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Chinese Medical Journal 2024年第2期137卷 232-234页

作者： Yucai Wu Di Cai Jian Fan Chang Meng Shiming He Zhihua Li Lianghao Zhang Kunlin Yang Aixiang Wang Xinfei Li Yicong Du shengwei xiong Mancheng Xia Tingting Li Lanlan Dong YanqingGong Liqun Zhou Xuesong Li Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Peking UniversityBeijing 100034China Wuhan Ammunition Life-tech Company Ltd.WuhanHubei 430200China

Diagnostic methods for urothelial carcinomas(UCs)are often invasive or have suboptimal accuracy.Methylation of exfoliated cell DNA or cell-free DNA in urine has shown great promise in the diagnosis of UCs.However,most current studies have focused on bladder cancer(BCa),and only a few high-plex methylated DNA panels based on large-volume urine have been reported to exhibit both high sensitivity and specificity.[1,2]The purpose of this study was to identify universal biomarkers for BCa and upper tract urothelial carcinoma(UTUC)using a small volume of urine.We developed a dual-target diagnostic panel comprising the novel marker AL021918.2 and the well-known BCa biomarker Vimentin(VIM).This panel can accurately detect UCs using only 1.8 mL of full-voided urine.

关键词： urine bladder diagnosis

The application of internal suspension technique in retroperitoneal robot-assisted laparoscopic partial nephrectomy with a new robotic system KangDuo Surgical Robot-01:Initial experience

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Asian Journal of Urology 2023年第4期10卷 482-487页

作者： Silu Chen Shubo Fan Hua Guan Kunlin Yang Zhihua Li shengwei xiong Xiang Wang Zhenyu Li Cheng Shen Liqun Zhou Xuesong Li Department of Urology Peking University First HospitalInstitute of UrologyPeking UniversityNational Urological Cancer CenterXicheng DistrictBeijingChina

Objective To assess the feasibility of internal suspension technique in retroperitoneal robot-assisted laparoscopic partial nephrectomy(rRAPN)with a new robotic platform called KangDuo Surgical Robot-01(KD-SR-01)system(Suzhou KangDuo Robot Co.,Ltd.,Suzhou,China)and discuss its surgical technique.Methods A 44-year-old male patient was admitted with a 2.5 cm tumor on dorsolateral upper pole of the left kidney.The R.E.N.A.L.nephrometry score of this patient was 4x.This patient underwent rRAPN with KD-SR-01.The perinephric fat between the tumor and Gerota's fascia was preserved,which was used for internal suspension traction during tumor resection.Postoperative follow-up data were collected.Results The surgery was successfully carried out with a duration of 127 min,in which the docking time was 6 min 25 s and console time was 60 min.The warm ischemia time was 19 min 53 s,and the estimated blood loss was 0 mL.The pathological histology showed a pathological tumor stage 1a clear cell renal cell carcinoma,with a negative surgical margin.The World Health Organization/International Society of Urological Pathology(WHO/ISUP)grade of this patient was Grade 2.No recurrence was observed during the 6-month follow-up.Conclusion Internal suspension in rRAPN is feasible and effective with use of the new robotic system KD-SR-01.

关键词： KangDuo Surgical Robot-01 Internal suspension Partial nephrectomy Retroperitoneal approach

Robotic urologic surgery using the KangDuo-Surgical Robot-01 system:A single-center prospective analysis

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Chinese Medical Journal 2023年第24期136卷 2960-2966页

作者： shengwei xiong Shubo Fan Silu Chen Xiang Wang Guanpeng Han Zhihua Li Wei Zuo Zhenyu Li Kunlin Yang Zhongyuan Zhang Cheng Shen Liqun Zhou Xuesong Li Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China

Background:The KangDuo-Surgical Robot-01(KD-SR-01)system is a new surgical robot recently developed in China.The aim of this study was to present our single-center experience and mid-term outcomes of urological procedures using the KD-SR-01 system.Methods:From August 2020 to April 2023,consecutive urologic procedures were performed at Peking University First Hospital using the KD-SR-01 system.The clinical features,perioperative data,and follow-up outcomes were prospectively collected and analyzed.Results:A total of 110 consecutive patients were recruited.Among these patients,28 underwent partial nephrectomy(PN),41 underwent urinary tract reconstruction(26 underwent pyeloplasty,3 underwent ureteral reconstruction and 12 underwent ureterovesical reimplantation[UR]),and 41 underwent radical prostatectomy(RP).The median operative time for PN was 112.5 min,157.0 min for pyeloplasty,151.0 min for ureteral reconstruction,142.5 min for UR,and 138.0 min for RP.The median intraoperative blood loss was 10 mL for PN,10 mL for pyeloplasty,30 mL for ureteral reconstruction,20 mL for UR,and 50 mL for RP.All procedures were successfully completed without conversion,and there were no major complications in any patient.The median warm ischemia time of PN was 17.3 min,and positive surgical margin was not noted in any patient.The overall positive surgical margin rate of RP was 39%(16/41),and no biochemical recurrence was observed in any RP patient during the median follow-up of 11.0 months.The surgical success rates of pyeloplasty and UR were 96%(25/26)and 92%(11/12)during the median follow-up of 29.5 months and 11.5 months,respectively.Conclusion:The KD-SR-01 system appears feasible,safe,and effective for most urological procedures,based on our single-center experience.

关键词： Robotics KangDuo-Surgical Robot-01 Partial nephrectomy Urinary tract reconstruction Radical prostatectomy

Application of Lattice Boltzmann Method to Simulation of Compressible Turbulent Flow

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Communications in Computational Physics 2010年第10期8卷 1208-1223页

作者： Congshan Zhuo Chengwen Zhong Kai Li shengwei xiong Xiaopeng Chen Jun Cao National Key Laboratory of Science and Technology on Aerodynamic Design and Research Northwestern Polytechnical UniversityXi’anShaanxi 710072China Center for High Performance Computing Northwestern Polytechnical UniversityXi’anShaanxi 710072China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Mechanical and Industrial Engineering Ryerson UniversityTorontoOntarioM5B 2K3Canada

The main goal of this paper is to develop the coupled double-distributionfunction(DDF)lattice Boltzmann method(LBM)for simulation of subsonic and transonic turbulent flows.In the present study,we adopt the second-order implicit-explicit(IMEX)Runge-Kutta schemes for time discretization and the Non-Oscillatory and NonFree-Parameters Dissipative(NND)finite difference scheme for space discretization.The Sutherland’s law is used for expressing the viscosity of the fluid due to considerable temperature change.Also,the Spalart-Allmaras(SA)turbulence model is incorporated in order for the turbulent flow effect to be pronounced.Numerical experiments are performed on different turbulent compressible flows around a NACA0012 airfoil with body-fitted grid.Our numerical results are found to be in good agreement with experiment data and/or other numerical solutions,demonstrating the applicability of the method presented in this study to simulations of both subsonic and transonic turbulent flows.

关键词： Lattice Boltzmann method compressible turbulent flow airfoil body-fitted grid

北羌塘坳陷东缘上三叠统巴贡组海相烃源岩特征及勘探启示

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海相油气地质 2024年第1期29卷 45-56页

作者：宁生伟谢渊付小东宋春彦刘琪熊绍云西藏大学中国石油杭州地质研究院中国地质调查局成都地质调查中心

羌塘盆地北羌塘坳陷晚三叠世发育了一套分布广、厚度大的黑色泥岩,对油气勘探具有重要意义。为明确北羌塘坳陷东缘巴贡组黑色泥岩的有机地球化学特征,采集了石油沟地区61块浅井岩心和64块手钻柱塞样品,开展地球化学和矿物学技术分析,对... 详细信息

羌塘盆地北羌塘坳陷晚三叠世发育了一套分布广、厚度大的黑色泥岩,对油气勘探具有重要意义。为明确北羌塘坳陷东缘巴贡组黑色泥岩的有机地球化学特征,采集了石油沟地区61块浅井岩心和64块手钻柱塞样品,开展地球化学和矿物学技术分析,对烃源岩生烃潜力、沉积环境进行了评价。结果表明:(1)巴贡组黑色泥岩TOC分布在0.06%~5.81%之间,整体为一套差―中等烃源岩,部分达到优质烃源岩标准;形成于弱氧化―弱还原环境,有机质类型为Ⅱ_(2)―Ⅲ型,以混合型有机质为主;R_(o)分布在0.95%~1.90%之间,处于成熟晚期至高成熟阶段。(2)巴贡组烃源岩有机质丰度较高,有机质类型好,成熟度适中,生烃潜力大。(3)巴贡组烃源岩与上覆雀莫错组底部砂砾岩形成“下生上储”的源储组合,为大中型油气田的形成奠定了基础,同时巴贡组也是页岩油勘探的有利层系。这套烃源岩对北羌塘坳陷东缘常规油气和非常规油气勘探均具有重要意义。

关键词：烃源岩有机地球化学生烃潜力勘探领域巴贡组北羌塘坳陷

Programming the lifestyles of engineered bacteria for cancer therapy

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National Science Review 2023年第5期10卷 138-153页

作者： shengwei Fu Rongrong Zhang Yanmei Gao Jiarui xiong Ye Li Lu Pu Aiguo Xia Fan Jin Hefei National Research Center for Physical Sciences at the Microscale Department of Polymer Science and Engineering University of Science and Technology of China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences West China School of Medicine West China Hospital of Sichuan University

Bacteria can be genetically engineered to act as therapeutic delivery vehicles in the treatment of tumors,killing cancer cells or activating the immune system.This is known as bacteria-mediated cancer therapy(BMCT).Tumor invasion,colonization and tumor regression are major biological events,which are directly associated with antitumor effects and are uncontrollable due to the influence of tumor microenvironments during the BMCT process.Here,we developed a genetic circuit for dynamically programming bacterial lifestyles(planktonic,biofilm or lysis),to precisely manipulate the process of bacterial adhesion,colonization and drug release in the BMCT process,via hierarchical modulation of the lighting power density of near-infrared(NIR) light.The deep tissue penetration of NIR offers us a modality for spatio-temporal and non-invasive control of bacterial genetic circuits in vivo.By combining computational modeling with a high-throughput characterization device,we optimized the genetic circuits in engineered bacteria to program the process of bacterial lifestyle transitions by altering the illumination scheme of NIR.Our results showed that programming intratumoral bacterial lifestyle transitions allows precise control of multiple key steps throughout the BMCT process and therapeutic efficacy can be greatly improved by controlling the localization and dosage of therapeutic agents via optimizing the illumination scheme.

关键词： genetic engineering drug delivery cancer therapy optogenetics synthetic biology

不同质量浓度Cu^(2+)和Ag^(+)对大麦成熟胚组培特性的影响

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云南农业大学学报（自然科学版） 2024年第1期39卷 9-17页

作者：周洪斌王卫斌王梦玥熊静蕾陈升位毛孝强云南农业大学农学与生物技术学院云南昆明650201

【目的】探究不同质量浓度Cu^(2+)和Ag^(+)对大麦成熟胚组培特性的影响。【方法】以Bowman、北青7号和光头大麦的成熟胚为材料,研究不同质量浓度Cu^(2+)和Ag^(+)对大麦成熟胚愈伤诱导率、长根率、长芽率、褐化率、绿化率、再分化率和愈... 详细信息

【目的】探究不同质量浓度Cu^(2+)和Ag^(+)对大麦成熟胚组培特性的影响。【方法】以Bowman、北青7号和光头大麦的成熟胚为材料,研究不同质量浓度Cu^(2+)和Ag^(+)对大麦成熟胚愈伤诱导率、长根率、长芽率、褐化率、绿化率、再分化率和愈伤湿质量的影响。【结果】Bowman、北青7号和光头大麦成熟胚的7种组培特性间存在不同程度差异。与对照相比,0.75 mg/L Cu^(2+)可减少10.43%的成熟胚长根、7.48%的成熟胚长芽、8.24%的愈伤组织褐化、20.74 mg的愈伤湿质量;4.00 mg/L Ag^(+)可提高6.47%的愈伤组织诱导率,可减少9.08%的成熟胚长根、7.96%的成熟胚长芽和9.67%的愈伤褐化;0.75 mg/L Cu^(2+)和4.00 mg/L Ag^(+)对愈伤细胞转绿、愈伤增殖和再分化均无抑制。【结论】适宜质量浓度的Cu^(2+)和Ag^(+)可有效抑制大麦成熟胚长根、长芽和愈伤组织褐化,Ag+还可有效提高愈伤诱导率;在基于MS培养基的大麦成熟胚愈伤组织诱导和再分化培养中,Cu^(2+)和Ag^(+)的适宜质量浓度分别为0.75和4.00 mg/L。研究结果可为构建大麦成熟胚的愈伤诱导及其再分化技术体系提供理论支持。

关键词：大麦成熟胚组培特性 Cu^(2+)质量浓度 Ag^(+)质量浓度

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制样设备参数对玉米脂肪酸值测定结果的影响

食品科技 2024年第3期49卷 300-306页

作者：陈静珂唐文强毛根武郭凤民邱家志唐涛熊升伟河南工业大学粮油食品学院河南郑州450001 中储粮成都储藏研究院有限公司四川成都610091

选择一种高纯度玉米作为测试样品,研究制样设备、筛片孔距、进料时间对脂肪酸值测定结果的影响。试验结果表明:(1)相同条件下,采用不同制样设备(1#机、2#机),对测试样品进行80 g定量连续10次重复性制样试验比对。1#机最高粉温为39.1℃,... 详细信息

选择一种高纯度玉米作为测试样品,研究制样设备、筛片孔距、进料时间对脂肪酸值测定结果的影响。试验结果表明:(1)相同条件下,采用不同制样设备(1#机、2#机),对测试样品进行80 g定量连续10次重复性制样试验比对。1#机最高粉温为39.1℃,第3次制样的粉温达到33.1℃时,脂肪酸值开始显著上升,10次测定结果的变异系数为5.38%。2#机最高粉温30.6℃,脂肪酸值基本无变化,10次测定结果的变异系数为0.90%。(2)选择脂肪酸值测定结果变异系数小的2#机,筛选3种孔距筛片(1.25、1.5、1.75倍),设置4个不同进料时间(30、40、50、60 s),排列组合形成12组测试参数。每组测试参数进行80 g定量连续10次重复性制样试验比对。筛片孔距1.75倍时,脂肪酸值测定结果波动较大且绝对差值超过国标允许的2 mg KOH/100 g范围。从进料效率角度筛选,最佳筛片孔距为1.25倍。从筛片材质要求、使用寿命和加工难度角度筛选,最佳筛片孔距为1.50倍。从进料效率和变异系数角度筛选,最佳进料时间为30 s。

关键词：玉米脂肪酸值制样设备进料时间筛片孔距

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药物配送控制系统的出药控制

湖南工业大学学报 2024年第2期38卷 20-24页

作者：戴圣伟刘忆熊一菲周源睿杨明霄湖南工业大学电气与信息工程学院湖南株洲412007 湖南化工职业技术学院智能控制工程学院湖南株洲412006

针对药物配送过程中时滞性、随机性、主观性等缺点,提出了一种智能药物配送算法。该系统参考了直流电机的转矩方程,结合对应药物的EAN-13编写规则,构成控制系统,可实现药房配送的自动化,解决药房出药慢、患者排队时间长等问题。最后以... 详细信息

针对药物配送过程中时滞性、随机性、主观性等缺点,提出了一种智能药物配送算法。该系统参考了直流电机的转矩方程,结合对应药物的EAN-13编写规则,构成控制系统,可实现药房配送的自动化,解决药房出药慢、患者排队时间长等问题。最后以实物模型验证了算法的可行性与有效性。

关键词：药物配送 EAN-13 直流电机出药控制

Regrowth-free AlGaInAs MQW polarization controller integrated with a sidewall grating DFB laser

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Photonics Research 2023年第4期11卷 622-630页

作者： XIAO SUN SONG LIANG WEIQING CHENG shengwei YE YIMING SUN YONGGUANG HUANG RUIKANG ZHANG JICHUAN xiong XUEFENG LIU JOHN HMARSH LIANPING HOU James Watt School of Engineering University of GlasgowGlasgow G128QQUK Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China

Polarization control is at the heart of high-capacity data optical communication systems,such as polarizationdivision multiplexers and Stokes vector modulation transmitters.Despite passive polarization control being mature,the realization of monolithically integrated polarization controllers and single longitudinal mode light sources,such as distributed-feedback(DFB)lasers,is of importance.In this research,we report an AlGaInAs multiple-quantum-well photonic integrated circuit device which can control the state of polarization of the output light source,consisting of a polarization mode converter(PMC),a differential phase shifter(DPS),and a sidewall grating DFB laser.We demonstrate an asymmetrical stepped-height ridge waveguide PMC to realize TE to TM polarization conversion and a symmetrical straight waveguide DPS to enable polarization rotation from approximately counterclockwise circular polarization to linear polarization.Based on the identical epitaxial layer scheme,all the PMC,DPS,and DFB lasers can be integrated monolithically using only a single step of metalorganic vapor-phase epitaxy and two steps of III-V material dry etching.For the DFB-PMC device,a high TE to TM polarization conversion efficiency(98.4%)over a wide range of DFB injection currents is reported at 1555 nm wavelength.For the DFB-PMC-DPS device,a nearly 60°rotation of the Stokes vector on the Poincarésphere was obtained with a range of bias voltage from 0 to-3.0 V at a laser drive current of 170 mA.

关键词： polarization waveguide rotation