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Modification strategies for non-aqueous, highly proton-conductive benzimidazole-based high-temperature proton exchange membranes

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Chinese Chemical Letters 2024年第4期35卷 43-51页

作者： Yunfa Dong Shijie Zhong Yuhui He Zhezhi Liu shengyu zhou Qun Li Yashuai Pang Haodong Xie Yuanpeng Ji Yuanpeng Liu Jiecai Han Weidong He National Key Laboratory of Science and Technology on Advanced Composites in Special Environments and Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080China School of Petroleum Engineering Chongqing University of Science and TechnologyChongqing 401331China School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401151China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

High-temperature proton exchange membranes(HT-PEMs) possess excellent thermal and outstanding electrochemical stability, providing an avenue to realize high-temperature proton exchange membranes fuel cells(HT-PEMFCs) with both superior power density and long-term durability. Unfortunately, polybenzimidazole(PBI), a typical material for conventional HT-PEMs, fails to compromise the high nonaqueous proton conductivity and high mechanical properties, thus hindering their practical *** efficient nonaqueous proton conduction is crucial for HT-PEMFC, and many insightful research works have been done in this area. However, there still lacks a report that integrates the host-guest interactions of phosphoric acid doping and the structural stability of polymers to systematically illustrate modification strategies. Here, we summarize recent advancements in enhancing the nonaqueous proton conduction of HT-PEMs. Various polymer structure modification strategies, including main chain and side group modification, cross-linking, blocking, and branching, are reviewed. Composite approaches of polymer, including compounding with organic porous polymers, filling the inorganic components and modifying with ionic liquids, etc., are also covered in this work. These strategies endow the HT-PEMs with more free volume, nanophase-separated structure, and multi-stage proton transfer channels, which can facilitate the proton transportation and improve their performance. Finally, current challenges and future directions for further enhancements are also outlined.

关键词： Benzimidazole Nonaqueous proton conduction Free volume Nanophase-separated structure Structure modification

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主客共享视域下城郊乡村旅游地的社会空间演化研究——以武汉柏泉古镇为例

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华中师范大学学报（自然科学版） 2024年第1期58卷 150-158页

作者：周盛雨冯娟华中师范大学城市与环境科学学院武汉430079 中国旅游研究院武汉分院武汉430079

城市郊区是城市和乡村过渡的重要地带,也是发展乡村旅游的热点区域.城郊乡村旅游地受到旅游化和城市化双重作用,社会空间演化相对复杂.该研究以旅游地生命周期和空间生产理论等为基础,运用非参与式观察、参与式观察、深入访谈以及扎根... 详细信息

城市郊区是城市和乡村过渡的重要地带,也是发展乡村旅游的热点区域.城郊乡村旅游地受到旅游化和城市化双重作用,社会空间演化相对复杂.该研究以旅游地生命周期和空间生产理论等为基础,运用非参与式观察、参与式观察、深入访谈以及扎根理论分析法等对典型城郊乡村旅游地柏泉古镇的社会空间演变过程及机制展开了实证分析与研究.研究发现:1)柏泉古镇尚处于旅游地生命周期中的参与阶段,社会总体满意度较高,不同权利主体之间矛盾较弱,呈现出良性互动的主客交往关系.2)从空间生产的视角来看,柏泉古镇社会空间演化过程可以分为物质环境日趋完善、政策资本逐步累积、主客共享协调发展三个层面.3)“东道主-游客”权利交互作用成为柏泉古镇社会空间演化的主导力量,具体表现为主客生产推动空间实践变迁、主客需求影响空间表征方向、主客共享体验表征空间和谐三个方面.主客共享驱动,也是其他城郊型乡村旅游地实践和相关研究借鉴的思路依据.

关键词：社会空间主客共享乡村旅游地柏泉古镇

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基于单边调制映射函数的LCC-HVDC直流侧阻抗精确建模

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电工技术学报 2024年第13期39卷 3928-3942页

作者：汪娟娟莫泽刘岳坤周盛宇傅闯华南理工大学电力学院广州510641 直流输电技术国家重点实验室(南方电网科学研究院有限责任公司) 广州510663

阻抗模型是电网换相换流器型高压直流输电系统小信号稳定性分析的重要基础,阻抗模型的准确程度直接影响系统小扰动稳定性分析。该文首先从同步触发原理出发,引入基于单边调制产生的映射函数,该函数蕴含控制及换相信息,可以准确建立换相... 详细信息

阻抗模型是电网换相换流器型高压直流输电系统小信号稳定性分析的重要基础,阻抗模型的准确程度直接影响系统小扰动稳定性分析。该文首先从同步触发原理出发,引入基于单边调制产生的映射函数,该函数蕴含控制及换相信息,可以准确建立换相/非换相期间交直流侧的映射关系;其次,考虑换相动态并通过谐波线性化和傅里叶变换建立完整的直流侧电压和交流侧电流的频域小信号动态模型;再次,考虑控制和换流阀阻尼回路,建立整流侧和逆变侧直流阻抗解析模型;最后,以CIGRE高压直流标准测试模型为例,基于PSCAD/EMTDC平台验证了直流侧阻抗模型的准确性及其用于小扰动稳定性分析的有效性。

关键词：电网换相换流器单边调制映射函数换相动态换流阀阻尼回路直流侧阻抗

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基于Zynq与千兆以太网的图像采集系统研究与实现

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长江信息通信 2024年第6期37卷 48-51页

作者：周晟宇彭向前湖南科技大学湖南湘潭411101

针对千兆以太网图像采集系统传输速度慢以及图像数据丢失的问题,采用千兆以太网高速图像传输技术(GigE Vision),设计了一种基于Zynq与GigE Vision的实时图像采集与显示系统。该系统采用Zynq-7000系列处理器,在处理器系统(Processing Sys... 详细信息

针对千兆以太网图像采集系统传输速度慢以及图像数据丢失的问题,采用千兆以太网高速图像传输技术(GigE Vision),设计了一种基于Zynq与GigE Vision的实时图像采集与显示系统。该系统采用Zynq-7000系列处理器,在处理器系统(Processing System, PS)中实现了采集调度模块,完成对整个采集系统的任务分配与功能调度;在可编程逻辑系统(Programmable Logic, PL)中,实现了基于GigE Vision的千兆以太网高速采集传输接口。实验结果表明,该系统以太网的传输速率可以达到932Mbps,对于分辨率为2540*1940的图像单帧采集时间为1.215ms,丢包率为0,同时可以完成图像数据的实时采集、显示及保存工作,还支持多路图像同时采集。

关键词：图像采集 Zynq 千兆以太网 GigE Vision

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替雷利珠单抗联合泽布替尼治疗难治弥漫大B细胞淋巴瘤的效果及安全性

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白血病．淋巴瘤 2024年第2期33卷 110-114页

作者：左立杰杨已起李蕊董毅君王月华周生余北京市朝阳区三环肿瘤医院肿瘤内科北京100122 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院肿瘤内科北京100021

目的探讨替雷利珠单抗联合泽布替尼治疗难治弥漫大B细胞淋巴瘤(DLBCL)的疗效和安全性。方法前瞻性观察性研究。前瞻性选取2020年11月至2023年2月中国医学科学院肿瘤医院专科医联体北京市朝阳区三环肿瘤医院收治的10例至少接受过含利妥... 详细信息

目的探讨替雷利珠单抗联合泽布替尼治疗难治弥漫大B细胞淋巴瘤(DLBCL)的疗效和安全性。方法前瞻性观察性研究。前瞻性选取2020年11月至2023年2月中国医学科学院肿瘤医院专科医联体北京市朝阳区三环肿瘤医院收治的10例至少接受过含利妥昔单抗一线全身系统性治疗的难治DLBCL患者。所有患者接受替雷利珠单抗(200 mg静脉滴注,第1天)和泽布替尼(160 mg口服,2次/d,第1天至第21天)治疗,21 d为1个周期,其中6例2线治疗,4例≥3线治疗。后续研究方案补充可同时联合利妥昔单抗(375 mg/m^(2)静脉滴注,第1天)。如果未发生疾病进展或其他需要退出研究的事件,则入组后12个月达到主要终点。随访至2023年3月,总结随访结果时疗效,采用Kaplan-Meier法进行生存分析,总结不良反应发生情况。结果10例患者中,男性6例,女性4例;年龄[M(Q_(1),Q_(3))]55岁(50岁,69岁);均为Ⅲ~Ⅳ期。10例共完成替雷利珠单抗联合泽布替尼90个周期治疗,治疗周期数为8个(2个,24个)。完全缓解4例,部分缓解3例,疾病稳定1例;随访时间19个月(11个月,28个月),无进展生存时间为8.5个月(1.3个月,27.0个月),中位缓解持续时间和中位总生存时间均未达到。治疗相关不良反应包括中性粒细胞减少(2例)、贫血(1例)、丙氨酸氨基转移酶及天冬氨酸氨基转移酶升高(1例),均为1~2级。结论替雷利珠单抗联合泽布替尼治疗难治DLBCL具有良好的临床效果和安全性。

关键词：淋巴瘤,大B细胞,弥漫性替雷利株单抗泽布替尼难治治疗结果

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Designing TiO_(2)/Au/Prussian blue heterostructures nanorod arrays for ultra-stable cycle and ultra-fast response electrochromism

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Nano Research 2023年第2期16卷 3294-3303页

作者： Miao Xu Kang Li Shen Wang shengyu zhou Hulin Zhang Hongbo Xu Jiupeng Zhao Yao Li School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China School of Physics Southeast UniversityNanjing 211189China Center for Composite Materials and Structure Harbin Institute of TechnologyHarbin 150001China

Prussian blue(PB)is an anodic coloring candidate in the wide area of electrochromic(EC)***,the co-influence of weak adhesion and low electrical conductivity leads to the poor stability and slow switching *** tackle this bottleneck,a novel TiO_(2)/Au/PB nanorod array is designed through hydrothermal and electrodeposition approaches on fluorine-doped tin oxide(FTO)*** a designed ternary array structure could not only increase reactive site and conductivity,but also improve ion storage capacity and promote charge transfer,attributed to the synergistic effect of TiO_(2)/Au/PB core–shell heterostructure and the localized surface plasmon resonance(LSPR)effect of Au ***,density functional theory(DFT)calculation confirms the strong interaction between rutile TiO_(2)and FTO substrate,which contributes to the improvement of EC cycle *** from these effects,the TiO_(2)/Au/PB film shows a fast coloration/bleaching response of 1.08/2.01 s(2.17/4.48 s,PB film)and ultra-stable EC performance of 86.8%after 20,000 cycles(50%after 600 cycles,PB film).Furthermore,the high-intensity light source can be shot clearly by the designed and assembled EC iris device(ECID)with TiO_(2)/Au/PB film as an EC layer,while the photograph without an ECID is blurry,confirming the feasibility of the material in portable digital products.

关键词： electrochromic Prussian blue Au nanoparticle TiO_(2)nanorod array heterojunction

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Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP

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Cancer Biology & Medicine 2022年第6期19卷 893-909页

作者： Yan Qin Haizhu Chen Peng Liu Changgong Zhang Jianliang Yang Lin Gui Xiaohui He Liqiang zhou shengyu zhou Shiyu Jiang Hongxin Jiang Yuankai Shi Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Suzhou Municipal HospitalAffiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215001China

Objective:Limited data about the prognostic significance of BCL2 mutations and BCL2 copy number variations in diffuse large B-cell lymphoma(DLBCL)are *** study aimed to comprehensively describe BCL2 genetic alterations in DLBCL patients,and examine correlation of BCL2,TP53 and other genetic alterations with outcomes in patients treated with ***:Probe capture-based high-resolution sequencing was performed on 191 patients diagnosed with de novo ***,BCL2,and BCL6 protein expressions were detected by ***:The presence of BCL2 alterations significantly correlated with poor progression-free survival(PFS)(5-year PFS:13.7%vs.40.8%;P=0.003)and overall survival(OS)(5-year OS:34.0%vs.70.9%;P=0.036).Importantly,patients who harbored BCL2 gain/amplifications(BCL2GA/AMP)also had a remarkably inferior 5-year PFS(11.1%vs.38.3%;P<0.001)and OS(22.1%vs.69.6%;P=0.009).In contrast,neither BCL2 mutations nor BCL2 translocations were significantly prognostic for *** analyses showed that the presence of BCL2 alterations,especially BCL2GA/AMP,TP53 mutations,and International Prognostic Index(IPI)were significantly associated with inferior PFS and *** prognostic models for OS were constructed based on 3 risk factors,including BCL2 alterations(Model 1)or BCL2GA/AMP(Model 2),TP53 mutations,and IPI,to stratify patients into 4 risk groups with different survival ***:This study showed that DLBCL patients treated with R-CHOP,BCL2 alterations,especially BCL2GA/AMP and TP53 mutations were significantly associated with inferior outcomes,which were independent of the *** novel prognostic models we proposed predicted outcomes for DLBCL patients treated with R-CHOP,but further validation of the prognostic models is still warranted.

关键词： BCL2 TP53 genetic alterations diffuse large B-cell lymphoma prognosis

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Real-world insights for the evolving intervention strategy for non-mild acute pancreatitis: 35-year experience in a Chinese Tertiary Center

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胰腺病学杂志(英文) 2024年第2期7卷 111-118页

作者： Yan Xiaxiao zhou Jingya Cao Jian Xu Qiang Han Xianlin Wang Duan Zhang shengyu Wu Dong Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Medical Records Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China WHO Family of International Classifications Collaborating Center of China Beijing China Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Background: With the accumulation of experience and evidence, guidelines for invasive intervention for acute pancreatitis (AP) have continuously evolved, followed in Peking Union Medical College Hospital (PUMCH). We aimed to review AP case series to help understand the impact of guideline evolution on the management and prognosis of AP in real-world ***: This was a single-center study of AP patients who had received invasive interventions from 1988 to 2022. Patient demographics, baseline severity, imaging findings, and the indication, timing, and specific modalities of invasive interventions were collected. The composite primary endpoint was death during hospitalization or major complications after intervention. Other endpoints included pancreatic fistula, incision infection, number of interventions, length of intensive care stay, length of hospitalization, and total medical ***: A total of 195 patients were included. The most common indication for invasive intervention was suspected infection, followed by persistent symptoms. The step-up and delayed strategies reduced the incidence of major complications or death. Over 35 years, the number of patients requiring surgery has gradually declined, and more patients need only minimally invasive procedures for remission. The incidence of the primary outcome decreased as well as the duration of ***: The management of AP patients at PUMCH in the last 35 years has undergone therapeutic guideline changes that support the efficacy and safety of the deferred step-up strategy in real-world practice.

关键词： Acute pancreatitis Drainage Invasive intervention Necrosectomy Step-up

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Clinical characteristics and treatment outcomes of Chinese diffuse large B-cell lymphoma patients in the era of rituximab(2005–2018)

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Cancer Pathogenesis and Therapy 2023年第1期1卷 3-11页

作者： Yuankai Shi Haizhu Chen Yan Qin Jianliang Yang Peng Liu Xiaohui He shengyu zhou Liqiang zhou Changgong Zhang Yongwen Song Yueping Liu Lin Gui Shulian Wang Jing Jin Hui Fang Shunan Qi Ning Li Yu Tang Xin Wang Sheng Yang Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

Background Rituximab combined with cyclophosphamide,doxorubicin hydrochloride,vincristine,and prednisone(R-CHOP)regimen has improved the survival of diffuse large B-cell lymphoma(DLBCL)patients worldwide,compared with CHOP *** limitations were seen in previous studies of Chinese DLBCL patients treated with R-CHOP or R-CHOP-like *** study aimed to investigate the clinical characteristics and treatment outcomes of Chinese DLBCL patients treated with the standard first-line *** Clinical data were collected from DLBCL patients who received frontline R-CHOP or R-CHOP-like regimens at the Cancer Hospital Chinese Academy of Medical Sciences&Peking Union Medical College(CHCAMS)between January 1,2005,and December 31,*** treatment outcomes were compared with those of patients diagnosed with DLBCL between 2004 and 2017 and who received immunochemotherapy from the United States Surveillance,Epidemiology,and End Results(SEER)*** rates were estimated using the Kaplan-Meier method and compared using the log-rank *** analysis of progression-free survival(PFS)and overall survival(OS)was performed using Cox proportional hazard *** Overall,1084 patients from the CHCAMS and 4013 patients from the SEER database were included in the *** of April 30,2022,the median follow-up period for the CHCAMS group was 87.3(range:0.5-195.4)*** the CHCAMS group,the 5-year PFS and OS rates were 61.7%(95%confidence interval[CI]:58.8-64.7%)and 70.6%(95%CI:67.8-73.4%),*** the SEER group,the 5-year OS rate was 66.5%(95%CI:65.0-68.0%),which was inferior to that of the CHCAMS group(P<0.001).After adjusting for clinical factors and treatment,no significant difference was observed in the OS between the CHCAMS and SEER groups(P=0.867).In the CHCAMS group,multivariate analysis showed that an Eastern Cooperative Oncology Group performance status score≥2,presence of B symptoms,Ann Arbor stage III-IV,elevated s

关键词： Diffuse large B-Cell lymphoma Treatment Prognosis SEER database

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Pathobiology of ovarian carcinomas

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Chinese Journal of Cancer 2015年第1期34卷 50-55页

作者： Yuankai Shi Ping zhou Xiaohong Han Xiaohui He shengyu zhou Peng Liu Jianliang Yang Changgong Zhang Lin Gui Yan Qin Sheng Yang Liya Zhao Jiarui Yao Shuxiang Zhang Department of Medical Oncology Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers(carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.

关键词：卵巢癌病理学卵巢肿瘤上皮细胞分子检测生殖细胞免疫组化靶向治疗

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