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CD4^+CD25^+T细胞在实验性重症肌无力中的作用研究

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广西医科大学学报 2012年第3期29卷 342-344页

作者：李劲频刘竞丽莫雪安孙圣刚广西医科大学第一附属医院神经内科南宁530021 华中科技大学同济医学院附属协和医院神经内科武汉430022

目的:探讨实验性自身免疫性重症肌无力(EAMG)模型小鼠外周免疫耐受机制异常在疾病发生、发展中的作用。方法:检测成模组小鼠CD4+脾细胞中CD4+CD25+T细胞(Treg)水平,脾细胞Foxp3mRNA的表达情况,并与未成模组、弗氏佐剂组及正常对照组进... 详细信息

目的:探讨实验性自身免疫性重症肌无力(EAMG)模型小鼠外周免疫耐受机制异常在疾病发生、发展中的作用。方法:检测成模组小鼠CD4+脾细胞中CD4+CD25+T细胞(Treg)水平,脾细胞Foxp3mRNA的表达情况,并与未成模组、弗氏佐剂组及正常对照组进行比较。结果:与未成模组、弗氏佐剂组及正常对照组相比,成模组小鼠CD4+脾细胞内Treg的水平明显下降(P<0.01),脾细胞Foxp3mRNA的表达降低(P<0.01)。结论:EAMG模型小鼠存在外周免疫耐受缺陷,FoxP3基因可能通过影响Treg的数量和功能在EAMG的发病中起作用。

关键词： EAMG CD4+CD25+调节性T细胞 Foxp3

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变截面挖掘机铲斗的设计与研究

农业装备与车辆工程 2013年第1期51卷 53-55页

作者：孙志民付君秦喜田孙胜刚程永涛钟波闵令强周进山东省农业机械科学研究所山东省济南市250100

随着我国基础建设的加快,我国工程机械发展迅速,挖掘机铲斗作为易损件成为技术改进的重点。通过对挖掘机铲斗现状概况,总结铲斗易损症状,利用力学进行磨损原因分析,通过投影和三点定面原理确定正确的变截面铲斗设计流程。

关键词：挖掘机铲斗变截面磨损

镁对脑缺血早期脑组织中谷氨酸及一氧化氮含量的影响

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同济医科大学学报 1999年第3期28卷 238-240页

作者：邓学军孙圣刚童萼塘同济医科大学附属协和医院神经科

为研究镁在脑缺血早期对神经元保护作用的机制，用电凝法建立大鼠大脑中动脉缺血模型，在造模前给大鼠注射２０ｇ／Ｌ硫酸镁，观察镁对脑组织中谷氨酸（Ｇｌｕ）及一氧化氮（ＮＯ）含量的影响。结果显示，高浓度镁可明显降低脑缺血皮质... 详细信息

为研究镁在脑缺血早期对神经元保护作用的机制，用电凝法建立大鼠大脑中动脉缺血模型，在造模前给大鼠注射２０ｇ／Ｌ硫酸镁，观察镁对脑组织中谷氨酸（Ｇｌｕ）及一氧化氮（ＮＯ）含量的影响。结果显示，高浓度镁可明显降低脑缺血皮质中Ｇｌｕ、ＮＯ含量，在缺血组Ｇｌｕ、ＮＯ的峰值浓度分别为９．８７、４４．９７ｎｍｏｌ／ｇ，而在加镁组两者浓度分别为７．６８、３３．９２ｎｍｏｌ／ｇ。提示：镁对脑缺血早期神经元的保护作用与其降低脑组织中Ｇｌｕ及ＮＯ含量有关。

关键词：硫酸镁脑缺血谷氨酸一氧化氮

局灶性短暂性鼠脑缺血及再灌注细胞因子介导的中性粒细胞化学吸附剂的动态变化

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同济医科大学学报 2000年第3期29卷 259-261页

作者：曹学兵孙圣刚黄怀钧童萼塘杨明山同济医科大学附属协和医院神经科武汉430022 湖北医科大学附属第二医院神经科武汉430070 同济医科大学附属同济医院神经科武汉430030

为探讨局灶性短暂性鼠脑缺血及再灌注时细胞因子介导的中性粒细胞化学吸附剂 (CINC)的动态变化和作用 ,用线栓法制备缺血 1h再灌不同时间的鼠局灶性脑缺血 /再灌注模型 ,采用 EL ISA法测定缺血侧大脑中动脉供血区(MCA区 )和大脑前动脉... 详细信息

为探讨局灶性短暂性鼠脑缺血及再灌注时细胞因子介导的中性粒细胞化学吸附剂 (CINC)的动态变化和作用 ,用线栓法制备缺血 1h再灌不同时间的鼠局灶性脑缺血 /再灌注模型 ,采用 EL ISA法测定缺血侧大脑中动脉供血区(MCA区 )和大脑前动脉供血区 (ACA区 )脑组织内 CINC浓度 ,并同步检测髓质过氧化物酶 (MPO)活性。结果发现 ,在再灌注 1h以上各组缺血脑组织内 CINC浓度与缺血 1h未再灌注时比较都有明显升高 ,差异均有极显著性意义(P<0 .0 1)。 CINC浓度达顶峰出现在再灌注 12 h。在再灌注 12 h以上各组 MCA区 MPO活性与再灌注 3 h比较 ,差异均有极显著性意义 (P<0 .0 1)。 MPO活性达顶峰出现在再灌注 2 4h。结果表明 :短暂缺血再灌注时 ,缺血脑组织产生的

关键词：脑缺血再灌注损伤 CINC 细胞因子介导

Relationship of cerebral arterial stenosis to cognitive and memory disorders

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Neural Regeneration Research 2006年第8期1卷 760-762页

作者： Jifeng Li1,2, Zhou Wang3, shenggang sun1, Gaomei Cai2, Kejin Gu2, Yaoqun Li4 1Department of Neurology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China 2Second Department of Neurology, Affiliated Hospital of Jining Medical College, Jining 242013, Shandong Province, China 3Department of Pathology, Jining Medical College, Jining 242013, Shandong Province, China 4TCD Room, Affiliated Hospital of Jining Medical College, Jining 242013, Shandong Province, China Department of Neurology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Second Department of Neurology Hospital of Jining Medical College Jining 242013 Shandong Province China Hospital of Jining Medical College Jining 242013 Shandong Province China Department of Pathology Jining Medical College Jining 242013 China

BACKGROUND: Cerebral arterial stenosis can cause cerebral hypoperfusion, and than result in the decline of cognitive function, whereas the cognitive dysfunction induced by different cerebral arterial stenosis have different manifestations and types. OBJECTIVE: To observe the differences of cognitive and memory dysfunctions in patients with cerebral arterial stenosis of different types. DESIGN: A comparative observation. SETTING: Affiliated Hospital of Jining Medical College. PARTICIPANTS: Forty-two outpatients or inpatients with cerebral arterial stenosis were selected from the Department of Neurology, Affiliated Hospital of Jining Medical College from February 2005 to January 2006, including 25 males and 17 females. There were 18 cases of internal carotid arterial stenosis, 14 cases of vertebrobasilar arterial stenosis and 10 cases of whole cerebral arterial stenosis. The diagnostic standards for cerebral arterial stenosis were identified according to North American Symptomatic Carotid Endarterectomy Trial (NASCET). Meanwhile, 18 healthy physical examinees were enrolled as the control group, including 10 males and 8 females, aged 58-80 years old. All the enrolled subjects were informed and agreed with the detection and evaluation. METHODS: ① The memory function was evaluated using revised Wechsler memory scale for adults, including long-term memory (experience, orientation and counting), short-term memory (visual recognition, picture memory, visual regeneration, association and thigmesthesia) and sensory memory (forward and backward recitation of numbers). The scale scores were turned to memory quotients. The higher the scores, the better the memory function. ② The cognitive function was evaluated using revised Wechsler adult intelligence scale: It consisted of eleven subtests, including six language scales (information, digit span, vocabulary, arithmetics, apprehension, similarity) and five operation scales (picture completion, picture arrangement, block design, g

关键词： than Relationship of cerebral arterial stenosis to cognitive and memory disorders

自研28 GHz/50 kW回旋管实现长时间连续运行

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强激光与粒子束 2024年第3期36卷 1-3页

作者：胡林林黄麒力卓婷婷胡鹏龚胜刚孙迪敏蒋艺马国武陈洪斌马弘舸中国工程物理研究院应用电子学研究所四川绵阳621900

介绍了中国工程物理研究院应用电子学研究所针对磁约束聚变装置电子回旋共振加热(ECRH)系统、重离子加速器电子回旋共振(ECR)离子源以及前沿科技探索应用研制的28 GHz/50 kW连续波回旋管最新实验结果。研究团队在2019年该回旋管实现50 k... 详细信息

介绍了中国工程物理研究院应用电子学研究所针对磁约束聚变装置电子回旋共振加热(ECRH)系统、重离子加速器电子回旋共振(ECR)离子源以及前沿科技探索应用研制的28 GHz/50 kW连续波回旋管最新实验结果。研究团队在2019年该回旋管实现50 kW/30 s运行的基础上,通过结构优化和稳定性设计验证,最终实现了在10~50 kW功率范围多个功率水平的稳定长时间连续运行,典型运行结果为16 kW/3000 s、26 kW/900 s、46 kW/1800 s、50 kW/300 s,特别在输出功率32 kW连续稳定工作了400 min。这是国内首次研制出小时级连续工作的中等功率回旋管。

关键词：回旋管电子回旋共振加热 ECR离子源连续波磁约束聚变

Sr-doping effects on La_2O_3 catalyst for oxidative coupling of methane

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Chinese Journal of Catalysis 2017年第5期38卷 899-907页

作者： Linna Cong Yonghui Zhao shenggang Li Yuhan sun CAS Key Laboratory of Low‐Carbon Conversion Science and Engineering Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201210 China University of Chinese Academy of Sciences Beijing 100049 China School of Physical Science and Technology ShanghaiTech University Shanghai 201210 China

Density‐functional theory calculations were carried out to study the strontium(Sr)‐doping effect on methane activation over a lanthanum‐oxide(La2O3)catalyst for the oxidative coupling of methane(OCM)using the cluster *** Sr‐doped La2O3cluster models were built from pure La2O3clusters that were used previously to model the *** form two distinct categories,namely,those without a radical character(LaSrO2(OH),La2SrO4,La3SrO5(OH),and La5SrO8(OH))and those with a radical character(LaSrO3,La2SrO4(OH),La3SrO6,and La5SrO9).The potential‐energy surface for CH4activation to form a CH3radical at different Sr-O and La-O pair sites on these Sr‐doped La2O3clusters was calculated to study the Sr‐doping effect on the OCM catalytic ***4physisorption and chemisorption energies,and activation barriers,and CH3desorption energies were *** with the pure La2O3clusters,in general,the Sr‐doped La2O3clusters are thermodynamically and kinetically more reactive with *** the Sr‐doped La2O3clusters without the radical character,the Sr-O pair site is more reactive with CH4than the La-O pair site,although a direct release of the CH3radical is also highly endothermic as in the case of the pure *** contrast,for the Sr‐doped La2O3clusters with a radical character,the activation of CH4at the oxygen radical site and the release of the CH3radical are much ***,our calculations suggest that the Sr dopant prompts the OCM catalytic activity of the La2O3catalyst by providing a highly active oxygen‐radical site and by strengthening the basicity of the M-O pair site,which leads to lower CH4activation energies and lower CH3desorption energies.

关键词： Methane activation Methyl radical generation Cluster models Density functional theory Strontium doping Lanthanum oxide

Effect of Pd doping on CH_4 reactivity over Co_3O_4 catalysts from density-functional theory calculations

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Chinese Journal of Catalysis 2017年第5期38卷 813-820页

作者： Chengcheng Zhao Yonghui Zhao shenggang Li Yuhan sun CAS Key Laboratory of Low‐Carbon Conversion Science and Engineering Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201210 China University of Chinese Academy of Sciences Beijing 100049 China School of Physical Science and Technology ShanghaiTech University Shanghai 201210 China

Palladium oxide(PdOx)and cobalt oxide(Co3O4)are efficient catalysts for methane(CH4)combustion,and Pd‐doped Co3O4catalysts have been found to exhibit better catalytic activities,which suggest synergism between the two *** carried out first‐principles calculations at the PBE+U level to investigate the Pd‐doping effect on CH4reactivity over the *** of the structural complexity of the Pd‐doped Co3O4catalyst,we built Pd‐doped catalyst models using Co3O4(001)slabs with two different terminations and examined CH4reactivity over the possible Pd?O active sites.A low energy barrier of0.68eV was predicted for CH4dissociation over the more reactive Pd‐doped Co3O4(001)surface,which was much lower than the0.98and0.89eV that was predicted previously over the more reactive pure Co3O4(001)and(011)surfaces,*** a simple model,we predicted CH4reaction rates over the pure Co3O4(001)and(011)surfaces,and Co3O4(001)surfaces with different amounts of Pd *** theoretical results agree well with the available experimental data,which suggests a strong synergy between the Pd dopant and the Co3O4catalyst,and leads to a significant increase in CH4reaction rate.

关键词： Spinel cobalt oxide Palladium dopant Methane combustion Density function theory calculation Reaction rate Collision theory

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大鼠可逆性局灶性脑缺血模型复制方法的改进

华中医学杂志 2000年第4期24卷 192-193页

作者：李小凤孙圣刚童萼塘重庆医科大学第二附属医院神经内科同济医科大学附属协和医院神经内科

目的　寻找操作简便、创伤较小的建立可逆性局灶性脑缺血模型的方法。方法　在现有线栓法的基础上作如下改进 :大鼠体重与线栓直径的匹配以及线栓插入深度的控制 ;线栓前段覆左旋多聚赖氨酸和肝素 ;麻醉后拔线。取脑组织作TTC染色和 HE... 详细信息

目的　寻找操作简便、创伤较小的建立可逆性局灶性脑缺血模型的方法。方法　在现有线栓法的基础上作如下改进 :大鼠体重与线栓直径的匹配以及线栓插入深度的控制 ;线栓前段覆左旋多聚赖氨酸和肝素 ;麻醉后拔线。取脑组织作TTC染色和 HE染色 ,并进行神经功能缺陷体征评分。结果　左侧大脑中动脉缺血区经 TTC染色颜色苍白 ,经 HE染色呈缺血性改变。不予再灌注其评分进行性增加 ,给予再灌注则评分呈不同程度下降。结论　改进后的线栓法复制的可逆性局灶性脑缺血模型是研究脑缺血再灌注损伤较为理想的模型。

关键词：可逆性局灶性脑缺血动物模型复制大鼠