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土地环境违规行政处罚对地区绿色生产效率的影响

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武汉大学学报(哲学社会科学版) 2024年第1期77卷 150-162页

作者：黄晓光李胜兰李倩广东海洋大学经济学院广东湛江524088 中山大学岭南学院经济学系广东广州510275 广东外语外贸大学会计学院广东广州510006

土地环境执法体系的完善,有助于激发土地空间资源的潜在能量,从而有力推动地区绿色发展。土地环境违规行政处罚作为土地环境执法的重要手段,随着社会经济的变化,不断维持着经济发展与环境治理两者的谐和关系,深刻影响着地区经济绿色发... 详细信息

土地环境执法体系的完善,有助于激发土地空间资源的潜在能量,从而有力推动地区绿色发展。土地环境违规行政处罚作为土地环境执法的重要手段,随着社会经济的变化,不断维持着经济发展与环境治理两者的谐和关系,深刻影响着地区经济绿色发展的方向。目前,我国的土地环境违规行政处罚尽管有力降低了污染物排放,却未能提升地区的绿色生产效率,这反映出地方政府未能有效权衡经济增长与污染治理的关系。欠发达地区通过减少处罚换取增长绩效,发达地区则以过度处罚换取污染治理绩效,二者都没有综合地从治理效率的角度考虑问题。为使治理效率整体上最大化,地方政府一方面应侧重于针对违法事件作出处罚,而非直接限制市场主体的生产经营活动,另一方面应完善环境治理的激励机制,调动市县及以下各级基层政府环境治理的积极性。

关键词：土地使用环境违规行政处罚绿色生产效率

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浅析脑胶质瘤临床试验中知情同意的问题

医学与哲学 2024年第1期45卷 16-19页

作者：王婵媛康庄李生兰李文斌首都医科大学附属北京天坛医院神经肿瘤综合治疗病区北京100070

通过对医院目前开展的脑胶质瘤临床试验知情同意过程中的观察,综合科室脑胶质瘤临床试验的开展情况,针对不同类型脑胶质瘤病人尤其是功能区受损以及伴有认知功能受限的病人,分析签署知情同意过程中存在的问题,经探讨并提出整改及解决办... 详细信息

通过对医院目前开展的脑胶质瘤临床试验知情同意过程中的观察,综合科室脑胶质瘤临床试验的开展情况,针对不同类型脑胶质瘤病人尤其是功能区受损以及伴有认知功能受限的病人,分析签署知情同意过程中存在的问题,经探讨并提出整改及解决办法。通过规范的签署知情同意,针对病情不同的脑胶质瘤受试者采取个体化签署知情同意,充分尊重受试者意愿,保证临床试验顺利进行,使受试者权益得到充分保障,促进临床试验规范、安全、有序的开展。

关键词：脑胶质瘤临床试验知情同意受试者权益

Drug clinical trials on high-grade gliomas: challenges and hopes

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Cancer Biology & Medicine 2023年第12期20卷 947-954页

作者： Mengqian Huang shenglan li Parker li Zhuang Kang Botao Zhang Wenbin li Cancer Center Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Clinical Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China

Gliomas are the most common group of malignant central nervous system tumors across all ages and have high *** to histopathologic criteria and molecular pathology,gliomas are classified as grades 1–***-grade gliomas(HGG),including the most aggressive subtype,glioblastoma(GBM),belong to grade 3 or *** a standard therapy comprising surgical resection,chemotherapy,and radiation is available,almost all patients with HGG experience recurrence within several months and a dismal prognosis1.

关键词： glioma chemotherapy pathology

龙氏手法联合施罗斯疗法在特发性脊柱侧弯患者中的应用效果

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中国医学创新 2024年第11期21卷 48-52页

作者：张新立周慧雯李胜兰新余市中医院康复科江西新余338000

目的:探讨龙氏手法联合施罗斯疗法对特发性脊柱侧弯患者竖直肌表面肌电、Cobb角及躯干畸形程度的影响。方法:选择2021年11月—2022年12月新余市中医院康复科收治的80例特发性脊柱侧弯患者为研究对象,采用硬币抛掷法分为联合组(n=42)与... 详细信息

目的:探讨龙氏手法联合施罗斯疗法对特发性脊柱侧弯患者竖直肌表面肌电、Cobb角及躯干畸形程度的影响。方法:选择2021年11月—2022年12月新余市中医院康复科收治的80例特发性脊柱侧弯患者为研究对象,采用硬币抛掷法分为联合组(n=42)与对照组(n=38)。对照组接受施罗斯疗法,联合组接受龙氏手法联合施罗斯疗法,两组患者治疗6个月。比较两组竖脊肌表面肌电相关指标、Cobb角、躯干畸形程度、总有效率及生活质量。结果:治疗后,联合组凹凸两侧竖脊肌中位频率(MF)、平均功率频率(MPF)及平均肌电值(AEMG)均明显高于对照组,差异均有统计学意义(P<0.05);治疗后,联合组Cobb角、躯干倾斜角(ATI)、躯干旋转角度(ATR)均明显小于对照组,差异均有统计学意义(P<0.05);联合组总有效率及治疗后健康调查量表36(SF-36)各维度评分均明显高于对照组,差异均有统计学意义(P<0.05)。结论:对特发性脊柱侧弯患者行龙氏手法联合施罗斯疗法能显著改善竖脊肌协调性与稳定性,使Cobb角降低,有助于恢复脊柱形态,改善躯干畸形,疗效显著,且能提升生活质量。

关键词：龙氏手法施罗斯疗法特发性脊柱侧弯

The m^(6)A reader SiYTH1 enhances drought tolerance by affecting the messenger RNA stability of genes related to stomatal closure and reactive oxygen species scavenging in Setaria italica

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Journal of Integrative Plant Biology 2023年第12期65卷 2569-2586页

作者： Weiwei Luo Yuxiang Tang shenglan li linlin Zhang Yuwei liu Renliang Zhang Xianmin Diao Jingjuan Yu State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing100193 China College of life Sciences Hebei Agricultural UniversityBaoding071001 China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing100081 China

Foxtail millet(Setaria italica),a vital drought-resistant crop,plays a significant role in ensuring food and nutritional ***,its drought resistance mechanism is not fully understood.N6-methyladenosine(m^(6)A)modification of RNA,a prevalent epi-transcriptomic modification in eukaryotes,provides a binding site for m^(6)A readers and affects plant growth and stress responses by regulating RNA *** this study,we unveiled that the YT521-B homology(YTH)family gene SiYTH1 positively regulated the drought tolerance of foxtail ***,the siyth1 mutant exhibited reduced stomatal closure and augmented accumulation of excessive H_(2)O_(2)under drought *** investigations demonstrated that SiYTH1 positively regulated the transcripts harboring m^(6)A modification related to stomatal closure and reactive oxygen species(ROS)scavenging under drought ***1 was uniformly distributed in the cytoplasm of SiYTH1-GFP transgenic foxtail *** formed dynamic liquid-like SiYTH1 cytosol condensates in response to drought ***,the cytoplasmic protein SiYTH1 was identified as a distinct m^(6)A reader,facilitating the stabilization of its directly bound SiARDP and ROS scavenging-related transcripts under drought ***,natural variation analysis revealed SiYTH1AGTG as the dominant allele responsible for drought tolerance in foxtail ***,this study provides novel insights into the intricate mechanism of m^(6)A reader-mediated drought tolerance and presents a valuable genetic resource for improving drought tolerance in foxtail millet breeding.

关键词： drought stress mRNA stability N^(6)-methyladenosine(m^(6)A)reader phase separation SiYTH1 Setaria italica

Signaling pathways in brain tumors and therapeutic interventions

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Signal Transduction and Targeted Therapy 2023年第2期8卷 423-445页

作者： shenglan li Can Wang Jinyi Chen Yanjie Lan Weichunbai Zhang Zhuang Kang Yi Zheng Rong Zhang Jianyu Yu Wenbin li Department of Neuro-Oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Brain tumors,although rare,contribute to distinct mortality and morbidity at all *** there are few therapeutic options for brain tumors,enhanced biological understanding and unexampled innovations in targeted therapies and immunotherapies have considerably improved patients’***,the reduced response rates and unavoidable drug resistance of currently available treatment approaches have become a barrier to further improvement in brain tumor(glioma,meningioma,CNS germ cell tumors,and CNS lymphoma)*** literature data revealed that several different signaling pathways are dysregulated in brain ***,a better understanding of targeting signaling pathways that influences malignant behavior of brain tumor cells might open the way for the development of novel targeted ***,there is an urgent need for a more comprehensive understanding of the pathogenesis of these brain tumors,which might result in greater progress in therapeutic *** paper began with a brief description of the epidemiology,incidence,risk factors,as well as survival of brain ***,the major signaling pathways underlying these brain tumors’pathogenesis and current progress in therapies,including clinical trials,targeted therapies,immunotherapies,and system therapies,have been systemically reviewed and ***,future perspective and challenges of development of novel therapeutic strategies in brain tumor were emphasized.

关键词： therapeutic epidemiology mortality

liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 625-627页

作者： shenglan li Jinyi Chen Yaqiong Fan Ce Wang Can Wang Xiaohong Zheng Feng Chen Wenbin li Department of Neuro-oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Dear Editor,Nowadays,medulloblastoma accounts for approximately 25% of all pediatric brain tumors.1 Even with the successful treatment of primary tumors,there are still serious side ***(HNK)is defined as small bisphen... 详细信息

关键词： tumors pediatric lipo

Progress in phase III clinical trials of molecular targeted therapy and immunotherapy for glioblastoma

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Cancer Innovation 2023年第2期2卷 114-130页

作者： Yuekun Wang shenglan li Yichen Peng Wenbin Ma Yu Wang Wenbin li Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Neuro-oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Glioblastoma(GBM)is the most common primary central nervous system tumor,whose prognosis remains poor under the sequential standard of care,such as neurosurgery followed by concurrent temozolomide radiochemotherapy and adjuvant temozolomide chemotherapy in the presence or absence of tumor treating ***,the advent of molecular targeted therapy and immunotherapy has opened a new era of tumor management.A diverse range of targeted drugs have been tested in patients with GBM in phase III clinical ***,these drugs are ineffective for all patients,as evidenced by the fact that only a minority of patients in these trials showed prolonged ***,there are several published phase III clinical trials that involve immune checkpoint inhibitors,peptide vaccines,dendritic cell vaccines,and ***,this review comprehensively overviews existing studies of targeted drugs and immunotherapy for glioma and discusses the challenge and perspective of targeted drugs and immunotherapy for glioma to clarify future directions.

关键词： glioblastoma immunotherapy phase III clinical trial target therapy

Health risk assessment of trace metal(loid)s in agricultural soils based on Monte Carlo simulation coupled with positive matrix factorization model in Chongqing, southwest China

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Journal of Mountain Science 2024年第1期21卷 100-112页

作者： MA Jie CHU lijuan SUN Jing WANG shenglan GE Miao DENG li Chongqing Ecological and Environmental Monitoring Center Chongqing 401147China Key Laboratory of Organic Pollutants in Environmental Chemical Behavior and Ecological Toxicology of Chongqing Chongqing 401147China Department of Pediatrics Chongqing Health Center for Women and ChildrenChongqing 401147China Department of Pediatrics Women and Children’s Hospital of Chongqing Medical UniversityChongqing 401147China

This study aimed to investigate the pollution characteristics, source apportionment, and health risks associated with trace metal(loid)s(TMs) in the major agricultural producing areas in Chongqing, China. We analyzed the source apportionment and assessed the health risk of TMs in agricultural soils by using positive matrix factorization(PMF) model and health risk assessment(HRA) model based on Monte Carlo simulation. Meanwhile, we combined PMF and HRA models to explore the health risks of TMs in agricultural soils by different pollution sources to determine the priority control factors. Results showed that the average contents of cadmium(Cd), arsenic (As), lead(Pb), chromium(Cr), copper(Cu), nickel(Ni), and zinc(Zn) in the soil were found to be 0.26, 5.93, 27.14, 61.32, 23.81, 32.45, and 78.65 mg/kg, respectively. Spatial analysis and source apportionment analysis revealed that urban and industrial sources, agricultural sources, and natural sources accounted for 33.0%, 27.7%, and 39.3% of TM accumulation in the soil, respectively. In the HRA model based on Monte Carlo simulation, noncarcinogenic risks were deemed negligible(hazard index linked to Cd and Pb, contributing to 13.1% of carcinogenic risks and 21.8% of non-carcinogenic risks, designating them as secondary control factors.

关键词： Monte Carlo simulation Health risk assessment Trace metal(loid)s Positive matrix factorization Agricultural soils