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Influence of Gravity on Structure of Colloidal Crystal Using Simulated Microgravity

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Chinese Journal of Chemical Physics 2009年第1期22卷 41-45页

作者： Lei Liu Jie Wang sheng-hua xu Zhi-wei Sun Jing-tong Wang . National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences BerlinE 100190 China Department of Physics Southern University and A&M College Baton Rouge LA 70813 USA

Liquid mixtures of water and deuterium oxide as the liquid phase, were used to match the density of charged colloidal particles. Kossel diffraction method was used to detect the crystal structures. The experiments under the density-matched （g=0） and unmatched （g=1） conditions are compared to examine the influence of gravity on the crystal structures formed by self-assembly of 110 nm （in diameter） polystyrene microspheres. The result shows that the gravity tends to make the lattice constants of colloidal crystals smaller at lower positions, which indicates that the effect of gravity should be taken into account in the study of the colloidal crystals.

关键词： Colloidal crystal Microgravity Density-match Lattice constant

Angiotensin II stimulates phosphorylation of 4E-binding protein 1 and p70 S6 kinase in cultured vascular smooth muscle cells

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Acta Pharmacologica Sinica 2004年第5期25卷 51-54页

作者： Na LI1, Ke-gui WU, Xiang-yu WANG, Liang-di XIE, Chang-sheng xu, hua-jun WANGHypertension Institute, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China Hypertension Institute First Affiliated Hospital Fujian Medical University Fuzhou 350005

AIM: To examine the regulatory effects of angiotensin II (Ang II) on the phosphorylation of 4E-binding protein 1(4E-BP1) and p70 S6 kinase in cultured vascular smooth muscle cells (VSMC), and the contribution ofphosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathway in this process. METHODS: VSMCobtained from rat thoracic aortas were cultured. The phosphorylation of 4E-BP1 and p70 S6 kinase was detectedby immunoblotting. RESULTS: Ang II significantly increased the phosphorylation of 4E-BP1 and p70 S6 kinase,with the peaks occurring at, respectively, 10 min and 30 min, after stimulation with Ang II. The stimulatory effectof Ang II on 4E-BP1 and p70 S6 kinase phosphorylation was abrogated by Ang II type 1 receptor (AT1 receptor)antagonist losartan, and suppressed by PI3K inhibitor LY294002 in a concentration-dependent ***: Ang II treatment of VSMC induces the phosphorylation of 4E-BP1 and p70 S6 kinase via AT1receptor, and PI3K signaling pathway is involved in this process.

关键词： angiotensin II 4E-binding protein 1 p70 S6 kinase phosphatidylinositol 3-kinase vascular smoothmuscle

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao sheng-Lan xu hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Location of the Protein of RSG6,a Predominantly Expressed Gene in Rice Sperm Cells

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Wuhan University Journal of Natural Sciences 2004年第3期9卷 375-380页

作者： LanLi-qiong Miaochen Zengyu Wangsheng-hua xuying TangLin BAIYu ChenFang CollegeofLifeSciences SichuanUniversityChengdu610064SichuanChina

Using Western blot and immunohistochemistry analysis, here the localization ofRSG6 protein was determined in various tissues of rice. Western blot showed only a weak signal in mature pollen. Nevertheless, according to the result of immunohistochemistry with DAB and fluorescent staining, the expression ofRSG6 protein appeared to begin at the bicellular microspore stage, and then keep activity in the sperm cells of mature pollens. The fluorescence pattern showedRSG6 polypeptide was present close to or attached to the surface of the isolated sperm cells. And this suggested thatRSG6 might take an important part in the process of recognition of sperm cell and ovum. Key words Western blot - immunohistochemistry - location - protein - RSG6 - rice CLC number Q 939.91 Foundation item: Supported by the National Natural Science Foundation of China (30270090); the Doctoral Foundation of the Ministry of Education (98061001) and the Key Project of Natural Science Foundation of Sichuan Province.Biography: Lan Li-qiong (1967-) female, Ph. D; research direction: plant developmental biology and reproductive engineering.

关键词： Western blot immunohistochemistry location protein RSG6 rice

A NEW FINITE DIFFERENCE SCHEME FOR 2-D FLOWS AT LARGE Re

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Journal of Hydrodynamics 1998年第2期10卷 60-73页

作者： Liao hua-sheng, xu Wei-linState Key Hydraulics laboratory of Hiqh Speed Flaws Sichuan Union University,Chengdu 610065, P. R. China

Based on the conventional ADI method and SOR method for solving the Navier-Stokes equations, averaging those linkage terms which also are the terms of varying coefficients of the equations, a new finite difference scheme-Averaging Finite Difference (AFD) scheme for 2-D flows was proposed. A 2-D driven cavity flow was calculated numerically as an example with the presented scheme at Re=100, 1000, 2000, 3200, 10000. The results were discussed and compared to those obtained with the conventional methods as well as experimental data. It showed that a slight change of the approximation pattern of the conventional scheme in the terms of varying-coefficients of the governing e-quations seems to have an obvious influence on the solutions at high Re which will be erroneous if the conventional schemes was employed.

关键词： finite difference scheme large Reynolds number averaging finite difference scheme cavity flow

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第1期68卷 337-349页

作者： Meiyun xu Song Gu Fulong Chen Zhe Zhao Peng Liu Daoben hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

关键词： quaternized polymer networks adsorption pertechnetate iodide liquid radioactive streams

pH值响应性毒死蜱/铜席夫碱配合物改性SBA-15的制备及缓释性能

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无机化学学报 2017年第3期33卷 446-454页

作者：林粤顺周红军周新华龚圣徐华陈铧耀仲恺农业工程学院化学化工学院广州市农用化学品高效利用重点实验室广州510225

以3-氨丙基三乙氧基硅烷(APTES)、水杨醛和铜离子为改性剂,通过后嫁接法制得铜席夫碱配合物改性SBA-15(Cu-SBA-15),并以毒死蜱为模型药物,制备了毒死蜱/铜席夫碱配合物改性SBA-15缓释体系。利用TEM、SEM、XRD、N2吸附-脱附、TG、FTIR和... 详细信息

以3-氨丙基三乙氧基硅烷(APTES)、水杨醛和铜离子为改性剂,通过后嫁接法制得铜席夫碱配合物改性SBA-15(Cu-SBA-15),并以毒死蜱为模型药物,制备了毒死蜱/铜席夫碱配合物改性SBA-15缓释体系。利用TEM、SEM、XRD、N2吸附-脱附、TG、FTIR和XPS对SBA-15、氨基改性SBA-15(NH_2-SBA-15)、水杨醛希夫碱改性SBA-15(SA-SBA-15)的形貌、结构和Cu-SBA-15的配位情况进行了表征,考察了SBA-15在改性前后对毒死蜱的吸附量和缓释性能,并着重探究了毒死蜱/铜席夫碱配合物改性SBA-15载药体系在不同pH值下的释药行为。结果表明,APTES和水杨醛能够通过后嫁接法修饰于SBA-15,修饰后仍保持十分有序的孔道结构。SBA-15通过改性后,其对毒死蜱的吸附量由100 mg·g^(-1)增加至195 mg·g^(-1),且其对药物的缓释性能也得到改善。毒死蜱/铜席夫碱配合物改性SBA-15缓释体系显示出明显的pH值响应性,pH=3时的释药速率大于pH=11时,而在中性条件下的缓释效果相对最好。载药体系的释药行为可用Riger-Peppas动力学模型来描述,其药物释放由Fick扩散控制。

关键词： SBA-15 铜席夫碱 pH值响应毒死蜱缓释

NUMERICAL SIMULATION OF 3-D TURBULENT FLOWS OF PLUNGE POOL AND ENERGY DISSIPATION ANALYSIS

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Journal of Hydrodynamics 1997年第1期9卷 1-10页

作者： Liao hua-sheng, xu Wei-lin, Yang Yong-quan, Wu Chi-gongState Key Hydraulics Laboratory of High Speed Flaws,Sichuan Union University,Chengdu610065, P. R. China

A 3-D numerical model for simulating the complicated turbulent flows was developed and the code was made. A numerical calculation of the plunge pool of Laxiwa project in China was carried on. Those 3-D distributions of velocity,pressure on bottom wall,turbulence kinetic energy and turbulence energy dissipation rate are revealed in detail and the detailed flow patterns of plunge pool were shown. By studying on the characteristics of turbulent diffusion and energy dissipation,the calculated results show that the major turbulence and energy dissipation are taken place near the axis of water jet. The calculated results also indicated that the calculated maximum impact pressures on the bottom wall of the plunge pool have a good agreement with those obtained by physical hydraulic model test.

关键词： plunge pool three dimension turbulence numerical model energy dissipation

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction