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Comparative assessment and analysis of Rortex vortex in swirling jets

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Journal of Hydrodynamics 2019年第3期31卷 495-503页

作者： Nan Gui Liang Ge Peng-xin Cheng Xing-tuan Yang Ji-yuan Tu sheng-yao jiang Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University Beijing 100084 China School of Engineering RMIT University Melbourne VIC 3083 Australia

Recently, a new definition, called Rortex, was proposed to quantify the purely rotational motion of fluids. In this work, based on the DNS data, the Rortex is used to assess and visualize the rotational motion and structure of the vortex in swirling jets in comparison with other kinds of vortex criteria, including Q , λ2,vorticity and Ω criteria. The Rortex vector,Ω, Q and criteria are found to be better than the vorticity criterion for the vortex core identification. The vector triangle formed by the Rortex R , the nonrotational shear S , and the vorticity R is analyzed to give mechanical explanations, especially of the effect of the non-rotational shear on the rotation of fluids. In addition, the probability density distributions (PDF) of the Rortex R , the nonrotational shear S, and the vorticity R are computed. The peak value of the PDF of the vorticity could be used to explain the pure rigid rotation effect and the combination effects of the rigid rotation and the non?rotational shear.

关键词： Swirling flow vortex Rortex direct numerical simulation rigid rotation non-rotational shear

Analysis and correlation of fluid acceleration with vorticity and Liutex(Rortex)in swirling jets

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Journal of Hydrodynamics 2019年第5期31卷 864-872页

作者： Nan Gui Hou-bo Qi Liang Ge Peng-Xin Cheng Hao Wu Xing-tuan Yang Ji-yuan Tu sheng-yao jiang Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyKey Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing100084China School of Engineering RMIT UniversityMelbourneAustralia

The characteristics of the acceleration a and its correlation with the vortex core in the swirling flow are analyzed in this paper.The swirling flows of four swirl numbers(Sn=n S 0,0.10,0.20 and 0.36)are simulated by the direct numerical simulation,and the fluid mass particles from the inlet of the swirling flow are traced as a database for the current study.The correlations of the acceleration a with the vortex identification parameters of R andωare quantified,where R is the parameter of the“Liutex”-method proposed by Prof.Liu,and its early version is“Rortex”.The probability density functions of the included angles of a-R and a-ωare computed,which are used to clarify the geometrical configuration between a and R.The covariance coefficients between a and the parameters of various vortex core criteria(Q,λ2,ΩL,ΩR,ωand R)are computed and their relative levels of correlation are compared.Compared to the velocity,the expectation and the rms of the acceleration magnitudes and its projections on R and the plane perpendicular to R are computed for better explaining the correlation features between a and R.It is found that a and R are always either perpendicular or parallel to each other with the quantized included angles of∠(a,R)=kπ/2,(k=0,1,2).This confirms the role of R which works as the axis of the vortex exclusively.

关键词： swirling flow acceleration correlation vortex Rortex Liutex direct numerical simulation

The biological functions and metabolic pathways of valine in swine

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Journal of Animal Science and Biotechnology 2024年第1期15卷 20-34页

作者： Chuni Wang yao Peng Yiru Zhang Juan Xu sheng jiang Leli Wang Yulong Yin Institute of Subtropical Agriculture Chinese Academy of SciencesChangshaChina Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life SciencesHunan Normal UniversityChangshaChina Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjinChina

Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branchedchain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and its role in animal physiology. In pigs, the interactions between valine and other branched-chain amino acids or aromatic amino acids are complex. In this review, we delve into the interaction mechanism, metabolic pathways, and biological functions of valine. Appropriate valine supplementation not only enhances growth and reproductive performances, but also modulates gut microbiota and immune functions. Based on past observations and interpretations, we provide recommended feed levels of valine for weaned piglets, growing pigs, gilts, lactating sows, barrows and entire males. The summarized valine nutrient requirements for pigs at different stages offer valuable insights for future research and practical applications in animal husbandry.

关键词： Additional dosage Biological function Metabolic pathway Pig Valine

Traditional Chinese medicine for the treatment of immune-related nephropathy:A review

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Acta Pharmaceutica Sinica B 2024年第1期14卷 38-66页

作者： Pu jiang Changliang yao De-an Guo School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Immune-related nephropathy(IRN)refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal failure.The pathogenesis of IRN is not fully understood;therefore,treatment is challenging.Traditional Chinese medicines(TCMs)have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy,lupus nephropathy,and diabetic nephropathy.The underlying mechanisms mainly include its inhibition of inflammation;improvements to renal interstitial fibrosis,oxidative stress,autophagy,apoptosis;and regulation of immunity.In this review,we summarize the clinical symptoms of the three IRN subtypes and the use of TCM prescriptions,herbs,and bioactive compounds in treating IRN,as well as the potential mechanisms,intending to provide a reference for the future study of TCM as IRN treatments.

关键词： IgA nephropathy Diabetic nephropathy Lupus nephritis Traditional Chinese medicine Immunity Pathogenesis Mechanism Pathophysiology

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun yao Tao sheng Feng Liu Wei Liu Peng Zhao Feifei Lv Jie Sun Hongjun Li Zhen Gu Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Recent advances in MXene for terahertz applications

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Optoelectronics Letters 2024年第5期20卷 272-288页

作者： ZHANG Yongzhi jiang Jiuxing yao Yongtao HE Xunjun Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) School of Electrical and Electronic EngineeringHarbin University of Science and TechnologyHarbin 150080China College of Science Harbin University of Science and TechnologyHarbin 150080China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin University of Science and TechnologyHarbin 150080China

Since first synthesized in 2011, MXenes have attracted extensive attention in many scientific fields as a new two-dimensional(2D) material because of the unique physical and chemical properties. Over the past decade, in particular, MXenes have obtained numerous exciting achievements in the field of terahertz applications. In this review, we first briefly introduce the MXene materials, such as the basic structure and main fabrication processes of MXenes. Then, we summarize the recent applications of MXene materials in various terahertz research areas, including terahertz modulation, terahertz absorption, terahertz shielding, terahertz communication, terahertz detection and terahertz generation, in which the representative results are presented. Finally, we give an outlook on the future research directions of MXene materials and their potential applications.

关键词： terahertz directions absorption

Study on the preservation effects of the amputated forelimb by machine perfusion at physiological temperature

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Chinese Journal of Traumatology 2024年第2期27卷 114-120页

作者： sheng-Feng Chen Bo-yao Yang Tie-Yuan Zhang Xiang-Yu Song Zhi-Bo Jia Lei-Jia Chen Meng-Yi Cui Wen-Jing Xu jiang Peng Guizhou Medical University Guiyang550025China Medical School of PLA Beijing100048 China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLADepartment of OrthopedicsThe Fourth Medical CenterChinese PLA General HospitalBeijing100048China Hebei North Universiy Zhangjiakou075000Hebei ProvinceChina

Purpose:Ischemia and hypoxia are the main factors limiting limb replantation and transplantation.Static cold storage(SCS),a common preservation method for tissues and organs,can only prolong limb ischemia time to 4-6 h.The normothermic machine perfusion(NMP)is a promising method for the preservation of tissues and organs,which can extend the preservation time in vitro by providing continuous oxygen and nutrients.This study aimed to evaluate the difference in the efficacy of the 2 limb preservation methods.Methods:The 6 forelimbs from beagle dogs were divided into 2 groups.In the SCS group(n=3),the limbs were preserved in a sterile refrigerator at 4°C for 24 h,and in the NMP group(n=3),the perfusate prepared with autologous blood was used for the oxygenated machine perfusion at physiological temperature for 24 h,and the solution was changed every 6 h.The effects of limb storage were evaluated by weight gain,perfusate biochemical analysis,enzyme-linked immunosorbent assay,and histological analysis.All statistical analyses and graphs were performed using GraphPad Prism 9.0 one-way or two-way analysis of variance.The p value of less than 0.05 was considered to indicate statistical significance.Results:In the NMP group,the weight gained percentage was 11.72%±4.06%;the hypoxia-inducible factor-1αcontents showed no significant changes;the shape of muscle fibers was normal;the gap between muscle fibers slightly increased,showing the intercellular distance of(30.19±2.83)μm;and the vascularα-smooth muscle actin(α-SMA)contents were lower than those in the normal blood vessels.The creatine kinase level in the perfusate of the NMP group increased from the beginning of perfusion,decreased after each perfusate change,and remained stable at the end of perfusion showing a peak level of 4097.6 U/L.The lactate dehydrogenase level of the NMP group increased near the end of perfusion and reached the peak level of 374.4 U/L.In the SCS group,the percentage of weight gain was 0.18%±0.10%,and the contents of hypoxia-inducible factor-1αin

关键词： Traumatic amputation Machine perfusion Static cold storage Limb replantation

A Catalog of 13CO Clumps from the MWISP in l=10°–20°

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Research in Astronomy and Astrophysics 2024年第5期24卷 218-234页

作者： Xiaoyu Luo sheng Zheng Zhibo jiang Zhiwei Chen yao Huang Shuguang Zeng Xiangyun Zeng Rui Zhang Chen Long Guangrong Zhou Jinbo Hu Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443000China College of Electrical Engineering and New Energy China Three Gorges UniversityYichang 443000China College of Science China Three Gorges UniversityYichang 443000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China

In this study, we present a catalog of molecular clumps extracted from 13CO(J=1-0) emission data of the Milky Way Imaging Scroll Painting(MWISP) project. The data covers the inner Milky Way within the longitude range10°≤l≤20° and the latitude strip of |b|≤ 5°. 25. The workflow for the extraction of clumps, namely Facet-SS-3DClump, consists of two parts: the identification of clump candidates and their verification. First, Facet-SS-3DClump employs FacetClumps to identify clump candidates. Subsequently, high-confidence clumps are obtained by cross-matching with the clumps detected by other algorithms, such as dendrogram. Second, these high-confidence clumps are used as prior knowledge to train a semi-supervised deep clustering approach, SS-3D-Clump, which is applied to verify clump candidates detected by FacetClumps, providing confidence levels for the molecular clumps. Finally, the catalog comprising 18,757 molecular clumps was obtained using Facet-SS-3D-Clump, and the catalog is 90% complete above 37 K km s^(-1). We observe a significant deviation of the mean Galactic latitude for clumps within |b|≤ 2° from the midplane, with b=-0°.110. We found that 82.3% of the dust clumps correspond to 13CO clumps by matching with Herschel infrared dust clumps. In the future, Facet-SS-3D-Clump will be applied to detect 13CO clumps in the entire MWISP data.

关键词： ISM molecules methods data analysis-stars formation

Porous TiFe_(2) intermetallic compound fabricated via elemental powder reactive synthesis

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 764-772页

作者： Qian Zhao Zhenli He Yuehui He Yue Qiu Zhonghe Wang yao jiang State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China

Porous intermetallics show potential in the field of filtration and separation as well as in the field of catalysis.Herein,porous Ti Fe2intermetallics were fabricated by the reactive synthesis of elemental powders.The phase transformation and pore formation of porous TiFe2intermetallics were investigated,and its corrosion behavior and hydrogen evolution reaction(HER)performance in alkali solution were studied.Porous TiFe2intermetallics with porosity in the range of 34.4%-56.4%were synthesized by the diffusion reaction of Ti and Fe elements,and the pore formation of porous TiFe2intermetallic compound is the result of a combination of the bridging effect and the Kirkendall effect.The porous TiFe2samples exhibit better corrosion resistance compared with porous 316L stainless steel,which is related to the formation of uniform nanosheets on the surface that hinder further corrosion,and porous TiFe2electrode shows the overpotential of 220.6 and 295.6 mV at 10 and 100 mA·cm-2,suggesting a good catalytic performance.The synthesized porous Fe-based intermetallic has a controllable pore structure as well as excellent corrosion resistance,showing its potential in the field of filtration and separation.

关键词： TiFe2 intermetallic compound porous materials reactive synthesis corrosion behavior hydrogen evolution reaction