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Cytokine receptor-like factor 1(CRLF1)promotes cardiac fibrosis via ERK1/2 signaling pathway

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第8期24卷 682-697页

作者： shenjian luo Zhi YANG Ruxin CHEN Danming YOU Fei TENG Youwen YUAN Wenhui LIU Jin LI Huijie ZHANG Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Southern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Endocrinology Shanxi Medical University Affiliated Second HospitalTaiyuan 030001China

Cardiac fibrosis is a cause of morbidity and mortality in people with heart ***-fibrosis treatment is a significant therapy for heart disease,but there is still no thorough understanding of fibrotic *** study was carried out to ascertain the functions of cytokine receptor-like factor 1(CRLF1)in cardiac fibrosis and clarify its regulatory *** found that CRLF1 was expressed predominantly in cardiac *** expression was up-regulated not only in a mouse heart fibrotic model induced by myocardial infarction,but also in mouse and human cardiac fibroblasts provoked by transforming growth factor-β1(TGF-β1).Gain-and loss-of-function experiments of CRLF1 were carried out in neonatal mice cardiac fibroblasts(NMCFs)with or without TGF-β1 ***1 overexpression increased cell viability,collagen production,cell proliferation capacity,and myofibroblast transformation of NMCFs with or without TGF-β1 stimulation,while silencing of CRLF1 had the opposite *** inhibitor of the extracellular signal-regulated kinase 1/2(ERK1/2)signaling pathway and different inhibitors of TGF-β1 signaling cascades,comprising mothers against decapentaplegic homolog(SMAD)-dependent and SMAD-independent pathways,were applied to investigate the mechanisms ***1 exerted its functions by activating the ERK1/2 signaling ***,the SMAD-dependent pathway,not the SMAD-independent pathway,was responsible for CRLF1 up-regulation in NMCFs treated with TGF-β*** summary,activation of the TGF-β1/SMAD signaling pathway in cardiac fibrosis increased CRLF1 ***1 then aggravated cardiac fibrosis by activating the ERK1/2 signaling ***1 could become a novel potential target for intervention and remedy of cardiac fibrosis.

关键词： Cytokine receptor-like factor 1(CRLF1) TGF-β1/SMAD signaling pathway ERK1/2 signaling pathway Cardiac fibrosis Myofibroblast transformation Extracellular matrix(ECM)

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Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in Apoe^(-/-)mice

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Life Metabolism 2024年第3期3卷 46-59页

作者： Yajuan Deng Xiaoyu Yang Xueru Ye Youwen Yuan Yanan Zhang Fei Teng Danming You Xuan Zhou Wenhui Liu Kangli Li shenjian luo Zhi Yang Ruxin Chen Guojun Shi Jin Li Huijie Zhang Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityShanxi Medical UniversityTaiyuanShanxi 030001China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China

Atherosclerosis is the major contributor to cardiovascular mortality *** day fasting(ADF)has gained growing attention due to its metabolic ***,the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal *** present study was designed to investigate the effects of ADF on atherosclerosis in apolipoprotein E-deficient(Apoe^(-/-))***-week-old male Apoe^(-/-)mice fed with Western diet(WD)were randomly grouped into ad libitum(AL)group and ADF group,and ADF aggravated both the early and advanced atherosclerotic lesion formation,which might be due to the disturbed cholesterol profiles caused by ADF *** significantly altered cholesterol metabolism pathways and down-regulated integrated stress response(ISR)in the *** hepatic expression of activating transcription factor 3(ATF3)was suppressed in mice treated with ADF and hepatocyte-specific overexpression of Aft3 attenuated the effects of ADF on atherosclerotic plaque formation in Apoe^(-/-)***,the expression of ATF3 could be regulated by Krüppel-like factor 6(KLF6)and both the expressions of ATF3 and KLF6 were regulated by hepatic cellular ISR *** conclusion,ADF aggravates atherosclerosis progression in Apoe^(-/-)mice fed on *** inhibits the hepatic ISR signaling pathway and decreases the expression of KLF6,subsequently inhibiting ATF3 *** suppressed ATF3 expression in the liver mediates the deteriorated effects of ADF on atherosclerosis in Apoe^(-/-)*** findings suggest the potentially harmful effects when ADF intervention is applied to the population at high risk of atherosclerosis.

关键词： alternate day fasting atherosclerosis cholesterol integrated stress response activating transcription factor 3

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Study on Improvement of Hygroscopicity of Magnesite-Bonded Wood Wool Panel

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Journal of Renewable Materials 2021年第10期9卷 1795-1803页

作者： Li luo Xiaoyu Wang Kang Zhou shenjian Ni Xiaonin Lu Bin Na Nanjing Forestry University Nanjing210037China

Magnesite-bonded wood wool panel(MWWP)is an inorganic-bonded panel product in which wood excelsior is bonded with *** the hygroscopicity is one of the key measures to improve the quality of the *** this study,moisture absorption mechanism of MWWP and measures generally applied to lower its hygroscopicity were *** methods were then experimented to improve the dimensional stability of the panel,including adjusting the molar ratio of raw materials,adding additives and optimizing the conditioning *** results showed that satisfying dimensional stability could be achieved when the molar ratio of MgO to MgCl_(2) was 5:1,the No.2 composite additive(aluminum powder+NH_(4)H_(2)PO_(4)+ferric alum)was adopted and a constant temperature and humidity treatment was applied in the first stage of conditioning.

关键词： Magnesite-bonded wood wool panel(MWWP) hygroscopicity steam pressing additive

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论侦查程序与策略

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广州市公安管理干部学院学报 2004年第3期15卷 13-15页

作者：谢盛坚罗茂怀

侦查程序和侦查策略是侦查教学和实践中两个重要的要素,侦查程序的特征表现为它的法的规定性、单向性和顺序性,而侦查策略的特征表现为它的机动性和灵活性,因而具有多向性。它们二者之间具有相互制约性和相互促进性,既相互区别又相互联... 详细信息

侦查程序和侦查策略是侦查教学和实践中两个重要的要素,侦查程序的特征表现为它的法的规定性、单向性和顺序性,而侦查策略的特征表现为它的机动性和灵活性,因而具有多向性。它们二者之间具有相互制约性和相互促进性,既相互区别又相互联系。在侦查教学和实践中,要充分认识侦查程序和侦查策略的范畴和特性,既反对把二者混为一谈,也反对偏重一方而轻视另一方,要最大限度地发挥二者各自最大的效能。

关键词：侦查程序侦查策略刑侦教学

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布地奈德联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床效果

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中国医院用药评价与分析 2016年第8期16卷 1057-1059页

作者：万江罗望梅郑申健张莉娅武汉科技大学附属孝感医院儿科湖北武汉432000

目的:探讨布地奈德联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床效果。方法:选取武汉科技大学附属孝感医院收治的咳嗽变异性哮喘患儿110例作为研究对象,以随机数字表法分为观察组和对照组各55例。对照组患儿给予布地奈德雾化吸入治疗,... 详细信息

目的:探讨布地奈德联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床效果。方法:选取武汉科技大学附属孝感医院收治的咳嗽变异性哮喘患儿110例作为研究对象,以随机数字表法分为观察组和对照组各55例。对照组患儿给予布地奈德雾化吸入治疗,观察组患儿在对照组的基础上给予孟鲁司特钠治疗。比较治疗前后2组患儿血清白细胞介素-4(IL-4)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)水平及肺功能指标,观察2组患儿的临床治疗效果及不良反应发生情况。结果:治疗后,2组患儿血清IL-4、IL-8和TNF-α水平均显著下降,且观察组较对照组下降更明显,差异均有统计学意义(P0.05)。结论:布地奈德联合孟鲁司特钠治疗小儿咳嗽变异性哮喘临床疗效较好,安全性较高。

关键词：布地奈德孟鲁司特钠小儿咳嗽变异性哮喘临床效果

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海口市112例少年儿童骨密度及影响因素分析

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中国骨质疏松杂志 2014年第7期20卷 804-806页

作者：骆彦霏王超群王小娜符尧天高胤群郑婷王身坚海南医学院在读本科生海口570102 海南医学院放射治疗与核医学教研室海口570102

目的研究海口地区少年儿童的骨密度（bone mineral density,BMD）及其影响因素,为了解本地区少年儿童的骨骼发育状况提供参考依据,同时为国家研究此方面的课题提供资料数据对比,对今后研究青少年儿童的骨骼发育情况具有重要的意义。方... 详细信息

目的研究海口地区少年儿童的骨密度（bone mineral density,BMD）及其影响因素,为了解本地区少年儿童的骨骼发育状况提供参考依据,同时为国家研究此方面的课题提供资料数据对比,对今后研究青少年儿童的骨骼发育情况具有重要的意义。方法对海口市112例少年,年龄12~14岁,其中男生61例,女生51例儿童行问卷调查,并使用双能X线骨密度测定仪检测其左手桡骨远端的BMD。每次测量前进行仪器性能校正检测,并由同一人负责测量。测量对象取坐位,左臂平放,测量其左手桡骨远端1/3BMD,测量时保持标准体位。结果随着年龄的增长,少年儿童的BMD也随之增长;但其运动时间、睡眠时间及营养状况的重视程度却逐年下降。结论运动、睡眠及营养状况是少年儿童骨密度的重要影响因素;应加大对海口地区少年儿童生长发育期提高骨密度的重视度。

关键词：骨密度少年儿童影响因素

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匹多莫德防治脑性瘫痪患儿反复呼吸道感染72例临床观察

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儿科药学杂志 2016年第3期22卷 26-29页

作者：杨恩华左满凤钟新郑申健刘静罗晓妹湖北省孝感市中心医院湖北孝感432000

目的:观察匹多莫德防治脑性瘫痪(简称脑瘫)患儿反复呼吸道感染(RRI)的临床疗效及安全性。方法:将72例脑瘫合并RRI患儿随机分成观察组37例和对照组35例。两组患儿同时进行康复治疗,观察组加服匹多莫德每次400 mg,每天1次,持续服用60 d。... 详细信息

目的:观察匹多莫德防治脑性瘫痪(简称脑瘫)患儿反复呼吸道感染(RRI)的临床疗效及安全性。方法:将72例脑瘫合并RRI患儿随机分成观察组37例和对照组35例。两组患儿同时进行康复治疗,观察组加服匹多莫德每次400 mg,每天1次,持续服用60 d。观察两组患儿的临床症状,血清免疫球蛋白Ig A、Ig G、Ig M水平,肝肾功能,外周血象变化及不良反应。结果:治疗后,观察组Ig A、Ig G水平比治疗前升高(P0.05);对照组Ig A、Ig G、Ig M水平与治疗前比较差异均无统计学意义(P均>0.05)。与对照组比较,观察组呼吸道感染次数减少,发热时间、抗生素使用时间、咳嗽时间均缩短(P0.05)。两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论:匹多莫德用于防治脑瘫患儿RRI安全有效,值得临床推广应用。

关键词：匹多莫德脑性瘫痪反复呼吸道感染血清免疫球蛋白

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重症毛细支气管炎患儿雾化吸入布地奈德的时机和剂量研究

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儿科药学杂志 2014年第7期20卷 9-12页

作者：左满凤舒琼璋江玲罗望梅万江张莉娅郑申健华中科技大学同济医学院附属孝感市中心医院湖北孝感432000

目的:探讨重症毛细支气管炎(BC)患儿雾化吸入布地奈德混悬液的适宜时机和剂量。方法:218例重症BC患儿,随机分为A组80例、B组70例、C组68例,均静脉输入甲泼尼龙,雾化吸入"生理盐水2 mL+特布他林1 mL",每8 h 1次。A组雾化液中加入布地奈德... 详细信息

目的:探讨重症毛细支气管炎(BC)患儿雾化吸入布地奈德混悬液的适宜时机和剂量。方法:218例重症BC患儿,随机分为A组80例、B组70例、C组68例,均静脉输入甲泼尼龙,雾化吸入"生理盐水2 mL+特布他林1 mL",每8 h 1次。A组雾化液中加入布地奈德2 mL(中等剂量);B组停用甲泼尼龙后再加入布地奈德2 mL(中等剂量);C组停用甲泼尼龙后再加入布地奈德1 mL(低剂量)。比较三组患儿临床症状体征恢复正常时间、住院时间、临床疗效及不良反应。结果:B组和A组比较,临床症状体征恢复正常时间、住院时间及临床疗效比较差异均无统计学意义(P>0.05),但B组不良反应发生率(5.71%)低于A组(18.75%),差异有统计学意义(P0.05)。结论:重症BC患儿在停用全身糖皮质激素后雾化吸入中等剂量布地奈德混悬液,不仅疗效好,还可减少不良反应,降低成本。

关键词：毛细支气管炎布地奈德混悬液时机剂量

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基于流-固-热耦合的超声速弹箭尾翼强度分析

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弹道学报 2022年第4期34卷 98-104页

作者：向熙封锋陈超王明亮罗飞南京理工大学机械工程学院江苏南京210094 安徽神剑科技股份有限公司安徽合肥230601

为评估超声速飞行时弹箭尾翼的安全性,结合弹道曲线,计算了某型火箭弹在不同马赫数下飞行时的稳态外流场,并研究了2 s内的瞬态传热。根据传热计算的结果调整了材料的力学性能参数,进而计算了在不同飞行马赫数下,弹箭尾翼受空气动力作用... 详细信息

为评估超声速飞行时弹箭尾翼的安全性,结合弹道曲线,计算了某型火箭弹在不同马赫数下飞行时的稳态外流场,并研究了2 s内的瞬态传热。根据传热计算的结果调整了材料的力学性能参数,进而计算了在不同飞行马赫数下,弹箭尾翼受空气动力作用产生的总变形和等效应力。结果表明:弹箭以高马赫数飞行时,前缘翼尖温度最高,且高温由该位置向内部迅速传递,马赫数越大,升温越剧烈,导致翼片前缘出现烧蚀,因此高速飞行的弹箭应对尾翼等结构进行热防护处理。高温会使材料性能下降,在气动热和气动压力共同作用下,翼片会产生较大变形,且应力可能超过许用应力。最大变形量出现在前缘翼尖,最大应力出现在翼根靠近前缘处,且都随飞行马赫数增加而增大。

关键词：弹箭尾翼流-固-热耦合变形应力强度分析

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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