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Surgical outcomes of hand-assisted laparoscopic liver resection vs. open liver resection: A retrospective propensity scorematched cohort study

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Chinese Journal of Cancer Research 2019年第5期31卷 818-824页

作者： shengtao lin Fan Wu Liming Wang Yunhe Liu Yiling Zheng Tana Siqin Weiqi Rong Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Objective: Hand-assisted laparoscopic liver resection has the advantages of open and laparoscopic *** is still lack of comparison of surgical outcomes between hand-assistied laparoscopic liver resection(HALLR)and open liver resection(OLR). This study compared the surgical outcomes of the two approaches between wellmatched patient ***: Patients who received liver resection during January 2014 and October 2017 in Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College were included in this retrospective study. Propensity score matching(PSM) was performed to reduce selection bias between the two groups. Operation and short-term surgical outcomes were compared between the well matched ***: During this period, 232 patients with a median age of 55.1 years old received OLR, while 49 patients with a median age of 54.7 years old received HALLR. Compared with HALLR group, OLR group has a higher proportion in male patients(190/232, 81.9% vs. 34/49, 69.4%, P=0.048) and lower albumin(43.2±4.5 vs. 44.8±3.7,P=0.020). After PSM, 49 patients from each group were included in the following analysis. Two groups were well balanced in their baseline characteristics, liver functions, preoperative treatments, abdominal surgery history, and surgical difficulty. None perioperative mortality was observed in both groups. Operation time and postoperative complications were similar in two groups(P=0.935, P=0.056). The HALLR group showed less bleeding amount(177.8±217.1 mL vs. 283.1±225.0 mL, P=0.003) and shorter postoperative stay period(6.9±2.2 d vs. 9.0±3.5 d,P=0.001).Conclusions: We demonstrated that hand-assisted laparoscopic surgery is feasible and safe for liver resection,including some difficult cases. HALLR can provide better bleeding control and faster recovery after surgery.

关键词： Surgical outcomes hand-assisted laparoscopic surgery liver resection

Optical-pulse-coding phase-sensitive OTDR with mismatched filtering

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Science China(Information Sciences) 2022年

作者： Yongxin LIANG Zinan WANG shengtao lin Yuyao WANG Jialin JIANG Zijie QIU Chunye LIU Yunjiang RAO Center for Information Geoscience University of Electronic Science and Technology of China Key Lab of Optical Fiber Sensing and Communications University of Electronic Science and Technology of China Research Center for Optical Fiber Sensing

Optical-pulse-coding (OPC) phase-sensitive optical time-domain reflectometry (Φ-OTDR) sends a train of pulses into a fiber, and has high spatial resolution decided by the duration of a subpulse while achieving signal-to-noise ratio (SNR) enhancement. OPCΦ-OTDR with a shorter measurement time is favorable. However, the scan rate, which is the reciprocal of the measurement time, is not easy to *** this paper, mismatched filtering is introduced into OPCΦ-OTDR for the first time, which can reach the theoretical limit of scan rate determined by the fiber length. Also, the initial phase of each subpulse can be set arbitrarily, showing the capacity for controlling the location of interference fading. Although the design of the mismatched filter is based on the least-squares criterion, satisfactory decoding results are obtained,indicating that more advanced mismatched filter designs are worthy of further investigation to achieve higher performance.

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Prediction of fiber Rayleigh scattering responses based on deep learning

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Science China(Information Sciences) 2023年第12期 164-178页

作者： Yongxin LIANG Jianhui SUN Jialei ZHANG Yuyao WANG Anchi WAN Shibo ZHANG Zhenyu YE shengtao lin Zinan WANG Key Lab of Optical Fiber Sensing and Communications University of Electronic Science and Technology of China Center for Information Geoscience University of Electronic Science and Technology of China

Distributed acoustic sensing(DAS) is a fiber sensing technology based on Rayleigh scattering,which transforms optical fiber into a series of sensing units. It has become an indispensable part in the field of seismic monitoring, vehicle tracking, and pipeline monitoring. Fiber Rayleigh scattering responses lay at the core of DAS. However, there are few in-depth studies on the purpose of acquiring fiber Rayleigh scattering responses. In this paper, we establish a deep learning framework based on the bidirectional gated recurrent unit, which is the first time to predict the fiber Rayleigh scattering responses, to the best of our knowledge. The deep learning framework is trained with a numerical simulation dataset only, but it can process experimental data successfully. Moreover, since the responses could have a wider effective bandwidth than the experimental probing pulses, a finer spatial resolution could be obtained after demodulation. This work indicates that the deep learning framework can capture the characteristics of the fiber Rayleigh scattering responses effectively, which paves the way for intelligent DAS.

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The role of intraoperative electron radiotherapy in centrally located hepatocellular carcinomas treated with narrow-margin (<1 cm) hepatectomy: a prospective, phase 2 study

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 515-529,I0004页

作者： Liming Wang Yunhe Liu Weiqi Rong Fan Wu Weibo Yu Kan Liu shengtao lin Yiling Zheng Kai Zhang Tana Siqin Changcheng Tao Mei Liu Bo Chen Qinfu Feng Jianxiong Wu Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Head and Neck Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesCAUSA Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Surgical Oncology Fujian Provincial Hospital/Shengli Clinical Medical College of Fujian Medical UniversityFuzhouChina Laboratory of Cell and Molecular Biology&State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Postoperative radiotherapy (RT) is known to play an important role in the treatment of hepatocellular carcinomas (HCCs), but the specific role of intraoperative electron radiotherapy (IOERT) in HCCs remains unclear. The aim of this study was to investigate the safety and efficacy of IOERT in centrally located HCCs treated with narrow-margin (<1 cm) hepatectomy. Methods: This was a single-center, phase 2, prospective non-randomized controlled study, including 268 patients with centrally located HCCs who underwent narrow-margin hepatectomy. The patients were subsequently allocated to the IOERT group (n=59) or to the control group (n=65). The primary outcome of the study was to compare recurrence-free survival (RFS) between the IOERT group and the control group, and the secondary outcome was to compare overall survival (OS) rate between the two groups. Results: Of 268 patients enrolled, a total of 124 were included in the study: 59 in IOERT group, 65 in control group. The 1-, 2-, 3-year RFS rates were 79.3%, 62.1% and 45.8% for patients in the IOERT group, and 47.6%, 28.6%, and 22.9% for patients in the control group, respectively (P=0.025). The 1-, 2-, and 3-year OS rates were 100.0%, 94.9%, and 83.7% for patients in the IOERT group, and 92.3%, 87.5%, and 79.4% for patients in the control group, respectively (P=0.314). Subgroup analysis of MVI (+) patients revealed that RFS and OS are significantly prolonged in the IOERT subgroup as compared to the control, whereas there was no significant difference of RFS and OS between the two groups in MVI (−) patients. Conclusions: IOERT for centrally located HCCs with concurrent narrow-margin hepatectomy was feasible and safe. Statistically better RFS rate was observed in the IOERT group compared to the control group. Subgroup analysis revealed that IOERT was more beneficial for postoperative survival of HCC patients with MVI. Trial Registration: ChiCTR-TRC-12002802;***/ictrp.

关键词： Hepatocellular carcinoma(HCC) intraoperative electron radiotherapy(IOERT) microvascular invasion(MVI) relapse survival overall survival(OS)

Full bandwidth statistical properties of the Raman random fiber laser

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Chinese Optics Letters 2024年第6期22卷 142-147页

作者： Jiaojiao Zhang shengtao lin Xingyu Bao Pan Wang Yifei Qi Han Wu Jing Liang Zinan Wang Key Laboratory of Optical Fiber Sensing and Communications University of Electronic Science and Technology of ChinaChengdu 611731China College of Electronics and Information Engineering Sichuan UniversityChengdu 610064China

The Raman random fiber laser (RRFL) is a typical complex physical system due to the intrinsic random feedback of the fiber,which causes complexity in the RRFL output. So far, the time-domain statistical attributes of the RRFL are still not fully characterized. In this paper, the temporal statistical properties of the RRFL are investigated comprehensively for the first time under the full bandwidth condition. First, the time-domain intensity statistical characteristics of the RRFL under the full bandwidth condition are theoretically studied: the results demonstrate that the intensity probability density function of the RRFL is related to the pump power and observing position and deviates inward from the exponential distribution, indicating that correlation exists between the different frequency components in the spectrum. Afterward, in the validation experiment, an elaborate structure is designed to realize a narrow-bandwidth 1053 nm RRFL, and its full bandwidth temporal intensity statistical features manifest an identical variation pattern to the simulation results. This work fills a vacancy in the study of RRFL temporal statistical features and rigorously reveals the different physical mechanisms between RRFL and amplified spontaneous emission light sources, providing instructions for the application of the RRFL.

关键词： random-distributed-feedback fiber laser Raman gain Rayleigh scattering statistical analysis

Spectrum-tailored random fiber laser towards ICF laser facility

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Matter and Radiation at Extremes 2023年第2期8卷 47-55页

作者： Mengqiu Fan shengtao lin Ke Yao Yifei Qi Jiaojiao Zhang Junwen Zheng Pan Wang Longqun Ni Xingyu Bao Dandan Zhou Bo Zhang Kaibo Xiao Handing Xia Rui Zhang Ping Li Wanguo Zheng Zinan Wang Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Graduate School of China Academy of Engineering Physics Beijing 100193China Key Laboratory of Optical Fiber Sensing and Communications University of Electronic Science and Technology of ChinaChengdu 611731China

Broadband low-coherence light is considered to be an effective way to suppress laser plasma *** studies have demonstrated the ability of low-coherence laser facilities to reduce back-scattering during beam–target ***,to ensure simultaneous low coherence and high energy,complex spectral modulation methods and amplification routes have to be *** this work,we propose the use of a random fiber laser(RFL)as the seed *** spectral features of this RFL can be carefully tailored to provide a good match with the gain characteristics of the laser amplification medium,thus enabling efficient amplification while maintaining low ***,a theoretical model is constructed to give a comprehensive description of the output characteristics of the spectrum-tailored RFL,after which the designed RFL is experimentally realized as a seed *** precise pulse shaping and efficient regenerative amplification,a shaped random laser pulse output of 28 mJ is obtained,which is the first random laser system with megawatt-class peak power that is able to achieve low coherence and efficient spectrum-conformal regenerative amplification.

关键词： fiber scattering random

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生物质气体液化过程的虚拟实验开发

实验室研究与探索 2019年第6期38卷 93-95,213页

作者：华洁林圣涛陈琳钱皓马晨波於秋萍南京林业大学机械电子工程学院南京210037 南京智诚月光信息科技有限公司南京210039

为解决高校人才培养方案中开展实习实训环节的困难,开发出一套生物质气体液化过程的虚拟实验。实验的基础是工艺过程的开发,包含过程参数的计算、设备的选型及设备和管道的布置。虚拟实验的交互设计过程包括装置搭建过程和装置运行过程... 详细信息

为解决高校人才培养方案中开展实习实训环节的困难,开发出一套生物质气体液化过程的虚拟实验。实验的基础是工艺过程的开发,包含过程参数的计算、设备的选型及设备和管道的布置。虚拟实验的交互设计过程包括装置搭建过程和装置运行过程两个部分,在设计过程中需要不断提取工艺开发过程中的有效数据。采用3D Studio Max进行三维建模及场景的搭建,采用Unity3D开发引擎设计出交互操作的步骤。开发结果展示了所有设备、连接管道和支架的空间视图。最后提出了虚拟与实际情境相结合以及拓展不同教学环节的讨论。

关键词：虚拟仿真实验生物质气体液化过程装备与控制工程

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98例小肝癌患者的临床病理特征及预后分析

中华肿瘤杂志 2017年第5期39卷 389-394页

作者：张扬王黎明吴凡荣维淇林圣涛柳云贺郑艺玲吴健雄国家癌症中心中国医学科学院北京协和医学院肿瘤医院肝胆外科 100021

目的分析小肝癌患者的临床病理特征及预后影响因素。方法回顾性分析2009年1月至2013年12月间行R0切除的98例小肝癌患者的临床病理资料和随访资料。结果98例患者全部获得随访，98例患者术后1、3、5年生存率分别为99.0%、91.7%和76.3%，... 详细信息

目的分析小肝癌患者的临床病理特征及预后影响因素。方法回顾性分析2009年1月至2013年12月间行R0切除的98例小肝癌患者的临床病理资料和随访资料。结果98例患者全部获得随访，98例患者术后1、3、5年生存率分别为99.0%、91.7%和76.3%，中位总生存时间（OS）为52个月。98例患者术后1、3、5年无进展生存率分别为86.7%、66.2%和55.0%，中位无进展生存时间（PFS）为43.5个月。单因素分析显示，卫星结节、肝被膜侵犯和术后复发时间与总生存有关（均P〈0.05），长期大量饮酒、卫星结节和肝被膜侵犯与无进展生存有关（均P〈0.05）。多因素分析显示，术后复发时间和肝被膜侵犯是影响小肝癌患者总生存的独立因素（均P〈0.05），长期大量饮酒是影响小肝癌无进展生存的独立因素（P＝0.003）。结论小肝癌的治疗仍是以手术为主的积极治疗，在保证肿瘤R0切除的前提下，尽量减少正常肝的切除范围对患者有利。小肝癌术后复发时间≤2年提示预后不良，长期大量饮酒能够促进小肝癌术后复发。

关键词：肝肿瘤肝切除术预后

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基于光谱快速探测的光纤随机激光动态传感

激光与光电子学进展 2023年第11期60卷 306-311页

作者：齐逸飞林圣淘包兴宇倪龙群王攀张娇娇王子南电子科技大学光纤传感与通信教育部重点实验室四川成都611731

拉曼光纤随机激光结合无源传感单元可以实现超长距离的准分布式传感。然而,受限于光谱探测速度,该传感方案通常只适用于静态传感领域。针对该问题,将拉曼光纤随机激光与拍频光谱探测技术相结合,提出了一种新型的拉曼光纤随机激光长距离... 详细信息

拉曼光纤随机激光结合无源传感单元可以实现超长距离的准分布式传感。然而,受限于光谱探测速度,该传感方案通常只适用于静态传感领域。针对该问题,将拉曼光纤随机激光与拍频光谱探测技术相结合,提出了一种新型的拉曼光纤随机激光长距离动态传感技术。首先,基于含时光谱稳态模型论证了光谱快速测量对长距离动态传感的适用性。随后,在原理性验证实验中通过处理本振光与光纤随机激光拍频后的时域信号,实现了对光纤随机激光光谱的快速测量,并突破了光波往返时间对传感带宽的限制。同时,利用去噪卷积神经网络对光谱的中心波长变化进行标定,大幅提高了扰动信号探测的信号质量,实现了对不同频率、不同波形的扰动信息的准确测量。该研究为进一步拓展光纤随机激光的应用领域提供了新的思路。

关键词：光纤传感光纤随机激光拉曼散射瑞利散射去噪卷积神经网络