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Unique and independent role of the GABAB1 subunit in embryo implantation and uterine decidualization in mice

Genes & Diseases 2021年第1期8卷 79-86页

作者： Wenhao chen Qian Zhang Haibin Wang Dongmei Tan yi Tan Laboratory Animal Center Chongqing Medical UniversityChongqing400016PR China Reproductive Medical Center The First Affiliated Hospital of Xiamen UniversityXiamen361003FujianPR China Fujian Provincial Key Laboratory of Reproductive Health Research Medical College of Xiamen UniversityXiamen361102FujianPR China

Embryo implantation and decidualization are crucial for successful pregnancy,which include multiple genes and signaling pathways,while the precise mechanism regarding embryo implantation and decidualization has yet to be *** GABA which activates GABA_(A)or GABA_(B)receptors has been found playing an important role in early *** we seek to investigate whether GABA_(B)receptors participate in embryo implantation in *** study first characterized the spatiotemporal expression pattern of GABA_(B)receptors in the uterus during the peri-implantation period and found that GABA_(B1)expression was drastically upregulated in stromal cells on days 4e6,a period of embryo implantation and early stages of *** delayed implantation and oil-induced decidualization models were further used to confirm that the GABA_(B1)was associated with embryo implantation and *** also found estrogen or progesterone had no directly effect on expression of GABA_(B1)in ovariectomized *** we were unable to detect significant GABA_(B2)which couples with GABA_(B1)to form whole GABA_(B)receptors,and the agonist and antagonist of whole GABA_(B)receptors had weak effect on the proliferation and differentiation of stromal cells as well,we excluded the possibility whole GABA_(B)receptors function,and concluded it should be non-classical signals of GABA_(B1)involving in embryo implantation and *** studies should focus on investigating the roles and mechanisms of GABA_(B1)during embryo implantation and decidualization.

关键词： Decidualization Embryo implantation Endometrial stromal cells GABAB1 Ovarian hormones Proliferation

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Involvement of ayu NOD2 in NF-κB and MAPK signaling pathways: Insights into functional conservation of NOD2 in antibacterial innate immunity

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Zoological Research 2019年第2期40卷 77-88页

作者： yi Ren Shui-Fang Liu Li Nie Shi-Yu Cai Jiong chen Laboratory of Biochemistry and Molecular Biology School of Marine Sciences Ningbo University Key Laboratory of Applied Marine Biotechnology of Ministry of Education Ningbo University

Nucleotide oligomerization domain 2(NOD2) is a major cytoplasmic sensor for pathogens and is critical for the clearance of cytosolic bacteria in ***, studies regarding NOD2, especially the initiated signaling pathways, are scarce in teleost species. In this study, we identified a NOD2 molecule(PaNOD2) from ayu(Plecoglossus altivelis).Bioinformatics analysis showed the structure of NOD2 to be highly conserved during vertebrate evolution. Dual-luciferase reporter assays examined the activation of NF-κB signaling and Western blotting analysis detected the phosphorylation of three MAP kinases(p-38, Erk1/2, and JNK1/2).Functional study revealed that, like its mammalian counterparts, PaNOD2 was the receptor of the bacterial cell wall component muramyl dipeptide(MDP), and the leucine-rich repeat motif was responsible for the recognition and binding of Pa NOD2 with the ligand. Overexpression of PaNOD2 activated the NF-κB signaling pathway, leading to the upregulation of inflammatory cytokines, including TNF-α and IL-1β in HEK293 T cells and ayu head kidney-derived monocytes/macrophages(MO/MΦ).Particularly, we found that PaNOD2 activated the MAPK signaling pathways, as indicated by the increased phosphorylation of p-38, Erk1/2, and JNK1/2, which have not been characterized in any teleost species previously. Our findings proved that the NOD2 molecule and initiated pathways are conserved between mammals and ayu. Therefore, ayu could be used as an animal model to investigate NOD2-based diseases and therapeutic applications.

关键词： Ayu NOD2 NF-κB signaling MAPK signaling Inflammatory cytokines Vibrio anguillarum infection

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Analysis of glistenings in hydrophobic acrylic intraocular lenses on visual performance

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 446-451页

作者： Lei Xi yi Liu Feng Zhao Chuan chen Bing cheng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

AIM:To assess patients’ visual performance with glistenings in one piece soft hydrophobic acrylic intraocular lenses(IOLs)(Alcon)2y ***:This cross section trial included 120 eyes with one piece IOL at 2y *** was classified in 4 groups,ranging from 0(none)to 3(most evident)according to their severity in IOLs optics observed under a slit *** eyes underwent a uncorrected and best-corrected visual acuity evaluation(UCVA and BCVA,LogMAR scale),a complete clinical examination,a contrast sensitivity(CS)evaluation by F.A.C.T chart,and a visual field test by Humphrey Field AnalyzerⅡ(HFA).One-way ANOVA was used for quantitative data,while Pearsonχ2test was used for qualitative data to analyze the visual function of 4glistening ***:Totally 120 eyes were enrolled with 30 eyes in each glistening *** was no statistical correlation between glistening grades and patients’age,IOLs power,postoperative UCVA and BCVA(P>0.05).Quantificationally,CS values among each group were not statistically ***,qualitative analysis showed there were more eyes in grade 3 group than in grade 0 group having abnormally declined CS at high spatial frequency(10%vs 36.7%at 18 cpd,P=0.029;6.7%vs 26.7%at 12 cpd,P=0.013).Mean deviation(MD)of the visual field test was-2.14±2.31,-1.97±2.23,-3.02±3.17,-4.12±3.38 in group 0 to 3 *** was a significant decrease in the most serious glistenings group(P=0.018).CONCLUSION:Glistenings may potentially have an impact on contrast sensitivity at high spatial frequency and MD in visual field test.

关键词： cataract intraocular lens hydrophobic acrylic contrast sensitivity mean deviation

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[Bmim]Br_3 as a New Reagent for Regioselective Mono-bromination of Activated Aromatics under Solvent-free Conditions

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Chinese Chemical Letters 2005年第8期16卷 1007-1009页

作者： Zhang Gao LE Zhen Chu chen yi HU Qin Guo ZHENG Department ofAppli.ed Chemistry East China Institute of Technology Fuzhou 344000 Ningbo Institute of Technology Zhejiang University Ningbo315100 Department of Chemistry Zhejiang University Hangzhou 310028 Pharmaceutical Science Reseach Institute Aston UniversityBimingham B4 7ETUK Birmingham B4 7ET UK

Reaction of activated aromatics containing phenobs, naphthol, methoxynaphthalenes,anisole etc. with 1-butyl-3-methylimidazolium tribromide （[Bmim]Br3） under solvent-free conditions, selectively gave the correspondin... 详细信息

关键词： Activated aromatics regioselective [Bmim]Br3.

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Modeling transport of arsenic through modified granular natural siderite filters for arsenic removal

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Geoscience Frontiers 2019年第5期10卷 1755-1764页

作者： Fulan Li Huaming Guo Kai Zhao Wei Xiu Jiaxing Shen yi chen State Key Laboratory of Biogeology and Environmental Geology MOE Key Laboratory of Groundwater Circulation and Environment EvolutionChina University of Geosciences (Beijing)Beijing 100083China School of Water Resources and Environment China University of Geosciences (Beijing)Beijing 100083China China Institute for Geo-environmental Monitoring Beijing 100081China

Groundwater arsenic (As) contamination is a hot issue,which is severe health concern ***,many Fe-based adsorbents have been used for As removal from *** granular natural siderite (MGNS),a special hybrid Fe(II)/Fe(III) system,had higher adsorption capacity for As(III) than As(V),but the feasibility of its application in treating high-As groundwater is still *** combination with transport modeling,laboratory column studies and field pilot tests were performed to reveal both mechanisms and factors controlling As removal by MGNS-filled *** show that weakly acid pH and discontinuous treatment enhanced As(III) removal,with a throughput of 8700 bed volumes (BV) of 1.0 mg/L As(III) water at breakthrough of 10 mg/L As at pH *** HCO3^- inhibited As removal by the *** mineral species,SEM and XRD patterns of As-loading MGNS show that the important process contributing to high As(III) removal was the mineral transformation from siderite to goethite in the *** homogeneous surface diffusion modeling (HSDM) shows that competition between As(III) and HCO3^- with adsorption sites on MGNS was *** inhibition of HCO3^- on As(III) removal was connected to inhibition of siderite dissolution and mineral *** loadings were lower in field pilot tests than those in the laboratory experiments,showing that high concentrations of coexisting anions (especially HCO3^-- and SiO4^4-),high pH,low EBCT,and low groundwater temperature decreased As *** was suggested that acidification and aeration of high- As groundwater and discontinuous treatment would improve the MGNS filter performance of As removal from real high-As groundwater.

关键词： Arsenite (As) Adsorption Mineral transformation Column Groundwater

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Jitter analysis and modeling of a 10 Gbit/s SerDes CDR and jitter attenuation PLL

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The Journal of China Universities of Posts and Telecommunications 2011年第6期18卷 122-126页

作者： WANG Hui chen ying-mei yi Lv-fan WEN Guan-guo Institute of RF- ＆ OE-ICs Southeast University Nanjing 210096 China Zhongxing Telecom Equipment Corporation Shenzhen 518055 China

Jitter analysis and a linear model is proposed in this paper which predicts the characteristics of serial-deserial （SerDes） clock and data recovery circuit, and the characteristics include jitter transfer, jitter tolerance and jitter generation are particularly analyzed. The simulation results of the clock data recovery （CDR） model show that the jitter specifications exceed the mask of ITU-T optical transport network （OTN） G.8251 recommendations. The whole systems are validated by 9.95-11.5 Gbit/s CDR and the jitter attenuation phase locked loops （PLL） circuits using TSMC 65 nm CMOS technology.

关键词： OTN SerDes Jitter CDR PLL

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1060Al/Al-Al_(2)O_(3)/1060Al层状铝基复合材料热变形模型对比分析

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塑性工程学报 2024年第3期31卷 107-118页

作者：郝朋程张兵张志娟赵田丽刘广龙陈乐徐依蔡军王快社西安建筑科技大学冶金工程学院陕西西安710055 西安建筑科技大学功能材料加工国家与地方联合工程研究中心陕西西安710055 甘肃金川镍钴新材料技术创新中心有限公司甘肃金昌737101

采用Gleeble-3500热模拟试验机在变形温度为25~400℃、应变速率为0.01~10s^(-1)和真应变为0.85的条件下,对1060Al/Al-Al_(2)O_(3)/1060Al层状铝基复合材料进行了热压缩试验,研究其热变形行为,建立了应变补偿的Arrhenius (SCA)、修正的Jo... 详细信息

采用Gleeble-3500热模拟试验机在变形温度为25~400℃、应变速率为0.01~10s^(-1)和真应变为0.85的条件下,对1060Al/Al-Al_(2)O_(3)/1060Al层状铝基复合材料进行了热压缩试验,研究其热变形行为,建立了应变补偿的Arrhenius (SCA)、修正的Johnson-Cook (MJC)和修正的Zerilli-Armstrong (MZA) 3种本构模型,并对流变应力的预测值与实验值进行对比。结果表明,层状复合材料流变应力呈加工硬化型,并随温度升高或应变速率降低而降低;在100℃/0.5s^(-1)、200℃/0.1s^(-1)和300℃/0.1s^(-1)条件下,层状复合材料组元层间变形较为协调;3种本构模型中,MZA模型的相关系数最高,R为0.99085、平均绝对相对误差最低,e_(AARE)为0.046966,更适合描述1060Al/Al-Al_(2)O_(3)/1060Al层状铝基复合材料的热变形行为。

关键词： 1060Al/Al-Al_(2)O_(3)/1060Al层状铝基复合材料流变应力宏观形貌本构方程

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干旱胁迫下2种内生真菌对烟草生理生化指标及NAC基因表达的影响

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华北农学报 2024年第1期39卷 113-119页

作者：孙文秀邵晨阳陈妍妍聂明皓李震曹毅刘应保长江大学生命科学学院湖北荆州434025 贵州省烟草公司黔西南州公司贵州兴义562400 贵州省烟草科学研究院贵州贵阳550081

为探究印度梨形孢联合丛枝菌根真菌(AMF)对烟草抗旱性的影响,在温室条件下开展盆栽试验,以云烟87为材料,设立接种无菌水(CC)、印度梨形孢(CP)、AMF(PC)、印度梨形孢和AMF(PP)处理,以自然干旱的方式进行胁迫,测定烟草叶片中脯氨酸(Pro)... 详细信息

为探究印度梨形孢联合丛枝菌根真菌(AMF)对烟草抗旱性的影响,在温室条件下开展盆栽试验,以云烟87为材料,设立接种无菌水(CC)、印度梨形孢(CP)、AMF(PC)、印度梨形孢和AMF(PP)处理,以自然干旱的方式进行胁迫,测定烟草叶片中脯氨酸(Pro)、超氧化物歧化酶(SOD)、过氧化物酶(POD)、丙二醛(MDA)生理生化指标和干旱相关基因NTNAC1和NAC4表达情况。结果表明,印度梨形孢和AMF均能促进烟草地上部分和地下部分生长,且干旱胁迫后褪绿不明显,干旱症状轻微。干旱胁迫7 d后,与CC组相比,CP、PC和PP组烟草叶片中Pro含量显著升高,分别为CC组的1.39,1.59,1.78倍;烟草叶片中SOD和POD活性呈现先升高后降低的趋势,CP、PC和PP组的SOD活性分别是CC组的1.15,1.22,1.33倍,POD活性分别是CC组的1.33,1.46,1.85倍;烟草叶片中MDA含量降低,CP、PC和PP组的MDA含量比CC组分别减少21.98%,23.98%,24.84%;烟草叶片干旱相关基因NTNAC1和NAC4表达上调,CP、PC和PP组NTNAC1基因表达量分别是CC组的3.37,3.88,5.07倍,NAC4基因表达量分别是CC组的3.04,3.59,5.56倍。该研究表明,印度梨形孢和AMF表现出显著的协同作用,能够显著提高烟草的抗旱性。

关键词：烟草印度梨形孢丛枝菌根真菌抗旱性

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Carbon and nitrogen isotopes analysis and sources of organic matter in surface sediments from the Sanggou Bay and its adjacent areas, China

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Acta Oceanologica Sinica 2014年第12期33卷 48-57页

作者： XIA Bin CUI yi chen Bijuan CUI Zhengguo QU Keming MA Feifei Key Laboratory of Sustainable Utilization of Marine Fisheries Resources of Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fisheries Sciences

Naturally existing stable carbon and nitrogen isotopes are important in the study of sedimentary organic matter sources. To identify the sources of sedimentary organic matter in Sanggou Bay and its adjacent areas, which is characterized by high-density shellfish and seaweed aquaculture, the grain size, organic carbon （OC）, total nitrogen （TN）, carbon and nitrogen isotopic composition （δ13C andδ15N） of organic matter in the surface sediment were determined. The results showed that, in August, sedimentary OC and TN ranged from 0.17% to 0.76% and 0.04% to 0.14%, respectively. In November, OC and TN ranged from 0.23% to 0.87% and 0.05% to 0.14%, respectively. There was a significant positive correlation between OC and TN （R=0.98, P＆lt;0.0001）, indicating that OC and TN were homologous. In August, theδ13C andδ15N of organic matter varied from -23.06‰ to -21.59‰ and 5.10‰ to 6.31‰, respectively. In November,δ13C andδ15N ranged from -22.87‰ to -21.34‰ and 5.13‰ to 7.31‰, respectively. This study found that the major sources of sedimentary organic matter were marine shellfish biodeposition, seaweed farming, and soil organic matter. Using a three-end-member mixed model, we estimated that the dominant source of sedimentary organic matter was shellfish biodeposition, with an average contribution rate of 65.53% in August and 43.00% in November. Thus, shellfish farming had a significant influence on the coastal carbon cycle.

关键词： carbon nitrogen stable isotopes organic matter sources sediment Sanggou Bay

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The role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer:a systematic review and meta-analysis

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Asian Journal of Andrology 2020年第4期22卷 383-389页

作者： Xu cheng Zhi-Hui Wang Mou Peng Zhi-Chao Huang Lu yi yi-Jian Li Lei yi Wen-Zhi Luo Jia-Wen chen yin-Huai Wang Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China T.H.Chan School of Public Health Harvard UniversityBostonMA 02115USA

The first-line treatment options for high-risk prostate cancer(PCa)are definitive external beam radiotherapy(EBRT)with or without androgen deprivation therapy(ADT)and radical prostatectomy(RP)with or without adjuvant ***,few randomized trials have compared the survival outcomes of these two *** systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRT-or RP-based therapy,a comprehensive and up-to-date meta-analysis was performed.A systematic online search was conducted for randomized or observational studies that investigated biochemical relapse-free survival(bRFS),cancer-specific survival(CSS),and/or overall survival(OS),in relation to the use of RP or EBRT in patients with high-risk *** summary hazard ratios(HRs)were estimated under the random effects *** identified heterogeneity between studies using Q tests and measured it using I2 *** evaluated publication bias using funnel plots and Egger's regression asymmetry *** studies(including one randomized controlled trial[RCT])of low risk of bias were selected and up to 9504 patients were *** comparing EBRT-based treatment with RP-based treatment,the pooled HRs for bRFS,CSS,and OS were 0.40(95%confidence interval[CI]:0.24–0.67),1.36(95%CI:0.94–1.97),and 1.39(95%CI:1.18–1.62),*** OS for RP-based treatment and better bRFS for EBRT-based treatment have been identified,and there was no significant difference in CSS between the two ***-based treatment is recommended for high-risk PCa patients who value long-term survival,and EBRT-based treatment might be a promising alternative for elderly patients.

关键词： high risk prostatectomy prostatic neoplasms radiotherapy survival

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