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Mesoporous Silica （HMS） Based Composite Adsorbents and Its CO2 Adsorption Performance

功能材料信息 2016年第3期13卷 48-48页

作者： Jie liu Qian Tan Junsong Bai Jianying liu Chenghua Xu shengyu liu Changwu Zou Wanglai Cen Chengdu University of Information Technology Chengdu 610225 P.R. China Air Environmental Modeling and Pollution Controlling Key Laboratory of Sichuan Higher Education Institutes Chengdu 610225 P.R. China Institute of New Energy and Low-Carbon Technology Sichuan University Chengdu 610065 P.R. China

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Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China

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Chinese Journal of Cancer Research 2019年第1期31卷 152-161页

作者： Yuankai Shi Ying Han Jianliang Yang Peng liu Xiaohui He Changgong Zhang shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping liu Shulian Wang Jing Jin Lin Gui Yan Sun Department of Medical Oncology Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Departement of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary site.Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site.Results: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis.

关键词： Diffuse large B-cell lymphoma(DLBCL) distribution nodal extranodal

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A new method for quantifying mitochondrial axonal transport

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Protein & Cell 2016年第11期7卷 804-819页

作者： Mengmeng Chen Yang Li Mengxue Yang Xiaoping Chen Yemeng Chen Fan Yang Sheng Lu shengyu Yao Timothy Zhou Jianghong liu Li Zhu Sidan Du Jane Y. Wu University of Chinese Academy of Sciences Beijing 100049 China School of Electronic Science & Engineering Nanjing University Nanjing 210093 China State Key Laboratory for Brain & Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

Axonal transport of mitochondria is critical for neuronal survival and function. Automatically quantifying and analyzing mitochondrial movement in a large quantity remain challenging. Here, we report an efficient method for imaging and quantifying axonal mitochondrial trans- port using microfluidic-chamber-cultured neurons together with a newly developed analysis package named ＂MitoQuant＂. This tool-kit consists of an automated program for tracking mitochondrial movement inside live neuronal axons and a transient-velocity analysis program for analyzing dynamic movement patterns of mitochondria. Using this method, we examined axonal mitochondrial movement both in cultured mammalian neurons and in motor neuron axons of Drosophila in vivo. In 3 different paradigms （temperature changes, drug treatment and genetic manipulation） that affect mitochondria, we have shown that this new method is highly efficient and sensitive for detecting changes in mitochondrial movement. The method significantly enhanced our ability to quantitatively analyze axonal mitochondrial movement and allowed us to detect dynamic changes in axonal mltochondrial transport that were not detected by traditional kymographic analyses.

关键词： mitochondrial transport image processing and analysis FUS proteinopathy and mitochondrial transport defect

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Pathobiology of ovarian carcinomas

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Chinese Journal of Cancer 2015年第1期34卷 50-55页

作者： Yuankai Shi Ping Zhou Xiaohong Han Xiaohui He shengyu Zhou Peng liu Jianliang Yang Changgong Zhang Lin Gui Yan Qin Sheng Yang Liya Zhao Jiarui Yao Shuxiang Zhang Department of Medical Oncology Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers(carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.

关键词：卵巢癌病理学卵巢肿瘤上皮细胞分子检测生殖细胞免疫组化靶向治疗

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Autologous peripheral blood stem cell mobilization following dose-adjusted cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy alone or in combination with rituximab in treating high-risk non-Hodgkin's lymphoma

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Chinese Journal of Cancer 2015年第11期34卷 522-530页

Background: The regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP) is an eicient treatment of non-Hodgkin's lymphoma(NHL). This study aimed to assess the eicacy and toxicity of dose-adjusted CHOP alone or in combination with rituximab(R-CHOP) by examining the stem cell mobilization in NHL patients. Factors afecting the collection of CD34+ cells were also explored.Methods: Our retrospective study included 39 patients eligible for autologous stem cell transplantation: 14 patients who expressed CD20 and were inancially eligible received R-CHOP for autologous peripheral blood stem cell(APBSC) mobilization; the remaining 25 patients received CHOP.Results: The median CD34+ cell yield was 7.01 × 106 cells/kg body weight(range 1.49–28.39 × 106 cells/kg body weight), with only two patients failing to meet the target CD34+ cell harvest of ber of apheresis procedures per patient was 1(range 1–3). The≥2.0 APBS× 106 cells/kg body weight. The median numC mobilization yield of the CHOP group appeared to be higher than that of the R-CHOP group(P response(CR) rate in = 0.005), whereas the success rate was similar between groups. R-CHOP elevated the completeB cell lymphoma patients as compared with CHOP(P = 0.01). No signiicant diferences in toxicity or engraftment were observed between the two groups.Conclusion: The present study demonstrated that dose-adjusted CHOP chemotherapy efectively mobilized APBSCs in NHL patients and that the addition of rituximab to dose-adjusted CHOP chemotherapy elevated the CR rate for patients with B-cell lymphoma.

关键词： Stem cell transplantation, Mobilization, CHOP regimen, Rituximab, Non-Hodgkin's lymphoma

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表面活性剂结构对细粒煤过滤脱水的影响及其机理研究

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日用化学工业 2022年第9期52卷 951-959页

作者：赵珂刘生玉张素红太原理工大学矿业工程学院山西太原030024

为降低细粒煤的水分,选取具有不同疏水基的聚氧乙烯型非离子表面活性剂AEO_(9),LAE_(9),OP_(9)和不同亲水基的AEO_(4),AEO_(7),AEO_(9),AEO_(15),AEO_(20)表面活性剂分别进行了细粒煤的过滤脱水试验。选取滤饼水分、过滤速度、滤饼比阻... 详细信息

为降低细粒煤的水分,选取具有不同疏水基的聚氧乙烯型非离子表面活性剂AEO_(9),LAE_(9),OP_(9)和不同亲水基的AEO_(4),AEO_(7),AEO_(9),AEO_(15),AEO_(20)表面活性剂分别进行了细粒煤的过滤脱水试验。选取滤饼水分、过滤速度、滤饼比阻、滤饼渗透率为脱水效果评价指标。进行了表面张力、红外、润湿热、吸附量、Zeta电位的测试表征。细粒煤脱水实验结果表明,不同疏水基表面活性剂中的AEO_(9)表现较好的过滤脱水性能,不同亲水基的AEO系列表面活性剂中AEO_(7)具有较好的过滤脱水性能。针对表面活性剂AEO_(7)进行了细粒煤的过滤脱水的机理研究,发现在药剂用量为120 mg/L时,含氧官能团减弱程度最大,润湿热最低,表明煤表面的疏水性增强最显著,此时滤饼水分降低4.66%。同时滤液表面张力在AEO_(7)药剂用量超过120 mg/L几乎不再降低。吸附量测试结果表明表面活性剂用量在超过120 mg/L后,可能煤表面发生双层吸附使得煤表面变得亲水,从而减弱过滤脱水性能。

关键词：细粒煤脱水表面活性剂疏水性

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行星齿轮机电耦合动力学及其电参数影响机理研究

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振动与冲击 2022年第20期41卷 78-85,175页

作者：肖正明刘佳伟谭加林郑胜予昆明理工大学机电工程学院昆明650500

针对机电系统动力学响应与电参数变化的相互作用机制问题,将时变啮合刚度及太阳轮处时变轴承刚度表示为转角的函数,建立了适用于不同转速工况的电机-齿轮机电耦合模型。使用dq轴坐标变换法推导了机械系统动态特性与电机定子电流的作用... 详细信息

针对机电系统动力学响应与电参数变化的相互作用机制问题,将时变啮合刚度及太阳轮处时变轴承刚度表示为转角的函数,建立了适用于不同转速工况的电机-齿轮机电耦合模型。使用dq轴坐标变换法推导了机械系统动态特性与电机定子电流的作用关系。基于精细的机电耦合模型,计算得出了振动响应及电机定子电流响应的频率特性,揭示了啮合频率与轴承频率在定子电流中的映射规律。研究结果表明:定子电流频率会受到机械部分频率调制作用从而产生相应边频,该边频成分可用于判断机械系统运行情况;啮合频率及其倍频直接与电流频率发生调制体现在电流频谱中,轴承频率先与啮合频率卷积再与电流频率发生调制才体现在电流频谱上;在不同转速下工况下,齿轮以及轴承特征频率偏移也能体现在电流频域上。

关键词：电机-齿轮系统机电耦合动力学特性定子电流特征分析

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一种改进的可消除Vienna整流器电流过零畸变的控制方法

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电工技术学报 2022年第15期37卷 3834-3844页

作者：王金平刘圣宇张庆岩姜卫东合肥工业大学电气与自动化工程学院合肥230009

该文首先介绍了Vienna整流器的基本原理,并在此基础上分析Vienna整流器的电流过零畸变问题。该文重点从空间矢量图的角度,分析在网侧单位功率因数运行条件下,Vienna整流器输入电流产生过零畸变的本质。此外,对比分析在整流器侧单位功率... 详细信息

该文首先介绍了Vienna整流器的基本原理,并在此基础上分析Vienna整流器的电流过零畸变问题。该文重点从空间矢量图的角度,分析在网侧单位功率因数运行条件下,Vienna整流器输入电流产生过零畸变的本质。此外,对比分析在整流器侧单位功率因数运行条件下的控制方法。在此基础上,推导出一种改进的可以消除Vienna整流器电流过零畸变且最大程度提高电网侧功率因数的方法。最后,对Vienna整流器网侧单位功率因数运行的控制方法、整流器侧单位功率因数运行的控制方法以及所提的改进控制方法进行实验对比。相应的实验结果验证了该文所提控制方法的可行性和优越性。

关键词： Vienna整流器电流过零畸变功率因数控制方法

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Unified throughout-pore microstructure enables ultrahigh separator porosity for robust high-flux lithium batteries

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Electron 2023年第1期1卷 37-49页

作者： Dongjiang Chen Yuanpeng liu Chao Feng Yuhui He shengyu Zhou Botao Yuan Yunfa Dong Haodong Xie Guangfeng Zeng Jiecai Han Weidong He National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbinChina Center for Composite Materials and Structures Harbin Institute of TechnologyHarbinChina State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of ChinaChengduChina Chongqing Research Institute Harbin Institute of TechnologyChongqingChina Interdisciplinary Graduate Program in Materials Science Vanderbilt UniversityNashvilleTennesseeUSA

With small thickness,commercial polyolefin separators own low porosity to ensure sufficient thermomechanical properties,resulting in tortuous and enlarged Li+diffusion pathways that induce large overpotentials and detrimental dendrite growth.As a dilemma,the exploration of highly porous separators has been challenged by their large thickness,impairing the applicability of such pursuits.Herein,an ultraporous architecture is designed to shorten Li+transfer pathways by impregnating electrolyteaffinitive poly(vinylidene fluoride-co-hexafluoropropylene)into ultralight~3μm 3D-polytetrafluoroethylene scaffold(abbreviated as UP3D).The UP3D separator with a porosity of 74%gives rise to 70%enhancement in Li+transference and 77%reduction in Li+transfer resistance(2.67 mΩmm^(−1))and thus enables an ultrahigh Li+flux of 22.7 mA cm^(−2),effectively alleviating Li+concentration gradient across the separator.With the separator,the LiFePO4 half cell delivers a capacity of 118 mAh g^(−1) with an unparalleled capacity retention of 90%after 1000 cycles at 2 C,and a graphite||LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)pouch full cell delivers an areal energy density of 6.8 mWh cm^(−2)at 8.848 mA(1.4 mA cm^(−2))with a high cathode loading of 134.9 mg.Such results,together with the scalable production of the separator,reflect its promising potential in high-flux battery applications of separators that require both ultrahigh porosity and reliability.

关键词： Li deposition Li-ion batteries polytetrafluoroethylene separator ultrahigh porosity

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Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88

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Journal of Animal Science and Biotechnology 2020年第1期11卷 132-146页

作者： Xie Peng Ru Wang Liang Hu Qiang Zhou Yang liu Min Yang Zhengfeng Fang Yan Lin shengyu Xu Bin Feng Jian Li Xuemei Jiang Yong Zhuo Hua Li De Wu Lianqiang Che Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China Institute of Animal NutritionSichuan Agricultural UniversityChengduSichuan 611130People’s Republic of China Animal Husbandry and Veterinary Department Chengdu Agricultural CollegeChengduSichuan 611130People’s Republic of China.

Background:This study aimed to investigate the effects of oral administration of Enterococcus faecium NCIMB10415(E.faecium)on intestinal development,immunological parameters and gut microbiota of neonatal piglets challenged with enterotoxigenic Escherichia coli K88(ETEC).A total of 961-day-old sow-reared piglets were randomly assigned to 2 groups,with 48 piglets in each group.The piglets were from 16 litters(6 piglets each litter),and 3 piglets each litter were allocated to the E.faecium-supplemented(PRO)group,while the other 3 piglets were allocated to the control(CON)group.After colostrum intake,piglets in the PRO group were orally administrated with 3×10~9 CFU E.faecium per day for a period of one week.On day 8,one piglet per litter from each group was challenged(CON+ETEC,PRO+ETEC)or not(CON-ETEC,PRO-ETEC)with ETEC in a 2×2 factorial arrangement of treatments.On day 10(2 days after challenge),blood and tissue samples were obtained from piglets.Results:Before ETEC challenge,there were no significant differences for the average daily gain(ADG)and fecal score between the two groups of piglets.After ETEC challenge,the challenged piglets had greater fecal score compared to the non-challenged piglets,whereas E.faecium administration was able to decrease the fecal score.Piglets challenged with ETEC had shorter villous height,deeper crypt depth,and reduced number of goblet cells in the jejunum and decreased m RNA abundance of claudin-1 in the ileum,whereas increased the percentage of lymphocytes,concentrations of IL-1βin the plasma and TNF-αin the ileal mucosa,as well as increased the m RNA abundances of innate immunity-related genes in the ileum tissue.These deleterious effects caused by ETEC were partly alleviated by feeding E.faecium.In addition,piglets in PRO-ETEC group had decreased the percentage of CD8^+T cells of the peripheral blood when compared to those in CON-ETEC group.Moreover,E.faecium administration increased Verrucomicrobia at phylum level and decreased Bilophila at genus level.Conclusions:These resul

关键词： Enterococcus faecium Enterotoxigenic Escherichia coli K88 Gut microbiota Immunity Intestine Neonatal piglets

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