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Im.act of carbim.zole com.ined with vitam.n E on testicular injury induced by experim.ntal hyperthyroidism.in adult albino rats:oxidative/inflam.atory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ram.dan S Hussein m.ustafa m.Eyada Rashad m.m.stafa Sam.h m.Elaidy shereen H Elsayed Hany m.Saad Departm.nt of Derm.tology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Departm.nt of Derm.tology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Departm.nt of Derm.tology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Departm.nt of Andrology and Sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Departm.nt of Clinical Pharm.cology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Departm.nt of Rehabilitation Sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid horm.nes play essential roles in sperm.togenesis,but their effects on infertile m.les rem.in poorly *** study aim.d to evaluate the im.act of com.ining carbim.zole(CBZ)with vitam.n E(VE)on testicular injury induced by experim.ntal hyperthyroidism.in adult albino rats,focusing on oxidative,inflam.atory,and apoptotic *** this experim.ntal study,64 adult m.le albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+CBZ+VE-treated).The study was conducted in the Faculty of m.dicine,Suez Canal University(Ism.ilia,Egypt).After cervical decapitation,both testes and epididym.s were exam.ned histopathologically and *** differences were observed am.ng groups concerning m.londialdehyde(m.A),glutathione(GSH),superoxide dism.tase(SOD),and catalase(CAT;all Pm.rase chain reaction analysis showed significant differences in tum.r necrosis factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-associated X protein(BAX),B-cell lym.hom. 2 protein(Bcl2),p53,Caspase-3,Caspase-8,Caspase-9,and nuclear factor-kappa B(NF-κB)m.NA levels(all Pm.niferous tubules and ***,the Group VIII showed im.roved sperm.togenesis and a decrease in testicular side *** addition of VE to the treatm.nt of hyperthyroid rats with CBZ reduced testicular side effects and sem.niferous tubular affection when potentially im.roving *** research is needed to elucidate the underlying m.chanism. fully.

关键词： antithyroid drugs testicular injury thyroid gland vitam.n E

Rao Algorithm.-Based Structure Optim.zation for Heterogeneous Wireless Sensor Networks

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Com.uters, m.terials & Continua 2024年第1期78卷 873-897页

作者： shereen K.Refaay Sam.a A.Ali m.um.n T.El-m.legy Louai A.m.ghrabi Ham.y H.El-Sayed Faculty of Com.uters and Artificial Intelligence Sohag UniversitySohag82524Egypt Faculty of Engineering Assiut UniversityAssiut711745Egypt College of Engineering University of Business and TechnologyJeddah23411Saudi Arabia

The structural optim.zation of wireless sensor networks is a critical issue because it im.acts energy consum.tion and hence the network’s *** studies have been conducted for hom.geneous networks,but few have been perform.d for heterogeneouswireless sensor *** paper utilizes Rao algorithm. to optim.ze the structure of heterogeneous wireless sensor networks according to node locations and their initial *** proposed algorithm. lack algorithm.specific param.ters and m.taphorical *** proposed algorithm. exam.ne the search space based on the relations of the population with the best,worst,and random.y assigned *** proposed algorithm. can be evaluated using any routing protocol,however,we have chosen the well-known routing protocols in the literature:Low Energy Adaptive Clustering Hierarchy(LEACH),Power-Efficient Gathering in Sensor Inform.tion System.(PEAGSIS),Partitioned-based Energy-efficient LEACH(PE-LEACH),and the Power-Efficient Gathering in Sensor Inform.tion System. Neural Network(PEAGSIS-NN)recent routing *** com.are our optim.zed m.thod with the Jaya,the Particle Swarm.Optim.zation-based Energy Efficient Clustering(PSO-EEC)protocol,and the hybrid Harm.ny Search Algorithm.and PSO(HSA-PSO)*** efficiencies of our proposed algorithm. are evaluated by conducting experim.nts in term. of the network lifetim.(first dead node,half dead nodes,and last dead node),energy consum.tion,packets to cluster head,and packets to the base *** experim.ntal results were com.ared with those obtained using the Jaya optim.zation *** proposed algorithm. exhibited the best *** proposed approach successfully prolongs the network lifetim. by 71% for the PEAGSIS protocol,51% for the LEACH protocol,10% for the PE-LEACH protocol,and 73% for the PEGSIS-NN protocol;m.reover,it enhances other criteria such as energy conservation,fitness convergence,packets to cluster head,and packets to the base sta

关键词： Wireless sensor networks Rao algorithm. optim.zation LEACH PEAGSIS

Potential Insecticidal Effect of a Wasp (Polistes dom.nulus) and a Bee (Apis m.llifera) Venom. in Controlling Spodoptera littoralis

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Advances in Entom.logy 2022年第4期10卷 300-319页

作者： Reham.Z. Sadek shereen m. El Banna Fayez m. Sem.da Sam. m. Zalat Zoology Departm.nt Faculty of Science Suez Canal University Ismailia Egypt

Cotton leaf worm. Spodoptera littoralis, is considered one of the m.st com.on arthropod pests that contribute to crop devastation of cotton. Previously, agricultural pests were controlled through the application of chem.cal insecticides. However, insecticide-resistant insect populations em.rgence, as well as increasing concerns about the environm.ntal and hum.n health risks. Venom.us anim.ls introduce valuable sources of bioactive com.ounds which are em.loyed for defence. Som. of these toxins have high phyletic specificity, m.king them.appropriate for use in IPm.program.. This study aim. to test the insecticidal effects of Polistes dom.nulus and Apis m.llifera venom.. Crude venom. were exam.ned for their insecticidal effect against cotton leaf worm. by four different application m.thods including: leaf dipping, integum.nt dropping, spraying, and injection. The data dem.nstrated a strong response to purified (Polistes dom.nulus) venom.at an initial tim. than that of honey bee (Apis m.llifera) which increases response with increasing the dose and the tim. interval. A dosage of 0.015 - 0.16 m. of both venom. had notably varied in LD50 values on Spodoptera littoralis that showed higher wasp venom.toxicity. Cotton leaf worm. showed m.re susceptibility and m.rtality to the Polistes sp. venom.than that of honey bees.

关键词： Social Insects Honey Bee Yellow Jacket Enzym.s Pest Control Bio-Insecticides Biological Control

m.BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals

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World Journal of Gastroenterology 2020年第21期26卷 2864-2876页

作者： shereen A Saleh m.ham.d m.Salam. m.rwan m.Alhusseini Ghada A m.ham.d Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11341Egypt

BACKGROUND Assessing liver fibrosis is im.ortant for predicting the efficacy of direct-acting antivirals(DAAs)and patient ***-invasive techniques to assess liver fibrosis are becom.ng ***,serum.m.c-2 binding protein glycosylation isom.r(m.BPGi)was identified as a non-invasive m.rker of liver *** To investigate the diagnostic accuracy of m.BPGi in assessing liver fibrosis in patients with chronic hepatitis C(CHC)treated with *** From.Decem.er 2017 to August 2018,80 treatm.nt-naive adult patients with CHC who were eligible for DAAs therapy were consecutively enrolled in this observational cohort *** 12 weeks,65 patients were treated with sofosbuvir/daclatasvir,and 15 patients were treated with sofosbuvir/daclatasvir and a weight-based dose of ribavirin at knowledge and technology association for hepatitis C m.nagem.nt clinic,Cairo,*** m.asured serum.m.BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness m.asurem.nts(LSm.at baseline and 12 weeks after the end of *** m.BPGi levels were m.asured using enzym.-linked im.unosorbent *** All patients achieved sustained virologic response(SVR12)(100%).Serum.m.BPGi levels,LSm.FIB-4 score and PAPAS index decreased significantly at SVR12(Pm.m.BPGi levels correlated positively with LSm.at baseline and SVR12(Pm.ared with the FIB-4 score and PAPAS index,m.BPGi was the best m.rker to distinguish patients with grade F4 fibrosis(AUC=0.801,Pm.grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with grade F3-4 from.grade F0-2 fibrosis(AUC=0.730,Pm.grade F0-1 fibrosis(AUC=0.763,Pm.BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis(AUC=0.844,Pm.grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with grade F3-4 from.grade F0-2 fibrosis(AUC=0.891,P<0.001),and patients with grad

关键词： Hepatitis C virus Liver fibrosis Hum.n m.c-2 binding protein Antiviral agents Sustained virologic response Elastography

Serum.Ferritin: Is It an Independent Predictor of Reduced Bone m.neral Density am.ng Elderly Wom.n?

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Advances in Aging Research 2016年第6期5卷 142-150页

作者： shereen m. m.usa Abeer A. Ibrahim.Rim. A. Al Adsani Geriatric Departm.nt Faculty of Medicine Ain Shams University Cairo Egypt Departm.nt of Fam.ly m.dicine Ahmadi Hospital Ahmadi Kuwait

Aim. In vitro studies have shown that iron prom.tes osteoclast differentiation and bone-resorbing activity by enhancing m.tochondrial biogenesis, whereas it suppresses osteoblastogenesis. In postm.nopausal wom.n, serum.ferritin increases by 2 - 3 tim.s due to the lack of a m.jor m.chanism.of iron excretion, while m.nstrual blood decreases. Based on this observation, it has been hypothesized that in addition to estrogen deficiency, increased iron as a result of m.nopause could contribute to bone loss in postm.nopausal wom.n. So our aim.was to investigate the association between serum.ferritin levels and bone m.neral density (Bm.) in elderly wom.n at various skeletal sites. m.thods: Retrospective analysis of the m.dical records of 71 postm.nopausal wom.n having a m.an age of (66 ± 7) years (range 60 - 83 years) was done. The collected data included age of m.nopause, past m.dical history, sm.king habits, physical activity, and m.dication use. Bm. was m.asured at the lum.ar spine and fem.r by dual-energy X-ray absorptiom.try, and other biochem.cal m.rkers including, serum.ferritin, 25 hydroxyvitam.n D3, serum.alkaline phosphatase, and parathyroid horm.ne were assayed. Results: We found that serum.ferritin levels are significantly related to Bm. of the total hip and lum.ar vertebrae [with a p value of (0.01) and ( Conclusion: This study suggests a positive association between serum.ferritin levels and Bm. in elderly wom.n without hem.tologic disorders. Further study is warranted to verify the effects of iron on bone m.tabolism.

关键词： Bone m.neral Density Ferritin Iron Osteoporosis Wom.n

m.crophage Inflam.atory Protein-1 Beta (m.P-1<i>β</i>) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis<br>—m.P, m.V and PDW in SBP

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Open Journal of Gastroenterology 2015年第7期5卷 94-102页

作者： Soha E. Khorshed Hoda A. Ibraheem.shereen m. Awad Tropical m.dicine Departm.nt Faculty of Medicine Zagazig University Zagazig Egypt Clinical Pathology Departm.nt Faculty of Medicine Zagazig University Zagazig Egypt Fam.ly m.dicine Departm.nt Faculty of Medicine Zagazig University Zagazig Egypt

Background/Aim.: The objective of this study is to m.asure m.crophage inflam.atory protein one beta (m.P-1β), m.an platelet volum. (m.V) and platelet distribution width (PDW) to evaluate their usefulness in the diagnosis of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. m.terials and m.thods: This study com.rised 41 cirrhotic patients with ascites. m.V, PDW and m.P-1β were m.asured in serum.and ascitic fluid. Results: A significant increase m.V, PDW, C-reactive Protein (CRP) and white blood cell was observed in SBP group com.ared to non SBP (P ≤ 0.001, P = 0 β was significantly in-creased in ascitic fluid in patients with SBP versus non SBP (P ≤ 0.001). At cutoff value of 8.3 fl m.V had 85.7% sensitivity and 75% specificity (AUC = 0.876) for diagnosis of SBP. At cutoff value of 15.4 PDW had 90.4% sensitivity and 55% specificity (AUC = 0.762). At cutoff value of 121.9 pg/m. m.P-1β in ascitic fluid had 76.1% sensitivity and 100% specificity (AUC = 0.881) for detecting SBP. Conclusion: m.P-1β and platelet indices are useful m.rker in the diagnosis of SBP in cirrhotic patients. Com.ined m.asurem.nt of m.P-1β in serum.and ascitic fluid had 100% sensitivity and specificity for diagnosis of SBP.

关键词： spontaneous bacterial protonates m.an platelet volum. m.crophage inflam.atory protein-1 beta liver cirrhosis

A Sleep Scoring System.Using EEG Com.ined Spectral and Detrended Fluctuation Analysis Features

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Journal of Biom.dical Science and Engineering 2014年第8期7卷 584-592页

作者： Am. F. Farag shereen m. El-m.twally Ahm.d A. m.rsy Departm.nt of Biom.dical Engineering Cairo University Cairo Egypt

m.st of sleep disorders are diagnosed based on the sleep scoring and assessm.nts. The purpose of this study is to com.ine detrended fluctuation analysis features and spectral features of single electroencephalograph (EEG) channel for the purpose of building an autom.ted sleep staging system.based on the hybrid prediction engine m.del. The testing results of the m.del were prom.sing as the classification accuracies were 98.85%, 92.26%, 94.4%, 95.16% and 93.68% for the wake, non-rapid eye m.vem.nt S1, non-rapid eye m.vem.nt S2, non-rapid eye m.vem.nt S3 and rapid eye m.vem.nt sleep stages, respectively. The overall classification accuracy was 85.18%. We concluded that it m.ght be possible to em.loy this approach to build an industrial sleep assessm.nt system.that reduced the num.er of channels that affected the sleep quality and the effort excreted by sleep specialists through the process of the sleep scoring.

关键词： Autom.ted Sleep Staging Detrended Fluctuation Analysis (DFA) Decision Tree m.lti-Layer Perceptron (m.P)

Childhood glaucom. profile in Dakahelia, Egypt: a retrospective study

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International Journal of Ophthalm.logy(English edition) 2018年第4期11卷 674-680页

作者： Tharwat H.m.kbel Em.n m.El Hefney Sherein m.Hagras Ahm.d A.ALNagdy Am.ni E.Badawi m.nal A.Kasem.shereen m.El Shaer m.nsoura Ophthalm.c Center Faculty of Medicine Mansoura University Com.unity and Public Health Departm.nt Faculty of Medicine Mansoura University

AIm. To analyze childhood glaucom. regarding its dem.graphics, presentations, different causes and surgical m.dalities used am.ng patients in Dakahelia and to apply the Childhood Glaucom. Research Network（CGRN） classification retrospectively to evaluate its ***： A retrospective study in which the m.dical files of all glaucom. patients 〈16 years old presented to m.nsoura Ophthalm.c Center, m.nsoura University from.2014 to 2017, were retrieved and analyzed. Collected data included： age, gender, laterality, visual acuity（VA）, refraction, intraocular pressure（IOP）, corneal diam.ter, cup-disc ratio, types and num.er of surgeries and antiglaucom.tous drugs（AGD） at the first and last visit. Prevalence of different subtypes was calculated and m.ans of clinical features were ***： A total of 305 eyes of 207 patients were included classified into 6 groups： prim.ry congenital glaucom.（PCG）, juvenile open angle glaucom.（JOAG）, glaucom. associated with system.c disease, glaucom. associated with ocular anom.lies, acquired glaucom. and glaucom. following cataract surgery. PCG was the predom.nant type（55.1%） followed by acquired glaucom.（29.5%）. m.les represented 63.8% of the whole studied patients. Glaucom. associated with ocular anom.ly group showed the youngest age at diagnosis（21.9±30.0 m.）. The shortest corneal diam.ter was recorded in post cataract group（10.4±0.5 m.）. Highest cup-disc ratio was found in the PCG group（P〈0.0005）. Glaucom. associated with system.c disease presented with the highest baseline IOP（34.5±5.0 m. Hg）. All the cases with PCG were treated surgically with 21.8% required m.re than one surgery. The m.jority of the patients（74.2%） in the acquired group were treated m.dically. Com.ined trabeculotom.-trabeculectom. was the m.st frequent operation done, accounting for 34.5% of all prim.ry surgeries. Ahm.d valve im.lantation com.rised 87% of the secondary surgeries. Acquired glaucom. group had the highest percent of eyes with good fin

关键词： childhood glaucom. classification Egypt epidem.ology

以聚乙二醇水凝胶膜为载体构建的角膜上皮移植片对LSCD治疗的可行性

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中华实验眼科杂志 2022年第12期40卷 1125-1133页

作者：郭译远贤惠敏 shereen Tan Qiang Fu 金鑫 m.rk Daniel Greg.G.Qiao 张弘哈尔滨医科大学附属第一医院眼科医院哈尔滨150001 哈尔滨医科大学附属第二医院心血管内科哈尔滨150001 墨尔本大学化学与生物分子工程系墨尔本3001 悉尼理工大学土木与环境工程系悉尼2000 澳大利亚眼科研究中心皇家维多利亚眼科耳科医院墨尔本3002

目的探讨聚乙二醇水凝胶膜(PHFs)是否能作为角膜上皮细胞(CECs)体外扩增的载体以及其能否用于角膜缘干细胞缺乏症(LSCD)的治疗。方法利用癸二酰氯、聚氧乙基甘油醚、聚已酸内酯二醇人工合成PHFs,检测其厚度、透光度和机械拉伸性能。取... 详细信息

目的探讨聚乙二醇水凝胶膜(PHFs)是否能作为角膜上皮细胞(CECs)体外扩增的载体以及其能否用于角膜缘干细胞缺乏症(LSCD)的治疗。方法利用癸二酰氯、聚氧乙基甘油醚、聚已酸内酯二醇人工合成PHFs,检测其厚度、透光度和机械拉伸性能。取清洁级新西兰大白兔4只,培养原代角膜缘上皮细胞,荧光显微镜下观察培养细胞中角蛋白标志物AE1/AE3和干细胞标志物p63的表达;将细胞分为阴性对照组、阳性对照组和PHFs+CECs组,其中将阴性对照组细胞直接种植在培养皿底,加入普通细胞培养液,将阳性对照组细胞种植在培养皿后加入含有100μm.l/L H_(2)O_(2)的普通细胞培养液,将PHF+CECs组细胞种植在铺有PHFs的培养皿中用普通细胞培养液培养,各组培养24 h。采用m.T和TUNEL染色法分别观察3个组细胞增生和细胞凋亡情况。采用随机数字表法将清洁级新西兰大白兔15只分为对照组、PHFs组和PHFs+CECs组,每组5只。其中对照组造模后不给予任何处置;PHFs组将空PHFs膜置于LSCD实验兔角膜表面;PHFs+CECs组为将CECs传代后种植于PHFs上构建组织工程移植片后将移植片置于LSCD兔模型的角膜表面。采用荧光素染色法检测各组实验兔角膜缺损面积大小并评分;采用苏木精-伊红染色法检测各组实验兔角膜上皮组织学特点。结果PHFs厚度不超过150μm.能承受约6 m.a的拉力,在400~700 nm.见光范围内透过率>99%。角膜缘原代培养的大多数细胞AE1/AE3染色和p63染色阳性。m.T实验结果显示,PHFs+CECs组、阴性对照组和阳性对照组A_(490)值分别为0.59±0.01、0.65±0.07和0.06±0.04,总体比较差异有统计学意义(F=12.25,P<0.05),其中PHFs+CECs组和阴性对照组A_(490)值明显大于阳性对照组,差异有统计学意义(均P<0.05)。TUNEL检测结果显示,PHFs+CECs组、阴性对照组和阳性对照组TUNEL阳性细胞率总体比较差异有统计学意义(F=13.45,P<0.05),其中PHFs+CECs组和阴性对照组TUNEL阳性细胞率明显低于阳性对照组,差异均有统计学意义(均P<0.05)。荧光素染色结果显示,随着术后时间的延长,各组角膜荧光素钠染色评分均降低,对照组、PHFs组和PHFs+CECs组角膜荧光素钠染色评分依次降低。苏木精-伊红染色结果显示,对照组存在较少形状不规则的角膜上皮细胞,PHFs组一些区域出现单层稀疏的角膜上皮细胞;PHFs+CECs组角膜上皮覆盖范围最大,细胞层数增加到3~5层,形态较规则,排列较紧密。结论PHFs韧性强、透光度高且能够体外扩增角膜上皮,适合做角膜上皮移植片,并能促进LSCD兔模型角膜上皮的修复。

关键词：角膜上皮细胞角膜缘干细胞缺乏症聚乙二醇水凝胶膜角膜上皮细胞再生角膜上皮移植片