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Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1243-1257页

作者： Yan-Xia Wang Haibo Wu Yong Ren shengqing lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University(former Third Military Medical University)400038 ChongqingChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of China230036 HefeiAnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of China230036 HefeiAnhuiChina Department of Pathology General Hospital of Central Theater Command of PLA627 Wuluo RoadHongshan District430070 WuhanHubeiChina Xinqiao Hospital Army Medical University400038 ChongqingChina Department of Pathology The First Affiliated Hospital of Wannan Medical College241001 WuhuAnhuiChina Department of Pathology Taihe HospitalHubei University of Medicine442000 ShiyanHubeiChina Laboratory of Cancer and Immunometabolism Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21703US

Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical *** WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic *** recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH *** the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling *** of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in ***,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the ***,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH *** findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs.

关键词： Kir2.1 invasion markedly

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei lv Wei Qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Downregulated GPR30 Expression in the Epileptogenic Foci of Female Patients with Focal Cortical Dysplasia Type Ⅱb and Tuberous Sclerosis Complex Is Correlated with 18F-FDG PET-CT Values

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Downregulated GPR30 Expression in the Epileptogenic Foci of ...

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

第十六届中国医师协会神经外科医师年会

作者： Zhongke Wang Kaixuan Huang Xiaolin Yang Kaifeng Shen Ling Yang Ruotong Ruan Xianjun Shi Miao Wang Gang Zhu Meihua Yang Chunqing Zhang shengqing lv Hui Yang Xiaotang Fan Shiyong Liu Department of Neurosurgery Xinqiao HospitalArmy Medical University (Third Military Medical University) Department of Developmental Neuropsychology School of PsychologyArmy Medical University (Third Military Medical University) Department of Basic Medical College Army Medical University (Third Military Medical University)

Focal cortical dysplasia type Ⅱb(FCDⅡb) and tuberous sclerosis complex(TSC) are typical causes of developmental delay and refractory epilepsy.G-protein-coupled receptor 30(GPR30) is a specific estrogen receptor that is critical in neurodevelopment,neuroinflammation,and neuronal excitability,suggesting that it plays a potential role in the epilepsy of patients with FCDⅡb and ***,we investigated the role of GPR30 in patients with FCDⅡb and *** found that the expression of GPR30 and its downstream protein kinase A(PKA) pathway were decreased and negatively correlated with seizure frequency in female patients with FCDⅡb and TSC,but not in male ***30 was widely distributed in neurons,astrocytes,and microglia,and its downregulation was especially notable in *** GPR30 agonist G-1 increased the expression of PKA and p-PKA in cultured cortical neurons,and the GPR30 antagonist G-15 exhibited the opposite effects of *** NF-κB signaling pathway was also activated in the specimens of female patients with FCDⅡb and TSC,and was regulated by G-1 and G-15 in cultured cortical *** also found that GPR30 regulated cortical neuronal excitability by altering the frequency of spontaneous excitatory postsynaptic currents and the expression of NR2A/***,the relationship between GPR30 and glycometabolism was evaluated by analyzing the correlations between GPR30 and F-FDG PET-CT values(standardized uptake values,SUVs).Positive correlations between GPR30 and SUVs were found in female patients,but not in male ***,GPR30 expression and SUVs were significantly decreased in the epileptogenic tubers of female TSC patients,and ROC curves indicated that SUVs could predict the localization of epileptogenic *** together,our results suggest a potential protective effect of GPR30 in the epileptogenesis of female patients with FCDⅡb and TSC.

关键词： G-protein-coupled receptor 30 Focal cortical dysplasia type Ⅱb Tuberous sclerosis complex Whole-cell patch-clamp 18F-FDG Positron emission tomography-computerized tomography Standardized uptake values

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

高压氧在慢性硬膜下血肿钻孔引流术后的应用分析

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重庆医学 2016年第31期45卷 4380-4381页

作者：张晓强孙凌云周辉吕胜青李宁四川大学华西广安医院神经外科四川广安638000 第三军医大学新桥医院神经外科重庆400037 第三军医大学新桥医院高压氧科重庆400037

目的研究慢性硬膜下血肿钻孔引流术后联合高压氧治疗的临床疗效。方法回顾性分析80例慢性硬膜下血肿患者的临床资料,分为对照组和治疗组,对照组行穿刺引流术后常规治疗,治疗组在常规治疗的基础上再加用高压氧治疗,对比两组患者术后症状... 详细信息

目的研究慢性硬膜下血肿钻孔引流术后联合高压氧治疗的临床疗效。方法回顾性分析80例慢性硬膜下血肿患者的临床资料,分为对照组和治疗组,对照组行穿刺引流术后常规治疗,治疗组在常规治疗的基础上再加用高压氧治疗,对比两组患者术后症状、体征恢复情况,残余血肿吸收时间,脑组织复张时间及术后复发率。结果两组患者术后症状、体征均恢复良好,但治疗组效果更佳(P<0.05)。治疗组脑组织复张及残余血肿吸收更快,复发率为0;对照组脑组织复张较慢,复发率为11.6%,两组比较差异有统计学意义(P<0.05)。结论慢性硬膜下血肿钻孔引流术后加用高压氧治疗,可更快缓解患者临床症状、体征,脑组织复张好,能有效控制复发。

关键词：慢性硬膜下血肿钻孔引流高压氧

长链非编码RNA失调在脑动脉瘤发病机制中的潜在作用研究

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肿瘤预防与治疗 2020年第7期33卷 554-560页

作者：薛军吕胜青周政牟科杰重庆市璧山区人民医院神经外科重庆402760 陆军军医大学新桥医院神经外科重庆400037

目的:通过分析动脉瘤中异常表达的lncRNA,探讨其在动脉瘤的发生发展中可能发挥的重要功能。方法:检测5例颅内动脉瘤患者的动脉瘤组织与正常颅内动脉组织中的lncRNA表达谱和mRNA表达谱,并探寻异常表达的lncRNA所靶向的mRNA。结果:LncRNA... 详细信息

目的:通过分析动脉瘤中异常表达的lncRNA,探讨其在动脉瘤的发生发展中可能发挥的重要功能。方法:检测5例颅内动脉瘤患者的动脉瘤组织与正常颅内动脉组织中的lncRNA表达谱和mRNA表达谱,并探寻异常表达的lncRNA所靶向的mRNA。结果:LncRNA芯片分析结果显示,与正常血管比较,血管瘤组织中存在1533种异常表达的lncRNA,其中520种lncRNA表达上调,1013种lncRNA表达下调。274种异常表达的lncRNA分别靶向于188种异常表达的mRNA,共形成了434对lncRNA和mRNA靶向关系。靶mRNA相关的信路分析显示,focal adhesion信号通路可能发挥了至关重要的作用。对lncRNA基因与靶mRNA互作关系的网络分析显示,lncRNA n345160、XR_171115.1、NR_027671.2和ENSG00000261903.1在动脉瘤发生中可能发挥了重要作用。结论:LncRNA可能在颅内动脉瘤发生发展中发挥了重要作用。同时lncRNA与编码蛋白的mRNA之间可能存在复杂的相互作用,这或许能为临床探索预防与治疗颅内动脉瘤的方法提供新的理论基础。

关键词：颅内动脉瘤蛛网膜下腔出血迟发性脑血管痉挛长链非编码RNA

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei lv Sam S.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device