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Increased human neutrophil lipocalin and its clinical relevance in adult-onset Still’s disease

Chinese Medical Journal 2023年第23期136卷 2867-2873页

作者： Ji li Yingni li Ru li Xiangbo Ma lianjie Shi shengguang li Qian Guo Yuan Jia Zhanguo li Department of Rheumatology and Immunology Peking University People’s HospitalBeijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis(BZ0135)Beijing 100044China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China Department of Rheumatology and Immunology Handan Central HospitalHandanHebei 056001China Peking-Tsinghua Center for life Sciences Beijing 100044China

Background:Human neutrophil lipocalin(HNL)has been used extensively to differentiate acute bacterial infection from febrile diseases as a biomarker to reflect the activation of the neutrophil.The serum HNL levels in the adult-onset Still’s disease(AOSD)patients with and without infection,as well as the healthy controls(HCs),were analyzed statistically in this study to evaluate the value of HNL for the diagnosis of AOSD.Methods:A total of 129 AOSD patients were enrolled,from whom blood samples were drawn and the AOSD diagnosis was confirmed through the review of the medical records,where the systemic score,demographic characteristics,clinical manifestations,and laboratory parameters were also collected for the patients;in addition,a total of 40 HCs were recruited among the blood donors from the healthcare center with the relevant information collected.The HNL test was done for the blood samples with the enzyme-linked immunosorbent assay and the analyses were done for the correlations of HNL with clinical manifestations and diagnostic effectiveness.Results:The serum HNL increased significantly in the patients with only AOSD as compared with that in the HCs(139.76±8.99 ng/mL vs.55.92±6.12 ng/mL;P<0.001).The serum HNL level was correlated with the white blood cell(WBC)count(r=0.335,P<0.001),neutrophil count(r=0.334,P<0.001),erythrocyte sedimentation rate(r=0.241,P=0.022),C-reactive protein(r=0.442,P<0.0001),and systemic score(r=0.343,P<0.0001)in the AOSD patients significantly.Patients with fever,leukocytosis≥15,000/mm^(3),and myalgia in the HNL-positive group were observed relatively more than those in the HNL-negative group(P=0.009,P=0.023,and P=0.007,respectively).HNL was a more sensitive indicator than ferritin and C-reactive protein(CRP)to differentiate the AOSD patients with bacterial infection from AOSD-only patients,and the Youden index was 0.6 for HNL and 0.29 for CRP.Conclusion:Serum HNL can be used as a biomarker for the diagnosis of the AOSD,and HNL is also observed to be associated with the disease activ

关键词： Adult-onset Still’s disease Human neutrophil lipocalin Diagnosis Biomarker Disease activity

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Research Progress on Effects of Continuous Cropping on Soil Microbial Florae and Its Restoration

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Agricultural Biotechnology 2024年第2期13卷 75-80页

作者： Zaixiang ZHU Zebin CHEN shengguang XU Zhiwei FAN li liN Tianfang WANG Qingmei li Yue YAN Agriculture and life Sciences College Kunming UniversityKunming 650214China Office of Academic Affairs Kunming UniversityKunming 650201China Yunnan Institute of Biological Carbon Engineering Research Center Kunming 650214China

Continuous cropping has become a common form of agricultural production at present, but with the increase of continuous cropping years, continuous cropping obstacles such as soil-borne diseases and plant growth potential decline are becoming more and more common. At present, the causes of continuous cropping obstacles and continuous cropping restoration have become a hot issue in agricultural research. This paper summarized the effects of continuous cropping obstacles on soil microbial community structure and main technical methods to repair continuous cropping obstacles, such as agricultural measure management, microbial balance adjustment and soil improvement, aiming to provide theoretical reference for protecting the sustainable utilization of soil ecosystem and ensuring the stability of crop production.

关键词： Continuous cropping obstacle Rhizosphere soil Microorganism Soil remediation Soil improvement

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Effects of simulated microgravity on the alkaline phosphatase activity and intracellular calcium concentration of cultured chondrocytes

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Chinese Science Bulletin 1999年第3期44卷 218-221页

作者： Xiaobing li Shuzhang Yang shengguang li Peidong Jiang Zhihuan lin Chinese Acad Sci Inst Biophys Beijing 100101 Peoples R China

The effects of simulated microgravity on matrix mineralization of chondrocytes were examined using cultured chicken embryonic chondrocytes as the model. In four days, there was a time course decrease in alkaline phosphatase activity of chondrocytes, a marker of matrix mineralization.Meanwhile, in two days, there was a significant drop in intracellular calcium concentration in contrast to the control. These results indicate that simulated microgravity can suppress matrix calcification of cultured chondrocytes, and intracellular calcium may be involved in the regulation of matrix calcification as the second messenger.

关键词： chondrocyte calcification simulated microgravity alkaline phosphatase activity intracellular calcium concentration.

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Effects of simulated microgravity on the cell growth and extracellular matrix of cultured chondrocytes

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Chinese Science Bulletin 1999年第15期44卷 1372-1375页

作者： Shuzhang Yang Xiaobing li shengguang li Peidong Jiang Zhihuan lin Chinese Acad Sci Inst Biophys Beijing 100101 Peoples R China

The effects of simulated microgravity on cell growth and extracellular matrix of chondrocytes have been examined by a light microscope and a scanning electron microscope using cultured chicken embryonic chondrocytes as the model. No notable difference of the cell density between the rotation group and the control group has been found. But during the same period,the growth spots of the rotation group were sparser than those of the control group. These results indicated that the lower level of cell development and differentiation happened in the rotation group. Observation by the scanning electron microscope showed that the extracellualr matrix decreased after rotating, and the fibres in the extracellular matrix were slighter and blurrier than those of the control group. It is concluded that the simulated microgravity can affect the secreting and assembly of the extracellular matrix. The possible mechanism for them is discussed.

关键词： chondrocyte simulated microgravity extracellular matrix.

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中文简化版运动病易感性量表的制订与评价

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中华医学杂志 2024年第22期104卷 2041-2050页

作者：李晓纹潘帅王帆邱传经卢佳美阎升光金占国华北理工大学公共卫生学院唐山华北理工大学心理与精神卫生学院唐山兴化市人民医院泰州河北省职业卫生与安全协同创新中心唐山河北省煤矿卫生与安全重点实验室唐山空军特色医学中心航空航天眩晕诊疗研究中心北京

目的制订中文简化版运动病易感性量表(MSSQ)长量表(MSSQ-L)和短量表(MSSQ-S)并对其进行评价。方法横断面研究。2023年5月向华北理工大学3 426名大学生发放中文版MSSQ-L和中文版MSSQ-S, 根据各项目的乘用率、条目-总分相关系数、Cronbach... 详细信息

目的制订中文简化版运动病易感性量表(MSSQ)长量表(MSSQ-L)和短量表(MSSQ-S)并对其进行评价。方法横断面研究。2023年5月向华北理工大学3 426名大学生发放中文版MSSQ-L和中文版MSSQ-S, 根据各项目的乘用率、条目-总分相关系数、Cronbach′s α系数、标准差情况对条目进行筛选, 得到中文简化版MSSQ-L和MSSQ-S。在前期调查人群中招募男生、女生各45名, 完成Coriolis加速度耐力试验和中文简化版MSSQ-L、中文简化版MSSQ-S和Graybiel症状积分问卷填写, 对中文简化版问卷的内部一致性、外部一致性、效标效度、区分度和运动病严重程度的预测准确率情况进行评估。结果中文版MSSQ共回收3 111份问卷, 有效回收率90.8%(3 111/3 426)。3 111名大学生中, 男965名, 女2 146名, 年龄(19.5±1.4)岁, 小汽车、公共汽车的乘用率最高, 分别为98.9%(3 077/3 111)和98.8%(3 073/3 111)。中文简化版MSSQ-S和中文简化版MSSQ-L分别包含4个和8个条目, Cronbach′s α系数分别为0.900、0.953, 重测信度分别为0.895、0.908, 效标效度分别为0.814、0.765。中文简化版MSSQ-S轻度易感者Graybiel症状积分低于中度易感者[0(0, 3)分比6(2, 10)分, P=0.006], 中度易感者低于重度易感者[6(2, 10)分比9(6, 13)分, P=0.030];中文简化版MSSQ-L轻度易感者Graybiel症状积分低于中度易感者[5(0, 3)分比7(3, 10)分, P=0.001], 但中度易感者与重度易感者间差异无统计学意义[7(3, 10)分比7(3, 10)分, P=0.081]。在对运动病严重程度预测准确率方面, 中文简化版MSSQ-S总体预测准确率由中文版MSSQ-S的55.6%(50/90)提升至62.2%(56/90), 中文简化版MSSQ-L总体预测准确率由中文版MSSQ-L的54.4%(49/90)提升至58.9%(53/90), 但差异均无统计学意义(均P>0.05)。结论中文简化版MSSQ-L和MSSQ-S在信度、效度方面均表现良好, 中文简化版MSSQ-S具有良好的区分度, 可作为一种简单高效的评估运动病易感性测量工具。

关键词：晕动病问卷调查信度效度

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Shifts in the bacterial community caused by combined pollutant loads in the North Canal River, China

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Journal of Environmental Sciences 2023年第5期127卷 541-551页

作者： shengguang Yuan Wenqiang Zhang Wenye li Zhenhan li Minshan Wu Baoqing Shan State Key Laboratory of Environmental Aquatic Chemistry Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Beijing Forestry University Beijing 100083China Hebei University of Engineering Handan 056038China

A typical anthropogenically disturbed urban river polluted by a combination of conventional pollutants(nitrogen and phosphorus pollution)and heavy metals was investigated along a 238 km stretch.Changes in the bacterial community were evaluated using high-throughput sequencing,and the relationships between bacteria,heavy metals,and conventional pollutants were investigated.There was large spatial heterogeneity in the bacterial community along the river,and bacterial diversity in the upstream and midstream sections was much higher than in the downstream section.Heavy metals and conventional pollutants both exhibited close correlations with bacterial diversity and composition.For instance,potential fecal indicator bacteria,sewage indicator bacteria and pathogenic bacteria,such as Ruminococcus and Pseudomonas,were closely associated with Cu,Zn,and NH_(4)^(+)-N.Rather than conventional pollutants,heavy metals were the main driving factors of the microbial community characteristics.These results confirm that bacterial communities play a crucial role in biogeochemical cycles.Therefore,heavymetals could be used as biomarkers of complex pollution to indicate the pollution status of riverine ecosystems and contribute to the restoration of habitats in anthropogenically disturbed urban rivers.

关键词： Bacterial community Heavy metal Nitrogen pollution Bioindicator

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4种黏虫板对蔬菜地实蝇成虫的诱杀效果

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浙江农业科学 2024年第2期65卷 371-374页

作者：李月红王敏夏声广金华市植物保护站浙江金华321017 永康市农业技术推广中心浙江永康321300

我们研究了4个厂家生产的黏虫板对实蝇成虫的诱杀效果,并明确了悬挂高度对黏虫板诱杀效果的影响。结果表明,4种黏虫板在永康市蔬菜地诱到的实蝇经鉴定为南瓜实蝇和具条实蝇2种,其中以南瓜实蝇为主;诱到雌虫比例最高的是万蝇迷牌诱黏板,... 详细信息

我们研究了4个厂家生产的黏虫板对实蝇成虫的诱杀效果,并明确了悬挂高度对黏虫板诱杀效果的影响。结果表明,4种黏虫板在永康市蔬菜地诱到的实蝇经鉴定为南瓜实蝇和具条实蝇2种,其中以南瓜实蝇为主;诱到雌虫比例最高的是万蝇迷牌诱黏板,雌虫占总诱杀量的35.14%。农庄宝诱黏板的诱杀效果最好,3 d内平均每张黏虫板诱到的实蝇数达到了170.22头,明显高于其他3种黏虫板。在丝瓜地应用黏虫板诱杀实蝇时,黏虫板的悬挂高度以瓜架的中下部为宜。

关键词：实蝇黏虫板诱杀效果

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Clinical Study on the Effects of Electroacupuncture Combined with Extracorporeal Shock Wave in the Treatment of Periarthritis of Shoulder

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Journal of Clinical and Nursing Research 2021年第2期5卷 5-10页

作者： Peng Qi Yu Zhang shengguang li Hongjian Yu Department of Rehabilitation Binzhou People's Hospital515 Huanghe Seventh RoadBinzhou 256600Shandong ProvinceChina Department of Joint Surgery Binzhou People's Hospital515 Huanghe Seventh RoadBinzhou 256600Shandong ProvinceChina Binzhou Medical College Shandong ProvinceChina

Objective:To investigate the clinical effects of electroacupuncture combined with extracorporeal shock wave in the treatment of periarthritis of shoulder.Methods:136 patients with periarthritis of shoulder admitted to our hospital from September 2018 to September 2019 were randomly divided into two groups by double-blind method.68 patients in the control group were treated with extracorporeal shock wave;68 patients in the observation group were treated with electroacupuncture combined with extracorporeal shock wave.The shoulder joint pain,joint function and activities of daily living were compared between the two groups.Results:The VAS score of shoulder joint pain in the observation group after treatment(1.92±0.24)was lower than that in the control group(3.51±0.32),and the UCLA score of shoulder joint function(31.28±1.96)was higher than that of the control group(27.42±2.36),the differences were statistically significant(Pliving was higher than that of the control group,with statistically significant differences(P<0.05)Conclusion:Electroacupuncture combined with extracorporeal shock wave treatment for periarthritis of shoulder has achieved ideal effects,safety and non-invasiveness,and can quickly restore the functions of shoulder joints.

关键词： Electroacupuncture Extracorporeal shock wave Periarthritis of shoulder Pain Shoulder functions

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视觉诱发运动病易感性量表的汉化及信效度检验

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听力学及言语疾病杂志 2024年第3期32卷 193-199页

作者：卢佳美石林谣邱传经王帆李晓纹潘帅赵璟阎升光金占国华北理工大学公共卫生学院唐山063210 华北理工大学心理与精神卫生学院空军特色医学中心眩晕诊疗中心

目的对英文版视觉诱发运动病易感性量表(visually induced motion sickness susceptibility questionnaire,VIMSSQ)长表和短表进行汉化,并检验中文版量表在大学生中的效度和信度。方法采用Brislin翻译模型对VIMSSQ进行汉化,通过专家咨... 详细信息

目的对英文版视觉诱发运动病易感性量表(visually induced motion sickness susceptibility questionnaire,VIMSSQ)长表和短表进行汉化,并检验中文版量表在大学生中的效度和信度。方法采用Brislin翻译模型对VIMSSQ进行汉化,通过专家咨询对翻译的量表进行跨文化调适,形成中文版视觉诱发运动病易感性量表;对757例大学生进行中文版问卷调查,分析量表的信度、效度。选取80例大学生同时填写仿真场景眩晕问卷(simulator sickness questionnaire,SSQ),分析VIMSSQ长表和短表得分与SSQ得分的相关性,以验证量表的预测效能。结果中文版VIMSSQ长表的总Cronbach'sα系数为0.94,5个维度的α的系数分别为0.85、0.85、0.85、0.84、0.83;总重测信度为0.79,5个维度的重测信度分别为0.73、0.77、0.76、0.66、0.62;折半信度为0.84。短表问卷的总Cronbach'sα系数为0.83,重测信度为0.81,折半信度为0.77。长、短表的条目水平的内容效度(item-level content validity index,I-CVI)及平均量表水平的内容效度(scale-level content validity index/Average,S-CVI/Ave)均为1。VIMSSQ长表(r=0.76,P<0.001)、短表得分(r=0.77,P<0.001)均与SSQ得分显著相关。结论中文版视觉诱发运动病易感性量表在大学生中具有较好的信度和效度,可作为评估大学生视觉诱发运动病易感性的测量工具。

关键词：视觉诱发运动病效度信度

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基于卡曼滤波的矿浆浓度计设计

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矿冶工程 2024年第2期44卷 34-37,42页

作者：肖晶峰刘石梅刘洋肖盛旺李然罗国奇张胜广长沙矿冶研究院有限责任公司湖南长沙410012

设计了一种基于卡曼滤波的γ射线浓度计。通过分析射线浓度计的测量原理,建立了射线强度与矿浆浓度的关系式;利用卡曼滤波对射线强度进行最优估计,以抑制测量结果的扰动;最后通过最小二乘法分段拟合计算对应的浓度。结果表明,该浓度计... 详细信息

设计了一种基于卡曼滤波的γ射线浓度计。通过分析射线浓度计的测量原理,建立了射线强度与矿浆浓度的关系式;利用卡曼滤波对射线强度进行最优估计,以抑制测量结果的扰动;最后通过最小二乘法分段拟合计算对应的浓度。结果表明,该浓度计测量及时、准确,最大误差0.328个百分点,均方根误差0.194个百分点,测量精度得到有效提高。

关键词：矿浆浓度浓度检测射线浓度计卡曼滤波最小二乘法

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