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Medical services for sports injuries and illnesses in the Beijing 2022 Olympic Winter Games

World Journal of Emergency Medicine 2022年第6期13卷 459-466页

作者： Peng-da Han Ding Gao Jie Liu Jing Lou Si-jia Tian Hui-xin Lian Sheng-mei Niu Lu-xi Zhang Yong Wang Jin-jun Zhang Emergence Medical Service Group for Beijing 2022 Olympic Winter Games Beijing Emergency Medical CenterBeijing 100031China Department of General Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Games Services Department Beijing Organizing Committee for the 2022 Olympic and Paralympic Winter GamesBeijing100041China

BACKGROUND:Beijing 2022 Olympic Winter Games was the second Games held amid the COVID-19 pandemic.To a certain extent,it has altered the way sporting activities operate.There is a lack of knowledge on injury risk and illness occurrence in elite winter sport athletes amid the COVID-19 pandemic.This study aimed to describe the incidence of injuries and illnesses sustained during the XXIV Olympic Winter Games in Beijing from February 4 to 20,2022.METHODS:We recorded the daily number of injuries and illnesses among athletes reported by Beijing 2022 medical staff in the polyclinic,medical venues,and ambulance.We calculated injury and illness incidence as the number of injuries or illnesses occurring during competition or training,respectively,with incidence presented as injuries/illnesses per 100 athlete-days.RESULTS:In total,2,897 athletes from 91 nations experienced injury or illness.Beijing 2022 medical staff reported 326 injuries and 80 illnesses,equaling 11.3 injuries and 2.8 illnesses per 100 athletes over the 17-day period.Altogether,11%of the athletes incurred at least one injury and nearly 3%incurred at least one illness.The number of injured athletes was highest in the skating sports(n=104),followed by alpine skiing(n=53),ice track(n=37),freestyle skiing(n=36),and ice hockey(n=35),and was the lowest in the Nordic skiing disciplines(n=20).Of the 326 injuries,14(4.3%)led to an estimated absence from training or competition of more than 1 week.A total of 52 injured athletes were transferred to hospitals for further care.The number of athletes with illness(n=80)was the highest for skating(n=33)and Nordic skiing(n=22).A total of 50 illnesses(62.5%)were admitted to the department of dentistry/ophthalmology/otolaryngology,and the most common cause of illness was other causes,including preexisting illness and medicine(n=52,65%).CONCLUSION:Overall,11%of athletes incurred at least one injury during the Games,which is similar to the findings during the Olympic Winter Games in 2014 and 2018.Regarding illness,2%of athlet

关键词： Injuries Illnesses Olympic Winter Games Emergency medical service

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Novel Wx alleles generated by base editing for improvement of rice grain quality

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Journal of Integrative Plant Biology 2021年第9期63卷 1632-1638页

作者： Xiaorui Huang Fei Su sheng Huang Fating mei Xiaomu niu Changle Ma Hui Zhang Xiaoguo Zhu Jian-Kang Zhu Jinshan Zhang College of Life Sciences Shandong Normal UniversityJi'nan 250014China Bellagen Biotechnology Co.Ltd Ji'nan 250000China College of Life Science Shanghai Normal UniversityShanghai 200234China Shanghai Center for Plant Stress Biology and Center for Excellence in Molecular Plant Sciences The Chinese Academy of SciencesShanghai 201602China

Amylose content(AC),which is regulated by the Waxy(Wx)gene,is a major indicator of eating and cooking quality(ECQ)in rice(Oryza sativa).Thus far,only a limited number of mutations in the N-terminal domain of Wx were found to have a major impact on the AC of rice grains and no mutations with such effects were reported for other regions of the Wx protein.Here,nucleotide substitutions in the middle region of Wx were generated by adenine and cytosine base editors.The nucleotide substitutions led to changes in 15 amino acid residues of Wx,and a series of novel Wx alleles with ACs of 0.3%-29.43%(wild type with AC of 19.87%)were obtained.Importantly,the waxy~(abe2)allele showed a"soft rice"AC,improved ECQ,favorable appearance,and no undesirable agronomic traits.The transgenes were removed from the waxy~(abe2)progeny,generating a promising breeding material for improving rice grain quality.

关键词： adenine base editing amylose content(AC) cytosine base editing eating and cooking quality(ECQ) grain appearance rice Wx

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Screening Peptide Inhibitors Using Phage Peptide Library with Isocitrate Lyase in Mycobacterium tuberculosis as Target

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Chemical Research in Chinese Universities 2011年第4期27卷 635-640页

作者： YIN Yu-he niu Xue SUN BO TENG Guo-sheng ZHAO Yun-hui WU Cong-mei College of Chemistry and Life Science Changchun University of Technology Changchun 130012 P. R. China College of Life Science Jilin University Changchun 130012 P. R. China

When devoured by macrophages,Mycobacterium tuberculosis remains persistent in macrophages and gains energy through the glyoxylate bypass to maintain its long-term existence in host cells.Therefore it is possible to stop persistent infections by interdicting the glyoxylate bypass in which the isocitrate lyase（ICL） is the key rate-limiting enzyme and a persistence factor.ICL is the target of anti-TB（TB：tubercular） drugs,which could screen ICL out and effectively inhibit the activity of ICL in Mycobacterium tuberculosis,and because of this,anti-TB drugs can be used to kill persistent Mycobacterium tuberculosis.In this study,the ICL gene of the Mycobacterium tuberculosis H37Rv was cloned successfully and recombinant protein with bioactivity was obtained through the enzyme characteristic appraisal.The specific activity of the recombined ICL is 24μmol·mg-1·min-1.The recombined ICL protein was used as the target,and phages which can specifically combine to ICL were screened in the phage 7 peptide library.According to the results of the ELISA and DNA sequence detection,eventually three 7-peptide chains were synthesized.Then the peptide chains were reacted with ICL,respectively,to detect their inhibitory effects on ICL.The results show that all the three 7-peptide chains possessed varying inhibitory effects on the activity of ICL.This study provided lead compounds for the research and development of new peptide anti-TB drugs.

关键词： Mycobacterium tuberculosis Isocitrate lyase Gene expression Phage peptide library Peptide inhibitor

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基于随机配置网络的非线性系统智能建模方法

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控制与决策 2022年第10期37卷 2559-2564页

作者：陶金梅牛宏张亚军李旭生辽宁石油化工大学理学院辽宁抚顺113001 东北大学流程工业综合自动化国家重点实验室沈阳110004

针对一类非线性离散动态系统,研究非线性系统的智能建模方法.首先,采用带遗忘因子的递推最小二乘法对低阶模型的未知参数进行辨识;然后,对高阶非线性部分采用随机配置网络进行估计;最后,利用两种辨识方法在外部误差准则下对系统进行交... 详细信息

针对一类非线性离散动态系统,研究非线性系统的智能建模方法.首先,采用带遗忘因子的递推最小二乘法对低阶模型的未知参数进行辨识;然后,对高阶非线性部分采用随机配置网络进行估计;最后,利用两种辨识方法在外部误差准则下对系统进行交替辨识,进而提出一种改进的非线性系统交替辨识的智能建模方法.将随机配置网络与递推最小二乘算法相结合,可有效提高非线性系统的辨识精度,并且通过数值仿真实验进行对比分析以验证所提出算法的有效性.

关键词：非线性系统高阶非线性项递推最小二乘法随机配置网络智能建模

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The anisotropy of hexagonal close-packed iron under inner core conditions: the effect of light elements

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Earth and Planetary Physics 2022年第4期6卷 399-423页

作者： Wei Zhang mei Tang ZhenWei niu Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang Sichuan 621010China Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Southwest University of Science and TechnologyMianyang Sichuan 621010China School of National Defense Science&Technology Southwest University of Science and TechnologyMianyang Sichuan 621010China

In recent decades,global seismic observations have identified increasingly complex anisotropy of the Earth’s inner core.Numerous seismic studies have confirmed hemispherical variations in the inner core’s anisotropy.Here,based on ab initio molecular dynamics calculations,we report how the anisotropy of hexagonal close-packed(hcp)-iron,under inner core conditions,could be altered when alloyed with light elements.We find that light elements in binary allows with iron-hcp-Fe-X(X=C,O,Si,and S)-could have significant effects on density,sound velocities,and anisotropy,compared with the behavior of pure hcp-iron;the anisotropy of these binary alloys depends on combined effects of temperature and the particular alloying light element.Furthermore,the change in anisotropy strength with increasing temperature can be charted for each alloy.Alloying pure iron with some light elements such as C or O actually does not increase but decreases core anisotropy at high temperatures.But the light element S can significantly enhance the elastic anisotropy strength of hcp-Fe.

关键词： iron elastic constants anisotropy inner core

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圆柱极化敏感阵列降维插值角度估计方法

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系统工程与电子技术 2023年第9期45卷 2659-2666页

作者：胡毅立赵永波陈胜张梅牛奔西安电子科技大学雷达信号处理全国重点实验室陕西西安710071

圆柱极化敏感阵列可直接利用同一母线上的阵列数据估计目标的俯仰角,但是在估计方位角时面临未知极化的影响。对此,提出一种降维插值方法,解决圆柱极化敏感阵列在未知极化下的二维波达方向(two-dimensional direction-of-arrival,2D-DOA... 详细信息

圆柱极化敏感阵列可直接利用同一母线上的阵列数据估计目标的俯仰角,但是在估计方位角时面临未知极化的影响。对此,提出一种降维插值方法,解决圆柱极化敏感阵列在未知极化下的二维波达方向(two-dimensional direction-of-arrival,2D-DOA)估计问题。首先通过母线阵列的旋转不变性估计俯仰角,然后利用估计的俯仰角降维设计插值方法的感兴趣范围(range of interest,ROI),最后利用降维插值方法得到对应的方位角估计值。圆柱天线阵的每个阵元只需由一个电偶极子构成,有效降低了系统运算负担和阵元间的互耦效应。数值实验验证了所提方法的2D-DOA估计性能。

关键词：圆柱极化敏感阵列插值方法降维感兴趣范围二维波达方向估计

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A study on the catalytic performance of carbide slag in transesterification and the calculation of kinetic parameters

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Science China(Technological Sciences) 2015年第2期58卷 258-265页

作者： LIU Meng Qi niu sheng Li LU Chun mei LI Hui HUO Meng Jia School of Energy and Power Engineering Shandong University

The catalytic performance of carbide slag in transesterification is investigated and the reaction kinetic parameters are calculated.After being activated at 650oC,calcium compounds of carbonate and hydroxide in the carbide slag are mainly transformed into calcium oxide.The activated carbide slag utilized as the transesterification catalyst is characterized by X-ray diffraction(XRD),attenuated total reflectance-Fourier transform infrared spectroscopy(ATR-FTIR),nitrogen adsorption-desorption and the Hammett indicator method.Compared with the carbide slag activated at 700 and 800oC,the largest surface area of 22.63m2 g?1,the smallest particle size of 265.12 nm and the highest catalytic efficiency of the carbide slag activated at 650oC guarantee its capacity in catalyzing transesterification.Then,the influences of activated temperature(Ta),molar ratio of methanol to oil(γ),catalyst added amount(ζ),reaction temperature(Tr)and reaction time(τ)on the catalytic performance are investigated.Under the optimal transesterification condition of Ta=650oC,γ=15,ζ=3%,Tr=60oC andτ=110 min,the catalytic efficiency of 92.98%can be achieved.Finally,the kinetic parameters of transesterification catalyzed by the activated carbide slag are calculated,where activation energy(E)is 68.45 k J mol?1 and pre-exponential factor(k0)is 1.75×109 min?1.The activated carbide slag shows better reused property than calcium hydroxide.

关键词：反应动力学参数催化性能电石渣计算傅里叶变换红外光谱 ATR-FTIR 催化剂性能催化效率

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Sodium current kinetics of transitional myocytes in Koch triangle of rabbit hearts

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Chinese Medical Journal 2008年第21期121卷 2185-2191页

作者： REN Fu-xian niu Xiao-lin OU Yan XIE Song-mei LING Feng-dong ZHOU Shi-sheng LI Ya-jie Department of Cardiology Second Hospital Xi'an Jiaotong University Xi'an Shaanxi 710004 China Key Laboratory of Environment and Genes Related to Diseases Ministry of Education Xi'an Shaanxi 710061 China Department of Anatomy Xi'an Jiaotong University School of Medicine Xi'an Shaanxi 710061 China Institute of Basic Medical Science Dalian University School of Medicine Dalian Liaoning 116622 China

Background Few studies have explored the inward sodium current （INa） kinetics of transitional cardiomyocytes. This study aimed to explore the kinetics of transitional cardiomyocytes types α and β. Methods The whole-cell patch clamp technique was used to study the rapid INa of isolated transitional cardiomyocytes in the Koch triangle of rabbit hearts. Results Maximal amplitude and density of INa in type a and type β was （-1627±288） pA （α）, （-35.17±6.56） pA/pF （β） and （-3845±467） pA （α）, （-65.64±10.23） pA/pF （β）（P 〈0.05）. Steady state activation curves of INa, fitted to a Boltzmann distribution for both types, were sigmoid in shape. Half activation voltage and slope factors did not significantly differ between types at （-43.46±0.85） mV （α）, （-41.39±0.47） mV （β） or （9.04±0.66） mV （α）, （11.08±0.89） mV （β）. Steady state inactivation curves of INa, fitted to a Boltzmann distribution in both types were inverse ＂S＂ shape. Half inactivation voltage and slope factors were （-109.9±0.62） mV （α）, （-107.5±0.49） mV （β） and （11.78±0.36） mV （α）, （11.57±0.27） mV （β）, （P〉0.05）, but time constants of inactivation were significantly different at （1.10±0.19） mV （α） and （2.37±0.33） ms （β）, （P 〈0.05）. Time constants of recovery from inactivation of INa for both types were （122.16±27.43） mV （α） and （103.84±2.8.97） ms （β）（P 〈0.05）. Conclusions Transitional cardiomyocytes in rabbit hearts show a heterogeneous, voltage gated and time dependent fast inward sodium current. Types α and β show the features of INa similar to those in slow- and fast-response myocytes, with probably better automaticity and conductivity, respectively.

关键词： sodium current transitional myocyte Koch triangle tachycardia

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亚临界水条件下废旧涤棉混纺织物的分离

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精细化工 2018年第9期35卷 1548-1554,1561页

作者：张美玲史晟侯文生张博楠凌晨王淑花牛梅太原理工大学轻纺工程学院山西晋中030600 山西瑞赛格纺织科技有限公司山西晋中030600

利用棉纤维和涤纶不同的耐酸性，结合亚临界水的特性，采用水热法对废旧涤棉混纺织物的分离回收进行了考察。以m（涤纶）：m（棉）=1：4的废旧涤棉织物为考察对象，HCl为催化剂，研究了水热温度、反应时间及HCl质量分数对分离过程的影... 详细信息

利用棉纤维和涤纶不同的耐酸性，结合亚临界水的特性，采用水热法对废旧涤棉混纺织物的分离回收进行了考察。以m（涤纶）：m（棉）=1：4的废旧涤棉织物为考察对象，HCl为催化剂，研究了水热温度、反应时间及HCl质量分数对分离过程的影响，并利用FTIR、XRD、SEM、HPLC及DSC对水热反应前后产物的物化性能进行了表征。结果表明：在水热温度150℃、反应时间3h、w（HCl）=1．5％的水解条件下，混纺织物中棉纤维一部分水解形成固体纤维素粉末，产率约为48．21％；其余水解生成水溶性糖类物质，其中葡萄糖质量分数为15．57％；水热处理后的涤纶纱线回收率高达96．24％，断裂强度约降低3％。含有水溶性糖类的水解液可循环使用5次。

关键词：废旧涤棉织物水热反应分离水解回收再利用

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亚临界水中废旧聚对苯二甲酸乙二醇酯的水解

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精细化工 2015年第2期32卷 126-132页

作者：牛振怀侯文生史晟陈旭红牛梅太原理工大学轻纺工程学院山西榆次030600 太原理工大学材料科学与工程学院山西太原030024

从聚对苯二甲酸乙二醇酯(PET)的化学结构着手,结合亚临界水的特殊性质,采用水热法使PET在中性条件下水解为对苯二甲酸(TPA)和乙二醇(EG)。通过考察投料比、反应时间和反应温度对PET降解率及TPA产率的影响,确定了最佳水解条件为:投料比(... 详细信息

从聚对苯二甲酸乙二醇酯(PET)的化学结构着手,结合亚临界水的特殊性质,采用水热法使PET在中性条件下水解为对苯二甲酸(TPA)和乙二醇(EG)。通过考察投料比、反应时间和反应温度对PET降解率及TPA产率的影响,确定了最佳水解条件为:投料比(去离子水与涤纶布料质量比)10,温度250℃,反应时间7 h。在最佳条件下,PET的降解率可以达到92.9%,TPA的产率为86.4%,TPA纯度为98.251%,TPA的酸度为657.14 mg KOH/g。且研究发现醋酸锌可以加速PET的水解,并对PET在亚临界水条件下的水解机理进行了初步探索。

关键词：亚临界水废旧聚对苯二甲酸乙二醇酯对苯二甲酸乙二醇功能材料

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