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Exploring the molecular mechanism of action of curcumin for the treatment of diabetic retinopathy,using network pharmacology,molecular docking,and molecular dynamics simulation

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Integrative Medicine Discovery 2024年第8期8卷 1-10页

作者： Yuan-Yuan Gan yan-Mei Xu quan Shu Qi-Zhi Huang Tian-Long Zhou Ju-Fang Liu Wei Yu School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Second Affiliated Hospital Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Department of Medicine Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Department of Obstetrics and Gynecology Xianning Central HospitalThe First Affiliated Hospital of Hubei University of Science and TechnologyXianning 437000China.

Background:Based on network pharmacology and molecular docking,the present study investigated the mechanism of curcumin(CUR)in diabetic retinopathy ***:Based on the DisGeNET,Swiss TargetPrediction,GeneCards,Online Mendelian Inheritance in Man,Gene Expression Omnibus,and Comparative Toxicogenomics Database,the intersection core targets of CUR and diabetic retinopathy were *** intersection target was imported into the STRING database to obtain the protein-protein interaction *** to the Database for Annotation,Visualization and Integrated Discovery database,the intersected targets were enriched in Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes *** Cytoscape 3.9.1 is used to make the drug-target-disease-pathway *** mechanism of CUR and diabetic retinopathy was further verified by molecular docking and molecular dynamics ***:There were 203 intersecting targets of CUR and diabetic retinopathy identified.1320 GO entries were enriched for GO functions,which were primarily involved in the composition of cells such as identical protein binding,protein binding,enzyme binding,*** was found that 175 pathways were enriched using Kyoto Encyclopedia of Genes and Genomes pathway enrichment methods,which were mainly included in the lipid and atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,pathways in cancer,*** the molecular docking analysis,CUR was found to have a good ability to bind to the core targets of albumin,IL-1B,and *** binding of albumin to CUR was further verified by molecular dynamics ***:As a result of this study,CUR may exert a role in the treatment of diabetic retinopathy through multi-target and multi-pathway regulation,which indicates a possible direction of future research.

关键词： curcumin diabetic retinopathy network pharmacology molecular docking molecular dynamics simulation

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热障涂层抗CMAS腐蚀的表面改性研究进展

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表面技术 2024年第16期53卷 35-50页

作者：韩志勇赖浩瀚张权严慧羽中国民航大学天津市民用航空器适航与维修重点实验室天津300300

近年来,CaO-MgO-Al_(2)O_(3)-SiO_(2)(CMAS)的高温腐蚀成为热障涂层(TBCs)失效的重要原因,严重影响航空发动机热端部件的服役安全。表面改性作为提升热障涂层耐CMAS腐蚀性能的重要途径,不仅能够抑制熔融CMAS黏附在涂层表面,还能通过物... 详细信息

近年来,CaO-MgO-Al_(2)O_(3)-SiO_(2)(CMAS)的高温腐蚀成为热障涂层(TBCs)失效的重要原因,严重影响航空发动机热端部件的服役安全。表面改性作为提升热障涂层耐CMAS腐蚀性能的重要途径,不仅能够抑制熔融CMAS黏附在涂层表面,还能通过物理屏障或化学牺牲层的形式来阻挡熔融CMAS的渗入与反应。重点围绕国内外表面改性技术提高热障涂层抗CMAS腐蚀性能方面取得的研究与突破,根据作用机理划分为机械法、物理表面改性、化学表面改性和电化学表面改性四大类,阐述了这4类改性技术的原理与应用,同时归纳了不同表面改性工艺的优缺点。探讨了第一性原理计算与有限元模拟在稀土氧化物掺杂的氧化钇稳定的氧化锆、稀土锆酸盐、稀土钽酸盐和钙钛矿等新型热障涂层陶瓷材料方面的研究进展,以充分了解涂层微观组织结构和界面结构演变,为新型热障涂层的设计研究提供指导。最后,展望了TBCs在高温环境应用以及腐蚀防护的发展方向。

关键词：热障涂层硅酸盐环境沉积物(CMAS) 表面改性技术材料计算与模拟新型热障涂层陶瓷材料

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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min Liu Hai-Lin Zhang Bi-quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang Ling Cao yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao Xiao-yan Dong Dao-Jiong Lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen Li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

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二叔丁基二环己基-18-冠-6的合成及其对锶的萃取

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核化学与放射化学 2024年第2期46卷 158-169,I0006页

作者：王婧曹世权朱杉颜玉芳晏敏皓西南科技大学环境友好能源材料国家重点实验室四川绵阳621010 西南科技大学材料与化学学院四川绵阳621010 四川长晏科技有限公司四川绵阳621000 中国科学技术大学核科学技术学院安徽合肥230026

^(90)Sr(T_(1/2)=28.9 a)是一种具有高释热性和强放射性的高毒性核素,高放废液在进行处置之前必须准确测量放射性废液中^(90)Sr的含量,而将^(90)Sr从放射性废液中分离出来是其准确测量的关键。本工作通过改变合成反应路径和优化合成反... 详细信息

^(90)Sr(T_(1/2)=28.9 a)是一种具有高释热性和强放射性的高毒性核素,高放废液在进行处置之前必须准确测量放射性废液中^(90)Sr的含量,而将^(90)Sr从放射性废液中分离出来是其准确测量的关键。本工作通过改变合成反应路径和优化合成反应参数,解决了二叔丁基二环己基-18-冠-6(DtBuCH18C6)合成反应存在的加氢危险、纯化困难的问题,实现了高纯度产品的合成;而后采用溶剂萃取法,以DtBuCH18C6为萃取剂,分别研究稀释剂种类、萃取剂浓度、硝酸浓度、相比等条件对Sr^(2+)萃取性能的影响,以此来确定Sr^(2+)选择性分离的最佳萃取条件,建立一种有效的快速分离Sr^(2+)的方法,为后续提取^(90)Sr提供了一种可供选择的材料。

关键词：高放废液 DtBuCH18C6 合成萃取 ^(90)Sr

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马来酸噻吗洛尔中有关物质的识别和测定

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药物分析杂志 2024年第3期44卷 450-461页

作者：田珩吴纯敏严全鸿广东省药品检验所国家药品监督管理局药用辅料质量控制与评价重点实验室广州510525

目的:采用超高效液相色谱-四极杆/静电场轨道阱质谱(UPLC-Q/Orbitrap HRMS)鉴定马来酸噻吗洛尔中的有关物质。方法:采用ACE Excel3 C18-AR(150 mm×4.6 mm,3μm)色谱柱,以含0.01 mol·L^(-1)乙酸铵的0.2%甲酸水-甲醇为流动相梯度洗脱,流... 详细信息

目的:采用超高效液相色谱-四极杆/静电场轨道阱质谱(UPLC-Q/Orbitrap HRMS)鉴定马来酸噻吗洛尔中的有关物质。方法:采用ACE Excel3 C18-AR(150 mm×4.6 mm,3μm)色谱柱,以含0.01 mol·L^(-1)乙酸铵的0.2%甲酸水-甲醇为流动相梯度洗脱,流速0.6 mL·min^(-1),紫外检测器检测波长295 nm,质谱检测器采用HESI离子源,正负离子检测模式,碎片和裂解分析借助Mass Frontier 8.0和Compound Discover 3.3软件,通过对主成分进行破坏可以获得系统适用性溶液对样品中的杂质采用UPLC-Q/Orbitrap进行鉴定和分析。结果:主成分在特定条件下可产生出噻吗洛尔杂质B{(±)-1-(叔丁氨基)-2-[(4-吗啉基-1,2,5-噻二唑-3-基)氧]-1-丙醇}、噻吗洛尔杂质D(4-吗啉基-1,2,5-噻二唑)、噻吗洛尔杂质E((S,Z)-4{(-)-1-(叔丁氨基)-2[(4-吗啉基-1,2,5-噻二唑-3-基)氧]-4-氧代丁烯二酸})和噻吗洛尔杂质C{(±)-N-(叔丁氨基)-2,3-二[(4-吗啉基-1,2,5-噻二唑-3-基)氧]-2-丙烷胺},噻吗洛尔峰和各杂质峰分离良好,采用紫外检测器测定,定量限为0.05μg·mL^(-1),检测限为0.015μg·mL^(-1)。结合UPLC-Q/Orbitrap HRMS结果和文献报道,推测了另外6个主要杂质的结构。4家企业生产的8批样品测定结果单个杂质含量在0.0004%~0.09%,总杂质含量在0.02%~0.12%。结论:通过主成分破坏可获得系统适用性溶液,并用于马来酸噻吗洛尔中杂质的检测与鉴定,结果可为马来酸噻吗洛尔的质量控制提供参考依据。

关键词：马来酸噻吗洛尔 β-受体阻断剂有关物质杂质鉴定超高效液相色谱-四极杆/静电场轨道阱质谱

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促进还是抑制:新能源车企被动型异地投资对创新产出的影响

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研究与发展管理 2024年第3期36卷 125-136页

作者：熊勇清颜泉润中南大学商学院长沙410083

中国新能源汽车市场发展过程中存在较多的“地方保护”现象,新能源车企为了迎合一些地方保护政策而不得不选择异地投资。这种被动型的异地投资会干扰企业既定的创新计划,进而影响新能源车企的创新产出。利用2009—2021年新能源汽车上市... 详细信息

中国新能源汽车市场发展过程中存在较多的“地方保护”现象,新能源车企为了迎合一些地方保护政策而不得不选择异地投资。这种被动型的异地投资会干扰企业既定的创新计划,进而影响新能源车企的创新产出。利用2009—2021年新能源汽车上市公司的数据,检验了被动型异地投资对创新产出的具体影响。结果表明,新能源车企被动型异地投资显著抑制了创新产出。影响渠道检验进一步表明,被动型异地投资主要通过“资源侵占效应”和“需求同质效应”两条影响渠道来抑制创新产出。在考虑了组别差异后,被动型异地投资对创新产出的抑制作用存在有效性边界:当被动型异地投资较为集中时,不存在显著的抑制作用;当中国新能源汽车市场处于推广前期时,仅表现为不显著的抑制趋势。研究结论丰富了异地投资影响创新产出的分析框架,优化了新能源车企异地投资的战略选择,同时为坚决破除中国新能源汽车地方保护提供了经验证据。

关键词：新能源汽车被动型异地投资创新产出资源侵占效应需求同质效应

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Regulation of TMEM100 expression by epigenetic modification,effects on proliferation and invasion of esophageal squamous carcinoma

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World Journal of Clinical Oncology 2024年第4期15卷 554-565页

作者： Yue-Feng Xu yan Dang Wei-Bo Kong Han-Lin Wang Xiu Chen Long Yao Yuan Zhao Ren-quan Zhang Department of Thoracic Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a prevalent malignancy with a high morbidity and mortality ***100 has been shown to be suppressor gene in a variety of tumors,but there are no reports on the role of TMEM100 in esophageal cancer(EC).AIM To investigate epigenetic regulation of TMEM100 expression in ESCC and the effect of TMEM100 on ESCC proliferation and *** Firstly,we found the expression of TMEM100 in EC through The Cancer Genome Atlas *** correlation between TMEM100 gene expression and the survival of patients with EC was further confirmed through Kaplan-Meier *** then added the demethylating agent 5-AZA to ESCC cell lines to explore the regulation of TMEM100 expression by epigenetic *** observe the effect of TMEM100 expression on tumor proliferation and invasion by overexpressing ***,we performed gene set enrichment analysis using the Kyoto Encyclopaedia of Genes and Genomes Orthology-Based Annotation System database to look for pathways that might be affected by TMEM100 and verified the effect of TMEM100 expression on the mitogen-activated protein kinases(MAPK)*** In the present study,by bioinformatic analysis we found that TMEM100 was lowly expressed in EC patients compared to normal ***-meier survival analysis showed that low expression of TMEM100 was associated with poor prognosis in patients with ***,we found that the demethylating agent 5-AZA resulted in increased expression of TMEM100 in ESCC cells[quantitative real-time PCR(qRT-PCR)and western blotting].Subsequently,we confirmed that overexpression of TMEM100 leads to its increased expression in ESCC cells(qRT-PCR and western blotting).Overexpression of TMEM100 also inhibited proliferation,invasion and migration of ESCC cells(cell counting kit-8 and clone formation assays).Next,by enrichment analysis,we found that the gene set was significantly enriched in the MAPK signaling *** involvement

关键词： Esophageal squamous cell carcinoma TMEM100 Invasion Mitogen-activated protein kinases pathway Epigenetic

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基于改进FWA的配电网优化重构方法研究

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控制工程 2024年第5期31卷 833-841页

作者：阎馨全洪燕屠乃威辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125105

针对配电网重构问题,以降低网络损耗、提高节点电压为目标,建立了配电网重构模型,提出了一种解决配电网重构问题的改进烟花算法(firework algorithm,FWA)。算法使用环路编码压缩解空间,提高求解效率。基于核心烟花给出了火花爆炸幅度的... 详细信息

针对配电网重构问题,以降低网络损耗、提高节点电压为目标,建立了配电网重构模型,提出了一种解决配电网重构问题的改进烟花算法(firework algorithm,FWA)。算法使用环路编码压缩解空间,提高求解效率。基于核心烟花给出了火花爆炸幅度的计算方法,采用高斯和均匀分布均值混合的变异方式以及精英选择策略,提高解的多样性、搜索效率和收敛速度。为了验证所提算法的适用性和正确性,在IEEE33和IEEE69节点系统上进行了算法测试,结果表明,重构后的网络损耗明显降低,节点电压得到提高,所提算法具有较好的鲁棒性。将所提算法与其他算法进行比较,结果表明,所提算法在降低网络损耗、提高节点电压、求解效率等方面均优于其他算法。

关键词：配电网重构改进烟花算法网络损耗节点电压混合变异

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贵州现代乡村表演与中华民族共同体意识的呈现——以贵州“村BA”与“村超”为例

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中南民族大学学报（人文社会科学版） 2024年第4期44卷 98-106,220页

作者：朱全国肖艳丽浙江师范大学人文学院浙江金华321000 浙江师范大学艺术学院浙江金华321000

从社会表演学与人类表演学的角度来看,贵州“村BA”与“村超”已经成为现代乡村表演的代表性存在。贵州“村BA”与“村超”之所以成为具有世界影响力的一种现象级的表演形式,主要原因有三点:一是它们满足了疫情后人们缓解焦虑、增强信... 详细信息

从社会表演学与人类表演学的角度来看,贵州“村BA”与“村超”已经成为现代乡村表演的代表性存在。贵州“村BA”与“村超”之所以成为具有世界影响力的一种现象级的表演形式,主要原因有三点:一是它们满足了疫情后人们缓解焦虑、增强信任、积极参与社会活动的心理需求;二是它们兼具民族传统体育、休闲体育、世界性与全民性、文化综合体等多种属性,满足了不同层面人们的精神需求;三是国家主流媒体的推动,互联网与各种自媒体以及完善的地方融媒体中心的热切关注,使其广泛传播。各个民族积极参与、团结和谐,展示了民众无处不在的家国情怀与对党的拥护,中华民族共同体意识自然而然地涌现出来。“村BA”与“村超”的成功案例,为铸牢中华民族共同体意识提供了一种由内而外的新思路。

关键词：现代乡村表演中华民族共同体意识村BA 村超民族文化

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Formation Enthalpy Calculation of Oxygen Vacancy Defect in Doped Lithium Niobate Crystals

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Chemical Research in Chinese Universities 2004年第1期20卷 65-67页

作者： QIANGLiang-sheng LIYao TANGDong-yan XUChong-quan WEIYong-de DepartmentofAppliedChemistry HarbinInstituteofTechnologyHarbin150001P.R.China CenterforCompositeMaterials HarbinInstituteofTechnologyHarbin150001P.R.China

The relationship between temperature and oxygen vacancy concentration is deduced in this paper. Based on the data of thermal weight-loss experiment, the formation enthalpies of congruent and several doped LN crystals have been calculated. It was found that the formation enthalpy of oxygen vacancies can be decreased evidently by doping valence-changeable ions. The experimental results were discussed and a new reduction process of the photorefractive LN crystal at a relatively low temperature was proposed, and the reduced crystals showed a good effect in practical use.

关键词： Formation enthalpy calculation Oxygen vacancy defect Doped lithium niobate crystal

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