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TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization

Neuroscience Bulletin 2024年第1期40卷 17-34页

作者： Siying Qu shengfeng hu huiting Xu Yongjian Wu Siqi Ming Xiaoxia Zhan Cheng Wang Xi huang Center for Infection and Immunity and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China The State Key Laboratory of Respiratory Disease Guangdong Provincial Key Laboratory of Allergy and Clinical ImmunologyThe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Division of Nephrology Department of Medicinethe Fifth Affliated Hospital of Sun Yat-sen UniversityZhuhai 519000China

Multiple sclerosis(MS)is a neuroinflammatory demyelinating disease,mediated by pathogenic T helper 17(Th17)***,the therapeutic effect is accompa-nied by the fluctuation of the proportion and function of Th17 cells,which prompted us to find the key regulator of Th17 differentiation in ***,we demonstrated that the triggering receptor expressed on myeloid cells 2(TREM-2),a modulator of pattern recognition receptors on innate immune cells,was highly expressed on pathogenic CD4-positive T lymphocyte(CD4^(+)T)cells in both patients with MS and experimental autoimmune encephalomyelitis(EAE)mouse *** knockout of Trem-2 in CD4^(+)T cells significantly alleviated the disease activity and reduced Th17 cell infiltration,activation,differentiation,and inflammatory cytokine production and secretion in EAE ***,with Trem-2 knockout in vivo experiments and in vitro inhibitor assays,the TREM-2/zeta-chain associated protein kinase 70(ZAP70)/signal transducer and activator of transcription 3(STAT3)signal axis was essential for Th17 activation and differentiation in EAE *** conclusion,TREM-2 is a key regulator of pathogenic Th17 in EAE mice,and this sheds new light on the potential of this therapeutic target for MS.

关键词： Multiple sclerosis Experimental autoimmune encephalomyelitis T helper 17 Triggering receptor expressed on myeloid cells 2

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USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ

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Cellular & Molecular Immunology 2023年第3期20卷 252-263页

作者： Xiaotong Zhu Peng Wang Xiaoxia Zhan Yuping Zhang Junli Sheng Shitong He Yitian Chen Dingnai Nie Xiaolong You Haiyan Mai Qinghong Yu Laisheng Li Ligang Jie shengfeng hu Department of Rheumatology and Clinical Immunology Zhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Emergency Medicine Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Institute of Molecular Immunology School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhouGuangdongChina Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhouGuangdongChina

The balance between inflammatory T helper type 17(Th17)and immunosuppressive regulatory T(Treg)cells is critical for maintaining immune homeostasis in the human body and is tightly regulated under healthy *** increasing number of studies have reported that deubiquitinases(DUBs)play a vital role in regulating Th17-and Treg-cell ***,the biological functions of only a small fraction of DUBs in Th17-and Treg-cell differentiation are well *** this study,we identified ubiquitin-specific peptidase 1(USP1)as a vital regulator of CD4+T-cell ***1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation,thereby promoting the development of inflammatory ***,USP1 in CD4+T cells enhanced the activity of RORγt but promoted the proteasomal degradation of Foxp3 through deubiquitination and stabilization of TAZ in vitro and in ***,ML323,a specific inhibitor of the USP1/UAF1 deubiquitinase complex,inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo,indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg *** study highlights the critical role of USP1 in regulating adaptive immune responses and suggests that USP1 might be a drug target for the treatment of diseases associated with an imbalance between Th17 and Treg cells.

关键词： USP1 TAZ Th17 Treg

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基于STM32的终端波形优化显示算法

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科技通报 2018年第9期34卷 164-167页

作者：胡胜丰湖南科技职业学院软件学院

波形显示终端近年来在各个领域的应用越来越广泛,随着社会的发展,人们对波形显示终端的界面友好性有越来越高的要求。在实际中,当显示变量出现突变时,传统的变量值和显示坐标直接对应的显示方法将会出现波形断续现象,严重影响到界面的... 详细信息

波形显示终端近年来在各个领域的应用越来越广泛,随着社会的发展,人们对波形显示终端的界面友好性有越来越高的要求。在实际中,当显示变量出现突变时,传统的变量值和显示坐标直接对应的显示方法将会出现波形断续现象,严重影响到界面的友好性。针对该问题,文中提出了基于相邻点阵间连续填充处理的波形优化显示算法,保证了在显示变量突变时刻波形的连续性,大大提高了显示终端的友好性。最后,采用STM32(ARM)微控制器和240128点阵LCD搭建了实验系统,验证了文中所提算法的有效性。

关键词：波形显示波形断续优化显示 STM32

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Pseudomonas aeruginosa activates NLRP3 inflammasome to evade intracellular killing by triggering autophagy in human macrophages

Pseudomonas aeruginosa activates NLRP3 inflammasome to evade...

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第九届全国免疫学学术大会

作者： shengfeng hu Qiuchan Deng Meiyu LiD Dandan Li Yuanqing Zhang Yongjian Wu Jieying Pu Xi huang Minhao Wu Zhongshan School of Medicine Sun Yat-sen University

Recently,assembly of inflammasome has been identified as a critical event to initiate ***,its role in bacterial killing remains *** present study demonstrates that Pseudomonas aeruginosa(PA)infection induces the assembly of NLRP3 inflammasome and sequential secretion of caspase-1 and IL-1b in human *** importantly,activation of NLRP3 inflammasome reduces killing of PA in macrophages,independently of oxygendependent and-independent bactericidal *** addition,our results demonstrate that PA infection in human macrophages induces obvious autophagic response,which is suppressed by RNAi targeting NLRP3 inflammasome,and is enhanced by IL-1b *** of autophagy decreases the activity of macrophages to eradicate intracellular PA,while treatment with IL-1b promotes the bactericidal efficiency of human ***,our study explores a novel mechanism employed by PA to escape from phagocyte killing,which may provide a better understanding of the interaction between PA and host immune cells including macrophages.

关键词： Pseudomonas aeruginosa NLRP3 inflammasome autophagy bacterial killing

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基于LDAP的企业统一资源管理研究

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微计算机应用 2008年第3期29卷 67-70页

作者：胡胜丰蒋平湖南大学软件学院中国科学院软件研究所北京100080

通过分析企业应用集成过程中对统一资源管理的需求及轻量级目录访问协议LDAP的技术特征,设计了一个基于LDAP的统一资源管理框架,用于实现企业的多种资源的融合;为用户提供标准、方便、高效的基础信息查询方法;同时为各种应用系统共享信... 详细信息

通过分析企业应用集成过程中对统一资源管理的需求及轻量级目录访问协议LDAP的技术特征,设计了一个基于LDAP的统一资源管理框架,用于实现企业的多种资源的融合;为用户提供标准、方便、高效的基础信息查询方法;同时为各种应用系统共享信息、统一认证提供支持。在此基础上建立起企业应用集成的基础框架体系,规范企业信息系统的建设,支持后续应用的有效集成。

关键词：企业应用集成 LDAP 企业统一资源

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肺结核患者外周血 CD4＋CD8＋T 细胞的检测及临床意义

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中华微生物学和免疫学杂志 2014年第10期34卷 781-786页

作者：廖春信方毅敏詹晓霞胡胜锋吴永坚吴敏昊黄曦广州市胸科医院呼吸内科 510095 中山大学中山医学院免疫学教研室 510080

目的：探讨结核病患者外周血中胸腺外CD4＋CD8＋T细胞（ CD4＋CD8＋double-positive T，DPT）的表达、抗结核功能和记忆表型。方法采用流式细胞术检测结核病患者和健康人外周血DPT细胞的表达，分析其与结核病发生发展以及转归的相关性... 详细信息

目的：探讨结核病患者外周血中胸腺外CD4＋CD8＋T细胞（ CD4＋CD8＋double-positive T，DPT）的表达、抗结核功能和记忆表型。方法采用流式细胞术检测结核病患者和健康人外周血DPT细胞的表达，分析其与结核病发生发展以及转归的相关性；检测DPT细胞因子的分泌水平（ IFN-γ和TNF-α）、活化标记和记忆表型，分析DPT细胞的抗结核免疫应答能力。结果与健康对照组相比，结核病患者外周血中DPT细胞比例显著升高（P＜0．005），随着治疗时间逐渐下降，恢复至正常水平；DPT细胞表面活化受体CD25表达高于CD4＋T细胞和CD8＋T细胞（P＜0．005）；结核抗原肽刺激下细胞因子IFN-γ和TNF-α分泌能力均明显增加（ P＜0．005）；DPT细胞具有记忆T细胞表型特性。结论结核病患者外周血DPT细胞具有抗结核免疫能力，其比例变化反映抗结核治疗的疗效，监测外周血DPT细胞表达可以评估患者预后是否良好。

关键词：结核病细胞免疫 DPT细胞

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水介质换能爆破技术机理探讨

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水利水电施工 2020年第1期 20-27页

作者：胡胜丰秦健飞秦如霞中国电建海外投资有限公司中国水利水电第八工程局有限公司

水介质换能爆破技术于2016年研发成功并开始生产性应用,当时从热力学、化学视角对其破岩机理进行了推理论证。为了证实其爆破机理的正确性,2019年开展了水介质换能爆破技术机理验证试验研究并取得突破性进展,于2019年12月20日顺利通过... 详细信息

水介质换能爆破技术于2016年研发成功并开始生产性应用,当时从热力学、化学视角对其破岩机理进行了推理论证。为了证实其爆破机理的正确性,2019年开展了水介质换能爆破技术机理验证试验研究并取得突破性进展,于2019年12月20日顺利通过中国电建海外投资有限公司组织的验收。验证试验研究成果对水介质换能爆破技术的爆破机理进行的研判证实,原先的推论是正确的,同时较为全面地诠释了水介质换能爆破技术的卓越功效以及全面降低炸药爆炸危害的内在原理。

关键词：水介质换能爆破系统爆炸仓制氢装置热分解二次爆炸模拟试验

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Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi Lian Kang hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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