检索结果-南通市图书馆

Chinese Journal of Structural Chemistry 2007年第3期26卷 295-298页

作者： WANG mei MA Cheng-Bing WANG Hui-sheng CHEN Chang-Neng liu Qiu-Tian State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

The title compound, [Mn4O2（O2CMe）6（MeOH）2（dbm）2]·2MeCOOH·2CH2Cl2 （Hdbm = dibenzoylmethane）, has been synthesized and structurally determined by single-crystal X-ray diffraction. The crystal belongs to triclinic, space group P/, with a = 10.729（3）, b = 12.269（3）, c = 13.085（4） A, a = 106.367（3）,β = 107.643（2）, γ = 94.771（2）°, V = 1547.9（7） A^3, Z = 1, C50H64Cl4Mn4O24, Mr= 1410.57, Dc= 1.513 g/cm^3, F（000） = 724, Rint = 0.0147, T= 293（2） K and p = 1.046 mm ^-1. The final R = 0.0359 and wR = 0.0938 for 5791 observed reflections with 1 〉 2σ（/）. The structure of the complex consists of one [Mn4（μ3-O）2]^8＋ core with four coplanar Mn atoms disposed in an extended ＂butterfly-like＂ arrangement and two O atoms triply bridging each ＂wing＂, and the peripheral ligation is provided by six by-MeCO2^-, two terminal ,μ2-dbm- groups at the two ends of the molecule, and two MeOH molecules on the central Mn atoms, lntermolecular O…H-O hydrogen bonding interactions are found within the structure of the compound.

关键词： manganese crystal structure photosystem Ⅱ hydrogen bonding

1^H NMR-based metabolomics approach to investigating the renal protective effects of Genipin in diabetic rats

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2018年第4期16卷 261-270页

作者： TIAN Jun-sheng ZHAO Lei SHEN Xiao-Li liu Huan QIN Xue-mei Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China College of Chemistry and Chemical Engineering of Shanxi University Taiyuan 030006China

Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studies have revealed that genipin can not only improve diabetes, but also induce cytotoxicity. Therefore, it is not clear which effect of genipin on kidneys occurs, when it is used in the treatment of diabetes. In the present study, we performed nuclear magnetic resonance(NMR)-based metabolomics analysis of urine and kidney tissue samples obtained from diabetic rats to explore the change of endogenous metabolites associated with diabetes and concomitant kidney disease. Nine significant differential metabolites that were closely related to renal function were screened. They were mainly related to three metabolic pathways: synthesis and degradation of ketone bodies, glycine, serine and threonine metabolism, and butanoate metabolism, which are involved in methylamine metabolism, energy metabolism and amino acid metabolism. In addition, after the intervention of genipin, the metabolic levels of all the metabolites tended to be normal, indicating a protective effect of genipin on kidneys. Our results may be helpful for understanding the antidiabetic effect of genipin.

关键词： Diabetes Diabetic nephropathy Genipin Protection Metabolomics

Syntheses and Structures of Two Novel Salicylate-containing Mononuclear Manganese Complexes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2007年第8期26卷 920-923页

作者： WANG Hui-sheng MA Cheng-Bing WANG mei CHEN Chang-Neng liu Qiu-Tian State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Two salicylate containing mononuclear manganese complexes formulated as [Mnand characterized by elemental analysis, IR and single-crystal X-ray diffraction analyses. Crystal data for compound 1： monoclinic, space group C2/c, a=30.748（6）, b=8.1933（13）, c=21.137（4） A, β=126.772（4）°, V=4265.5（13）A^3, Z=8, Mr=471.34, Dc=1.468 g/cm^3, μ=0.667 mm^-1, F（000）=1952,the final R=0.0637, wR=0.1783 （I 〉 2σ（I）） and GOOF=1.073; and those for compound 2： monoclinic,space group C2/c, a=14.505（5）, b=11.048（4）, c=20.711 （7）（A）, β=103.603（6）°, V=3225.6 （18）A^3, Z=4, Mr=668.65, Dc=1.377 g/cm^3, μ=0.466 mm^-1, F（000）=1416, the final R=0.0373, wR=0.1125 （I 〉2σ（I））, and GOOF=1.000. The Mn atoms of both complexes are six-coordinated in an axially elongated octahedral geometry for 1 and an axially compressed octahedral geometry for 2, and their oxidation states have been determined to be trivalent by bond valence sum calculation.

关键词： Mn(Ⅲ) salicylate crystal structure axially compressed octahedral geometry

Performance of Three Adelphocoris spp.(Hemiptera: Miridae) on Flowering and Non-flowering Cotton and Alfalfa

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2014年第8期13卷 1727-1735页

作者： GAO Zhen PAN Hong-sheng liu Bing LU Yan-hui LIANG Ge-mei State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences

The genus Adelphocoris（Hemiptera： Miridae） is a group of key insect pests in cotton fields in China that includes three dominant species： A. suturalis（Jakovlev）, A. lineolatus（Goeze） and A. fasciaticollis（Reuter）. Previous field surveys have found that adults of these Adelphocoris species usually move onto specific host plants when the plants enter the flowering stage. To determine the potential trade-offs for this host-plant preference behavior, the performance of these three Adelphocoris spp. on flowering and non-flowering cotton and alfalfa were compared in the laboratory. The results showed that Adelphocoris spp. had significantly higher nymphal developmental and survival rates, along with increased adult longevity and fecundity on flowering cotton and alfalfa than on non-flowering plants of either species. In addition, compared with cotton plants, alfalfa generally promoted better performance of these three Adelphocoris species, especially for A. lineolatus. Simple correlation analysis indicated that female adult longevity was positively correlated to male adult longevity and female fecundity, and female fecundity was positively correlated to nymphal development and survival rates. This study demonstrated a positive correlation between adult preference and offspring/adult performance for all three Adelphocoris species, with no evidence of any trade-offs for this preference for flowering host plants. These findings support the hypothesis that hemimetabolous insects such as mirid bugs have positive adult preference-adult/nymphal performance relationships, which is likely due to the similar feeding habits and nutritional requirements of adults and nymphs.

关键词： Adelphocoris lineolatus Adelphocoris suturalis Adelphocoris fasciaticollis preference-performance relationship cotton alfalfa flowering stage

A nanoplatform self-assembled by coordination delivers siRNA for lung cancer therapy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2023年第5期42卷 1483-1493页

作者： Zi-Yao Wang Jie mei Dong-Qi Ni sheng-mei Li Jin-Min Ye Shi-Lin Li Ya-Ling Wang Ying liu CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing100190China University of Chinese Academy of Sciences Beijing100049China GBA National Institute for Nanotechnology Innovation Guangzhou510700China

The high incidence and mortality of lung cancer have present threaten in front of people all over the *** in clinical trials find that mutations of some genes influence progress of lung cancer directly or indirectly,therefore,some kinds of molecular inhibitors benefit patients in clinical therapy,which helpfully prolong survival time of patients and show great potential in lung cancer *** is a kind of nucleic acid molecules which can silence targeted gene translation through binding to mRNA completely to cure *** delivery of siRNA for cancer therapy mostly can be classified into loading through electrostatic interaction,physical surrounding,and chemically *** delivering siRNA by coordination has not been *** study unprecedently utilizes the coordination between siRNA and Fe^(2+)to form a self-assembly structure in which doxorobicin(DOX) and human serum albumin(HSA) were used to stabilize the whole nanoplatform followed polyethylenimine(PEI) *** the heat incubation strategy,highly loading efficiency for siRNA and DOX was *** nanoplatform with stability and sustain release of drugs exhibited good lysosome escape,gene silencing effect and cytotoxicity which provided new horizon for co-deli very of siRNA and other molecular or protein drugs.

关键词： Lung cancer siRNA Coordination Nanoparticles Drug delivery

Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第10期14卷 1450-1467页

作者： Feifei Li Youyang Shi mei Ma Xiaojuan Yang Xiaosong Chen Ying Xie sheng liu Department of Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200030China Institute of Chinese Traditional Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200030China Institute of Toxicology School of Public HealthLanzhou UniversityLanzhou730000China Department of General Surgery Comprehensive Breast Health CenterRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200001China

Trastuzumab has improved survival rates in human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC),but drug resistance leads to treatment *** killer(NK)cell-mediated antibody-dependent cell cytotoxicity(ADCC)represents an essential antitumor immune mechanism of *** Chinese medicine(TCM)has been used for centuries to treat diseases because of its capacity to improve immune *** Lianxia formula(XLLXF),based on the principle of“strengthening body and eliminating toxin”,exhibits a synergistic effect in the trastuzumab treatment of patients with HER2-positive ***,this synergistic effect of XLLXF was executed by enhancing NK cells and ADCC,as demonstrated through in vitro co-culture of NK cells and BC cells and in vivo intervention ***,the augmented impact of XLLXF on NK cells is linked to a decrease in cytokine inducible Src homology 2(SH2)containing protein(CISH)expression,which in turn activates the Janus kinase 1(JAK1)/signal transducer and activator of transcription 5(STAT5)***,these findings suggested that XLLXF holds promise for enhancing NK cell function and sensitizing patients with HER2-positive BC to trastuzumab.

关键词： HER2-positive breast cancer Traditional chinese medicine Trastuzumab NK cell ADCC effect

Effects of loose deposits on debris flow processes in the Aizi Valley, southwest China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2020年第1期17卷 156-172页

作者： liu mei ZHANG Yong TIAN Shu-feng CHEN Ning-sheng MAHFUZR Rahman JAVED Iqba Key Lab of Mountain Hazards and Surface Processes Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China Department of Civil Engineering International University of Business Agriculture and TechnologyDhaka 1230Bangladesh Department of geology The university ofHaripurHaripur 22620Pakistan

Loose deposits, rainfall and topography are three key factors that triggering debris ***, few studies have investigated the effects of loose deposits on the whole debris flow *** June 28, 2012, a catastrophic debris flow occurred in the Aizi Valley, resulting in 40 *** Aizi Valley is located in the Lower Jinsha River,southwestern Sichuan Province, China. The Aizi Valley debris flow has been selected as a case for addressing loose deposits effects on the whole debris flow process through remote sensing, field investigation and field experiments. Remote sensing interpretation and laboratory experiments were used to obtain the distribution and characteristics of the loose deposits, respectively. A field experiment was conducted to explore the mechanics of slope debris flows, and another field investigation was conducted to obtain the processes of debris flow formation, movement and amplification. The results showed that loose deposits preparation, slope debris flow initiation,gully debris flow confluence and valley debris flow amplification were dominated by the loose *** droughts and earthquake activities may have increased the potential for loose soil sources in the Aizi Valley, which laid the foundation for debris flow formation. Slope debris flow initiated under rainfall, and the increase in the water content as well as the pore water pressure of the loose deposits were the key factors affecting slope failure. The nine gully debris flows converged in the valley, and the peak discharge was amplified 3.3 times due to a blockage and outburst caused by a large boulder. The results may help in predicting and assessing regional debris flows in dry-hot and seismic-prone areas based on loose deposits, especially considering large boulders.

关键词： Aizi Valley Loose deposits Debris flow process Slope debris flow Boulder blockage Discharge amplification

Active flow control of S-duct by plasma synthetic jet

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第8期23卷 652-668页

作者： Ru-bing liu Xiao-yin mei sheng-hui XUE Yu-wen LU Zhe-zhe SU Qi LIN School of Aerospace Engineering Xiamen UniversityXiamen 361102China Fujian Key Laboratoryof Plasmaand Magnetic ResonanceResearch Xiamen 361102China

Flow separation and secondary flow in the S-duct of an aircraft engine cause severe pressure loss and airflow distortion at the outlet,lowering engine ***,a serial two-electrode plasma synthetic jet(PSJ)actuator array is used to actively control the flow field in the duct and improve its *** results show that the PSJ significantly increases the wall pressure recovery coefficient,suppresses flow separation,and improves the outlet pressure *** primary and secondary orders of the influencing factors are as follows:control position>jet momentum coefficient>excitation frequency>jet *** best jet control position is near the separation location,and the best jet configuration is the‘Λ’*** higher the jet momentum coefficient and excitation frequency,the better the flow *** wall pressure coefficient increases by up to 127.8%,and the outlet steady pressure distortion index decreases by 9.15%.The control mechanism is the direct energy injection into the flow boundary layer through a high-speed jet and the indirect control effect of the induced streamwise *** the one hand,the PSJ suppresses flow separation by improving the ability of the boundary layer to resist the inverse pressure *** the other hand,it reduces pressure distortion by decreasing the intensity of the secondary flow and weakening the *** study thus provides a new technology for the active control of the flow-field characteristics in an S-duct and has significance for guiding the application of synthetic jet technology in S-ducts.

关键词： S-duct Flow control Plasma synthetic jet(PSJ) Flow separation Pressure distortion

Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2022年第9期40卷 1120-1128页

作者： mei-Yu Jiang Jia-sheng Wu Wei-Min liu Hao-Hui Ren Xin Wang Peng-Fei Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer ***-targeted sonodynamic therapy(SDT)can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven ***,we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting,which constituted a nano sonosensitizer(T-cRGD NPs)for fluorescence imaging-guided sonodynamic therapy.A comparable sonosensitizer(T-PEG NPs)without the targeting unit was also prepared for illustration of therapeutic *** to the role of peptide targeting,T-cRGD NPs can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than T-PEG NPs in *** imaging in vivo reveals that T-cRGD NPs can enrich in tumor tissues within 14 h with a good biocompatibility.

关键词： Sonodynamic therapy Glioma Cyclic peptide Target enrichment Deep penetration

Preparation and Characterization of Multi-layer Poly(arylene sulfide sulfone) Nanofibers Membranes for Liquid Filtration

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2019年第12期37卷 1248-1256,I0006页

作者： Zhen-Yan liu Zhi-mei Wei Xiao-Jun Wang Gang Zhang sheng-Ru Long Jie Yang College of Polymer Science and Engineering Sichuan UniversityChengdu 610065China Analytical&Testing Center Sichuan UniversityChengdu 610064China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Owing to the excellent filtration performance and low energy cost,polymeric nanofibers microfiltration(MF)membranes have attracted increasing ***(arylene sulfide sulfone)(PASS),as one of the structurally modified polymers based on poly-(phenylene sulfide)(PPS),has been selected as the raw material to fabricate nanofibers MF membranes via electrospun *** effects of PASS solution and the electrospinning processing parameters on the structural morphology of nanofibers were investigated in *** average diameter of PASS nanofibers was(296±46)nm under the optimal condition:polymer concentration of 0.27 g·m L^–1 PASS/DMI,applied voltage of 20 kV,and speed of collector drum of 300 r·min^–*** then the multi-layer PASS nanofibers MF membranes were fabricated from cold-pressing the optimized PASS nanofibers(as-prepared PASS nanofibers)*** morphology,porosity,pore size,mechanical properties,and surface wettability of the multi-layer PASS nanofibers MF membranes could be tuned by the layers of as-prepared nanofibers *** results demonstrated that the membrane with 6 layers(marked as PASS-6)exhibited the smallest porosity,smallest pore size,highest mechanical property,and best surface ***,the multi-layer PASS nanofibers MF membranes showed that the rejection ratio gradually increased,while the pure water flux decreased with increasing membranes *** PASS-6 membrane exhibited large water flux of 747.76 L·m^–2·h^–1 and high separation efficiency of 99.9%to 0.2μm particles,making it a promising candidate for microfilter.

关键词： Poly(arylene sulfide sulfone) Electrospinning Nanofibers membranes Microfiltration