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Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after radical hepatectomy

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Cancer Biology & Medicine 2013年第3期10卷 158-164页

作者： Yang Ke Liang Ma Xue-Mei You sheng-xin huang Yong-Rong Liang Bang-De Xiang Le-Qun Li Jian-Hong Zhong Hepatobiliary Surgery Department Tumor Hospital of Guangxi Medical University

Objective： To assess the effect of antiviral therapy for hepatitis B virus （HBV）-related hepatocellular carcinoma （HCC） after radical hepatectomy. Methods： A total of 478 HBV-related HCC patients treated by radical hepatectomy were retrospectively collected. Patients in the treatment group （n=141） received postoperative lamivudine treatment （100 rag/d）, whereas patients in the control group （n=337） did not. Recurrence-free survival （RFS） rates, overall survival （OS） rates, treatments for recurrent HCC and cause of death were compared between the two groups. Propensity score matching （PSM） analysis was also conducted to reduce confounding bias between the two groups. Results： The 1-, 3-, and 5-year RFS rates didn＇t significantly differ between the two groups （P=0.778）; however, the 1-, 3-, and 5-year OS rates in the treatment group were significantly higher than those in the control group （P=0.002）. Similar results were observed in the matched data. Subgroup analysis showed that antiviral treatment conferred a significant survival benefit for Barcelona Clinical Liver Cancer stage A/B patients. Following HCC recurrence, more people in the treatment group were able to choose curative treatments than those in the control group （P=0.031）. For cause of death, fewer people in the treatment group died of liver failure than those in the control group （P=0.041）. Conclusion： Postoperative antiviral therapy increases chances of receiving curative treatments for recurrent HCC and prevents death because of liver failure, thereby significantly prolonging OS, especially in early- or intermedian-stage tumors.

关键词： Antiviral therapy hepatocellular carcinoma propensity score matching recurrence-free survival rate

Transcatheter closure of patent foramen ovale with the Spider（TM） patent foramen ovale occluder： a prospective, single-center trial

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Chinese Medical Journal 2010年第7期123卷 834-837页

作者： ZHANG Cao-jin huang Yi-gao huang xin-sheng huang Tao huang Wen-hui SHEN Jun-jun XUN Zheng-rong Department of Cardiology Guangdong General Hospital & Guangdong Cardiovascular Institute Guangzhou Guangdong 510100 China)

Background Transcatheter closure of patent foramen ovale （PFO） is a promising alternative to surgical closure or anticoagulation therapy to prevent paradoxical embolic events in patients with PFO. Several different devices have been used for transcatheter PFO closure. The aim of the present study was to evaluate the safety and feasibility for closure of PFO with a new PFO occluder, the Spider^（TM） PFO occluder. Methods The device was implanted in the PFO patients under fluoroscopy and transthoracic echocardiography （TTE） using a 10 French delivery sheath employing a femoral vein approach. Aspirin was administered at 100 mg/d for six months after occlusion. The clinical and echocardiographic follow-up of patients were performed at the 24th hour, 1st month, 3rd month, 6th month, and 12th month after occlusion, and yearly thereafter. Results The device was implanted successfully in all 55 patients. No major complications occurred during the perioperative period, such as thromboembolism, occluder dislodgement, infection or myocardial infarction. No residual shunt of the atrial level was shown by transesophageal echocardiography, and no latent arrhythmia or cerebral vesselevents occurred in any cases during follow-up （（35±9） months, range 6-51 months）.Conclusion Transcatheter closure of a PFO with the Spider^（TM） PFO occluder is a safe and effective therapeutic option for the secondary prevention of presumed paradoxical embolism. However, randomized trials comparing this device with other devices and therapies have to be performed.

关键词： patent foramen ovale occluder follow-up

Extraordinary Vessels Needling for Vascular Dementia

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Journal of Acupuncture and Tuina Science 2003年第1期1卷 17-19页

作者： YU Jin LAI xin-sheng huang Qiu-tang XIAO Yuan-chun Acupuncture and Tuina School Guangzhou University of TCM Guangdong 510405 China Acupuncture and Tuina School Guangzhou University of TCM Guangdong 510405 China The First Hospital Affiliated to Guangzhou University of TCM Guangdong 510405 China

Purpose To observe the clinical efficacy of extraordinary vessels needling in treating vascular *** 39 cases vascular dementia were treated by acupoints selected from the eight extraordinary meridians and the time needling techniques such as eight methods of spiritual turtle, in accordance with time period and pattern *** 2 cases were cured, 30 cases improved and 7 cases failed; the total effective rate was 82.1%.Conclusion Extraordinary vessels needling has positive effects in treating vascular dementia. Key Words Dementia, Vascular - Acupuncture Therapy - Chronotherapeutics - Eight extra-meridians Foundation Item: Natural Science Fund of Guangdong Province (960548)Author: YU Jin (1972-), female, lecture and attending physicianTranslator: XIAO Yuan-chun

关键词： Dementia, Vascular Acupuncture Therapy Chronotherapeutics Eight extra-meridians

The association between three common polymorphisms in microRNA and the risk of primary liver cancer:A Meta-analysis

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The association between three common polymorphisms in microR...

HPLC-荧光法测定贝伐珠单抗注射液中聚山梨醇酯20的含量

第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： Min Luo sheng-xin huang Yuan-dong Li Xiao-ling Luo Yu-an Xie Biomedical Research Center Affiliated Tumor Hospital of Guangxi Medical University Deportment of Surgery Shantou Central Hospital Affiliated Shantou Hospital of Sun Yat-sen University

＜正＞Objective MicroRNAs（miRNAs）affect biological function and may act as either tumor suppressors or *** nucleotide polymorphism（SNP）in miRNA may contribute to cancer *** polymorphisms of miR-146a（rs2910164）,m...

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中国生物制品学杂志 2018年第3期31卷 294-298页

作者：赵威郭圣荣黄馨上海交通大学药学院上海200240

目的采用HPLC-荧光法测定贝伐珠单抗注射液中聚山梨醇酯20的含量。方法对HPLC色谱条件进行优化后,检测贝伐珠单抗注射液中聚山梨醇酯20含量,并进行方法的专属性、线性、准确度、精密度、检测限、耐用性验证。用建立的方法检测3批贝伐珠... 详细信息

目的采用HPLC-荧光法测定贝伐珠单抗注射液中聚山梨醇酯20的含量。方法对HPLC色谱条件进行优化后,检测贝伐珠单抗注射液中聚山梨醇酯20含量,并进行方法的专属性、线性、准确度、精密度、检测限、耐用性验证。用建立的方法检测3批贝伐珠单抗注射液中聚山梨醇酯20的含量。结果该方法专属性良好;聚山梨醇酯20浓度在0.20~0.60 mg/mL范围内,线性关系良好,R^2=0.999 9;不同浓度的聚山梨醇酯20溶液检测结果的准确度在98%~100%范围内,RSD为0.8%;精密度各考察项RSD均不高于2%;检测限为0.002 0 mg/mL;耐用性各考察项与原始条件的相对百分比均在100%~102%范围内。3批贝伐珠单抗注射液中聚山梨醇酯20的含量分别为0.40、0.39和0.39 mg/mL,分别为标示量(0.40 mg/mL)的100%、98%和98%。结论建立的HPLC-荧光法快速、准确、可靠,可用于测定贝伐珠单抗注射液中聚山梨醇酯20的含量。

关键词：聚山梨醇酯20 贝伐珠单克隆抗体高效液相色谱荧光法 N-苯基-1-萘胺

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI huang FU CHENG xinDAN sheng xin YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

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Science China Technological Sciences 2025年

作者： Yun FANG Jingchen huang Yujun WU Jiaqi DONG Weichao GUO xinjun sheng State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

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地质雷达检测在保护性建筑结构加固中的应用

同济大学学报（自然科学版） 2000年第1期28卷 19-23页

作者：谢雄耀李永盛黄新才同济大学地下建筑与工程系上海200092 上海地质勘查技术院上海200336

结合原上海汇丰银行大楼的加固工程 ,介绍了地质雷达方法应用于混凝土结构物无损检测的原理、方法和效果 ,以及在保护性建筑物加固工程中耐久性诊断 .

关键词：地质雷达无损检测结构加固建筑结构保护性建筑

Autosomal recessive spinocerebellar ataxia type 4 with a VPS13D mutation:A case report

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World Journal of Clinical Cases 2022年第2期10卷 703-708页

作者： xin huang Dong-sheng Fan Department of Neurology Peking University Third HospitalBeijing 100191China Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases Beijing 100191China

BACKGROUND Autosomal recessive spinocerebellar ataxia type 4(SCAR4)is a type of SCA that is a group of hereditary diseases characterized by gait *** main clinical features of SCAR4 are progressive cerebellar ataxia,pyramidal signs,neuropathy,and macrosaccadic *** date,many gene dysfunctions have been reported to be associated with *** SUMMARY Here,we report a novel compound heterozygous mutation,c.3288delA(***1097-ThrfsTer6),in the VPS13D gene in a young female Chinese *** patient found something wrong with her legs about 10 years ago and presented with the typical characteristics of SCAR4 when she came to the hospital,including ataxia,neuropathy,and positive pyramidal *** was then diagnosed with SCAR4 and went home with symptomatic *** SCAR4 is a hereditary disease characterized by ataxia,pyramidal signs,neuropathy,and macrosaccadic *** report a novel compound heterozygous mutation,c.3288delA(***1097ThrfsTer6),in the VPS13D gene,which enriches the gene mutation spectrum and provides additional information about SCAR4.

关键词： Spinocerebellar ataxia Recessive VPS13D gene Compound heterozygous mutation Case report