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Characteristics of HIV-1 Molecular Epidemiology in Suzhou,China,from 2009 to 2014

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Virologica Sinica 2018年第2期33卷 209-212页

作者： Ying Yuan shengjie tang Yuan Li Dongmei Yan Qunxin Peng Xuerong Ya Yanhui Song Department of Clinical Laboratory The First Affiliated Hospital of Soochow University Soochow University Suzhou 215031 China The Institutes of Biological and Medical Sciences Soochow University Suzhou 215123 China Basic Medical College of Jiamusi University Jiamusi University Jiamusi 154007 China Suzhou Center for Disease Control and Prevention Suzhou 215004 China

Human immunodeficiency virus（HIV）and acquired immunodeficiency syndrome（AIDS）remain major public health problems in China,where approximately 780,000people currently live with HIV,according to the 2012 China AIDS Response Progress *** was an early epidemic region in Jiangsu province and the current situation of HIV-1 prevalence is complicated.

关键词： HIV-1 中国传染病学苏州特征分子免疫不全健康问题

Construction of a Metallacyclopentadiene Ring through the Attack of Carbanions to M≡C Bond Followed by C—H Activation

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Chinese Journal of Chemistry 2024年第3期42卷 235-242页

作者： Chun tang shengjie Zhang Zhengyu Lu Qian Li Ming Luo Dafa Chen Haiping Xia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringCollaborative Innovation Center of Chemistry for Energy MaterialsXiamen UniversityXiamenFujian361005 China Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis Department of ChemistrySouthern University of Science and TechnologyShenzhenGuangdong518055 China

Metallacyclopentadienes are important metallacycles and regarded as intermediates in many reactions,therefore,new methods to achieve them are *** this study,a formal[3+2]method,through the reactions of an osmapentalyne with benzyl carbanions,was *** reactions underwent a nucleophilic attack of carbanions to the Os≡C bond,followed by C—H activation to form the five-membered osmacyclopentadiene *** of the reactions were carried out at room temperature,the substituents on the aromatic rings of benzyl carbanions are diverse,and the resulting products contain an Os—H bond,representing a novel type of 10C-carbolong *** work provides a new convenient route to construct metallacyclopentadienes,which is expected to further promote the development of such a type of substances.

关键词： Metallacyclopentadiene Carbolong chemistry Osmium C–H activation Nucleophilic addition

HIV-1 hijacks host karyopherin KPNA2 for efficient nuclear import in macrophages

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HIV-1 hijacks host karyopherin KPNA2 for efficient nuclear i...

基于SCADE模型的车载ATP测试用例生成方法

第十一届全国免疫学学术大会

作者： Dong Chunsheng tang shengjie Xiong Sidong The Institutes of Biology and Medical Sciences Soochow University

Objective: Monocytes from peripheral blood are insensitive for HIV-1 infection. However, when monocytes differentiate into macrophages, they show an increased sensitivity for HIV infection. Our previous RNAseq analysis demonstrated more than 1100 host genes including KPNA2 were different expressed in monocytes and monocytes derived macrophages(MDM) including KPNA2. In the present study, we investigated the role of KPNA2 in HIV replication. Methods: 293 T cells were infected with HIV single cycle luciferase reporter virus. KPNA2 expression was down-regulated with siRNA. The HIV replication was measured by lucifierase activity in the cell lysates. HIV reverse transcription and nuclear import were measured by the quantitative PCR for Late-RT and 2-LTR products, repectively. Results: KPNA2 was up-regulated in the monocytes to macrophages differentiation. The siRNA mediated knockdown of KPNA2 demonstrated that it was important for HIV replication. Quantitative 2-LTR PCR revealed that KPNA2 enhanced the HIV pre-integration complex nuclear imort. Conclusion: Taken together, our results showed that KPNA2 may be one of the key factors contributing to the sensitivity of HIV replication during monocytes to macrophages differentiation.

关键词： HIV KPNA2 Nuclear Import macrophages

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铁道学报 2020年第9期42卷 102-110页

作者：李兰心王海峰齐志华汤圣杰张启鹤北京交通大学电子信息工程学院北京100044 北京交通大学轨道交通运行控制系统国家工程研究中心北京100044 中国铁道科学研究院集团有限公司通信信号研究所北京100081 广州铁科智控有限公司广东广州510220

车载ATP是保证列车安全运行的关键列控设备。为满足其苛刻的安全要求,实际应用之前需要对其进行全面严格的测试。传统的编写测试用例的方法过分依赖人工经验,耗时耗力,且测试质量难以保证。提出一种基于SCADE模型自动生成车载ATP测试用... 详细信息

车载ATP是保证列车安全运行的关键列控设备。为满足其苛刻的安全要求,实际应用之前需要对其进行全面严格的测试。传统的编写测试用例的方法过分依赖人工经验,耗时耗力,且测试质量难以保证。提出一种基于SCADE模型自动生成车载ATP测试用例的方法。首先,利用SCADE对车载ATP系统进行建模,并针对安全状态机模型生成满足全迁移覆盖准则的测试用例;再根据MC/DC覆盖准则生成测试数据,将抽象的测试用例转化为可直接用于测试的具体测试用例集;最后,通过变异分析对生成的测试用例进行评估。结果表明,测试用例具有良好的覆盖度,优于传统人工方法。

关键词：车载ATP系统 SCADE模型测试用例基于模型的测试 MC/DC覆盖准则

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao Sun Mengge Wang Qiuxia Sun Yan Liu Shuhan Duan Zhiyong Wang Yunyu Zhou Jun Zhong Yuguo Huang Xinyu Huang Qingxin Yang Xiangping Li Haoran Su Yan Cai Xiucheng Jiang Jing Chen Jiangwei Yan shengjie Nie Liping Hu Junbao Yang Renkuan tang Chuan-Chao Wang Chao Liu Xiaohui Deng Libing Yun Guanglin He West China School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science Institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of Life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic ***,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain ***,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking *** identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin *** finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish *** signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in ***-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Genetic profile Natural selection Genetic diversity Biological adaptation

胸主动脉瘤腔内隔绝术后远期主动脉食管瘘1例并文献复习

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中国医药导报 2021年第6期18卷 181-184页

作者：唐晟杰周海宁遵义医科大学研究生院贵州遵义563000 四川省遂宁市中心医院胸外科四川遂宁629000

主动脉食管瘘(AEF)是一种罕见的疾病,误诊率及致死率高,可由胸主动脉瘤、异物摄入、主动脉支架置入腔内隔绝术(TEVAR)等引起。本病例2016年2月因胸背部疼痛就诊于四川省遂宁市中心医院(以下简称“我院”),经胸部增强CT检查诊断降主动脉... 详细信息

主动脉食管瘘(AEF)是一种罕见的疾病,误诊率及致死率高,可由胸主动脉瘤、异物摄入、主动脉支架置入腔内隔绝术(TEVAR)等引起。本病例2016年2月因胸背部疼痛就诊于四川省遂宁市中心医院(以下简称“我院”),经胸部增强CT检查诊断降主动脉瘤,行胸主动脉支架置入腔内隔绝术,术后半年复查发现Ⅰ型内漏,患者拒绝外科手术干预,4年后因心累、心悸再入我院,胸部增强CT提示AEF,拟行reTEVAR+食管重建杂交手术,患者拒绝手术,1个月后因出血及感染死亡。主动脉瘤支架置入远期发生AEF的病例极少。本文报道TEVAR术后远期AEF 1例,结合现有报道对其临床表现、诊断及治疗进行文献复习,以提高对该疾病的认识。

关键词：主动脉食管瘘主动脉瘤腔内隔绝术并发症文献复习

少见非结核分枝杆菌病药物治疗新方案的研究进展

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新发传染病电子杂志 2023年第5期8卷 85-91页

作者：胡毅唐莉歆李同心唐神结杨松重庆市巫溪县人民医院感染科重庆404800 重庆市公共卫生医疗救治中心呼吸老年病科重庆400030 重庆市公共卫生医疗救治中心中心实验室重庆400036 首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所北京101149 重庆市公共卫生医疗救治中心老年结核病·综合内科重庆400036

非结核分枝杆菌病呈全球增长之势,仍然是全球公共卫生问题之一,其发病率、病死率和经济成本仍居高不下。分枝杆菌对大多数抗生素具有固有耐药性,治疗难度较大,尤其免疫功能低下及合并慢性基础疾病的患者常需要使用多药联合治疗方案和延... 详细信息

非结核分枝杆菌病呈全球增长之势,仍然是全球公共卫生问题之一,其发病率、病死率和经济成本仍居高不下。分枝杆菌对大多数抗生素具有固有耐药性,治疗难度较大,尤其免疫功能低下及合并慢性基础疾病的患者常需要使用多药联合治疗方案和延长疗程的应对策略,但非结核分枝杆菌病的治愈率较低,紧迫需要更加有效的治疗药物组成新的治疗方案。目前比较常见的非结核分枝杆菌如鸟分枝杆菌复合群、脓肿分枝杆菌复合群等导致的成人非结核分枝杆菌肺病的治疗有相关指南可供参考,但临床相关的少见非结核分枝杆菌如海分枝杆菌、戈登分枝杆菌、溃疡分枝杆菌、玛尔摩分枝杆菌、日内瓦分枝杆菌、隐藏分枝杆菌、猿分枝杆菌复合群、副戈登分枝杆菌、苏尔加分枝杆菌、嗜血分枝杆菌或瘰疬分枝杆菌等导致的临床疾病的治疗药物方案的选择却非常有限。目前无论是基于指南的治疗策略或个体化治疗策略,均需要多种药物组成的联合治疗方案,但免疫功能低下患者及合并慢性疾病患者的治疗成功率不到50%,急需高效和低毒的新治疗方案用于临床实践以挽救患者生命、提高疗效和降低药物的毒副作用。本文将近年来少见非结核分枝杆菌病的治疗药物及其治疗新方案的研究进展作一综述。

关键词：非结核分枝杆菌新药物治疗方案进展

基于动态故障树的地铁自动监控系统可靠性分析

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铁道通信信号 2020年第12期56卷 81-88页

作者：汤圣杰刘广泽林保罗广州铁科智控有限公司广州510385 广州地铁集团有限公司

自动监控系统是地铁系统安全运行的重要保障,具有可修性、容错性及冗余性等特点。本文基于动态故障树对广州地铁4号线自动监控系统进行可靠性分析。首先,对系统动态故障树进行模块化;然后,对各个子树模块采用马尔科夫矩阵迭代法计算其... 详细信息

自动监控系统是地铁系统安全运行的重要保障,具有可修性、容错性及冗余性等特点。本文基于动态故障树对广州地铁4号线自动监控系统进行可靠性分析。首先,对系统动态故障树进行模块化;然后,对各个子树模块采用马尔科夫矩阵迭代法计算其稳态可靠性参数;最后,通过参数传递计算系统的稳态可靠性参数。研究分析结果表明,本文采用的可靠性计算方法能够更好地描述系统的冗余性和容错性,提高了可靠性指标的精度,避免了由于系统复杂而造成的状态爆炸问题,提高了可靠性分析的实时性和有效性。

关键词：地铁自动监控系统可靠性动态故障树马尔科夫矩阵

静脉联合治疗和延长强化期治疗对复治肺结核疗效的影响

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中国防痨杂志 2009年第12期31卷 713-717页

作者：顾瑾肖和平王凯唐神结同济大学附属上海市肺科医院上海200433

目的探讨静脉联合治疗和延长强化期治疗对初次复治肺结核患者的临床应用价值。方法研究对象随机分为治疗组1和治疗组2,治疗组1采用2AHPRZE/6HRE方案,在强化期间给予静脉联合治疗,治疗组2采用2SHRZE/1HRZE/5HRE方案。结果可评价病例治疗... 详细信息

目的探讨静脉联合治疗和延长强化期治疗对初次复治肺结核患者的临床应用价值。方法研究对象随机分为治疗组1和治疗组2,治疗组1采用2AHPRZE/6HRE方案,在强化期间给予静脉联合治疗,治疗组2采用2SHRZE/1HRZE/5HRE方案。结果可评价病例治疗组1(132例)在1月内可有效改善咳嗽、咳痰、发热、乏力症状,症状消失率为76.23%～87.50%。治疗1月时,涂阳阴转率为80.90%,高于治疗组2(95例)的59.02%,P<0.01,培阳阴转率为73.42%,高于治疗组2的56.14%,P<0.05;疗程结束时后,2组的阴转率差异无统计学意义。治疗组1的病灶吸收显效率,疗程结束时可达73.48%,明显高于治疗组2的51.58%,P<0.01。治疗1月时,治疗组1的病灶空洞缩小率为66.07%,明显高于治疗组2的36.36%,P<0.01;疗程结束时,其病灶空洞闭合率为62.50%,高于治疗组2的36.36%,P<0.05。结论强化期静脉联合治疗或延长强化期治疗复治肺结核可望提高疗效,前者效果更佳。

关键词：结核肺/药物疗法输注静脉内治疗结果