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Spatial Pattern and Benefit Allocation in Regional Collaborative Innovation of the Yangtze River Delta, China

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Chinese Geographical Science 2021年第5期31卷 900-914页

作者： WANG Yue WANG Chengyun MAO Xiyan Liu Binglin ZHANG Zhenke jiang shengnan School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Collaborative Imnovation Center of SouthChina Sea Studies Nanjing UniversityNanjing 210093China School of Environmental and Geographical Sciences Shanghai Normal UniversiryShanghai 200234China

As an important step enhancing regional innovation, researches on collaborative innovation have attracted much more attention recently. One significant reason is that cities can get excessive benefits while they take collaborative innovation activities. Based on the theories of innovation geography, this paper takes the collaborative innovation of the Yangtze River Delta(YRD) Urban Agglomeration as a case study and measures the collaborative innovation capacity from innovation actors and innovation cities by adopting the catastrophe progression model. Then on this basis, the study depicts the spatial pattern and the benefit allocation of collaborative innovation by using the coupling collaborative degree model and benefit allocation model of collaborative innovation. The results show that:1) The collaborative innovation capacity of cities in the Yangtze River Delta has strengthened largely, while the capacity still is not high enough. Cities with high collaborative innovation capacity are concentrated in Shanghai, the southern part of jiangsu, and Hangzhou Bay, yet the cooperation of the universities-industries-research institutes need to improve. 2) The spatial pattern of collaborative innovation of the Yangtze River Delta presents several innovation circles, which are in Suzhou-Wuxi-Changzhou Metropolitan Circle, Nanjing Metropolitan Circle, Hangzhou Metropolitan Circle, Ningbo Metropolitan Circle, and Hefei Metropolitan Circle. Shanghai plays the role of the central city of collaborative innovation, while Suzhou, Nanjing, Hangzhou, Ningbo, and Hefei act as sub-central cities. 3) The benefit each city allocated from collaborative innovation activities has increased. However, the allocations of the benefit show that cities with higher innovation capacity have significant advantages in most cases, which lead to serious disparities in space.

关键词： Yangtze River Delta(YRD) collaborative innovation spatial pattern benefits allocation

Establishment of a comprehensive indicator to nondestructively analyze watermelon quality at different ripening stages

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Journal of Innovative Optical Health Sciences 2014年第4期7卷 1-11页

作者： Shuye Qi Shuhui Song shengnan jiang Yingrui Chen Wu Li Donghai Han College of Food Science and Nutritional Engineering China Agricultural University 17 Qinghua East Road Haidian District BeijingP.R.China National Engineering Research Center for Vegetables 50 Zhanghua Street Haidian District BeijingP.R.China

Two nondestructive methods based on visible and near-infrared(VIS-NIR)spectroscopy and X-ray image have been used for the evaluation of watermelon *** prediction perform-ance based on partial least squares(PLS)by diffuse transmittance measurement(500-1010 nm)was evaluated for_chemical quality attributes SSC(Rc=0.903;RMSEC=0.572%Brix;Rp=0.862;RMSEP=0.717%Brix;RPD=1.83),lycopene(Rc=0.845;RMSEC=0.266 mg/100 gFW;Rp=0.751;RMSEP=0.439 mg/100 gFW;RPD=1.13)and moisture(Rc=0.917;RMSEC=0.280%;Rp=0.937;RMSEP=0.276%;RPD=2.79).The X-ray calibration linearequations developed by extracting the appropriate gray threshold were sufficiently precise forvolume(R?=0.986)and weight(R?=0.993).In order to optimize prediction model of water-melon quality in growth period,multivariate multi-block technique factor analysis enabled in-tegration of these traits:chemical information is related to physical *** component analysis to extract common factors and varimax with Kaiser normalizationto improve explanatory,the comprehensive indicator based on variances was established *** with Rc=0.94,RMSEC=0.244,Rp=0.93,RMSEP=0.344 and RPD=*** of these models indicates that the comprehensive indicator determined only by portable VIS-NIR spectrometer appears as a suitable method for appraising watermelon qualitynondestructively on the plant at diferent ripen *** method contributes to infer the picking date of watermelon with higher accuracy and bigger economic benefits than that byexperience.

关键词： Visible and near-infrared spectroscopy X-ray imaging maturity process factoranalysis comprehensive indicator.

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秦岭“七药”凤尾七的研究进展

中国药师 2024年第1期27卷 171-176页

作者：宗时宇刘洋李晔姜盛楠安玉叶张红陕西省中医药研究院西安710003 陕西中医药大学药学院陕西咸阳712046

凤尾七为小丛红景天的带根全草,是一种天然珍贵的民间常用药用植物,主要分布于海拔1600~4100 m的山坡岩石上及石隙中。凤尾七主要含有黄酮类化合物、挥发油、多糖以及多种氨基酸和微量元素。现代药理学研究表明,凤尾七具有抗氧化、抗疲... 详细信息

凤尾七为小丛红景天的带根全草,是一种天然珍贵的民间常用药用植物,主要分布于海拔1600~4100 m的山坡岩石上及石隙中。凤尾七主要含有黄酮类化合物、挥发油、多糖以及多种氨基酸和微量元素。现代药理学研究表明,凤尾七具有抗氧化、抗疲劳、耐缺氧和抑菌等多种显著的药理活性。本文主要对凤尾七的本草考证、化学成分、药理作用以及人工培育情况等进行综述,以期为凤尾七资源的进一步研究和开发利用提供参考。

关键词：七药凤尾七化学成分药理作用研究进展

白刺花叶总生物碱通过抑制MAPK/NF-κB信号通路减轻脂多糖诱导的RAW264.7细胞炎症反应

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实用医学杂志 2024年第20期40卷 2835-2840页

作者：姜盛楠支文冰陈静孙婷婷许宗仁刘帅张红李晔刘洋陕西省中医药研究院(陕西省中医医院) 陕西西安710003 陕西中医药大学陕西咸阳712046

目的探讨白刺花叶总生物碱(Sophora davidii Hance leaves total alkaloids,SDLTAs)的体外抗炎作用及可能的分子机制。方法采用脂多糖(LPS)诱导RAW264.7细胞炎症模型,给予不同浓度(50、100、200μg/mL)SDLTAs,Griess法检测SDLTAs对细胞NO表达的影响;ELISA法检测SDLTAs对细胞因子IL-6、TNF-α和IL-1β表达的影响;RT-qPCR法检测细胞中iNOS、NF-κB p65和IκBαmRNA的表达;Western blotting法检测细胞中p-p38、p-p65和p-JNK以及细胞核内NF-κB p65的蛋白表达。结果SDLTAs显著抑制LPS诱导的RAW264.7细胞炎症反应。SDLTAs极显著降低细胞中NO、IL-6、TNF-α和IL-1β的分泌(P<0.01),极显著下调细胞中iNOS、NF-κB p65和IκBαmRNA的表达(P<0.01),极显著降低细胞中p-p38、p-p65和p-JNK以及细胞核内NF-κB p65的蛋白表达(P<0.01)。结论SDLTAs可通过调节MAPK/NF-κB信号通路发挥抗炎作用。

关键词：白刺花叶总生物碱抗炎作用机制

基于Keap1/Nrf2/ARE信号通路探讨丹皮酚改善酒精性肝、脑损伤小鼠氧化应激损伤与炎症的作用机制

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安徽中医药大学学报 2024年第2期43卷 73-80页

作者：刘玲玲张鲁宁姜胜男吴琦峰颜贵明安徽中医药大学药学院安徽合肥230012 安徽中医药大学中西医结合学院安徽合肥230012

目的探讨丹皮酚基于Kelch样环氧氯丙烷相关蛋白1(Kelch-like ECH-associated protein 1,Keap1)/核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)/抗氧化反应元件(antioxidant response element,ARE)信号通路改善乙醇刺激所致小鼠肝、脑炎症和氧化应激损伤的作用机制。方法将C57BL/6小鼠随机分为空白组,模型组,水飞蓟宾组(36.8 mg/kg),丹皮酚高、中、低(480、240、120 mg/kg)剂量组,每组15只;适应期各组小鼠自由饮用Liber-DeCarli对照液体饲料,模型复制期空白组小鼠自由饮用Lieber-DeCarli对照液体饲料,其他组小鼠自由饮用Lieber-DeCarli乙醇液体饲料并连续灌胃相对应的药液10 d;测定小鼠血脂[三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)]、肝功能[丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)]、炎症因子[白细胞介素(interleukin,IL)-6、IL-1α、IL-1β、肿瘤坏死因子(tumor necrosis factor,TNF)-α]以及氧化应激指标[过氧化氢酶(catalase,CAT)、还原型谷胱甘肽(glutathione,GSH)、超氧化物歧化酶(super oxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)]水平;采用苏木精—伊红染色法、油红O染色观察各组小鼠肝、脑组织形态变化;采用Western blot法、免疫荧光法以及qRT-PCR法检测小鼠肝、脑组织Keap1/Nrf2/ARE信号通路相关蛋白及mRNA表达水平。结果与模型组比较,丹皮酚高剂量组小鼠体质量显著增加(P<0.05),血脂(TG、TC)、肝功能(ALT、AST)、炎症因子(IL-6、IL-1α、IL-1β、TNF-α)、氧化应激指标(CAT、GSH、SOD)水平显著升高(P<0.05),MDA含量显著降低(P<0.05);小鼠肝、脑组织Nrf2、血红素氧合酶-1、醌NADH脱氢酶1、谷氨酸—半胱氨酸连接酶催化亚基蛋白及mRNA表达水平显著升高(P<0.05),Keap1蛋白及mRNA表达水平显著降低(P<0.05);丹皮酚高剂量组小鼠肝、脑组织病理状态明显改善。结论丹皮酚能显著减轻乙醇诱导的小鼠肝、脑炎症和氧化应激损伤,其机制可能是通过调控Keap1/Nrf2/ARE信号通路实现的。

关键词：丹皮酚酒精性肝脑损伤氧化应激 Keap1 Nrf2 ARE信号通路炎症反应

Experimental and simulation research on hollow AZ31 magnesium alloy three-channel joint by hot extrusion forming with sand mandrel

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Journal of Magnesium and Alloys 2024年第1期12卷 98-109页

作者： Shi shengnan Wang Hongyu Teng Fei jiang Lei Sun Juncai Sun Jie Zhang Shunhu Transportation Engineering College Dalian Maritime UniversityDalianLiaoning 106026China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangLiaoning 110819China Shagang School of Iron and Steel Soochow UniversitySuzhouJiangsu 215021China

Magnesium alloy is one of the lightest metal structural *** weight is further reduced through the hollow ***,the hollow structure is easily damaged during *** order to maintain the hollow structure and to transfer the stresses during the high temperature deformation,the sand mandrel is *** this paper,the hollow AZ31 magnesium alloy three-channel joint is studied by hot extrusion *** as one of solid granule medium is used to fill the hollow magnesium *** extrusion temperatures are 230℃ and 300℃,*** process parameters(die angle,temperature,bottom thickness,sidewall thickness,edge-to-middle ratio in bottom,bottom shape)of the hollow magnesium alloy are analyzed based on the results of experiments and the finite element *** results are shown that the formability of the hollow magnesium alloy will be much better when the ratio of sidewall thickness to the bottom thickness is 1:*** when edge-to-middle ratio in bottom is about 1:1.5,a better forming product can be *** best bottom shape in these experiments will be convex based on the forming *** grain will be refined obviously after the *** the microstructures will be shown as *** these lines will be well agreement with the mold in the corner.

关键词： AZ31 magnesium alloy Three-channel joint Sand Experiments and the finite element Die angle

Identification of P-type plasma membrane H^(+)-ATPases in common wheat and characterization of TaHA7 associated with seed dormancy and germination

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Journal of Integrative Agriculture 2024年第7期23卷 2164-2177页

作者： Bingli jiang Wei Gao Yating jiang shengnan Yan Jiajia Cao Litian Zhang Yue Zhang Jie Lu Chuanxi Ma Cheng Chang Haiping Zhang Key Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow&Huai River Valley Ministry of Agriculture and Rural Affairs/College of AgronomyAnhui Agricultural UniversityHefei 230036China

The P-type plasma membrane(PM)H^(+)-ATPases(HAs)are crucial for plant development,growth,and *** HAs have been thoroughly characterized in many different ***,despite their importance,the functions of HAs in germination and seed dormancy(SD)have not been validated in ***,we identified 28 TaHA genes(TaHA1-28)in common wheat,which were divided into five *** examination of gene expression in strong-and weak-SD wheat varieties led to the discovery of six candidate genes(TaHA7/-12/-14/-16/-18/-20).Based on a single nucleotide polymorphism(SNP)mutation(C/T)in the TaHA7 coding region,a CAPS marker(HA7)was developed and validated in 168 wheat varieties and 171 Chinese mini-core collections that exhibit diverse germination and SD *** further verified the roles of the two allelic variations of TaHA7 in germination and SD using wheat mutants mutagenized with ethyl methane sulphonate(EMS)in‘Jimai 22’and‘Jing 411’backgrounds,and in transgenic Arabidopsis ***7 appears to regulate germination and SD by mediating gibberellic acid(GA)and abscisic acid(ABA)signaling,metabolism,and *** results presented here will enable future research regarding the TaHAs in wheat.

关键词： wheat P-type plasma membrane H^(+)-ATPase seed dormancy abscisic acid gibberellin

Be One＇s True Self in New Era Web-Fiction Writer Highlights Women in Novels About History

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Women of China 2018年第7期 12-14页

作者： FAN WENJUN jiang shengnan

Web fiction refers to a work of fiction ilterture available primarly,or solely,on the Interner. A common type of web fiction is a web *** years ago,jiang shengnan began publishing *** was widely known by the public in 2015,when her work,The legend of Miyue,was adapted into a TV *** people consider jiang to be a writer who specializes in recording history based on outstangding women＇s *** jiang says she is just changing the angle as she presents *** obective is to highlight outstanding women in the long history of her home country.

关键词：小说女人历史作家传说

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美国高校学生学习共同体的类型和特征

外国教育研究 2015年第7期42卷 102-114页

作者：蒋盛楠北京工商大学教育研究中心北京100048

美国高校学生学习共同体经历了试验萌芽期、重新兴起期和深入发展期,在全国范围推广并取得成效,是近年来高校教育改革的一个重要方面。高校学生学习共同体的形式多样,根据主要联结要素分为基于学生、课程、教师和环境等四种主要类型。... 详细信息

美国高校学生学习共同体经历了试验萌芽期、重新兴起期和深入发展期,在全国范围推广并取得成效,是近年来高校教育改革的一个重要方面。高校学生学习共同体的形式多样,根据主要联结要素分为基于学生、课程、教师和环境等四种主要类型。美国高校学生学习共同体具有秉承以学生为中心的理念、包含不同程度的合作或整合、形式灵活多样等特征,对我国高等教育改革具有一定借鉴意义。

关键词：学习共同体高校美国