the selective radical trapping experiment confirmed that the holes and oxidative superoxide radicals are crucial on dyes photodegradation pathway.Owing to their superior performance,AlZnO@G and AlZnO@CN nanocomposites can offer an effective in-situ solar-assisted adsorption/photocatalytic remediation of textile wastewater effluents.

关键词： Carbon nanomaterials AlZnO photocatalyst Hybrid adsorption/photo-catalysis Kinetic and isotherm modeling Textile wastewater remediation

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Special Column on Recent Advances in PCms as Thermal Energy Storage in Energy Systems

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Journal of Thermal Science 2024年第2期33卷 395-395页

作者： mohammad Hossein AHmADI Tingzhen mING marc A.ROSEN S.A.sherif mohammad mehdi RASHIDI Shahrood University of Technology Iran Wuhan University of Technology China University of Ontario Institute of Technology Canada University of Florida USA University of electronic Science and Technology of China China

Thermal energy storage technology has the advantages of high energy storage density,small size,and high energy conversion efficiency.It is one of the key energy storage technologies and an important way to achieve carbon peaking and carbon neutrality goals.Phase change materials (PCms) offer this opportunity to store high amount of energy and release it in the form of latent heat when needed,and therefore have the advantage of being capable to alleviate the intrinsic intermittency of renewable power production,especially in wind and solar farms.

关键词： efficiency store latent

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Glycated Hemoglobin HbA1c:Permittivity Experimental Applications with Some mathematical Concepts,Temperature and Frequency Variations

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Journal of Renewable materials 2022年第9期10卷 2335-2354页

作者： Soliman Abdalla sherif Kandil Waleed el-Shirbeeny Fatma Bahabri Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of materials Science Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt Department of Physics Faculty of ScienceJeddah UniversityJeddahSaudi Arabia

Diabetes disorder turns smoothly to be a global epidemic disorder and the glycated hemoglobin(HbA1c)starts to be an efficient marker of it.The dielectric spectroscopy on different human normal-and diabetic-blood samples is used to characterize and to estimate the HbA1c concentration.“dc-”and ac-measurement of the complex conductivity in the temperature range from 280 K up to 320 K,and in the frequency range from one Hz up to 32 mHz have been performed.The thermal activation energy,ΔEσ,of dc-electric conductivity lies in the range 95 meVmeV;while the thermal activation energy,ΔEτ,of RBCs relaxation time is aboutΔEτ=140 meV.The experimental data have been modeled by a physical-model and good fittings have been found between calculated and experimental values.The effective number of charges,nG,T,is estimated after Cole and Cole curves.One has found that nG,T increases with both temperature,T,and with the glycation rate GG.This increase may shed some light on an effective and possible way to treat(and to detect)diabetes disorders via eliminating the excess electric charges produced by glycation processes.The present work sheds the light on the possible combination of focused ultrasound with magnetic resonance imaging to study the dielectric-thermal variations of glycated-RBCs,which can lead to very precise and non-invasive monitoring of glycation concentration in vivo and in vitro via magnetic resonance-thermometry.

关键词： Glycated-hemoglobin rate thermal characterization red blood cells RBCs relaxation of RBCs dielectric constant mathematical model

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