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Efficacy of Shenlingbaizhu formula on irritable bowel syndrome:a systematic review

Journal of Traditional Chinese Medicine 2020年第6期40卷 897-907页

作者： Wang Yuxian zhang shengsheng Zhou Qiang Meng Meng Chen Wenwen Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

OBJECTIVE:To evaluate the effectiveness and safety of a Shenlingbaizhu(SLBZ)formula in the treatment of irritable bowel syndrome(IBS).The effectiveness of SLBZ with or without conventional treatment was compared to that of conventional treatment ***:A comprehensive literature search of four Chinese electronic databases,three English language databases,and two English language trial registries from inception to June 2019 was *** authors independently screened the citations and retrieved full publications of randomized trials on the use of SLBZ with or without conventional treatment for *** methodological quality of the trials was assessed with the Cochrane Collaboration’s tool for assessing the risk of *** were extracted and subjected to Meta-analysis to compare the efficacy of the SLBZ formula with or without conventional treatment to conventional treatment ***:Thirteen trials(comprising a total of 868 patients with IBS)were included in this *** risk of bias of all 13 included trials was assessed as *** SLBZ formula was associated with significant improvements in cure rate[relative risk(RR)score of 2.38,95%confidence interval(CI)1.43 to 3.95,I2=0%;8 trials,n=487,fixed-effects model(FEM)],diarrhea severity score[mean difference(MD)score of-0.62,95%CI-1.05 to-0.20,I2=88%;4 trials,n=286,random effects model(REM)],abdominal pain severity score(MD score of-0.61,95%CI-0.70 to-0.52,I2=63%;4 trials,n=286,FEM),and abdominal distention severity score(MD score of-0.88,95%CI-1.54 to-0.21,I2=91%;3 trials,n=226,REM)compared to the conventional treatment *** events were reported in five trials but only one of these indicated any adverse events associated with ***:Based on the 13 trials reviewed here,the SLBZ formula with or without conventional treatment appeared to be safe and more effective in improving the cure rate and reducing the severity of diarrhea,abdominal pain,and abdominal distention compared

关键词： Irritable bowel syndrome Shenlingbaizhu formula Review

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Coal facies evolution of the main minable coal-bed in the Heidaigou Mine, Jungar Coalfield, Inner Mongolia, northern China

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Science China Earth Sciences 2007年第Z2期50卷 144-152页

作者： DAI ShiFeng REN DeYi LI shengsheng ZHAO Lei zhang Yong State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology Beijing 100083 China Department of Resources and Earth Science China University of Mining and Technology Beijing 100083 China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology Beijing 100083 China Department of Resources and Earth Science China University of Mining and Technology Beijing 100083 China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology Beijing 100083 China Department of Resources and Earth Science China University of Mining and Technology Beijing 100083 China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology Beijing 100083 China

The No. 6 Coal-bed from the Heidaigou Mine, Jungar Coalfield, Inner Mongolia is a super-large Ga deposit. The dominant carrier of Ga is boehmite in coal. The study of coal facies may provide genetic enrichment information of Ga and its carrier (boehmite) in the Ga deposit. On the basis of study on coal petrology and mineralogy, it was found that the No. 6 Coal-bed from the Heidaigou Mine of Jungar was enriched in inertinites and the microlitho-types were dominated by clarodurite. The maceral morphological features and association indicate that the coal-bed was formed in a dry sedimentary environment or in a periodic dry sedimentary environment caused by the alternating variations of groundwater level. The optimum conditions for the enrichment of Ga and its particular carrier (boehmite) were dominated by four transitional conditions: (1) the upper delta plain which was the transitional zone between alluvial and lower delta plains, (2) the transitional zone between the dry and wet forest swamps, being slightly apt to the dry one, (3) the transitional tree density between the thick and loose ones, and (4) the low moor that was the transitional zone between two high moors during peat accumulation.

关键词： coal, coal facies, Ga-deposit, maceral, mineral, Jungar Coalfield

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Role of gut microbiota in functional constipation

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Gastroenterology Report 2021年第5期9卷 392-401,I0001页

作者： shengsheng zhang Ruixin Wang Danyan Li Luqing Zhao Lixin Zhu Digestive Disease Center Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijingP.R.China Department of Colorectal Surgery Guangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Functional constipation(FC)is common,yet the etiology is not *** evidence suggests an association between FC and abnormal gut *** relationship between the gut microbiota and the gut transit is likely *** review summarizes the current evidence regarding the impact of gut microbiota on the pathogenesis of *** modulating the colonic motility,secretion,and absorption,gut microbiota may contribute to the development of FC through microbial metabolic activities involving bile acids,short-chain fatty acids,5-hydroxytryptamine,and *** support of the key roles of the gut microbiota in FC,treatment with probiotics,prebiotics,synbiotics,and traditional Chinese medicine often result in compositional and functional changes in the gut *** studies on the pathogenesis of FC and the therapeutic mechanism of microecological agents will provide a knowledge base for better management of FC.

关键词： gut microbiota functional constipation bile acids SCFA serotonin traditional Chinese medicine

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Heat Aggregation Mechanisms of Hot Dry Rocks Resources in the Gonghe Basin, Northeastern Tibetan Plateau

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Acta Geologica Sinica(English Edition) 2021年第6期95卷 1793-1804页

作者： LIN Wenjing WANG Guiling zhang shengsheng ZHAO Zhen XING Linxiao GAN Haonan TAN Xianfeng Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technical Innovation Center for Geothermal and HDR Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Institute of the Hydrogeology and Engineering Geology of Qinghai Shijiazhuang 050061China Qinghai Bureau of Environmental Geology Exploration Xining 810007China Shandong Provincical Lunan Geo-engineering Exploration Institute(The Second Geological Brigade of Shandong Geological Exploration Bureau) JiningShangdong 272100China

Hot dry rock(HDR) is an important geothermal resource and clean energy source that may play an increasingly important role in future energy management. High-temperature HDR resources were recently detected in deep regions of the Gonghe Basin on the northeastern edge of the Tibetan Plateau, which led to a significant breakthrough in HDR resource exploration in China. This research analyzes the deep temperature distribution, radiogenic heat production, heat flow, and crustal thermal structure in the Qiaboqia Valley, Guide Plain, and Zhacanggou area of the Gonghe Basin based on geothermal exploration borehole logging data, rock thermophysical properties, and regional geophysical exploration data. The results are applied to discuss the heat accumulation mechanism of the HDR resources in the Gonghe Basin. The findings suggest that a low-velocity layer in the thickened crust of the Tibetan Plateau provides the most important source of constant intracrustal heat for the formation of HDR resources in the Gonghe Basin, whereas crustal thickening redistributes the concentrated layer of radioactive elements, which compensates for the relatively low heat production of the basal granite and serves as an important supplement to the heat of the HDR resources. The negative effect is that the downward curvature of the lithospheric upper mantle caused by crustal thickening leads to a small mantle heat flow component. As a result, the heat flows in the Qiaboqia Valley and Guide Plain of the Gonghe Basin are 106.2 and 77.6 m W/m2, respectively, in which the crust-mantle heat flow ratio of the former is 3.12:1, indicating a notably anomalous intracrustal thermal structure. In contrast, the crust-mantle heat flow ratio in the Guide Plain is 1.84:1, which reflects a typical hot crust-cold mantle thermal structure. The Guide Plain and Zhacanggou area show the same increasing temperature trend with depth, which reflects that their geothermal backgrounds and deep high-temperature environment

关键词： radiogenic heat production heat flow crustal thermal structure hot dry rock heat source mechanism

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Qingre Jianpi decoction(清热健脾汤)attenuates inflammatory responses by suppressing NOD-like receptor family pyrin domain-containing 3 inflammasome activation in dextran sulfate sodium-induced colitis mice

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Journal of Traditional Chinese Medicine 2021年第1期41卷 68-78页

作者： zhang Jiayan KANG Xiuhong SUN Mengyun zhang shengsheng Department of Digestive System Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China Department of Digestive system Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China

OBJECTIVE:To investigate the effects of Qingre Jianpi decoction(清热健脾汤,QRJPD)on dextran sulfate sodium(DSS)-induced colitis mice and explore its ***:All mice were randomly divided into six *** changes,disease activity index values,and histological damage were *** cytokines and immune cell infiltration were measured using enzyme-linked immunosorbent assays(ELISA)and immunohistochemistry(IHC)*** key protein expression levels of the NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome were detected by western blot analysis,IHC,and quantitative reverse transcription polymerase chain ***:QRJPD played an anti-inflammatory role in the treatment of ulcerative colitis(UC),reduced the secretion of inflammatory cytokines,and inhibited the inflammatory infiltration of immune cells by suppressing DSS-induced activation of the NLRP3 ***:QRJPD exerts protective effects by inhibiting DSS-induced NLRP3 inflammasome activation.

关键词： Colitis,ulcerative anti-inflammatory agents NLR family,pyrin domain-containing 3 protein inflammasomes

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Consensus on Epigastralgia Diagnosis and Treatment of Chinese Medicine (2017)

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World Journal of Integrated Traditional and Western Medicine 2018年第3期4卷 11-20页

作者：无 zhang shengsheng zhou qiang The Spleen and Stomach Disease Branch of China Association of Chinese Medicine 不详

Epigastralgia is one of the most common syndromes in internal medicine of Traditional Chinese Medicine (TCM). Many upper gastrointestinal diseases such as peptic ulcer, chronic gastritis, functional dyspepsia and so on can induce the symptom of epigastralgia. In September 1983, National Symposium on Spleen and Stomach Disease was held by China Association of Chinese Medicine of Physicians, and programmed Diagnosis and evaluation standard of stomachache (draft )[1]. In 1993, Clinical research guideline of new drugs for traditional Chinese medicine on epigastralgia was promulgated by Ministry of Health of the People's Republic of China[2].

关键词： Epigastralgia internal medicine China Association

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Antispasmodic effect of Bupi Yichang pill on colonic contraction of rats in vitro

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Journal of Traditional Chinese Medical Sciences 2017年第2期4卷 167-173页

作者： Yueqi Wang Zhengfang Wang Xiongfei Chang shengsheng zhang Beijing University of Chinese Medicine Beijing 100029China Digestive Disease Center Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China

Objective:To investigate the pharmacological effect of Bupi Yichang (BPYX) pill on colonic contraction of rats and explore its underlying ***:The experiments were performed on colonic longitudinal smooth muscle strips (CLSMs) under isometric *** suspended in tissue chambers were stimulated by KCl (80 mM) or acetylcholine (ACh,0.1 mM),or exhausting intracellular Ca2+ and internal flow of extracellular Ca2+ to induce muscle contraction and their responses to different doses of BPYX pill were *** that,incubation with different inhibitors was conducted to verify its underlying ***:Bupi Yichang pill dose-dependently and reversibly inhibited colonic *** antispasmodic effect of BPYC pill was partially blocked by 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester hydrochloride (TMB-8,an intracellular Ca2+ antagonist,500 μM),thapsigargin (a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase,1 μM),and nifedipine (a voltage-dependent Ca2+ channel blocker,10 μM) (P .05).Conclusion:Bupi Yichang pill could inhibit colonic contraction of rats in vitro and its antispasmodic effect might be partially mediated by calcium channels.

关键词： Muscle contraction Calcium channels Herbal medicine Smooth muscle Colon

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Laiwu Steel’s Mode and Practice in Developing Circular Economy

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莱钢科技 2007年第3期 1-11页

作者： zhang shengsheng Laiwu Steel Group Ltd

1. General SituationLaiwu Steel Group, Ltd, founded in Jan.,1970,is the largest enterprise directly under the supervision of Shandong Provincial Government. It is now the holding company of two listed companies,i.e. L... 详细信息

关键词：循环经济莱钢公司发展模式发展策略资源节约

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FORMATION MECHANISM OF FRESH GROUNDWATER IN NORTHERN ALM OF ARID NORTHWEST CHINA-AS EXEMPLIFIED BY THE SUHONGTU AREA

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Scientia Geologica Sinica 1999年第3期 425-431页

作者： Wu Xuanmin Shi shengsheng and zhang Yilong(China Institute of Hydrogeology and Engineering Geology Exploration,Beijing)

By means of comprehensive geological and hydrogeological investigation, geophysical prospecting andhydrogeological drilling the fresh groundwater in Suhongtu area is successfully founded. According tothe analysis on the features of morphosequen, stratum, tectonics, groundwater recharge and discharge,hydrochemistry, and environmental isotopic, the preliminary findings about the formation mechanism ofthe fresh groundwater are presented in the pape. The findings may provide reference to groundwaterexploration in arid regions elsewhere.

关键词： AS FORMATION MECHANISM OF FRESH GROUNDWATER IN NORTHERN ALM OF ARID NORTHWEST CHINA-AS EXEMPLIFIED BY THE SUHONGTU AREA ALM

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Research on Concurrent Engineering Oriented Integrated Product Development Process Management System

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Computer Aided Drafting,Design and Manufacturing 2001年第1期11卷 48-55页

作者： Cao Jian zhang shengsheng He Yuanjun CIT Lab, Shanghai Jiaotong University, Shanghai 200030, China CIT Lab Shanghai Jiaotong University Shanghai 200030 China

In concurrent engineering, effective process management is the key to improve the efficiency and quality of product development. Although in project management system, workflow management system and PDM system, process management functions are provided, they can not meet the needs of product development. In this paper, we integrate the project management, workflow management and product management technique together and a concurrent engineering oriented integrated product development process management system is proposed. The system structure, integrated product development model and running method are introduced. The practice proves this system is powerful in supporting product development process.

关键词： product development process project management workflow management product data management

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