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Frontiers of Medicine 2010年第3期4卷 342-345页

作者： sheng-xuan liu Zhi-Hua HUANG Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The aim of this study was to investigate the value of technetium etifenin injection(^(99m)Tc-EHIDA)hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis between infantile hepatitis syndrome and biliary atresia.^(99m)Tc-EHIDA hepatobiliary scintigraphy in combination with duodenal fluid examination was used for evaluation in 84 infants with persistent infantile *** diagnosing biliary atresia,the sensitivity and specificity of scintigraphy were 100% and 74.5%,respectively;the sensitivity and specificity of scintigraphy in combination with duodenal fluid examination were 100% and 100%,*** conclusion,hepatobiliary scintigraphy,which is a noninvasive,safe,valuable examination method,in combination with examination of duodenal fluid,is of value for the differential diagnosis between infantile hepatitis syndrome and biliary atresia.

关键词： jaundice radionuclide hepatobiliary scintigra-phy duodenal drainage

Seismic fine imaging and its significance for natural gas hydrate exploration in the Shenhu Test Area, South China Sea

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China Geology 2020年第4期3卷 524-532页

作者： Hua Xue Min Du Bin Zhao Bao-jin Zhang sheng-xuan liu Peng-fei Wen Bin liu Ru-wei Zhang Yun-xia Xu Xi Chen Guangzhou Marine Geological Survey China Geological SurveyMinistry of Natural ResourcesGuangzhou 510760China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China

Shenhu area in South China Sea includes extensive collapse and diapir structures,forming high-angle faults and vertical fracture system,which functions as a fluid migration channel for gas hydrate *** order to improve the imaging precision of natural gas hydrate in this area,especially for fault and fracture structures,the present work propose a velocity stitching technique that accelerates effectively the convergence of the shallow seafloor,indicating seafloor horizon interpretation and the initial interval velocity for model *** the depth domain,pre-stack depth migration and residual curvature are built into the model based on high-precision grid-tomography velocity inversion,after several rounds of tomographic iterations,as the residual velocity field converges *** results of the Shenhu area show that the imaging precision of the fault zone is obviously improved,the fracture structures appear more clearly,the wave group characteristics significantly change for the better and the signal-to-noise ratio and resolution are *** improvements provide the necessary basis for the new reservoir model and field drilling risk tips,help optimize the favorable drilling target,and are crucial for the natural gas resource potential evaluation.

关键词： Natural gas hydrate Fine seismic imaging Velocity stitching technique High-precision grid-tomography velocity inversion Fault Residual curvature analysis NGH exploration trial engineering South China Sea

Fecal microbiota transplantation induces remission of infantile allergic colitis through gut microbiota re-establishment

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World Journal of Gastroenterology 2017年第48期23卷 8570-8581页

作者： sheng-xuan liu Yin-Hu Li Wen-Kui Dai Xue-Song Li Chuang-Zhao Qiu Meng-Ling Ruan Biao Zou Chen Dong Yan-Hong liu Jia-Yi He Zhi-Hua Huang Sai-Nan Shu Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Microbial Research We Health Gene InstituteShenzhen 518000Guangdong ProvinceChina Department of Computer Science College of Science and EngineeringCity University of Hong KongHong KongChina

AIM To investigate the impact of fecal microbiota transplantation(FMT) treatment on allergic colitis(AC) and gut microbiota(GM).METHODS We selected a total of 19 AC infants,who suffered from severe diarrhea/hematochezia,did not relieve completely after routine therapy or cannot adhere to the therapy,and were free from organ congenital malformations and other contraindications for FMT. Qualified donor-derived stools were collected and injected to the AC infants via a rectal tube. Clinical outcomes and follow-up observations were noted. Stools were collected from ten AC infants before and after FMT,and GM composition was assessed for infants and donors using 16 S r DNA sequencing *** After FMT treatment,AC symptoms in 17 infants were relieved within 2 d,and no relapse was observed in the next 15 mo. Clinical improvement was also detected in the other two AC infants who were lost to followup. During follow-up,one AC infant suffered from mild eczema and recovered shortly after hormone therapy. Based on the 16 S r DNA analysis in ten AC infants,most of them(n = 6) had greater GM diversity after FMT. As a result,Proteobacteria decreased(n = 6) and Firmicutes increased(n = 10) in post-FMT AC infants. Moreover,Firmicutes accounted for the greatest proportion of GM in the patients. At the genus level,Bacteroides(n = 6),Escherichia(n = 8),and Lactobacillus(n = 4) were enriched in some AC infants after FMT treatment,but the relative abundances of Clostridium(n = 5),Veillonella(n = 7),Streptococcus(n = 6),and Klebsiella(n = 8) decreased *** FMT is a safe and effective method for treating pediatric patients with AC and restoring GM balance.

关键词： Pediatric Infantile allergic colitis Fecal microbiota transplantation Gut microbiota Immune reaction

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong xuan Ye Hongzhang Cheng Xiaoming liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin xuan Shuai Chen Dan liu Qian Xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang Yuntao liu Beibei Du xuan Wang Tianxu Zhao Bingqiang liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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汉语作为方法:从早期文字记录看汉语诗学的当代价值

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河北学刊 2025年第1期45卷 67-73页

作者：张晶刘璇中国传媒大学辽宁师范大学文学院

汉语兼具“文”与“言”的双重属性,与以“言”为主的印欧语相区别。语法与逻辑的同根同源使印欧语在理论表述中陷入了概念与经验的争执,而汉语贯通形而上与形而下的特质使汉语表述本身即构成一种方法。作为“道”之文的载体,中国早期... 详细信息

汉语兼具“文”与“言”的双重属性,与以“言”为主的印欧语相区别。语法与逻辑的同根同源使印欧语在理论表述中陷入了概念与经验的争执,而汉语贯通形而上与形而下的特质使汉语表述本身即构成一种方法。作为“道”之文的载体,中国早期记录及其文法结构提供了关键信息,甲骨卜辞的体例制式为“易”类文献的结构提供了可追溯的原型,也为探索“论出于易”对汉语诗学功能的塑造提供了重要线索。其中,干支配伍的宇宙纪日为“以时系事”的话语表述提供了超线性时空结构;“正反对贞”以对言的形式表现语义的动态平衡与赋形必变的道理;“主题+阐释”的体例结构以逐层累积的文本层次为断言的疑难提供了积极的方案。汉语文法能够在表述判断的同时保持对“变”的关切,这为建构既能规范描述艺术经验又能直面人类自身处境的理论话语提供了时代价值。

关键词：汉语早期文字记录文法结构汉语诗学当代价值

全国地球化学基准网建立与土壤地球化学基准值特征

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中国地质 2016年第5期43卷 1469-1480页

作者：王学求周建徐善法迟清华聂兰仕张必敏姚文生王玮刘汉粮刘东盛韩志轩柳青青国土资源部地球化学探测技术重点实验室中国地质科学院地球物理地球化学勘查研究所河北廊坊065000 联合国教科文组织全球尺度地球化学国际研究中心河北廊坊065000

全球一致性和权威性地球化学观测数据是资源与环境评价的定量标尺。中国实施的"全国地球化学基准计划"作为"全球地球化学基准计划"的一部分,于2008—2014年实施,建立了覆盖全国的地球化学基准网。按照1∶20万图幅为网格单元,在全国1600... 详细信息

全球一致性和权威性地球化学观测数据是资源与环境评价的定量标尺。中国实施的"全国地球化学基准计划"作为"全球地球化学基准计划"的一部分,于2008—2014年实施,建立了覆盖全国的地球化学基准网。按照1∶20万图幅为网格单元,在全国1600个网格单元中,共部署3382个汇水域采样基准点,每个基准点同时采集了表层和深层土壤样品,共计采集6617件样品,使用高精度分析技术和严格的质量控制,分析了81个地球化学指标。本文首次给出了全国土壤81个指标地球化学基准值数据,初步阐释了地球化学基准值数据和空间分布特征与地质背景、成矿作用、表生作用以及人类活动的关系。

关键词：中国地球化学基准网基准值 76种元素

An Uncertain Optimal Energy Flow Model for CCHP Campus Microgrid Using Parameterized Probability Boxes

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Journal of Modern Power Systems and Clean Energy 2023年第5期11卷 1618-1633页

作者： Shunjiang Lin xuan sheng Yuquan Xie Yanghua liu Mingbo liu IEEE School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China Digital Grid Research Institute China Southern Power GridGuangzhou 510700China School of Electromechanical Engineering Guangdong Polytechnic Normal UniversityGuangzhouChina

Due to the uncertain fluctuations of renewable energy and load power, the state variables such as bus voltages and pipeline mass flows in the combined cooling, heating, and power campus microgrid(CCHP-CMG) may exceed the secure operation limits. In this paper, an optimal energy flow(OEF) model for a CCHP-CMG using parameterized probability boxes(p-boxes) is proposed to describe the higher-order uncertainty of renewables and loads. In the model, chance constraints are used to describe the secure operation limits of the state variable p-boxes, and variance constraints are introduced to reduce their random fluctuation ranges. To solve this model, the chance and variance constraints are transformed into the constraints of interval cumulants(ICs) of state variables based on the p-efficient point theory and interval Cornish-Fisher expansion. With the relationship between the ICs of state variables and node power, and using the affine interval arithmetic method, the original optimization model is finally transformed into a deterministic nonlinear programming model. It can be solved by the CONOPT solver in GAMS software to obtain the optimal operation point of a CCHP-CMG that satisfies the secure operation requirements considering the higher-order uncertainty of renewables and loads. Case study on a CCHP-CMG demonstrates the correctness and effectiveness of the proposed OEF model.

关键词： Combined cooling heating and power campus microgrid(CCHP-CMG) chance-constrained programming higher-order uncertainty optimal energy flow parameterized probability box

Influence of Sedimentation on Crystallization of Charged Colloidal Particles

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Chinese Journal of Chemical Physics 2012年第3期25卷 318-324,374页

作者： xuan Du sheng-hua Xu Zhi-wei Sun Lei liu Key Laboratory of Microgravity Institute oF Mechanics Chinese Academy of Sciences Beijing 100190China National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences Beiijing100190 China

The method of density matching between the solid and liquid phases is often adopted to effectively eliminate the effect of sedimentation of suspensions on dynamic behavior of a colloidal system. Experiments on crystallization of charged colloidal microspheres with di- ameter of 98 nm dispersed in density-matched and -unmatched media （mixtures of H20 and D20 in proper proportion） are compared to examine the influence of sedimentation. Reflection spectra of colloidal suspensions were used to monitor the crystallization process. Results showed that the crystal size of the density-unmatched （namely, in the presence of sedimentation） sample grew faster than that of the density-matched （in the absence of sedi- mentation） case at the initial stage of the crystallization, and then the latter overtook and outstripped the former. To explain these observations, we assume that in the settling of crystals sedimentation facilitates result in more particles getting into the crystal structures. However, as the crystals increase to varying sizes, the settling velocities become large and hydrodynamic friction strips off some particles from the delicate crystal structures. Overall, the sedimentation appears to accelerate the crystal size growth initially and then retard the growth. In addition, the crystal structures formed under microgravity were more closely packed than that in normal gravity.

关键词： Colloidal crystal Density matching Sedimentation Reflection spectrum