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Durability evaluation for existing railway engineering: a review

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Railway Sciences 2024年第1期3卷 59-68页

作者： Jiahe Wang Huajian Li Chengxian Ma Chaoxun cai Zhonglai yi Jiaxuan Wang Railway Engineering Research Institution CARSBeijingChina

Purpose – This study aims to analyze the factors, evaluation techniques of the durability of existing ***/methodology/approach – China has built a railway network of over 150,000 km. Ensuring thesafety of the existing railway engineering is of great significance for maintaining normal railway operationorder. However, railway engineering is a strip structure that crosses multiple complex environments. Andrailway engineering will withstand high-frequency impact loads from trains. The above factors have led todifferences in the deterioration characteristics and maintenance strategies of railway engineering compared toconventional concrete structures. Therefore, it is very important to analyze the key factors that affect thedurability of railway structures and propose technologies for durability *** – The factors that affect the durability and reliability of railway engineering are mainly divided intothree categories: material factors, environmental factors and load factors. Among them, material factors alsoinclude influencing factors, such as raw materials, mix proportions and so on. Environmental factors varydepending on the service environment of railway engineering, and the durability and deterioration of concretehave different failure mechanisms. Load factors include static load and train dynamic load. The on-site rapiddetection methods for five common diseases in railway engineering are also proposed in this paper. Thesemethods can quickly evaluate the durability of existing railway engineering ***/value – The research can provide some new evaluation techniques and methods for thedurability of existing railway engineering.

关键词： Durability assessment Existing railway engineering Evaluation techniques

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong Jing Yang yiyin Zhang Xiaoxiao Fan Yang Fan Ning Hua Duguang Li shengxi Jin yirun Li Peng Chen Yongle Chen Xiaobo cai yi Zhang Linhua Jiang Wei Yang Peilin Yu Hui Lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK Department of Toxicology and Department of Medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and *** recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still ***,we examined the role of transient receptor potential melastatin 2(TRPM2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR *** data showed that TRPM2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in ***,RNA sequencing analysis indicated that TRPM2-induced IR injury occurs via ferroptosis-related ***,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPM2 inhibitor suppressed ***,TRPM2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR ***,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPM2 inhibitor or calcium depletion,both in vitro and in ***,these findings demonstrate a crucial role for TRPM2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPM2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPM2 Lipid Hepatic

Counterfactual analysis of the 2023 Omicron XBB wave in China

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Infectious Disease Modelling 2024年第1期9卷 195-203页

作者： Hengcong Liu Xiangyanyu Xu Xiaowei Deng Zexin Hu Ruijia Sun Junyi Zou Jiayi Dong Qianhui Wu Xinhua Chen Lan yi Jun cai Juanjuan Zhang Marco Ajelli Hongjie Yu School of Public Health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghaiChina Laboratory for Computational Epidemiology and Public Health Department of Epidemiology and BiostatisticsIndiana University School of Public HealthBloomingtonINUSA

Background:China has experienced a COVID-19 wave caused by Omicron XBB variant starting in April *** aim is to conduct a retrospective analysis exploring the dynamics of the outbreak under counterfactual scenarios that combine the use of vaccines,antiviral drugs,and nonpharmaceutical ***:We developed a mathematical model of XBB transmission in China,which has been calibrated using SARS-CoV-2 positive rates per *** age-specific infection-hospitalization risk,infection-ICU risk,and infection-fatality risk were used to estimate disease burdens,characterized as number of hospital admissions,ICU admissions,and ***:We estimated that in absence of behavioral change,the XBB outbreak in spring 2023 would have resulted in 0.86 billion infections(∼61%of the total population).Our counterfactual analysis shows that the synergetic effect of vaccination(70%vaccination coverage),antiviral treatment(20%receiving antiviral treatment),and moderate nonpharmaceutical interventions(20%isolation and L1 PHSMs)could reduce the number of deaths to levels close to seasonal influenza(1.17 vs.0.65 per 10,000 individuals and 5.85 vs.3.85 per 10,000 individuals aged 60+,respectively).The maximum peak prevalence of hospital and ICU admissions are estimated to be lower than the corresponding capacities(8.6 vs.10.4 per 10,000 individuals and 1.2 vs.2.1 per 10,000 individuals,respectively).Conclusion:Our findings suggest that the capacity of the Chinese healthcare system was adequate to face the Omicron XBB wave in spring 2023 but,at the same time,supports the importance of administering highly effective vaccine with long-lasting immune response,and the use of antiviral treatments.

关键词： wave analysis starting

Digital twin modeling and controlling of optical power evolution enabling autonomous-driving optical networks: a Bayesian approach

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Advanced Photonics 2024年第2期6卷 69-80页

作者： Xiaomin Liu yihao Zhang Yuli Chen yichen Liu Meng cai Qizhi Qiu Mengfan Fu Lilin yi Weisheng Hu Qunbi Zhuge Shanghai Jiao Tong University State Key Laboratory of Advanced Optical Communication Systems and NetworksDepartment of Electronic Engineering

Optical networks are evolving toward ultrawide bandwidth and autonomous operation. In this scenario, it is crucial to accurately model and control optical power evolutions(OPEs) through optical amplifiers(OAs), as they directly affect the signal-to-noise ratio and fiber nonlinearities. However, a fundamental contradiction arises between the complex physical phenomena in optical transmission and the required precision in network control. Traditional theoretical methods underperform due to ideal assumptions, while data-driven approaches entail exorbitant costs associated with acquiring massive amounts of data to achieve the desired level of accuracy. In this work, we propose a Bayesian inference framework(BIF) to construct the digital twin of OAs and control OPE in a data-efficient manner. Only the informative data are collected to balance the exploration and exploitation of the data space, thus enabling efficient autonomous-driving optical networks(ADONs). Simulations and experiments demonstrate that the BIF can reduce the data size for modeling erbium-doped fiber amplifiers by 80% and Raman amplifiers by 60%. Within 30 iterations, the optimal controlling performance can be achieved to realize target signal/gain profiles in links with different types of OAs. The results show that the BIF paves the way to accurately model and control OPE for future ADONs.

关键词： optical fiber communications digital twin Bayesian inference optical amplifiers autonomous-driving optical networks

多无人机吊挂负载运输系统的非线性鲁棒控制设计

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吉林大学学报（工学版） 2024年第6期54卷 1788-1795页

作者：鲜斌王光怡蔡佳明天津大学电气自动化与信息工程学院天津300072

针对多无人机吊挂负载运输系统中负载的位置跟踪和姿态控制问题,提出了一种新型非线性鲁棒控制策略。首先,在存在未知外界扰动和考虑系统内部状态耦合的基础上,基于拉格朗日力学建立了多无人机吊挂负载运输系统的动力学模型。其次,设计... 详细信息

针对多无人机吊挂负载运输系统中负载的位置跟踪和姿态控制问题,提出了一种新型非线性鲁棒控制策略。首先,在存在未知外界扰动和考虑系统内部状态耦合的基础上,基于拉格朗日力学建立了多无人机吊挂负载运输系统的动力学模型。其次,设计了一种基于误差符号函数积分(RISE)和几何控制方法的非线性鲁棒控制策略,用于补偿未知外界扰动的影响,实现了对负载位姿的精确控制。基于Lyapunov方法的稳定性分析证明了闭环系统的稳定性和吊挂负载跟踪误差的渐近收敛。仿真结果表明,本文提出的控制策略可以实现良好的轨迹跟踪效果,并对外界干扰有较好的鲁棒性。

关键词：控制理论与控制工程多无人机吊挂负载几何控制非线性控制鲁棒控制

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RuCo alloy nanoparticles embedded within N-doped porous two-dimensional carbon nanosheets:a high-performance hydrogen evolution reaction catalyst

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Tungsten 2024年第1期6卷 114-123页

作者： Jin-Hui Wang Shao-Wei Yang Fu-Bin Ma yi-Ke Zhao Shi-Nuo Zhao Zheng-Yu Xiong Dong cai Hai-Dong Shen Kai Zhu Qiu-Yu Zhang Yue-Ling Cao Tian-Shuai Wang He-Peng Zhang Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Xi’an Key Laboratory of Functional Organic Porous Materials School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China Chongqing Science and Technology Innovation Center of Northwestern Polytechnical University Chongqing 401135China

Developing cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water splitting to hydrogen production but still remains ***,we report an effective confinement pyrolysis strategy to fabricate embedded ruthenium-cobalt nanoclusters supported on N-doped porous two-dimensional carbon nanosheets(RuCo@CN).Markedly,the embedded structure can effectively prevent the migration,agglomeration,and leaching of nanoparticles,thus endowing the RuCo@CN catalyst with high *** be exact,high stability with up to 650 h can be achieved at high current density(-500 and-1000 mA·cm^(-2)).Besides,the RuCo@CN catalysts also exhibit highly reactive with low overpotentials of only 11mV at-10 mA·cm^(-2).Density functional theory calculations reveal that the introduction of cobalt reduces the decomposition barrier of H_(2)O for RuCo@CN alloy,thus promoting hydrogen evolution reaction.

关键词： Hydrogen evolution reaction Confinement pyrolysis strategy Mosaic structure Stability

TSPO deficiency exacerbates acute lung injury via NLRP3 inflammasome-mediated pyroptosis

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Chinese Medical Journal 2024年第13期137卷 1592-1602页

作者： Jingyi Han Xue Zhang Menghua cai Feng Tian yi Xu Hui Chen Wei He Jianmin Zhang Hui Tian Department of Thoracic Surgery Qilu Hospital of Shandong UniversityJinanShandong 250012China CAMS Key Laboratory of T Cell and Immunotherapy Department of ImmunologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeState Key Laboratory of Medical Molecular BiologyBeijing 100005China Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy ChangzhouJiangsu 213000China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

Background:Acute respiratory distress syndrome(ARDS)is a common cause of respiratory failure in many critically ill *** inflammasome activation plays an important role in the induction of acute lung injury(ALI)and ARDS,the regulatory mechanism of this process is still *** cells are stimulated by inflammation,the integrity and physiological function of mitochondria play a crucial part in ***,the underlying mechanisms and function of mitochondrial proteins in the process of pyroptosis are largely not yet ***,we identified the 18-kDa translocator protein(TSPO),a mitochondrial outer membrane protein,as an important mediator regulating nucleotide-binding domain,leucine-rich repeat,and pyrin domain-containing protein 3(NLRP3)inflammasome activation in macrophages during ***:TSPO gene knockout(KO)and lipopolysaccharide(LPS)-induced ALI/ARDS mouse models were employed to investigate the biological role of TSPO in the pathogenesis of *** macrophages were used to further characterize the effect of TSPO on the NLRP3 inflammasome *** of NLRP3 inflammasome was preformed through LPS+adenosine triphosphate(ATP)co-stimulation,followed by detection of mitochondrial membrane potential,reactive oxygen species(ROS)production,and cell death to evaluate the potential biological function of *** between two groups were performed with a two-sided unpaired ***:TSPO-KO mice exhibited more severe pulmonary inflammation in response to LPS-induced *** deficiency resulted in enhanced activation of the NLRP3 inflammasome pathway,promoting more proinflammatory cytokine production of macrophages in LPS-injured lung tissue,including interleukin(IL)-1β,IL-18,and macrophage inflammatory protein(MIP)-*** in TSPO-KO macrophages tended to depolarize in response to cellular *** increased production of mitochondrial damage-associated molecular pattern led to enhanced mitochondrial membr

关键词： Acute respiratory distress syndrome Acute lung injury 18-kDa translocator protein Macrophage NLRP3 inflammasome Inflammation

二十碳五烯酸和二十二碳六烯酸及其组合对斑马鱼阿尔茨海默病模型认知障碍的改善作用和机制

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中国药理学通报 2024年第4期40卷 701-709页

作者：黄城益邓淑怡宋采广东海洋大学食品科技学院广东湛江524088 广东海洋大学深圳研究院广东深圳518117

目的omega-3多不饱和脂肪酸二十碳五烯酸(eicosapentaenoic acid,EPA)和二十二碳六烯酸(docosahexaenoic acid,DHA)能够抑制M1型小胶质细胞的过度激活促炎细胞因子的释放和细胞凋亡,而EPA具有抗抑郁的作用。与EPA比较,DHA似对记忆的改... 详细信息

目的omega-3多不饱和脂肪酸二十碳五烯酸(eicosapentaenoic acid,EPA)和二十二碳六烯酸(docosahexaenoic acid,DHA)能够抑制M1型小胶质细胞的过度激活促炎细胞因子的释放和细胞凋亡,而EPA具有抗抑郁的作用。与EPA比较,DHA似对记忆的改善作用更强。由于两者在食物、衰老和疾病中的比值多变,其单一和最佳组合的功效不明,本实验拟利用AD模型比较研究EPA、DHA及最佳组合改善认知障碍及神经炎症的机制。方法Al 3+诱导斑马鱼AD模型,饲予EPA、DHA或EPA+DHA(1∶2),评估新物体识别和T迷宫奖赏的记忆,GC-MS检测躯体PUFAs浓度变化,qPCR检测脑内AChE、Axl、APP、Bace1、IL-6、TNF-α、CD11b、CD206、VDAC1、Caspase-3、Caspase-9和Bax的变化,ELISA试剂盒检测脑内Aβ的浓度。结果与模型组相比,EPA仅明显改善了斑马鱼的新物体识别能力,而DHA与EPA+DHA均恢复了新物体识别和T迷宫中的记忆。给予EPA、DHA和EPA+DHA均明显抑制了Aβ的蛋白浓度变化以及IL-6、CD206、Caspase-3、Caspase-9、Bax和AChE的mRNA表达,EPA和DHA均明显抑制了Bace1、APP和TNF-α的mRNA表达。DHA和EPA+DHA还明显降低了Axl和VDAC1的mRNA表达。结论EPA+DHA的组合对Al 3+诱导斑马鱼AD模型的记忆和认知障碍具有更好的改善作用,其作用机制可能通过抑制脑内细胞凋亡情况来改善记忆和认知障碍。

关键词： EPA DHA 阿尔茨海默病斑马鱼认知记忆神经炎症

Optimize Purcell filter design for reducing influence of fabrication variation

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Chinese Physics B 2024年第6期33卷 589-594页

作者：蔡晓周翼彪于文龙熊康林冯加贵 Gusu Laboratory of Materials Suzhou 215123China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China

To protect superconducting qubits and enable rapid readout, optimally designed Purcell filters are essential. To suppress the off-resonant driving of untargeted readout resonators, individual Purcell filters are used for each readout ***, achieving consistent frequency between a readout resonator and a Purcell filter is a significant challenge. A systematic computational analysis is conducted to investigate how fabrication variation affects filter performance, through focusing on the coupling capacitor structure and coplanar waveguide(CPW) transmission line specifications. The results indicate that the T-type enclosing capacitor(EC), which exhibits lower structural sensitivity, is more advantageous for achieving target capacitance than the C-type EC and the interdigital capacitor(IDC). By utilizing a large-sized CPW with the T-type EC structure, fluctuations in the effective coupling strength can be reduced to 10%, given typical micro-nanofabrication variances. The numerical simulations presented in this work minimize the influence of fabrication deviations, thereby significantly improving the reliability of Purcell filter designs.

关键词： superconducting circuit Purcell filter coplanar waveguide capacitor structure