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Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

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Bioactive Materials 2021年第9期6卷 2956-2968页

作者： Luoxiao Ran Bitao Lu Haoyu Qiu Guofang Zhou Jing Jiang Enling Hu Fangyin dai Guangqian Lan State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China Chongqing General Hospital University of Chinese Academy of Sciences No.118Xingguang AvenueLiangjiang New AreaChongqingChina

The increase in the number of resistant bacteria caused by the abuse of antibiotics and the emergence of biofilms significantly reduce the effectiveness of *** infections are detrimental to our life and *** reduce the abuse of antibiotics and treat biofilm-related bacterial infections,a biomimetic nano-antibacterial system,RBCM-NW-G namely,that controls the release of antibiotics through near infrared was *** hollow porous structure and the high surface activity of nanoworms are used to realize antibiotic loading,and then,biomimetics are applied with red blood cell membranes(RBCM).RBCM-NW-G,which retains the performance of RBCM,shows enhanced permeability and retention *** imaging in mice showed the effective accumulation of RBCM-NW-G at the site of *** addition,the biomimetic nanoparticles showed a longer blood circulation time and good ***-biofilm test results showed damage to biofilms due to a photothermal effect and a highly efficient antibacterial performance under the synergy of the photothermal effect,silver iron,and ***,by constructing a mouse infection model,the great potential of RBCM-NW-G in the treatment of in vivo infections was confirmed.

关键词： Red blood cell membrane Nanoworms Antibiotics release Bacterial infection

Advances and challenges in thermal runaway modeling of lithium-ion batteries

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The Innovation 2024年第4期5卷 172-186,171页

作者： Gongquan Wang Ping Ping Depeng Kong Rongqi Peng Xu He Yue Zhang Xinyi dai Jennifer Wen Center for Offshore Engineering and Safety Technology China University of Petroleum(East China)Qingdao 266580China College of Chemical Engineering China University of Petroleum(East China)Qingdao 266580China Centre for Energy Resilience School of Mechanical Engineering SciencesUniversity of SurreyGuildfordSurrey GU27XHUK

The broader application of lithium-ion batteries(LIBs)is constrained by safety concerns arising from thermal runaway(TR).Accurate prediction of TR is essential to comprehend its underlying mechanisms,expedite battery design,and enhance safety protocols,thereby significantly promoting the safer use of *** complex,nonlinear nature of LIB systems presents substantial challenges in TR modeling,stemming from the need to address multiscale simulations,multiphysics coupling,and computing efficiency *** paper provides an extensive review and outlook on TR modeling technologies,focusing on recent advances,current challenges,and potential future *** begin with an overview of the evolutionary processes and underlying mechanisms of TR from multiscale perspectives,laying the foundation for TR *** a comprehensive understanding of TR phenomena and mechanisms,we introduce a multiphysics coupling model framework to encapsulate these *** this framework,we detail four fundamental physics modeling approaches:thermal,electrical,mechanical,and fluid dynamic models,highlighting the primary challenges in developing and integrating these *** address the intrinsic trade-off between computational accuracy and efficiency,we discuss several promising modeling strategies to accelerate TR simulations and explore the role of AI in advancing next-generation TR ***,we discuss challenges related to data availability,model scalability,and safety standards and regulations.

关键词： lithium thermal modeling

Carbon dioxide insufflation in esophageal endoscopic submucosal dissection reduces mediastinal emphysema: A randomized, double-blind, controlled trial

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World Journal of Gastroenterology 2016年第32期22卷 7373-7382页

作者： Yuki Maeda dai Hirasawa Naotaka Fujita Tetsuya Ohira Yoshihiro Harada Taku Yamagata Yoshiki Koike Kenjirou Suzuki Department of Gastroenterology Sendai City Medical Center Sendal 983-0824 Japan Miyagi Medical Check-up Plaza Sendai 984-0015 Japan

AIM To assess the efficacy of CO2 insufflation for reduction of mediastinal emphysema(ME) immediately after endoscopic submucosal dissection(ESD).METHODS A total of 46 patients who were to undergo esophageal ESD were randomly assigned to receive either CO2 insufflation(CO2 group, n = 24) or air insufflation(Air group, n = 22). Computed tomography(CT) was carried out immediately after ESD and the next morning. Pain and abdominal distention were chronologically recorded using a 100-mm visual analogue scale(VAS). The volume of residual gas in the digestive tract was measured using CT imaging. RESULTS The incidence of ME immediately after ESD in the CO2 group was significantly lower than that in the Air group(17% vs 55%, P = 0.012). The incidence of ME the next morning was 8.3% vs 32% respectively(P= 0.066). There were no differences in pain scores or distention scores at any post-procedure time points. The volume of residual gas in the digestive tract immediately after ESD was significantly smaller in the CO2 group than that in the Air group(808 m L vs 1173 m L, P = 0.013).CONCLUSION CO2 insufflation during esophageal ESD significantly reduced postprocedural ME. CO2 insufflation also reduced the volume of residual gas in the digestive tract immediately after ESD, but not the VAS scores of pain and distention.

关键词： Endoscopic submucosal dissection Carbon dioxide insufflation Mediastinal emphysema Superficial esophageal cancer Complication

Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry for Quantification of Glycyrrhetic Acid in Human Plasma

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Chemical Research in Chinese Universities 2011年第2期27卷 185-189页

作者： TIAN Li GAO Xtao-li CHEN Xiao-yan ZHONG Da-fang ZHANG Yi-fan dai Xiao-jian College of Trditional Chinese Medicine 2. College of Pharmacy Xinjiang Medical University Urumqi 830011 P R. China Center for Drug Metabolism and Pharmacokinetic Research Shanghai 201203 P. R. China

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometry（LC-MS/MS） for the determination of glycyrrhetic acid in human plasma with ginsenoside Rh2 as internal standard was developed and validated. The plasma samples were prepared via liquid-liquid extraction with ethyl acetate. Chromatographic separation was accomplished on a Venusil MP-C18（50 mm×2.1 mm, 5 μm i.d.） column at 25 °C. The mobile phase consisted of acetonitrile/5 mmol？L-1 ammonium acetate（10：90, volume ratio） at a flow rate of 0.4 mL/min. Negative electrospray ionization was utilized as the ionization source. Glycyrrhetic acid and internal standard were determined via the mutiple reaction monitoring of precursor→production ion transitions at m/z 469→425, 409 and m/z 621→161, respectively. Each sample was chromatographed within 2.5 min. The lower limit of quantification was 0.50 ng/mL for 200 μL of plasma sample and the linear range was from 0.50 ng/mL to 800 ng/mL. The intra- and inter-day precisions were less than 8.76% in terms of relative standard deviation（RSD）, and the accuracy was within a range of -3.25%-1.32% in terms of relative error（RE）. The method was successfully applied to the pharmacokinetic studies of glycyrrhetic acid in healthy male Chinese volunteers after a single oral administration of 75 mg of glycyrrhizin.

关键词： Liquid chromatography-tandem mass spectrometry(LC-MS/MS) Glycyrrhetic acid Pharmacokinetics

Lysyl oxidase and hypoxia-inducible factor 1α: biomarkers of gastric cancer

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World Journal of Gastroenterology 2019年第15期25卷 1828-1839页

作者： Ya-Lin Han Li Chen Rui Qin Guan-Qing Wang Xiao-Hua Lin Guang-Hai dai Department of Medical Oncology Chinese PLA General Hospital Department of Oncology the General Hospital of PLA Rocket Force

BACKGROUND Gastric cancer(GC) is one of the main causes of cancer mortality *** studies on tumor microenvironments have shown that tumor metabolism exerts a vital role in cancer *** To investigate whether lysyl oxidase(LOX) and hypoxia-inducible factor 1α(HIF1α) are prognostic and predictive biomarkers in *** A total of 80 tissue and blood samples were collected from 140 patients admitted to our hospital between August 2008 and March 2012. Immunohistochemical staining was performed to measure the expression of LOX and HIF1α in tumor and adjacent tissues collected from patients with GC. Real-time quantitative reverse transcription polymerase chain reaction(qRT-PCR) analysis was used to detect the mRNA expression levels of LOX and HIF1α in patients with GC. In addition, single-factor analysis was applied to analyze the relationship between LOX, HIF1α and prognosis of *** Immunohistochemical staining suggested that the expression levels of LOX and HIF1α increased in tumor tissues from patients with GC. QRT-PCR analysis indicated that mRNA expression of LOX and HIF1α was also upregulated in tumor tissues, which was in accordance with the above results. We also detected expression of these two genes in blood samples. The expression level of LOX and HIF1α was higher in patients with GC than in healthy controls. Additional analysis showed that the expression level of LOX and HIF1α was related to the clinicopathological characteristics of GC. Expression of LOX and HIF1α increased with the number of lymph node metastases, deeper infiltration depth and later tumor–node–metastasis stages. Single-factor analysis showed that high expression of LOX and HIF1α led to poor prognosis of patients with *** LOX and HIF1α can be used as prognostic and predictive biomarkers for GC.

关键词： Lysyl oxidase Hypoxia-inducible factor 1α Gastric cancer Biomarker Prognosis

Clinical Analysis of Primary Tracheobronchial Tumors in Children and Evaluation of the Predicting Models for Mucoepidermoid Carcinoma

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Current Medical Science 2022年第4期42卷 778-784页

作者： Chen ZHANG Wen-long FU Ji-hong dai Yong-gang LI Xing-ye TANG Xiao-feng MA Gang GENG Ying LI Ting YANG Li YAN Jing-yue LIU Zheng LIU Xiao-ping YUAN dai-yin TIAN Department of Pulmonology Children s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pediatrics Chongqing Fifth People's HospitalChongqing 400014China

Objective:To determine the clinical characteristics and prognosis of primary tracheobronchial tumors(PTTs)in children,and to explore the most common tumor identification ***:The medical records of children with PTTs who were hospitalized at the Children's Hospital of Chongqing Medical University from January 1995 to January 2020 were reviewed *** clinical features,imaging,treatments,and outcomes of these patients were statistically *** learning techniques such as Gaussian na?ve Bayes,support vector machine(SVM)and decision tree models were used to identify mucoepidermoid carcinoma(ME).Results:A total of 16 children were hospitalized with PTTs during the study *** included 5(31.3%)children with ME,3(18.8%)children with inflammatory myofibroblastic tumors(IMT),2 children(12.5%)with sarcomas,2(12.5%)children with papillomatosis and 1 child(6.3%)each with carcinoid carcinoma,adenoid cystic carcinoma(ACC),hemangioma,and schwannoma,*** was the most common tumor type and amongst the 3 ME recognition methods,the SVM model showed the best *** main clinical symptoms of PPTs were cough(81.3%),breathlessness(50%),wheezing(43.8%),progressive dyspnea(37.5%),hemoptysis(37.5%),and fever(25%).Of the 16 patients,7 were treated with surgery,8 underwent bronchoscopic tumor resection,and 1 child *** the 11 other children,3 experienced recurrence,and the last 8 remained *** deaths were observed during the follow-up ***:PTT are very rare in children and the highest percentage of cases is due to *** SVM model was highly accurate in identifying *** CT and bronchoscopy can effectively diagnose *** and bronchoscopic intervention can both achieve good clinical results and the prognosis of the 11 children that were followed up was good.

关键词： tracheobronchial tumors children bronchoscopy clinical characteristics support vector machine model

Influence of Anglo-American culture on college English teaching reform

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International Journal of Technology Management 2014年第2期 47-49页

作者： Min dai Liuzhou Railway Vocational Technical College LiuzhouGuangxi545007 China

English is the world＇ s most widely used one language, English and Anglo-American culture is also included in the impact on the world. The official language English is not just Britain and other countries, but also one of the main working languages of the United Nations. Under the trend of economic globalization, the English influence is gradually increased. Speaking from Europe, about half of the enterprises to carry out the business is conducted in English, but the vast majority of information exchange and transfer the whole world need to rely on English to complete. Thus, English is an international language. Because of this huge influence of English, many countries have carried out a study and research of English.

关键词： Anglo-American culture college English teaching reform.

Spacetime Curvature drives the Big Bounce

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科学中国人 2017年第7Z期 132-134,136页

作者： Qiaochu dai University of Alberta

Instead of the hypothesis of the dark matter and dark energy, curvature of a four dimensional Lorentzian manifold can be used to explain the accelerating expansion of the universe today and the shrink of that in the future, as well as two critical points for each period life of the ***, the Big Bang can be treated as the beginning point of the process that the total energy changes to total mass along the positive direction of entropy on the cosmic scales,where the curvature is positive and, conversely, the Big Crunch can be treated as the beginning point of the process that total mass changes to total energy along the negative direction of entropy, where the curvature is *** derivative, sinusoidal functions obtained to describe the change rate of the scale and that of the curvature along the periodic life of the universe.

关键词： In Spacetime Curvature drives the Big Bounce

Application of Complementary Error Function to the Transition Zone of Myopic Ablation Shapes in Refractive Surgery

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Journal of Applied Mathematics and Physics 2017年第8期5卷 1521-1528页

作者： Guang-Ming dai Research and Development Johnson and Johnson Vision Milpitas CA USA

In refractive surgery, the cubic spline fit for the transition zone breaks down for myopia and myopic meridians in mixed astigmatism as in many cases the cubic spline function runs into negative values. In this paper, the complementary error function is proposed instead of the cubic spline function as the transition zone function, due to the availability of analytical expression of its derivatives and the nonnegativity fact. It is shown that with the use of the complementary error function, transition zones for all refractive types work correctly.

关键词： Error Function Complementary Error Function Vision Correction Refractive Surgery Treatment Algorithm