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环状RNA在新生儿缺氧缺血性脑病中的作用研究进展

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中国临床药理学与治疗学 2024年第4期29卷 466-474页

作者：党银霞沈富辉王生霞鲁霞王凡兰州大学第二临床医学院甘肃兰州730030 兰州大学第二医院新生儿科甘肃兰州730030

新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是新生儿死亡及儿童伤残的主要原因之一。尽管亚低温治疗已成为常规手段,但目前治疗HIE的方法有限且效果不理想。此外,由于时间和设备的限制,亚低温治疗无法及时应用,治疗后... 详细信息

新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是新生儿死亡及儿童伤残的主要原因之一。尽管亚低温治疗已成为常规手段,但目前治疗HIE的方法有限且效果不理想。此外,由于时间和设备的限制,亚低温治疗无法及时应用,治疗后仍存在较高的死亡率或不同程度的神经功能障碍。因此,探索HIE的其他有效治疗方法成为新生儿领域研究的热点和难点。研究证明HIE可引起神经系统在生理、细胞和分子水平上复杂变化,环状RNA(circRNA)在中枢神经系统中高度表达,并参与调节生理和病理生理过程,因此有望成为HIE的潜在治疗靶点。本文综述HIE中circRNA对不同神经细胞的调控作用,旨在为治疗HIE提供新的理论依据。

关键词：新生儿缺氧缺血性脑病环状RNA 神经细胞

A review of the interaction between the cryosphere and atmosphere

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Research in Cold and Arid Regions 2020年第6期12卷 329-342页

作者： YongJian Ding JianPing Yang shengxia wang YaPing Chang State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China China-Pakistan Joint Research Center on Earth Science CAS-HECIslamabadPakistan University of Chinese Academy of Sciences Beijing 100049China

The interaction between the cryosphere and atmosphere is an essential and extremely sensitive mutual action process on the *** to global warming and the cryospheric melting,more and more attention has been paid to the interaction process between the cryosphere and atmosphere,especially the feedback of the cryosphere change to the atmosphere.A comprehensive review of the studies on the interaction between the cryosphere and atmosphere is conducted from two aspects:(1)effects of climate change on the cryosphere or responses of the cryosphere to climate change;and(2)feedback of the cryosphere change to the *** response of the cryosphere to climate change is *** a lagging and cumulative effect of temperature rise within the cryosphere have resulted in a rapid change in the cryosphere in the 21st century,and its impacts have become more *** feedback from cryosphere change on the climate are *** them,the effects of sea ice loss and snow cover change,especially the Arctic sea ice loss and the Northern Hemisphere snow cover change,are the most *** Arctic amplification(AA)associated with sea ice feedback is disturbing,and the feedback generated by the effect of temperature rise on snow properties in the Northern Hemisphere is also of great *** are growing evidence of the impact of the Arctic cryosphere melting on mid-latitude weather and *** storm troughs,steered jet stream and amplified planetary waves associated with energy propagation become the key to explaining the links between Arctic cryosphere change and atmospheric *** is still a great deal of uncertainty about how cryosphere change affects the weather and climate through different atmospheric circulation processes at different spatial and temporal scales due to observation and simulation problems.

关键词： climate warming cryosphere atmosphere response feedback

Long-lived lunar volcanism sustained by precession-driven core-mantle friction

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National Science Review 2024年第2期11卷 114-123页

作者： Shuoran Yu Xiao Xiao shengxia Gong Nicola Tosi Jun Huang Doris Breuer Long Xiao Dongdong Ni State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology Planetary Science Institute State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences CAS Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Institute of Planetary Research German Aerospace Centre(DLR)

Core-mantle friction induced by the precession of the Moon's spin axis is a strong heat source in the deep lunar mantle during the early phase of a satellite's evolution, but its influence on the long-term thermal evolution still remains poorly explored. Using a one-dimensional thermal evolution model, we show that core-mantle friction can sustain global-scale partial melting in the upper lunar mantle until ～3.1 Ga, thus accounting for the intense volcanic activity on the Moon before ～3.0 Ga. Besides, core-mantle friction tends to suppress the secular cooling of the lunar core and is unlikely to be an energy source for the long-lived lunar core dynamo. Our model also favours the transition of the Cassini state before the end of the lunar magma ocean phase(～4.2 Ga), which implies a decreasing lunar obliquity over time after the solidification of the lunar magma ocean. Such a trend of lunar obliquity evolution may allow volcanically released water to be buried in the lunar regolith of the polar regions. As a consequence, local water ice could be more abundant than previously thought when considering only its accumulation caused by solar wind and comet spreading.

关键词： Moon precession orbit volcanism

Understanding the impact of mountain landscapes on water balance in the upper Heihe River watershed in northwestern China

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Journal of Arid Land 2013年第3期5卷 366-383页

作者： Jia QIN YongJian DING JinKui WU MingJie GAO ShuHua YI ChuanCheng ZHAO BaiSheng YE Man LI shengxia wang State Key Laboratory of Cryospheric Sciences Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Division of Hydrology Water-Land Resources in Cold and Arid Regions Chinese Academy of Sciences

Estimating the impact of mountain landscape on hydrology or water balance is essential for the sus- tainable development strategies of water resources. Specifically, understanding how the change of each landscape influences hydrological components will greatly improve the predictability of hydrological responses to mountain landscape changes and thus can help the government make sounder decisions. In the paper, we used the VIC （Variable Infiltration Capacity） model to conduct hydrological modeling in the upper Heihe River watershed, along with a frozen-soil module and a glacier melting module to improve the simulation. The improved model performed satisfactorily. We concluded that there are differences in the runoff generation of mountain landscape both in space and time. About 50% of the total runoff at the catchment outlet were generated in mid-mountain zone （2,900-4,000 m asl）, and water was mainly consumed in low mountain region （1,700-2,900 m asl） because of the higher requirements of trees and grasses. The runoff coefficient was 0.37 in the upper Heihe River watershed. Barren landscape produced the largest runoff yields （52.46% of the total runoff） in the upper Heihe River watershed, fol- lowed by grassland （34.15%）, shrub （9.02%）, glacier （3.57%）, and forest （0.49%）. In order to simulate the impact of landscape change on hydrological components, three landscape change scenarios were designed in the study. Scenario 1, 2 and 3 were to convert all shady slope landscapes at 2,000-3,300 m, 2,000-3,700 m, and 2,000-4,000 m asl respectively to forest lands, with forest coverage rate increased to 12.4%, 28.5% and 42.0%, respectively. The runoff at the catchment outlet correspondingly declined by 3.5%, 13.1% and 24.2% under the three scenarios. The forest landscape is very important in water conservation as it reduced the flood peak and increased the base flow. The mountains as ＂water towers＂ play important roles in water resources generation and the impact of mountai

关键词： mountain landscape runoff modeling water balance VIC model Heihe River watershed

The 2018 Academic annual meeting of China Society of Cryospheric Science was held successfully in Foshan on November 17–18, 2018

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Research in Cold and Arid Regions 2018年第6期10卷 525-528页

作者： wang, ShiJin Li, ChuanJin Mu, Yanhu wang, shengxia Yu, Jie Northwest Inst Ecoenvironm & Resources Lanzhou Gansu Peoples R China

On November 17–18, the 2018 Academic Annual Meeting of China Society of Cryospheric Science was held successfully in Foshan City, Guangdong Province. In the context of global warming, the cryosphere is undergoing significant changes and has major impacts on global and regional ecosystems and socio-economic sustainability. In order to further promote the development process of China’s cryosphere science, strengthen the exchanges between scientific research personnel in different sectors and fields, further condense the scientific research team of the cryosphere science, explore the new development directions of the cryosphere science, and

关键词： Zhang The 2018 Academic annual meeting of China Society of Cryospheric Science was held successfully in Foshan on November 17

Global status and trends in hepatitis B virus DNA mutation research from 2003 to 2022:A comprehensive bibliometric view

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Portal Hypertension & Cirrhosis 2024年第1期3卷 14-21页

作者： Ming Li Xiaoming Xu Yong Liu Minxin Mao Yu Geng shengxia Yin Xin Tong Chao Wu Jie Li Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Infectious Diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina Department of Laboratory Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina Institute of Viruses and Infectious Diseases Nanjing UniversityNanjingJiangsuChina

Aims:Hepatitis B virus(HBV)is an enveloped DNA virus belonging to the Hepadnaviridae *** is a significant contributor to the prevalence of chronic liver disease on a global *** in HBV DNA can affect the diagnosis,treatment,and prognosis of patients with chronic hepatitis *** numerous studies on HBV DNA mutations have been conducted,few bibliometric studies have been performed to *** study aimed to analyze changes in scientific output to gain a better understanding of the current research status and identify potential new research directions in the field of HBV DNA ***:Relevant studies published between 2003 and 2022 were retrieved from the Web of Science Core Collection *** version 6.1.R6 was used to construct network maps to evaluate collaborations among countries,institutions,authors,journals,and ***:In total,1508 publications over the past 20 years were obtained,mainly from China,the United States,and *** major research institutions in China included the University of Hong Kong,Fudan University,and Peking *** Ching Lung was the most productive author,whereas Anna Suk-Fong Lok was the most frequently co-cited *** keyword“HBsAg”was the strongest burst keyword in recent years,indicating possible future study ***:This bibliometric analysis intuitively revealed the overall research status of HBV DNA mutations,providing valuable information for researchers,funding agencies,and policymakers to explore the current research status,research hotspots,and new directions for future research.

关键词： bibliometrics DNA hepatitis B virus mutation

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河西内陆河流域绿洲面积对地表径流的响应

中国沙漠 2021年第2期41卷 231-241页

作者：王生霞王飞中国科学院西北生态环境资源研究院中国科学院内陆河流域生态水文重点实验室/冰冻圈科学国家重点实验室甘肃兰州730000 兰州财经大学甘肃兰州730101

利用NASA AVHRR NDVI 3g遥感资料计算得出河西内陆河流域植被归一化指数(Normalized Difference Vegetation Index,NDVI),将NDVI>0.20区域视为绿洲,通过计算绿洲区NDVI的变差系数和线性斜率分析1982-2013年绿洲面积变化,并进一步分析其... 详细信息

利用NASA AVHRR NDVI 3g遥感资料计算得出河西内陆河流域植被归一化指数(Normalized Difference Vegetation Index,NDVI),将NDVI>0.20区域视为绿洲,通过计算绿洲区NDVI的变差系数和线性斜率分析1982-2013年绿洲面积变化,并进一步分析其对地表径流的响应特征。结果表明:河西内陆河流域绿洲整体呈扩张趋势,扩张区域主要在绿洲边缘区、河流两侧和尾闾;小规模斑块绿洲的破碎度呈增加趋势,连片的绿洲核心区相对稳定;绿洲面积随着出山径流变化呈现出阶段性特征,山区降水量对绿洲变化的贡献率约为地表径流贡献率的一半,冰川融水对绿洲面积变化的贡献率自东向西依次增加,绿洲区降水的贡献率则依次减少。

关键词：河西内陆河绿洲动态变化出山径流绿洲区降水响应

Influences of two patterns of El Ni o on hydrological and meteorological elements in the Hexi Corridor region of China

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Research in Cold and Arid Regions 2012年第4期4卷 296-302页

作者： Jia Qin YongJian Ding BaiSheng Ye shengxia wang MingJie Gao Man Li Hao Wu State Key Laboratory of Cryospheric Science Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou Gansu 730000 China Division of Hydrology Water-Land Resources in Cold and Arid Regions Chinese Academy of Sciences Lanzhou Gansu 730000 China

In this study, two types of E1 Nifio events are distinguished and the correlations between the respective precipitation, temperature, and runoff are analyzed by a 5-point moving average method. Also, changes of the temperature, precipitation, and runoff from mountainous watersheds of the Hexi Corridor region caused by these two types of E1 Nifio events from 1959 to 2005 are studied by the anomaly analysis method. The results indicate that the Hexi Corridor region is strongly influenced by El Nifio： rising tem- peratures and decreasing precipitation and runoff are features of the first E1 Nifio pattern, while decreasing temperature and in- creasing precipitation and runoff characterise the second pattern. The responses of temperature to E1 Nifio events are stronger in plains than in mountain regions, but the responses of precipitation are obvious in both types of regions. The response of runoff to E1 Nifio events is lower than the precipitation and temperature response because runoff from mountainous watersheds has a com- plex generation and concenlration process.

关键词： two patterns of E1 Nifio Hexi Corridor precipitation runoff

基于密切值法模型的我国31省市安全生产综合评价

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工业安全与环保 2010年第12期36卷 13-15页

作者：王盛夏戴兴国中南大学资源与安全工程学院长沙410083

基于2008年我国安全生产事故统计数据,选取万人事故率、万人死亡率、万人受伤率3个评价指标,建立了由熵权法确定权重的密切值法模型,模型具有原理简单、概念清晰、易于实现等特点。将模型应用于我国31省市的安全生产综合评价中,得出了3... 详细信息

基于2008年我国安全生产事故统计数据,选取万人事故率、万人死亡率、万人受伤率3个评价指标,建立了由熵权法确定权重的密切值法模型,模型具有原理简单、概念清晰、易于实现等特点。将模型应用于我国31省市的安全生产综合评价中,得出了31省市的安全生产状况排名,得出了吉林省的生产状况最优等结论,结果与原始数据相符合,表明密切值法在安全评价中具有一定的推广应用价值。

关键词：密切值熵权重安全生产排序