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Role of TSH Inhibition Therapy in the Postoperative Management of Patients with Differentiated Thyroid Cancer

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Proceedings of Anticancer Research 2024年第2期8卷 20-23页

作者： Xudong Gao Bo Zhao Ya Su shenglin he Department of Otorhinolaryngology Head and Neck SurgeryShaanxi Provincial People’s HospitalXi’an 710068China Department of Endocrinology Shaanxi Provincial People’s HospitalXi’an 710068China

Objective:To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid ***:Seventy patients diagnosed with differentiated thyroid cancer were selected for the *** inhibition therapy was administered to the research group,while thyroxine replacement therapy was provided to the control group during the postoperative management *** allowed for a comparative analysis between the two ***:In comparison with the control group,the research group exhibited significant decreases in serum TSH,T3,and T4 levels after treatment,while FT4 and FT3 levels significantly increased(Phe research group after treatment(Phe two groups(P>0.05).Conclusion:The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes.

关键词： TSH inhibition therapy Differentiated thyroid cancer Postoperative management Effect

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基于多尺度分段的长时间序列预测方法

深圳大学学报（理工版） 2024年第2期41卷 232-240页

作者：何胜林龙琛郑静王爽文振焜吴惠思倪东何小荣吴雪清深圳大学计算机与软件学院广东深圳518060 深圳市卫生健康发展研究和数据管理中心广东深圳518028 深圳市荔康科技有限公司广东深圳518052 深圳大学总医院妇产科广东深圳518071

针对目前长时间序列预测(long sequence time-series forecasting,LSTF)存在历史数据量大、计算复杂度高、预测精度要求高等问题,提出一种基于多尺度分段的Transformer模型.该模型基于Transformer架构进行改进和优化,使用多尺度分段将... 详细信息

针对目前长时间序列预测(long sequence time-series forecasting,LSTF)存在历史数据量大、计算复杂度高、预测精度要求高等问题,提出一种基于多尺度分段的Transformer模型.该模型基于Transformer架构进行改进和优化,使用多尺度分段将时间序列切片成多个时间段进行训练和预测,降低了长时间序列的复杂性,并实现了更高精度的预测.在电力变压器油温(electricity transformer temperature,ETT)数据集、用电负荷(electricity consumption load,ECL)数据集和天气(Weather)数据集中,分别采用传统Transfomer、Informer、门控循环单元(gated recurrent unit,GRU)、时序卷积网络(temporal convolutional network,TCN)和长短期记忆(long short-term memory,LSTM)5种基准模型与本研究提出的多尺度分段的Transformer模型,对长时间序列进行预测.结果表明,采用基于多尺度分段的Transformer模型在Weather数据集上对预测长度为192的时间序列预测的均方误差和平均绝对误差分别为0.367和0.407,均优于其他模型.基于多尺度分段的Transformer模型可以综合Transformer模型的优点,且计算速度更快,预测性能更高.

关键词：计算机神经网络时间序列预测 Transformer模型多尺度分段深度学习电力预测

Geological Structure and Dynamics of the Yinggehai Active Rift Basin,South China Sea

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Journal of Earth Science 2023年第6期34卷 1732-1743页

作者： Yue Yao Shaobin Guo Xiaopeng Li Xiaobo Zhao shenglin he College of Environmental Science and Engineering Tongji UniversityShanghai 200092China The Administrative Centre for China's Agenda 21(ACCA21) Beijing 100038China School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China School of Earth Sciences and Spatial Information Engineering Hunan University of Science and TechnologyChangsha 411100China School of Earth Resources China University of GeosciencesWuhan 430074China Zhanjiang Branch of CNOOC Ltd. Zhanjiang 524057China

The Yinggehai Basin is a unique NNW-trending petroliferous basin in the northwestern South China *** paper mainly utilized stratigraphic,tectonic and seismic data by characterizing the geological structures and conducting the geo-mechanical analysis to study the formation,evolution and dynamics of the Yinggehai *** study indicates that the Ailaoshan-Truong Son extruded terrane is composed of multiple secondary extruded *** Red River fault zone,located within the Qiangtang-Simao-Yinggehai mantle flow channel and basin zone,experienced transform-type sinistral strike-slip motion before the basin forming stage and formed a NW-trending extruded mantle uplift,which activated the Yinggehai *** experiencing the rift depression,fault depression,and fault subsidence,the basin eventually formed large-scale,thick sedimentation features with ideal hydrocarbon-forming conditions at the end of the ***,the basin dynamically transformed and entered a period of tectonic superposition,reworking,and thermal *** of the NNW thrust sinistral strike-slip fault zone on the northern Hanoi sub-basin complicated the basin *** the Pliocene,the southern Yinggehai main basin has been transformed into an extensional dextral strike-slip environment that hosted numerous mud *** thin crust and high geothermal gradient provide favorable conditions for the large-scale accumulation of natural gas.

关键词： Yinggehai Basin Ailaoshan-Truong Son extruded terrane mantle flow channel active rift geodynamics naturalgas

Automatic SOC Equalization Strategy of Energy Storage Units with DC Microgrid Bus Voltage Support

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Energy Engineering 2024年第2期121卷 439-459页

作者： Jingjing Tian shenglin Mo Feng Zhao Xiaoqiang Chen School of Automation&Electrical Engineering Lanzhou Jiaotong UniversityLanzhou730070China Key Laboratory of Opto-Technology and Intelligent Control(Lanzhou Jiaotong University) Ministry of EducationLanzhou730070China

In this paper,an improved sag control strategy based on automatic SOC equalization is proposed to solve the problems of slow SOC equalization and excessive bus voltage fluctuation amplitude and offset caused by load and PV power variations in a stand-alone DC *** strategy includes primary and secondary *** them,the primary control suppresses the DC microgrid voltage fluctuation through the I and II section control,and the secondary control aims to correct the P-U curve of the energy storage system and the PV system,thus reducing the steady-state bus voltage *** simulation results demonstrate that the proposed control strategy effectively achieves SOC balancing and enhances the immunity of bus *** proposed strategy improves the voltage fluctuation suppression ability by approximately 39.4%and 43.1%under the PV power and load power fluctuation conditions,***,the steady-state deviation of the bus voltage,△U_(dc) is only 0.01–0.1 V,ensuring stable operation of the DC microgrid in fluctuating power environments.

关键词： Automatic equalization independent DC microgrid improve droop control secondary control state of charge

heterostructure of 2D MoSe_(2) nanosheets vertically grown on bowllike carbon for high-performance sodium storage

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Nano Research 2024年第5期17卷 4023-4030页

作者： Nianxiang Shi Guangzeng Liu Baojuan Xi Xuguang An Changhui Sun shenglin Xiong School of Chemistry and Chemistry Engineering Qilu Normal UniversityJinan 250200China School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Transition metal dichalcogenides are attractive anode materials for sodium ion batteries(SIBs)due to their high theoretical capacity and large interlayer ***,its practical application is hampered by the sluggish kinetics of Na^(+)insertion and structure collapse caused by Na^(+)insertion/***,the heterostructures of MoSe_(2) nanosheets vertically growing on bowl-like carbon(MoSe_(2)@C)are designed and prepared by a template method coupled with selenization treatment to boost storage sodium *** hollow and collapse could provide enough storage space for Na^(+)and alleviate the volume expansion during the charge/discharge ***_(2) nanosheets vertically grown on carbon could expose more active sites for adsorbing Na^(+)to enhance the utilization rate of electrode ***,building heterostructures by combining different phase components could facilitate Na^(+)diffusion and advance reaction *** from these merits,the bowl-like MoSe_(2)@C shows outstanding reversible capacity(356.8 mAh·g^(-1) after 1500 cycles at 1 A·g^(-1))and remarkable rate performance(249.9 mAh·g^(-1)10 A·g^(-1)).

关键词： MoSe_(2)nanosheets bowl-like carbon heterostructure sodium ion batteries

Performance optimization of chalcogenide catalytic materials in lithium-sulfur batteries:Structural and electronic engineering

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Chinese Chemical Letters 2024年第7期35卷 147-166页

作者： Jianmei Han Peng Wang Hua Zhang Ning Song Xuguang An Baojuan Xi shenglin Xiong College of Chemistry and Chemical Engineering Taishan UniversityTai'an 271021China Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShandong UniversityJi'nan 250100China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Lithium-sulfur batteries(LSBs)boasting remarkable energy density have garnered significant attention within academic and industrial ***,the progression of LSBs remains constrained by the languid redox kinetics intrinsic to sulfur and the pronounced shuttle effect induced by lithium polysulfides(Li PSs),which seriously affecting the energy density,cycling life and rate *** conceptualization and implementation of catalytic materials stand acknowledged as a propitious stratagem for orchestrating kinetic modulation,particularly in excavating the conversion of LiPSs and has evolved into a focal point for *** them,chalcogenide catalytic materials(CCMs)have shown satisfactory catalytic effects ascribe to the unique physicochemical properties,and have been extensively developed in recent *** the lack of systematic summary regarding the development of CCMs and corresponding performance optimization strategies,herein,we initiate a comprehensive review regarding the recent progress of CCMs for effective collaborative immobilization and accelerated transformation kinetics of Li *** that,the modulation strategies to improve the catalytic activity of CCMs are summarized,including structural engineering(morphology engineering,surface/interface engineering,crystal engineering)and electronic engineering(doping and vacancy,etc.).Finally,the application prospect of CCMs in LSBs is clarified,and some enlightenment is provided for the reasonable design of CCMs serving practical LSBs.

关键词： Lithium-sulfur batteries Chalcogenide Catalytic materials Lithium polysulfides Structural engineering Electronic engineering

Directly targeting BAX for drug discovery:Therapeutic opportunities and challenges

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2378-2401页

作者： Zhenwei Zhang Linghui Hou Dan Liu shenglin Luan Min Huang Linxiang Zhao Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China

For over two decades,the development of B-cell lymphoma-2(Bcl-2)family therapeutics has primarily focused on anti-apoptotic proteins,resulting in the first-in-class drugs called BH3 mimetics,especially for Bcl-2 inhibitor *** pro-apoptotic protein Bcl-2-associated X protein(BAX)plays a crucial role as the executioner protein of the mitochondrial regulated cell death,contributing to organismal development,tissue homeostasis,and *** dysregulation of BAX is closely associated with the onset and progression of diseases characterized by pathologic cell survival or death,such as cancer,neurodegeneration,and heart *** addition to conducting thorough investigations into the physiological modulation of BAX,research on the regulatory mechanisms of small molecules identified through biochemical screening approaches has prompted the identification of functional and potentially druggable binding sites on BAX,as well as diverse all-molecule BAX *** review presents recent advancements in elucidating the physiological and pharmacological modulation of BAX and in identifying potentially druggable binding sites on ***,it highlights the structural and mechanistic insights into small-molecule modulators targeting diverse binding surfaces or conformations of BAX,offering a promising avenue for developing next-generation apoptosis modulators to treat a wide range of diseases associated with dysregulated cell death by directly targeting BAX.

关键词： Apoptosis Pro-apoptotic protein BAX Dynamic conformational activation Small-molecule apoptosis modulators

One-step growth of ultrathin CoSe_(2)nanobelts on N-doped MXene nanosheets for dendrite-inhibited and kinetic-accelerated lithium-sulfur chemistry

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Science Bulletin 2024年第13期69卷 2059-2070页

作者： Chuanliang Wei Zhengran Wang Peng Wang Xinlu Zhang Xuguang An Jinkui Feng Baojuan Xi shenglin Xiong School of Chemistry and Chemical Engineering School of Materials Science and EngineeringShandong UniversityJinan 250100China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

The practical application of lithium–sulfur(Li–S)batteries is inhibited by the shuttle effect of lithium polysulfides(LiPSs)and slow polysulfide redox kinetics on the S cathode as well as the uncontrollable growth of dendrites on the Li metal ***,both cathode and anode sides must be considered when modifying LiS ***,two-dimensional(2D)ultrathin CoSe_(2)nanobelts are in situ grown on 2D N-doped MXene nanosheets(CoSe_(2)@N-MXene)via one-step solvothermal process for the first *** to its unique 2D/2D structure,CoSe_(2)@N-MXene can be processed to crumpled nanosheets by freeze-drying and flexible and freestanding films by vacuum *** crumpled CoSe_(2)@NMXene nanosheets with abundant active sites and inner spaces can act as S hosts to accelerate polysulfide redox kinetics and suppress the shuttle effect of LiPSs owing to their strong adsorption ability and catalytic conversion effect with ***,the CoSe_(2)@N-MXene film(CoSe_(2)@NMF)can act as a current collector to promote uniform Li deposition because it contains lithiophilic CoSe_(2)and N *** the systematic effect of CoSe_(2)@N-MXene on S cathode and Li metal anode,the electrochemical and safety performance of Li–S batteries are ***_(2)@NMF also shows excellent storage performances in flexible energy storage devices.

关键词： Ultrathin CoSe_(2)nanobelts N-doped MXene nanosheets In situ growth Flexible MXene-based films Li-S batteries

Rational design of F,N-rich artificial interphase via chemical prelithiation initiation strategy enabling high coulombic efficiency and stable micro-sized SiO anodes

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Journal of Energy Chemistry 2024年第5期92卷 224-232页

作者： Quanyan Man hengtao Shen Chuanliang Wei Baojuan Xi shenglin Xiong Jinkui Feng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061ShandongChina School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100ShandongChina

Silicon monoxide(SiO)is regarded as a potential candidate for anode materials of lithium-ion batteries(LIBs).Unfortunately,the application of SiO is limited by poor initial Coulombic efficiency(ICE)and unsteady solid electrolyte interface(SEI),which induce low energy,short cycling life,and poor rate *** address these drawbacks of SiO,we achieve in-situ construction of robust and fast-ion conducting F,N-rich SEI layer on prelithiated micro-sized SiO(P-μSiO)via the simple and continuous treatment ofμSiO in mild lithium 4,4′-dimethylbiphenyl solution and nonflammable hexafluorocyclotriphosphazene *** prelithiation eliminates irreversible capacity through pre-forming inactive lithium ***,the symbiotic F,N-rich SEI with good mechanical stability and fast Li^(+)permeability is conductive to relieve volume expansion ofμSiO and boost the Li+diffusion ***,the P-μSiO realizes an impressive electrochemical performance with an elevated ICE of 99.57%and a capacity retention of 90.67%after 350 ***,the full cell with P-μSiO anode and commercial LiFePO_(4) cathode displays an ICE of 92.03%and a high reversible capacity of 144.97 mA h g^(-1).This work offers a general construction strategy of robust and ionically conductive SEI for advanced LIBs.

关键词： Chemical prelithiation Silicon monoxide SEI Lithium-ion batteries Interphase engineering