检索结果-南通市图书馆

Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing yang Jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

78例重型和危重型新型冠状病毒肺炎患者中医临床特点分析

引用

中国中医急症 2020年第10期29卷 1702-1705页

作者：尚罗锐刘宇寒潘广涛程范军杨胜兰华中科技大学同济医学院附属协和医院湖北武汉430022

目的对78例重型和危重型新型冠状病毒肺炎(COVID-19)患者中医证候进行分析,为临床辨证论治提供科学依据。方法以2020年2月8日至2020年3月1日收治于武汉协和医院的78例重型和危重型新型冠状病毒肺炎患者为研究对象,统计基本信息、基础疾... 详细信息

目的对78例重型和危重型新型冠状病毒肺炎(COVID-19)患者中医证候进行分析,为临床辨证论治提供科学依据。方法以2020年2月8日至2020年3月1日收治于武汉协和医院的78例重型和危重型新型冠状病毒肺炎患者为研究对象,统计基本信息、基础疾病情况、症状、体征及舌象等信息,分析重型和危重型患者证型分布。结果重型和危重型患者主要临床症状占比排前5位:胸闷气喘(92.30%)、纳呆(82.05%)、自汗(76.92%)、咳嗽(64.10%)、发热(43.59%),其余还有咯痰(41.03%)、咽干咽痛(38.46%)、胸痛(23.07%)、乏力(15.38%)、肌肉酸痛(10.26%)、心悸(7.69%)、便秘(8.97%)等全身症状。舌象方面,舌质以淡红舌(43.58%)和暗红舌(38.46%)多见,另有紫暗舌8例(10.26%),红绛舌6例(7.69%);舌苔多为腻苔(71.79%),其中黄腻苔有38例(48.72%),白腻苔26例(33.33%),少或无苔者6例(7.69%);另有舌体胖大者18例(23.08%),齿痕舌22例(51.28%)。中医证型分布为湿热壅肺证(23.08%)、疫毒闭肺证(64.10%)、内闭外脱证(10.26%)、阴竭阳脱证(2.56%)。结论重型COVID-19中医证候以湿热壅肺证、疫毒闭肺证为多见,疾病至危重期,可能出现内闭外脱、阴竭阳脱等危症。

关键词：新型冠状病毒肺炎危重症中医证候

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

引用

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： Fan yang Zhaoyang MA Xingming GUO Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

内镜逆行胰胆管造影术与腹腔镜胆总管探查术对胆总管结石的临床治疗特征比较

引用

安徽医药 2023年第3期27卷 580-583页

作者：陈旭峰郑扬向正国杨胜兰汤小龙张妮娜中国人民解放军联勤保障部队第九〇四医院(无锡市太湖医院)消化内科江苏无锡214044

目的比较内镜逆行胰胆管造影术(ERCP)与腹腔镜胆总管探查术(LCBDE)对胆总管结石(CBDS)的临床治疗特征。方法回顾性纳入2017年1月至2020年12月中国人民解放军联勤保障部队第九〇四医院收治的200例CBDS病人,分析临床资料及随访资料,按... 详细信息

目的比较内镜逆行胰胆管造影术(ERCP)与腹腔镜胆总管探查术(LCBDE)对胆总管结石(CBDS)的临床治疗特征。方法回顾性纳入2017年1月至2020年12月中国人民解放军联勤保障部队第九〇四医院收治的200例CBDS病人,分析临床资料及随访资料,按照手术方式分为ERCP组(102例)与LCBDE组(98例),比较两组病人的基线资料、围术期相关指标、术后短期并发症及复发情况。结果 ERCP组的年龄[(68.13±7.22)岁比(61.20±5.59)岁]明显高于LCBDE组(P0.05)。两组之间其他指标的比较差异无统计学意义(P>0.05)。结论 ERCP与LCBDE均是治疗CBDS的有效手段,高龄病人更倾向于选择ERCP,结石长径较大者更倾向于选择LCBDE,ERCP的住院时间更短。

关键词：胆总管结石病内镜逆行胰胆管造影术腹腔镜胆总管探查术临床治疗特征并发症复发

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于NLRP3炎症小体探讨中医药防治溃疡性结肠炎的机制

引用

中国中西医结合消化杂志 2021年第7期29卷 524-528页

作者：张海明梁凤霞杨胜兰张君丽袁昌劲陈瑞湖北中医药大学针灸骨伤学院针灸治未病湖北省协同创新中心武汉430061 华中科技大学同济医学院附属武汉中心医院中西医结合肿瘤科华中科技大学同济医学院附属协和医院中西医结合科华中科技大学同济医学院附属协和医院消化内科

溃疡性结肠炎(ulcerative colitis,UC)是一种病因不明、易反复的慢性非特异性肠道疾病[1],其增加结直肠癌的风险已被证实[2]。近期Ola Olén团队在柳叶刀上发表的研究表明,UC患者结直肠癌的发病率和死亡率显著高于非UC患者[3],严重威胁... 详细信息

溃疡性结肠炎(ulcerative colitis,UC)是一种病因不明、易反复的慢性非特异性肠道疾病[1],其增加结直肠癌的风险已被证实[2]。近期Ola Olén团队在柳叶刀上发表的研究表明,UC患者结直肠癌的发病率和死亡率显著高于非UC患者[3],严重威胁着人们的生命健康。目前,氨基水杨酸类、皮质类固醇和免疫抑制剂等为轻、重度UC的治疗药物。一般认为UC的潜在发病机制为:免疫介导的慢性肠道非可控性炎症,导致肠黏膜屏障损伤。

关键词：核苷酸结合寡聚化结构域样受体蛋白3 炎症小体溃疡性结肠炎结直肠癌中医药炎-癌转化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

消脂护肝方对脂肪肝模型大鼠血脂、肝功能的恢复作用及对下丘脑瘦素和瘦素受体表达的影响

引用

广州中医药大学学报 2005年第6期22卷 458-461,F0003页

作者：杨玲顾恪波张卓李道本谢纪文刘建国杨胜兰陈瑞华中科技大学同济医学院附属协和医院中医科武汉430022

[目的]观察消脂护肝方对脂肪肝模型大鼠血脂、肝功能的恢复作用及其机理。[方法]Wistar大鼠24只,随机分为正常对照组、模型组和消脂护肝方组(中药组),除正常组外,采用体积分数为40%CCl4豆油溶液按前3周2 ml/kg,后3 周1 mL/kg剂量皮下注... 详细信息

[目的]观察消脂护肝方对脂肪肝模型大鼠血脂、肝功能的恢复作用及其机理。[方法]Wistar大鼠24只,随机分为正常对照组、模型组和消脂护肝方组(中药组),除正常组外,采用体积分数为40%CCl4豆油溶液按前3周2 ml/kg,后3 周1 mL/kg剂量皮下注射结合高脂饮食复制大鼠脂肪肝模型;造模期间中药组灌服消脂护肝方(12.4 g·kg-1·d-1),6周后处死所有大鼠,检测肝功能、血脂并观察肝组织病理变化;采用免疫组化方法检测下丘脑组织中瘦素(Leptin)、瘦素长型受体OB-RL的含量。[结果]消脂护肝方组大鼠肝功能指标血清丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)及血脂指标甘油三酯(TG)、总胆固醇(TC)均较模型组显著降低(P0.05),表明该方具有抑制脂肪肝形成作用;免疫组化法结果显示,消脂护肝方组大鼠下丘脑组织内Leptin、OB-RL的表达均较模型组升高(P0.05)。[结论]消脂护肝方可使脂肪肝大鼠升高的血脂和损伤的肝功能恢复至正常,其可能的机理是与升高下丘脑组织中Leptin、OB—RL的表达有关。

关键词：消脂护肝方/药理学脂肪肝/中药疗法脂肪肝/病理学疾病模型,动物大鼠

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Initial Mesoscale Vortexes Leading to the Formation of Tropical Cyclones in the Western North Pacific

引用

Advances in Atmospheric Sciences 2023年第5期40卷 804-823页

作者： shenglan WU Juan FANG Shanghai Central Meteorological Observatory CMAShanghai 200030China Key Laboratory of Mesoscale Severe Weather(MOE) School of the Atmospheric SciencesNanjing University163 Xianlin RoadNanjing 210046China

A statistical analysis of the initial vortexes leading to tropical cyclone(TC)formation in the western North Pacific(WNP)is conducted with the ECMWF ERA5 reanalysis data from 1999 to *** is found that TCs in the WNP basically originate from three kinds of vortexes,i.e.,a mid-level vortex(MV),a low-level vortex(LV),and a relatively deep vortex with notable vorticity in both the lower and middle troposphere(DV).Among them,LV and DV account for 47.9%and 24.2%of tropical cyclogenesis events,respectively,while only 27.9%of TCs develop from the MV,which is much lower than that which occurs in the North Atlantic and eastern *** a difference might be ascribed to the active monsoon systems in the WNP all year *** to the nearly upright structure of mid-level convergence in the early pre-genesis stage,TC genesis efficiency is the highest in *** with MV,LV generally takes a shorter time to intensify to a TC because of the higher humidity and the stronger low-level cyclonic circulation,which is related to air-sea interaction and boundary-layer *** examination of the relationship between tropical cyclogenesis and large-scale flow patterns indicate that the TC genesis events associated with LV are primarily related to the monsoon shear line,monsoon confluence region,and monsoon gyre,while those associated with MV are frequently connected with easterly waves and wave energy dispersion of preexisting *** with other flow patterns,tropical cyclones usually form and intensify faster in the monsoon confluence region.

关键词： TC formation initial mesoscale vortexes TC genesis efficiency large-scale flow patterns

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sex differences in aging and injured brain

引用

Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson Yuan yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantification of neomangiferin in rat plasma by liquid chromatography–tandem mass spectrometry and its application to bioavailability study

引用

Journal of Pharmaceutical Analysis 2016年第5期6卷 335-340页

作者： Bo yang Zhirui Liu shenglan Shang Xiaojian Qin Peiyuan Xia Department of Pharmacy Southwest Hospital Third Military Medical University

Neomangiferin, a natural C-glucosyl xanthone, has recently received a great deal of attention due to its multiple biological activities. In this study, a rapid and sensitive ultra-high performance liquid chromatography tandem mass spectrometry(UHPLC–MS/MS) method for the quantification of neomangiferin in rat plasma was developed. Using chloramphenicol as an internal standard(IS), plasma samples were subjected to a direct protein precipitation process using methanol(containing 0.05% formic acid). Quantification was performed by multiple reactions monitoring(MRM) method, with the transitions of the parent ions to the product ions of m/z 583.1-330.9 for NG and m/z 321.1-151.9 for IS. The assay was shown to be linear over the range of 0.2–400 ng/m L, with a lower limit of quantification of 0.2 ng/m L. Mean recovery of neomangiferin in plasma was in the range of 97.76%–101.94%. Relative standard deviations(RSDs) of intra-day and inter-day precision were both o 10%. The accuracy of the method ranged from94.20% to 108.72%. This method was successfully applied to pharmacokinetic study of neomangiferin after intravenous(2 mg/kg) and intragastric(10 mg/kg) administration for the first time. The oral absolute bioavailability of neomangiferin was estimated to be 0.53% 7 0.08% with an elimination half-life(t_(1/2)) value of 2.747 0.92 h, indicating its poor absorption and/or strong metabolism in vivo.

关键词： Neomangiferin UHPLC–MS/MS Rat plasma Pharmacokinetics Bioavailability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：