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Molecular pathology and clinical implications of diffuse glioma

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Chinese Medical Journal 2022年第24期135卷 2914-2925页

作者： Ruichao Chai shengyu Fang Bo Pang Yuqing liu Yongzhi Wang Wei Zhang Tao Jiang Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijing 100070China

The prognosis for diffusely infiltrating gliomas at World Health Organization(WHO)grade 2-4 remains dismal due to their heterogeneity.The rapid development of genome-wide molecular-profiling-associated studies has greatly promoted the accuracy of glioma classification.Thus,the latest version of the WHO classification of the central nervous system tumors published in 2021 has incorporated more molecular biomarkers together with histological features for the diagnosis of gliomas.Advanced usage of molecular pathology in clinical diagnostic practice provides also new opportunities for the therapy of patients with glioma,including surgery,radiotherapy and chemotherapy,targeted therapy,immunotherapy,and more precision clinical trials.Herein,we highlight the updates in the classification of gliomas according to the latest WHO guidelines and summarize the clinically relevant molecular markers by focusing on their applications in clinical practice.We also review the advances in molecular features of gliomas,which can facilitate the development of glioma therapies,thereby discussing the challenges and future directions of molecular pathology toward precision medicine for patients with glioma.

关键词： Glioma Molecular pathology tumor classification O^(6)-methylguanine-DNA methyltransferase Therapy

Optimizing hairy root production from explants of Phyllanthus hainanensis,a shrub used for traditional herbal medicine

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Frontiers of Agricultural Science and Engineering 2020年第4期7卷 513-522页

作者： Zhaogui YAN Shengyu Liu Junlian ZHANG Guan HUANG Lijun DUAN Yaomei YE College of Horticulture and Forestry Sciences/Hubei Engineering Technology Research Center for Forestry Information Huazhong Agricultural UniversityWuhan 430070China School of Environmental&Rural Science The University of New EnglandArmidaleNSW 2351Australia Wuhan Garden Constructional Engineering Company Wuhan 430050China Hubei Wildlife and Plant Conservation Agency Wuhan 430070China

Phyllanthus hainanensis is a shrub that has been used in traditional herbal medicine.It has great pharmaceutical potential for treating diseases such as cancer and diabetes.As a prerequisite for propagation of this species on a large scale,hairy roots in P.hainanensis were induced using Rhizobium rhizogenes and various factors affecting hairy root induction and growth evaluated.Seven factors were tested:(1)type of explant,(2)type of culture medium,(3)duration of pre-culture,(4)R.rhizogenes inoculum cell density,(5)duration of infection,(6)acetosyringone concentration in the culture medium,and(7)duration of incubation.The optimal protocol for hairy root induction and growth was:young shoots,pre-cultured in Y1 for 2 d,inoculated with R.rhizogenes broth with an OD600 of 0.6 for 20 min,and incubated for 3 d.Putative transgenic hairy roots were initially identified by morphology and then confirmed by polymerase chain reaction.Successful and optimal production of hairy roots is a critical prerequisite for industrial scale clonal propagation of P.hainanensis.Being able to cultivate the plant on a large scale will provide rapid and ready supply of the plant materials that can be used in herbal medicine and in scientific and industrial exploitation.

关键词： hairy root induction medicinal plant MS growth medium Phyllanthus hainanensis Rhizobium rhizogenes

Remarkable Wear Resistance in a Complex Concentrated Alloy with Nanohierarchical Architecture and Composition Undulation

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Research 2024年第1期2023卷 403-416页

作者： Yushan Geng Wenyuan Chen Hui Tan Jun Cheng shengyu Zhu Jun Yang Weimin liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049PR China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264000PR China

Sustained wear damages on the sliding surfaces of alloys are generally the culprit responsible for the failure of various mechanical systems.Inspired by high-entropy effects,here we deliberately deploy nanohierarchical architecture with composition undulation in a Ni50(AlNbTiV)_(50) complex concentrated alloy,which yields ultralow wear rate within the order of 10^(−7) to 10^(−6) mm^(3)/Nm between room temperature and 800℃.Such remarkable wear resistance heretofore represents one of the highest wear resistance reported for the bulk alloys or composites,and originates from the multi-type adaptive friction interface protection governed by intrinsically nano-coupled grains and nanoprecipitates.This cooperative heterostructure releases gradient frictional stress in stages upon wear at room temperature through the coexistence of multiple deformation pathways while activating a dense nanocrystalline glaze layer upon wear at 800℃ to minimize adhesive and oxidative wear.Our work uncovers a practical avenue for tailoring wear properties with multicomponent heterostructures over a wide temperature range.

关键词： wear alloys friction

3D FEM Simulation of Milling Force in Corner Machining Process

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Chinese Journal of Mechanical Engineering 2017年第2期30卷 286-293页

作者： Caixu YUE Cui HUANG Xianli liu shengyu HAO Jun liu State Engineering Laboratory of High Efficiency Cutting andTool Harbin University of Science TechnologyHarbin 50080China

To optimize milling force and machining accuracy quality in corner milling process, the changing law of milling force is revealed by Finite Element Method（FEM）. Based on DEFORM software a serial of 3D FEM models for corner milling process are devloped. Tool curved trajectory is achieved by establishing accurate relationship of tool location with milling time. Adaptive remeshing technique and iterative algorithm are adopted to ensure convergence of FEM model. Component force characteristics are revealed by analyzing FEM simulation results. It indicates that the milling force in Y direction becomes negative comparing with forces in X and Z direction. Magnitude of forces in three directions decreases with increase of spindle speed, while it increases with increase of milling feedrate. The simulation results for cutting force are in good agreement with those obtained from experiment. The FEM simulation model is first successfully established for corner milling process in this study, and the results provide a guide for optimizing cutting parameters in cutting process.

关键词： FEM simulation Corner milling Hardened steel Milling force

Topological bound state in the continuum induced unidirectional acoustic perfect absorption

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Science China(Physics,Mechanics & Astronomy) 2023年第8期66卷 75-82页

作者： Haiyan Zhang Shanshan liu Zhiwei Guo shengyu Hu Yuguang Chen Yunhui Li Yong Li Hong Chen MOE Key Laboratory of Advanced Micro-structured Materials School of Physics Sciences and EngineeringTongji UniversityShanghai 200092China Institute of Acoustics Tongji UniversityShanghai 200092China Department of Electrical Engineering Tongji UniversityShanghai 201804China

The interaction between cavity field and atoms plays an important role in exploring the abundant non-Hermitian physics and constructing powerful wave function devices.In this work,we propose theoretically and realize experimentally unidirectional perfect absorption in a non-Hermitian acoustic system with the help of the topological bound state in the continuum(BIC),which is established by the hybrid interaction between one trivial BIC and another conventional resonant state.In the 2D parameter space spanned by frequency and distance between the two resonators,the topological scattering singularities appear in pairs and are associated with topological distinguished charges.Meanwhile,we reveal the origin of topological charges and their continuous evolution with the loss factor.At a specific loss factor,two topological charges just annihilate together,and acoustic perfect absorption induced by topological BIC is realized at the left incidence,while there is no phase singularity and near-total reflection is observed at the right incidence,hence the system presents extreme asymmetry.Our work bridges the gap between scattering characteristics of non-Hermitian acoustic systems and topological scattering singularities,which may contribute to the research of novel non-Hermitian physics and the practical applications of advanced absorbers and sensors.

关键词： non-Hermitian physics topological scattering singularities bound state in the continuum unidirectional perfect absorption exceptional points

Adaptive enhancement design of triply periodic minimal surface lattice structure based on non-uniform stress distribution

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Applied Mathematics and Mechanics(English Edition) 2023年第8期44卷 1317-1330页

作者： Yijin ZHANG Bin liu Fei PENG Heran JIA Zeang ZHAO shengyu DUAN Panding WANG Hongshuai LEI Beijing Key Laboratory of Lightweight Multi-functional Composite Materials and Structures Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

The Schwarz primitive triply periodic minimal surface(P-type TPMS)lattice structures are widely used.However,these lattice structures have weak load-bearing capacity compared with other cellular structures.In this paper,an adaptive enhancement design method based on the non-uniform stress distribution in structures with uniform thickness is proposed to design the P-type TPMS lattice structures with higher mechanical properties.Two types of structures are designed by adjusting the adaptive thickness distribution in the TPMS.One keeps the same relative density,and the other keeps the same of non-enhanced region thickness.Compared with the uniform lattice structure,the elastic modulus for the structure with the same relative density increases by more than 17%,and the yield strength increases by more than 10.2%.Three kinds of TPMS lattice structures are fabricated by laser powder bed fusion(L-PBF)with 316L stainless steel to verify the proposed enhanced design.The manufacture-induced geometric deviation between the as-design and as-printed models is measured by micro X-ray computed tomography(μ-CT)scans.The quasi-static compression experimental results of P-type TPMS lattice structures show that the reinforced structures have stronger elastic moduli,ultimate strengths,and energy absorption capabilities than the homogeneous P-TPMS lattice structure.

关键词： additive manufacturing(AM) triply periodic minimal surface(TPMS) enhanced design model mechanical property micro X-ray computed tomography(u-CT)

Microstructure, mechanical and tribological properties of TiAl-based composites reinforced with high volume fraction of nearly network Ti_2AlC particulates

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Journal of Materials Science & Technology 2018年第4期34卷 670-678页

作者： Jun Cheng shengyu Zhu Yuan Yu Jun Yang Weimin liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of Sciencestanzhou 730000China

TiAl-based composites reinforced with different high volume fractions of nearly network TizAIC phase have been successfully prepared by mechanical alloying and hot-pressing method. Their microstructure. mechanical and tribological properties have been investigated. Ti2AIC network becomes continuous but the network wall grows thicker with increasing the Ti2AIC content. The continuity and wall size of the network Ti2AIC phase exert a significant influence on the mechanical properties. The bending strength of the composites first increases and then decreases with the Ti2A1C content. The compressive strength of the composite decreases slightly compared to the TiAI alloy, but the hardness is enhanced. Due to the high hardness and load-carrying capacity of the network structure, these composites have the better wear resistance. And this enhancement is more notable at low applied loads and high Ti2A1C content. The mechanisms simulating the role of network Ti2AIC phase on the wear behavior and the wear process of TiAl/Ti2AIC composites at different applied loads have been proposed.

关键词： TiAl/Ti2AIC composites Network structure Wear resistance

Preparation of lignin/TiO2 nanocomposites and their application in aqueous polyurethane coatings

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 59-69,F0004页

作者： Dongjie Yang shengyu Wang Ruisheng Zhong Weifeng liu Xueqing Qiu School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 China

A simple method using a water soluble lignin quaternary ammonium salt (LQAS) and TiO2 has been developed for the preparation of lignin/TiO2 nanocomposites in an aqueous medium under mild conditions. The LQAS/TiO2 nanocomposites contain well-dispersed small particles with excellent ultraviolet (UV) shielding abilities and good compatibilities with waterborne polyurethane (WPU). When the LQAS/TiO2 nanocomposites were blended with WPU, the UV absorbance and the tensile ductility of the WPU increased significantly. The composite WPU hybrid film containing 6 wt-% LQAS/TiO2 nanocomposite had the highest visible light transmittance and had excellent ultraviolet aging properties. After 192 h of UV light irradiation, the tensile strength of the composite film was above 8 MPa and the elongation at break was 800%. This work highlights new possibilities for the utilization of alkali lignin.

关键词： lignin TiO2 nanocomposite particle polyurethane film

Research progress of functional near-infrared spectroscopy in patients with psychiatric disorders

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Forensic Sciences Research 2021年第2期6卷 141-147页

作者： Fan Chang Haozhe Li shengyu Zhang Chen Chen Chao liu Weixiong Cai Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeShanghai Forensic Service PlatformAcademy of Forensic ScienceShanghaiChina School of Mental Health Wenzhou Medical UniversityWenzhouChina

Functional near-infrared spectroscopy(fNIRS)is a technique of detecting cerebral cortical function by using near-infrared light,which is a multifunctional neuroimaging technique and provides a convenient and efficient detection method in neuroscience.In consideration of acceptability,safety,high spatial and temporal resolutions compared with electroencephalogram(EEG)and functional magnetic resonance imaging(fMRI),fNIRS is widely used to study different psychiatric disorders,most prominently affective disorders,schizophrenic illnesses,brain organic mental disorders and neurodevelopmental disorders,etc.The article focuses on the latest research progress and practical application of fNIRS in psychiatric disorders,especially traumatic brain,including studies on the characterization of phenomenology,treatment effects and descriptions of neuroimaging data.

关键词： Forensic sciences psychiatric disorder functional near-infrared spectroscopy traumatic brain injury