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Expression and Distribution Characteristics of Human Ortholog of Mammalian Enabled (hMena) in Glioma

Chinese Journal of Cancer Research 2011年第4期23卷 312-316页

作者： Xue-tao Dong Xue-jun Yang Hua-min Wang Wei Wang Li yu Bin Zhang sheng-ping yu hao-lang ming Department of Neurosurgery Tianjin Medical University General Hospital Tianjin Neurological Institute Tianjin 300052 China

Objective: To investigate the utility of hMena, a family of enabled/vasodilator-stimulated phosphoprotein (Ena/VASP), we sought to characterize the expression profile and distribution characteristics of hMena in a large panel of glioma samples and determine whether hMena expression levels might correlate with the pathological grade of glioma. Methods: Sixty-five specimens of glioma with different pathological grades and five control brain tissues were collected. In 6 of the 21 glioblastoma patients, multi-specimens were obtained respectively from the main tumor mass, the junction zone between the tumor and the normal tissue, and adjacent brain tissue 1.5 cm away from the tumor boundary under assistance of neuronavigation system during the operation. Immunohistochemistry was used to detect the expression and distribution characteristics of hMena. hMena expression was analyzed by Western blot in 20 specimens. Results: The hMena expression was negative in control brain tissue but positive in different grades of glioma. The expression rate of hMena was positively correlated with the increasing grade of the World Health Orgnization (WHO) classification (rs=0.682, P=0.000). hMena was located in cytoplasm. Positive cells only distributed around the vessels within the tumor mass in low grade glioma, while in high grade glioma, these cells were able to be detected not only in the tumor but also in the boundary zone and adjacent brain parenchyma. In the tumor mass, hMena expressed highly and diffusedly. In the junction zone, hMena positive cells formed radiolitic pattern around the vessels. In adjacent brain parenchyma, single positive cell was scattered. hMena expression was markedly elevated in Grade III and IV glioma compared with Grade II and I. Conclusion: Our data suggested that the expression of hMena is closely related to malignant grade of glioma. hMena can label the migrating cells, and indicate the migrating path of glioma cells from the tumor to adjacent tissue al

关键词： Glioma hMena Migration Immunohistochemistry

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Astragaloside Ⅳ protects RGC-5 cells against oxidative stress

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Neural Regeneration Research 2018年第6期13卷 1081-1086页

作者： ming hao yu Liu ping Chen Hong Jiang Hong-yu Kuang Department of Endocrinology The First Clinical Hospital of Harbin Medical University Department of Endocrinology Heilongjiang Provincial Hospital Department of Endocrinology The First Hospital of Harbin

Astragaloside Ⅳ is the main active compound of Astragalus membranaceus. Astragaloside Ⅳ has strong anti-oxidative activities and protective effects against progression of peripheral neuropathy. In this study, we determined whether astragaloside Ⅳ protects retinal ganglion cells（RGC） from oxidative stress injury using the rat RGC-5 cell line. Hydrogen peroxide（H_2O_2） was used to induce oxidative stress injury, with the protective effect of astragaloside Ⅳ examined. Cell Counting Kit-8 and 4′,6-diamidino-2-phenylindole staining showed that astragaloside Ⅳ increased cell survival rate and decreased apoptotic cell number. Flow cytometry showed that astragaloside Ⅳ decreased H_2O_2-induced reactive oxygen species levels. While laser confocal microscopy showed that astragaloside Ⅳ inhibited the H_2O_2-induced decrease of mitochondrial membrane potential. Western blot assay showed that astragaloside Ⅳ reduced cytochrome c release induced by H_2O_2, inhibited Bax and caspase-3 expression, and increased Bcl-2 expression. Altogether, these results indicate that astragaloside Ⅳ has potential protective effects against H_2O_2-induced oxidative stress in retinal ganglion cells.

关键词： nerve regeneration Astragalus membranaceus hydrogen peroxide H2O2 retinopathy neuroprotective effects retinal ganglion cells apoptosis reactive oxygen species mitochondrial membrane potential mitochondrial pathway neural regeneration

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Structure and mechanical properties of nc-TiC/a-C:H nanocomposite films deposited by filtered cathodic arc technique

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Rare Metals 2016年第2期35卷 177-183页

作者： yu-hao Zhai yu-Juan Zhang Yi Peng sheng-Mao Zhang ping-yu Zhang Xiao-Min Zhang Key Laboratory of Ministry of Education for Special Functional Materials Henan University College of Materials and Mineral Resources Xi’an University of Architecture and Technology

nc-Ti C/a-C：H nanocomposite films were prepared by filtered cathodic arc technique. The influence of C_2H_2/Ar flow ratio on the composition, structure, and mechanical properties of films was investigated by X-ray photoelectron spectroscopy（XPS）, X-ray diffraction（XRD）, Fourier transform infrared spectroscopy（FTIR）,Raman spectroscopy, nanoindentation, and ball-on-disc tribometry. The films show a nanocomposite structure in which Ti C crystallites are embedded in the amorphous matrix of a-C：H phase. C content in films increases with the flow ratio of C_2H_2/Ar, simultaneously, the crystallite size of TiC decreases. Contrary to the nc-Ti C/a-C：H films deposited by magnetron sputtering in which the sp3 C content increases with C_2H_2 flow rate, the increase of C_2H_2 flow rate leads to the increase of sp2 C content in films deposited by filtered cathodic arc technique. The nc-Ti C/a-C：H films deposited by cathodic arc technique have a pronounced hardness maximum of 30 GPa under the C_2H_2/Ar flow ratio of 12. Tribological performance of films is controlled by the sp2 content in films. Higher sp2 content promotes the formation of graphite-like transfer layer during sliding,and results in lower wear rate and friction coefficient.

关键词： Nanocomposite films Tribological performance Hardness

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Filiform needle acupuncture for allergic rhinitis:A systematic review and meta-analysis

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Journal of Integrative Medicine 2022年第6期20卷 497-513页

作者： Shi-hao Du Wei Guo Chao Yang sheng Chen sheng-nan Guo Shuo Du Zhong-ming Du yu-tong Fei Ji-ping Zhao Dongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing100700China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine100029BeijingChina

Background:Filiform needle acupuncture(FNA),the most classical and widely applied acupuncture method based on traditional Chinese medicine theory,has shown a promising effect in the treatment of allergic rhinitis(AR).Objective:To evaluate the efficacy,safety,cost-effectiveness,and patient preference of FNA in the treatment of AR by comparing FNA with sham acupuncture,no treatment,and conventional *** strategy:Eight electronic databases were systematically searched from inception to October 14,*** studies were acquired from clinical trial registration platforms and reference *** criteria:Randomized controlled trials were included if they compared FNA with either sham acupuncture,no treatment or conventional medication for *** extraction and analysis:Two researchers extracted data independently of each other using a predesigned data acquisition form,and results were cross-checked after *** primary outcome was symptom score(Total Nasal Symptom Score or Visual Analogue Scale),and the secondary outcomes were the AR control questionnaire,quality of life(QoL)score(Different versions of Rhinoconjunctivitis Quality of Life Questionnaire),medication score(use of rescue medication),mental health score,total IgE,adverse event rate,clinical economic indicators,and patient satisfaction *** mean difference(SMD)or mean difference(MD)with 95% confidence interval was used to calculate the effect size for continuous data,while risk ratio with 95%CI was used for dichotomous ***:Thirty studies were included in this *** with sham acupuncture,FNA significantly reduced the symptom score(SMD:-0.29[-0.43,-0.15]),AR’s impact on QoL(SMD:-0.23[-0.37,-0.08])and medication score(SMD:-0.3[-0.49,-0.11]).Compared with no treatment,FNA dramatically reduced the symptom score(SMD:-0.8[-1.2,-0.39])and AR’s impact on QoL(SMD:-0.82[-1.13,-0.52]).There were no increased rates of adverse events with FNA compared to sham

关键词： Allergic rhinitis Filiform needle acupuncture Systematic review Meta-analysis

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磁场下碳化物析出的热力学机制

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原子与分子物理学报 2025年第4期42卷 121-130页

作者：廖已莹侯廷平杨雨豪郑一航于涛刘伍明吴开明武汉科技大学理学院武汉430081 冶金工业过程系统科学湖北省重点实验室武汉430081 省部共建耐火材料与冶金国家重点实验室武汉430081 江汉大学光电材料与技术学院光电化学材料与器件教育部重点实验室武汉430056 中国科学院物理研究所北京100190

钢中碳化物的形成主要由合金元素的种类以及含量的决定,碳化物对钢铁材料的显微组织形态和力学性能有重要影响.磁场是影响碳化物析出规律发生改变的重要因素之一.以常见的碳化物M_(6)C(M=Fe,Mo)作为研究对象,利用第一性原理计算η-Fe_(... 详细信息

钢中碳化物的形成主要由合金元素的种类以及含量的决定,碳化物对钢铁材料的显微组织形态和力学性能有重要影响.磁场是影响碳化物析出规律发生改变的重要因素之一.以常见的碳化物M_(6)C(M=Fe,Mo)作为研究对象,利用第一性原理计算η-Fe_(2)C、Fe_(3)C、Fe_(2)Mo_(4)C、Fe_(3)Mo_(3)C-Ⅰ、Fe_(3)Mo_(3)C-Ⅱ和Fe_(4)Mo_(2)C等合金碳化物的磁矩,计算结果表明其中Fe_(4)Mo_(2)C的磁矩最大,达到了7.04μB.磁矩不仅由碳化物晶胞中Fe原子个数有关,还与Fe Wyckoff占位紧密相关.通过模拟计算碳化物的磁致磁热熔、磁熵、磁焓和磁自由能,从热力学角度对各碳化物进行分析,结果表明磁场会使碳化物的磁致磁热熔和磁熵增加;强磁场会降低M_(6)C的磁自由能进而提高其稳定性.此工作为研究核聚变材料磁性能提供理论基础和技术参考.

关键词：磁场碳化物析出相热力学机制

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An hourly shallow landslide warning model developed by combining automatic landslide spatial susceptibility and temporal rainfall threshold predictions

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Journal of Mountain Science 2022年第12期19卷 3370-3387页

作者： CAO Yi-ming GUO Wei WU yu-ming LI lang-ping ZHANG Yi-xing LAN Heng-xing State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Fujian Meteorological Service Centre Fuzhou350025China School of Geological Engineering and Geomatics Chang’an UniversityXi’an710064China Key Laboratory of Ecological Geology and Disaster Prevention of Ministry of Natural Resources Chang’an UniversityXi’an710064China Tianjin University of Commerce Tianjin300134China

Landslide warning models are important for mitigating landslide *** rainfall threshold model is the most widely used early warning model for predicting rainfall-triggered ***,the rainfall threshold model has been coupled with the landslide susceptibility(LS)model to improve the accuracy of early warnings in the spatial *** coupled models,designed based on a matrix including predefined rainfall thresholds and susceptibility levels,have been used to determine the warning *** predefined classifications inevitably have subjective rainfall thresholds and susceptibility levels,thus affecting the probability distribution information and eventually influencing the reliability of the produced early *** this paper,we propose a novel landslide warning model in which the temporal and spatial probabilities of landslides are coupled without predefining the classified *** temporal probability of landslides is obtained from the probability distribution of rainfall intensities that triggered historical *** spatial probability of landslides is then obtained from the susceptibility probability distribution.A case study shows that the proposed probability-coupled model can successfully provide hourly warning results before the occurrence of a *** all three models successfully predicted the landslide,the probability-coupled model produced a warning zone comprising the fewest grid ***,the probabilitycoupled model produced only 39 grid cells in the warning zone,while the rainfall threshold model and the matrix-coupled model produced warning zones including 81 and 49 grid cells,*** proposed model is also applicable to other regions affected by rainfall-induced landslides and is thus expected to be useful for practical landslide risk management.

关键词： Landslide Hourly warning Temporal probability Spatial probability Rainfall threshold Susceptibility

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Effect of existence state of asphaltenes on the asphaltenes-wax interaction in wax deposition

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Petroleum Science 2023年第1期20卷 507-514页

作者： yun Lei Han Wang Shuang-Shuang Li Xue-Qian Liu hao-Ran Zhu yu-ming Gao hao-ping Peng Peng-Fei yu Jiangsu Key Laboratory of Oil and Gas Storage&Transportation Technology Changzhou UniversityJiangsu213164China

Asphaltenes are the most elusive substances in waxy crude oil,especially the complex structures,which leads to significant precipitation and aggregation characteristics of asphaltenes,and affects the asphaltenes-wax *** this study,the concept of the existence state of asphaltenes was introduced to semi-quantitatively investigate the precipitation and aggregation characteristics of *** this basis,the influence of the existence state of asphaltenes on wax deposition was studied by coldfinger device and high-temperature gas chromatography,and the composition and properties of the deposits were *** main findings were made:(1)As the asphaltene concentration increases,the existence state of asphaltenes gradually transitions from dispersed state to aggregated state,and the asphaltene concentration of 0.30 wt%in this study is the starting point of the transition.(2)The existence state of asphaltenes in crude oil does affect the process of wax deposition,as shown in the fact that the dispersed asphaltenes promote the occurrence of wax deposition,while the aggregated asphaltenes can inhibit wax deposition.(3)In the presence of the aggregated asphaltenes,that is,when the asphaltene concentration is higher than 0.30 wt%,the shedding phenomenon of deposit layer was observed,and with the increase of aggregated asphaltenes,the deposit layer fell off earlier.(4)With the increase of the dispersed asphaltenes,the wax appearance temperature(WAT)and wax content of the deposits all showed an increasing trend,while with the appearance of the aggregated asphaltenes,the above situation was *** findings of this study can help for better understanding of the interaction between the asphaltenes and wax in wax deposition.

关键词： Asphaltenes Precipitation/aggregation Existence state of asphaltenes Deposition

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Austenite grain growth behavior of Q1030 high strength welded steel

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International Journal of Minerals,Metallurgy and Materials 2012年第8期19卷 711-716页

作者： Rong-ting Xiao hao yu ping Zhou School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Laiwu Iron & Steel Group Co. Ltd. Laiwu 271104 China

The austenite grain growth behavior of Q1030 steel was studied under different heating conditions. The austenite grain size increases with the heating temperature and holding time increasing. Austenite grains grow in an exponential manner with rising heating tem- perature and in a parabolic manner with prolonging holding time. A mathematical model for describing the austenite grain growth behavior of Q 1030 steel was obtained on the basis of experimental results using regression analysis. When the heating temperatures lie between 1000 and 1100℃ at a certain holding time, abnormal grain growth appears, which causes mixed grains in Q1030 steel.

关键词： high strength steel heat treatment austenite grain size grain growth mathematical models

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Copositive approximation by rational functions with prescribed numerator degree

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Applied Mathematics(A Journal of Chinese Universities) 2009年第4期24卷 411-416页

作者： yu Dan-sheng ZHOU Song-ping Department of Mathematics Hangzhou Normal University Hangzhou 310036 China Department of Mathematics Statistic and Computer Science St. Francis Xaiver University Antigonish Nova Scotia Canada B2G 2W5 Institute of Mathematics Zhejiang Sci-Tech University Hangzhou 310028 China

The paper proves that, if f（x） ∈ L^p[-1,1],1≤p〈∞ ,changes sign I times in （-1, 1）,then there exists a real rational function r（x） ∈ Rn^（2μ-1）l which is eopositive with f（x）, such that the following Jackson type estimate ｜｜f-r｜｜p≤Cδl^2μωφ（f,1/n）p holds, where μ is a natural number ≥3/2＋1/p, and Cδ is a positive constant depending only on δ.

关键词： copositive approximation rational functions approximation rate

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