检索结果-南通市图书馆

Machine learning prediction model for gray-level co-occurrence matrix features of synchronous liver metastasis in colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1571-1581页

作者： Kai-feng Yang sheng-jie Li Jun Xu Yong-Bin Zheng Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichang Central People’s HospitalYichang 443008Hubei ProvinceChina

BACKGROUND Synchronous liver metastasis(SLM)is a significant contributor to morbidity in colorectal cancer(CRC).There are no effective predictive device integration algorithms to predict adverse SLM events during the diagnosis of *** To explore the risk factors for SLM in CRC and construct a visual prediction model based on gray-level co-occurrence matrix(GLCM)features collected from magnetic resonance imaging(MRI).METHODS Our study retrospectively enrolled 392 patients with CRC from Yichang Central People’s Hospital from January 2015 to May *** were randomly divided into a training and validation group(3:7).The clinical parameters and GLCM features extracted from MRI were included as candidate *** prediction model was constructed using a generalized linear regression model,random forest model(RFM),and artificial neural network *** operating characteristic curves and decision curves were used to evaluate the prediction *** Among the 392 patients,48 had SLM(12.24%).We obtained fourteen GLCM imaging data for variable screening of SLM prediction *** difference,mean sum,sum entropy,sum variance,sum of squares,energy,and difference variance were listed as candidate variables,and the prediction efficiency(area under the curve)of the subsequent RFM in the training set and internal validation set was 0.917[95%confidence interval(95%CI):0.866-0.968]and 0.09(95%CI:0.858-0.960),*** A predictive model combining GLCM image features with machine learning can predict SLM in *** model can assist clinicians in making timely and personalized clinical decisions.

关键词： Colorectal cancer Synchronous liver metastasis Gray-level co-occurrence matrix Machine learning algorithm Prediction model

In-situ growth of MIL-53(Fe)on charcoal sponge as a highly efficient and recyclable photocatalyst for removal of Cr(Ⅵ)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4344-4355页

作者： Zhuo-Fan Yu Ye Yang Hai-feng Zhuang sheng-Dao Shan Mihail-Simion Beldean-Galea Qing-Quan Xue Xiao-feng Shen Shi-jie Li Key Laboratory of Recycling and Eco-Treatment of Waste Biomass of Zhejiang Province School of Environmental and Natural ResourcesZhejiang University of Science and TechnologyHangzhou 310023China Faculty of Environmental Science and Engineering Babes-Bolyai University400294 Cluj-NapocaRomania Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province Interdisciplinary Research Academy(IRA)Zhejiang Shuren UniversityHangzhou 310015China National Engineering Research Center for Marine Aquaculture Institute of Innovation&ApplicationZhejiang Ocean UniversityZhoushan 316022China

The application of metalDorganic frameworks(MOFs)is hindered by several crucial factors,including low photocatalytic efficiency,poor stability and challenges in *** this study,MIL-53(Fe)was grown in situ on a charcoal sponge(CS)with a large surface area,excellent mechanical properties,and high photocatalytic efficiency using a solvothermal method,thus addressing the above-mentioned shortcomings of MOF ***,CS/MIL-53(Fe)has an amazing light-harvesting capacity in the visible range,leading to a significant improvement in the utilization of *** results of the experiments indicate that CS/MIL-53(Fe)displays a higher photocatalytic activity(87%Cr(Ⅵ))when exposed to visible light than CS(58%)or MIL-53(Fe)(27%),attributing to the increased separation of photogenerated carriers.e-is the main reactive radical and dominates the photocatalytic reduction process,rooting from that e-can reduce Cr(Ⅵ)to low-toxicity Cr(Ⅲ).This study presents a novel method for constructing photocatalysts with large surface areas,superior mechanical characteristics,and enhanced photocatalytic ***,it achieves the resource utilization of agricultural and forestry waste.

关键词： Cr(Ⅵ) Charcoal sponge MIL-53(Fe) Photocatalysis Light absorption

Precisely modulating covalent and coordination bonds in the porous network for highly selective metal ion extraction

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第4期67卷 1039-1040页

作者： jie Li Xiao feng Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster ScienceMinistry of EducationAdvanced Technology Research Institute(Jinan)Frontiers Science Center for High Energy MaterialSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Scandium(Sc)is recognized as a“strategic”and“critical”element by several countries,including the *** Russia,owing to its wide range of applications in high-tech fields such as superconductivity,alloys,lasers,nucle... 详细信息

关键词： alloys coordination network

Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI jie CHEN Ya-feng GAO Lei LI Yi-jie feng Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(P<0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao sheng feng Liu Wei Liu Peng Zhao Feifei Lv jie Sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Fully sprayed MXene-based high-performance flexible piezoresistive sensor for image recognition

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Materials Science 2024年第1期6卷 77-85页

作者： Zhi-Dong Zhang Xue-feng Zhao Qing-Chao Zhang jie Liang Hui-Nan Zhang Tian-sheng Zhang Chen-Yang Xue Key Laboratory of Instrumentation Science&Dynamic Measurement of Ministry of Education North University of ChinaTaiyuan030051People's Republic of China State Key Laboratory of ASIC and System Shanghai Institute of Intelligent Electronics&SystemsSchool of MicroelectronicsFudan UniversityShanghai200433People's Republic of China Shanxi Hosipital of Acupuncture and Moxibustion Taiyuan030006People's Republic of China

High-performance flexible pressure sensors provide comprehensive tactile perception and are applied in human activity monitoring,soft robotics,medical treatment,and human-computer ***,these flexible pressure sensors require extensive nano-architectural design and complicated manufacturing and are ***,a highly sensitive,flexible piezoresistive tactile sensor is designed and fabricated,consisting of three main parts:the randomly distributed microstructure on T-ZnOw/PDMS film as a top substrate,multilayer Ti_(3)C_(2)-MXene film as an intermediate conductive filler,and the few-layer Ti_(3)C_(2)-MXene nanosheetbased interdigital electrodes as the bottom *** MXene-based piezoresistive sensor with randomly distributed microstructure exhibits a high sensitivity over a broad pressure range(less than 10 kPa for 175 kPa^(-1))and possesses an out-standing permanence of up to 5000 ***,a 16-pixel sensor array is designed,and its potential applications in visualizing pressure distribution and an example of tactile feedback are *** fully sprayed MXene-based pressure sensor,with high sensitivity and excellent durability,can be widely used in,electronic skin,intelligent robots,and many other emerging technologies.

关键词： Piezoresistive sensor Ti_(3)C_(2)-MXene T-ZnOw/PDMS film Randomly distributed microstructure

Al-doped ZnO/WO_(3) heterostructure films prepared by magnetron sputtering for isopropanol sensors

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第1期43卷 247-256页

作者： Wei-Xiang Gao Xue-Ting Chang Xiao-jie Zhu Jun-feng Li Ying-Chang Jiang Dong-sheng Wang Chuan-Xiao Yang Shi-Bin Sun College of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China Institute of Logistics Science and Engineering Shanghai Maritime UniversityShanghai 201306China

Metal oxide semiconductors(MOSs) are ideal sensing materials for detecting volatile organic compounds due to their low cost, diversity, high stability, and ease of production. However, it remains a grand challenge to develop the MOSs-based gas sensors for sensing isopropanol with desired performance via a simple, effective,and controllable method. Herein, we reported the preparation of the Al-doped Zn O(AZO)/WO_(3) heterostructure films by directly depositing the AZO coating onto the WO_(3) coating using a strategy of magnetron sputtering. The AZO/WO_(3) heterostructure films were constructed by numbers of irregular nanoparticles that were interconnected with each other. The AZO/WO_(3) heterostructure films-based gas sensors exhibited excellent isopropanolsensing performance with high response, promising selectivity, low detection limit, fast response rate, wide detection range, and ideal reproducibility. The promising isopropanol-sensing performance of the AZO/WO_(3) heterostructure films arises mainly from their high uniformity, unique microstructures with high surface roughness,and the construction of the heterostructure between the AZO and WO_(3) coatings. This work provides a versatile approach to prepare the MOSs-based heterostructure films for assembling the gas sensors.

关键词： Metal oxide semiconductors Gas sensors Aldoped ZnO/WO_(3) Heterostructure films Isopropanol Magnetron sputtering

Optimizing extractants selection for efficient separation of phenols and nitrogen-containing heteroaromatics using hydrogen bond interaction strategies

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第4期68卷 43-52页

作者： Pengzhi Bei Rui Zhang jie feng Antony Rajendran Wenying Li State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024China Department of Chemistry Mepco Schlenk Engineering College(Autonomous)Sivakasi 626005India

Focusing on the use of imidazolium ionic liquids and quaternary ammonium salts-based deep eutectic solvents for the separation of phenols and nitrogen-containing heteroaromatics,the role of heteroaromatics as specific sites for hydrogen bond-based separation has been *** environmentally friendly solvents are known for their ability to form hydrogen bonds with heteroatoms,a key aspect in separation *** quantified the hydrogen bond interaction energy to reach the threshold energy for efficient O-and N-heteroaromatics *** article provides an in-depth study of the structural nuances of different hydrogen bonding sites and their affinity properties while conducting a comparative evaluation of the separation efficiency of ionic liquids and deep eutectic solvents from a thermodynamic *** showed that phenols with dual hydrogen bonding recognition sites were easier to separate than nitrogen-containing *** ionic liquids were more suitable for the extraction of nonbasic nitrogen-containing heteroaromatics,and quaternary ammonium salts-based deep eutectic solvents are more effective for phenols and basic nitrogen-containing heteroaromatics,which was confirmed by Fourier transform infrared spectroscopy and empirical ***,this study provides a theoretical basis for the strategy design and selection of extractants for the efficient separation of O-and N-containing aromatic compounds.

关键词： Deep eutectic solvents Hydrogen bond Ionic liquids Separation Solvents Structural characteristics

Development of a clinical nomogram for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第2期16卷 396-408页

作者： Bing Liu Yu-jie Xu feng-Ran Chu Guang Sun Guo-Dong Zhao sheng-Zhong Wang Department of Gastrointestinal Surgery Central South University Xiangya School of Medicine Affiliated Haikou HospitalHaikou 570208Hainan ProvinceChina Clinical College Hainan Medical UniversityHaikou 571199Hainan ProvinceChina

BACKGROUND The efficacy of neoadjuvant chemotherapy(NAC)in advanced gastric cancer(GC)is still a controversial *** To find factors associated with chemosensitivity to NAC treatment and to provide the optimal therapeutic strategies for GC patients receiving *** The clinical information was collected from 230 GC patients who received NAC treatment at the Central South University Xiangya School of Medicine Affiliated Haikou Hospital from January 2016 to December *** absolute shrinkage and selection operator logistic regression analysis was used to find the possible predictors.A nomogram model was employed to predict the response to *** In total 230 patients were finally included in this study,including 154 males(67.0%)and 76 females(33.0%).The mean age was(59.37±10.60)years,ranging from 24 years to 80 *** to the tumor regression grade standard,there were 95 cases in the obvious response group(grade 0 or grade 1)and 135 cases in the poor response group(grade 2 or grade 3).The obvious response rate was 41.3%.Least absolute shrinkage and selection operator analysis showed that four risk factors significantly related to the efficacy of NAC were tumor location(P<0.001),histological differentiation(P=0.001),clinical T stage(P=0.008),and carbohydrate antigen 724(P=0.008).The C-index for the prediction nomogram was *** calibration curve revealed that the predicted value exhibited good agreement with the actual *** curve analysis showed that the nomogram had a good value in clinical *** A nomogram combining tumor location,histological differentiation,clinical T stage,and carbohydrate antigen 724 showed satisfactory predictive power to the response of NAC and can be used by gastrointestinal surgeons to determine the optimal treatment strategies for advanced GC patients.

关键词： Advanced gastric cancer Predictor Neoadjuvant chemotherapy Nomogram Tumor regression grade