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Application Research of PETD Combined with MRI Nerve Root Water Imaging in the Minimally Invasive Treatment of LDH

International Journal of Clinical Medicine 2024年第4期15卷 167-176页

作者： Guanhua Wang Zhe Shen Jinben Yu shengjie xu Weinan xu Bing xu Xiaoyu Ye Wenzhou Combined Traditional Chinese and Western Medicine Hospital of Zhejiang Chinese Medicine University Wenzhou China The Third Clinical Medical College Zhejiang Chinese Medical University Hangzhou China

Objective: This study aims to evaluate the safety and efficacy of PETD combined with nerve root water imaging of MRI for the treatment of lumbar disc herniation. Methods: A retrospective review was performed on 62 patients with lumbar disc herniation from March 2019 to March 2021. The study included an experimental group of 30 patients and a control group of 32 patients. The experimental group underwent PETD combined with nerve root water imaging of MRI, while the control group received traditional PETD treatment. The visual analogue scoring method (VAS score), and JOA lumbar spine function score before and after surgery were compared between the two groups, and efficacy was assessed and compared using the MacNab score. Results: The mean operation time was significantly reduced in the experimental group (56.43 ±10.40 minutes) compared to the control group (65.69 ±14.12 minutes). The VAS score was compared between the two groups with preoperative (p = 0.624), one month after surgery (p = 0.325), three months after surgery (p = 0.676), one year after surgery (p = 0.341);The JOA score was compared between the two groups with preoperative (p = 0.961), one month after the surgery (p = 0.266), three months after surgery (p = 0.185), one year after surgery (p = 0.870), they were no significant statistical difference;The efficacy evaluation of the last follow-up Macnab showed that all the 30 patients in the experimental group were excellent, 31 of 32 patients in the control group were excellent, 1 case was good;There was no statistical difference in the comparison between the two groups (p > 0.05). Conclusion: The study concludes that the combined approach of PETD with nerve root water imaging of MRI is a safe, effective, and more efficient alternative to conventional PETD for treating lumbar disc herniation.

关键词： Lumbar Disc Herniation Nerve Root Water Imaging Percutaneous Interforaminal Endoscopy Minimally Invasive Spine Surgery Discectomy

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局部应用不同剂量万古霉素预防腰椎融合术后手术部位感染疗效分析

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中华骨与关节外科杂志 2024年第3期17卷 228-233页

作者：徐胜杰柳晓林史金鹏施进兴福建医科大学附属第二医院骨科福建泉州362000

目的:评价局部应用不同剂量万古霉素预防腰椎融合术后手术部位感染(SSI)的疗效。方法:回顾性分析2019年3月至2022年8月行后路腰椎融合术的180例腰椎退行性疾病患者的临床资料。其中58例患者采用常规围手术期预防感染方案(常规组);122例... 详细信息

目的:评价局部应用不同剂量万古霉素预防腰椎融合术后手术部位感染(SSI)的疗效。方法:回顾性分析2019年3月至2022年8月行后路腰椎融合术的180例腰椎退行性疾病患者的临床资料。其中58例患者采用常规围手术期预防感染方案(常规组);122例患者采用常规围手术期预防感染方案联合局部应用0.5 g万古霉素粉剂(0.5 g万古霉素组,62例)或1.0 g万古霉素粉剂(1.0 g万古霉素组,60例)。观察患者术后SSI情况,比较三组患者术后C反应蛋白(CRP)水平、红细胞沉降率(ESR)、疼痛视觉模拟评分(VAS)、腰椎日本骨科协会(JOA)评分,同时记录并发症发生情况。结果:1.0 g万古霉素组患者术后未发生SSI,0.5 g万古霉素组1例(1.6%)患者术后发生非葡萄球菌感染,常规组5例(8.6%)患者术后发生SSI,常规组与1.0 g万古霉素组SSI发生率差异有统计学意义(P<0.05)。术后1周,0.5 g和1.0 g万古霉素组患者CRP水平、ESR均低于常规组患者(P均<0.05),且1.0 g万古霉素组与0.5 g万古霉素组患者CRP水平、ESR差异均有统计学意义(P均<0.05)。术后1周、术后1个月0.5 g和1.0 g万古霉素组患者疼痛VAS评分均低于常规组患者(P均<0.05),腰椎JOA评分均高于常规组患者(P均<0.05);万古霉素组无一例患者发生药物相关不良反应。结论:腰椎融合术中局部应用0.5 g、1.0 g万古霉素粉剂能够显著降低SSI发生率,局部应用1.0 g万古霉素能够更好地降低患者术后炎症水平,改善术后疗效。

关键词：万古霉素腰椎融合术手术部位感染

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经椎间孔选择性神经根封闭治疗腰椎间盘突出症的中期临床观察

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中国伤残医学 2024年第6期32卷 60-63,67页

作者：施进兴柳晓林徐胜杰福建医科大学附属第二医院脊柱外科福建泉州362000

目的:探讨腰椎间盘突出症患者实施经椎间孔选择性神经根封闭治疗的临床效果.方法:选取我院2021年3月-2022年12月收治的52例腰椎间盘突出症患者为研究对象,采用经椎间孔选择性神经根封闭治疗,分析治疗干预效果.结果:封闭治疗后,各个时间... 详细信息

目的:探讨腰椎间盘突出症患者实施经椎间孔选择性神经根封闭治疗的临床效果.方法:选取我院2021年3月-2022年12月收治的52例腰椎间盘突出症患者为研究对象,采用经椎间孔选择性神经根封闭治疗,分析治疗干预效果.结果:封闭治疗后,各个时间段的疼痛视觉模拟评分均低于术前,差异有统计学意义(P0.05).结论:针对腰椎间盘突出症患者实施经椎间孔选择性神经根封闭治疗,效果良好.

关键词：腰椎间盘突出症经椎间孔选择性神经根封闭疗效

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Near-Infrared All-Fused-Ring Nonfullerene Acceptors Achieving an Optimal Efficiency-Cost-Stability Balance in Organic Solar Cells

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CCS Chemistry 2023年第3期5卷 654-668页

作者： Wenrui Liu shengjie xu Hanjian Lai Wuyue Liu Feng He Xiaozhang Zhu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049 Department of Chemistry Shenzhen Grubbs InstituteSouthern University of Science and TechnologyShenzhen 518055

Synergistically achieving stability,cost,and efficiency is crucial for the commercialization of organic solar cells(OSCs).Despite the rapid development of 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malo nonitriletypenon fullerene acceptors(NFAs),they areinherently unstable due to the vulnerable exocyclic double bond and possess high synthesis complexity(SC).Based on the“all-fused-ring electron acceptor(AFAR)”concept,we report two new near-infrared NFAs,F11 and F13,featuring all fused dodecacyclic *** developing a whole set of synthetic procedures,F11 and F13 can be conveniently prepared at a 10 g scale within a notably short period,displaying both the low SC and the lowest costs among reported NFAs,even comparable to the classical photovoltaic material,*** comparison with the one-dimensional stacking of ITYM(ITYM=2,2′-(7,7,15,15-tetrahexyl-7,15-dihydro-s-indaceno[1,2-b:5,6-b′]diindeno[1,2-d]thiophene-2,10(2H)-diylidene)dimalononitrile),the first AFRA,and mixed J-and H-aggregations in Y6,F-acceptors show a compact honeycomb-type three-dimensional stacking with exclusive J-aggregations,favoring multichannel charge *** matching a medium-bandgap polymer donor,F13 delivers greater than 13%power conversion efficiencies,which is the highest performance among non-INCN acceptors,and shows device stability superior to the typical ITIC-and Y6-based OSCs as evidenced by the negligible burn-in *** work presents a first and successful example of NFAs achieving an optimal efficiency-cost-stability balance in OSCs.

关键词： nonfullerene acceptors near-infrared cost stability power conversion efficiency

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Seabed structures and foundations related to deep-sea resource development:A review based on design and research

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Deep Underground Science and Engineering 2024年第2期3卷 131-148页

作者： shengjie Rui Haojie Zhang Hang xu Xing Zha Mengtao xu Kanmin Shen Key Laboratory of Offshore Geotechnics and Material of Zhejiang Province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhouChina Advanced Modelling Offshore EnergyNorwegian Geotechnical InstituteOsloNorway Geotechnical Technology Center(Overseas Engineering Center) PowerChina Huadong Engineering Corporation LimitedHangzhouChina

The deep‐sea ground contains a huge amount of energy and mineral resources,for example,oil,gas,and *** infrastructures such as floating structures,seabed structures,and foundations have been developed to exploit these *** seabed structures and foundations can be mainly classified into three types:subsea production structures,offshore pipelines,and *** study reviewed the development,installation,and operation of these infrastructures,including their structures,design,installation,marine environment loads,and *** this basis,the research gaps and further research directions were explored through this literature ***,different floating structures were briefly analyzed and reviewed to introduce the design requirements of the seabed structures and ***,the subsea production structures,including subsea manifolds and their foundations,were reviewed and ***,the basic characteristics and design methods of deep‐sea pipelines,including subsea pipelines and risers,were analyzed and ***,the installation and bearing capacity of deep‐sea subsea anchors and seabed trench influence on the anchor were *** the review,it was found that marine environment conditions are the key inputs for any offshore structure *** fabrication,installation,and operation of infrastructures should carefully consider the marine loads and geological *** structures have their own mechanical *** fatigue and stability of pipelines mainly depend on the soil‐structure *** selection should consider soil types and possible trench *** focuses and research gaps can provide a helpful guide on further research,installation,and operation of deep‐sea structures and foundations.

关键词： anchors floating structures pipelines risers subsea foundations

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亚甲基四氢叶酸还原酶纯合突变的颅内静脉窦血栓一例并文献复习

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北京医学 2024年第5期46卷 370-373页

作者：许胜杰杨艳华李想王岩陈玉萍邱峰解放军总医院第八医学中心神经内科北京100091

目的总结亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)纯合突变致同型半胱氨酸(homocystine,Hcy)升高、诱发颅内静脉窦血栓形成(cerebral venous sinus thrombosis,CVST)的临床特点和诊疗过程。方法选取2023年1月3日解放军总医院第八医学中心的CVST患者1例,回顾性分析患者的临床、实验室资料,并复习既往相关文献。结果患者男,18岁,因“头痛伴恶心呕吐2 d”就诊,临床表现为头部持续胀痛,伴恶心呕吐,Hcy异常升高,影像学示上矢状窦、右侧横窦、乙状窦血栓形成,基因测序结果为MTHFR纯合突变。既往文献显示,MTHFR纯合突变与CVST无直接因果关系,但可导致Hcy水平升高,并间接增加CVST的风险。结论应重视CVST患者的Hcy检测,如发现Hcy无明显诱因的异常升高,应进一步完善CVST相关遗传因素的基因检测,尽早针对病因进行治疗。

关键词：颅内静脉窦血栓形成同型半胱氨酸亚甲基四氢叶酸还原酶基因检测纯合突变

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溺亡后肠道菌群变化综述

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工业微生物 2024年第1期54卷 149-151页

作者：马玉欣马渊徐胜杰宋积寿马琴傅思武西北民族大学医学部甘肃兰州730030

对死后间隔时间(postmortem interval,PMI)的推断,是法医界最大的难题之一,从传统的根据尸体现象推断PMI到如今利用硅藻检验、影像学、分子生物学及人工智能等众多高新技术,极大地提高了PMI判断的准确性。人体死亡后,肠道菌群将发生剧... 详细信息

对死后间隔时间(postmortem interval,PMI)的推断,是法医界最大的难题之一,从传统的根据尸体现象推断PMI到如今利用硅藻检验、影像学、分子生物学及人工智能等众多高新技术,极大地提高了PMI判断的准确性。人体死亡后,肠道菌群将发生剧烈变化,因此,分析肠道菌群的变化特点可以为法医鉴定提供新思路。通过肠道微生物分析,建立PMI与肠道菌群之间的关系,从而提高PMI的精确性,极大地拓展了肠道菌群的研究范畴。文章就溺亡尸体肠道菌群的时序性变化进行了简要综述,旨在探讨肠道菌群在法医实践中推断死亡时间的应用现状及应用前景。

关键词：法医病理水中尸体肠道菌群死亡时间推断

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Synthesis of spherical nano-ZSM-5 zeolite with intergranular mesoporous for alkylation of ethylbenzene with ethanol to produce m-diethylbenzene

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Chinese Journal of Chemical Engineering 2024年第3期67卷 298-309页

作者： Siyue Wang Jinhong Li Qingxin xu shengjie Song Yu'ni Jiang Lidong Chen Xin Shi Weiguo Cheng Faculty of Chemistry and Chemical Engineering Liaoning Normal UniversityDalian 110629China Beijing Key Laboratory of Ionic Liquids Clean Process Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Catalytic synthesis of m-diethylbenzene(m-DEB)through alkylation of ethylbenzene(EB)may be a promising alternative route in comparison with traditional rectification of mixed DEB,for which the top priority is to develop efficient and stable heterogeneous ***,the spherical nano-ZSM-5 zeolite with abundant intergranular mesoporous is synthesized by the seed-mediated growth method for alkylation of EB with ethanol to produce *** results show that the spherical nano-ZSM-5 zeolite exhibits better stability and higher alkylation activity at a lower temperature than those of commercial micropore *** then,the spherical nano-ZSM-5 is further modified by La_(2)O_(3) through acid treatment followed by immersion *** acid treatment causes nano-ZSM-5 to exhibit the increased pore size but decreased the acid sites,and subsequent La_(2)O_(3) loading reintroduces the weak acid *** a result,the HNO_(3)-La_(2)O_(3)-modified catalyst exhibits a slight increase in EB conversion and DEB yield in comparison with unmodified one,and meanwhile,it still maintains high m-DEB *** catalyst after acid treatment achieves higher catalytic stability besides maintaining the high alkylation activity of EB with *** present study on the spherical nano-HZSM-5 zeolite and its modification catalyst with excellent alkylation ability provides new insights into the production of mDEB.

关键词： Zeolite Modification Alkylation reaction m-diethylbenzene Catalyst Fixed-bed

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Efficient organic solar cells achieved at a low energy loss

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Science Bulletin 2019年第16期64卷 1144-1147页

作者： Wenrui Liu Jianyun Zhang shengjie xu Xiaozhang Zhu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100190China

Organic photovoltaics(OPVs)have attracted much attention because of the advantages in low-cost and large-area fabrication and the great potentials in achieving flexible and semi-transparent devices(1)However,compared with inorganic and perovskite solar cells[2],OPVs show relatively low photoelectric conversion efficiencies,which is admittedly attributed to intrinsically low dielectric constants of organic materials[3]resulting in large energy losses(Eloss=EgqVoc,where Eg is the optical bandgap of the photoactive layer,Voc is the open-circuit voltage of photovoltaic devices and q is elementary charge).

关键词： Efficient organic solar cells at a low energy loss Organic photovoltaics

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Genome-wide and candidate gene association studies identify BnPAP17 as conferring the utilization of organic phosphorus in oilseed rape

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Journal of Integrative Agriculture 2024年第4期23卷 1134-1149页

作者： Ping xu Hao Li Haiyuan Li Ge Zhao shengjie Dai Xiaoyu Cui Zhenning Liu Lei Shi Xiaohua Wang College of Agriculture and Forestry Science Linyi UniversityLinyi 27600China National Key Laboratory of Crop Genetic Improvement/Microelement Research Centre/Key Laboratory of Arable Land Conservation(Middle and Lower Reaches of Yangtze River) Ministry of Agriculture and Rural Affairs/Huazhong Agricultural UniversityWuhan 430070China

Phosphorus(P)is essential for living plants,and P deficiency is one of the key factors limiting the yield in rapeseed production *** the most important organ for plants,root morphology traits(RMTs)play a key role in P *** investigate the genetic variability of RMT under low P availability,we dissected the genetic structure of RMTs by genome-wide association studies(GWAS),linkage mapping and candidate gene association studies(CGAS).A total of 52 suggestive loci were associated with RMTs under P stress conditions in 405 oilseed rape *** purple acid phosphatase gene BnPAP17 was found to control the lateral root number(LRN)and root dry weight(RDW)under low P *** expression of BnPAP17 was increased in shoot tissue in P-efficient cultivars compared to root tissue and P-inefficient cultivars in response to low P ***,the haplotype of BnPAP17^(Hap3)was detected for the selective breeding of P efficiency in oilseed ***-expression of the BnPAP17^(Hap3)could promote the shoot and root growth with enhanced tolerance to low P stress and organic phosphorus(Po)utilization in oilseed ***,these findings increase our understanding of the mechanisms underlying BnPAP17-mediated low P stress tolerance in oilseed rape.

关键词： genome-wide association studies(GWAS) root morphology traits(RMTs) organic phosphorus(Po) oilseed rape BnPAP17

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