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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-Hua Chen Ming-Yuan Kang Yi-Ting Chang sheng-yang huang Yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

A New Furost-20(22)-ene Oligoglycoside from Asparagus cochinchinensis

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Chinese Chemical Letters 2003年第7期14卷 717-719页

作者： Yong Chun yang sheng yang huang Shun Yan MO Chun yang Jian Gong SHI Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

A new furost-20(22)-ene oligoglycoside named as aspacochioside C was isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Its structure was elucidated to be 26-O-b- D-glucopyranosyl-(25S)-5b-furost-20(22)-en-3b,26-diol-3-O-a-L-rhamnopyranosyl-(14)-b-D- glucopyranoside on the basis of spectroscopic techniques including 1D and 2D NMR experiments.

关键词： Asparagus cochinchinensis (Lour.) Merr Liliaceae, furost-20(22)-ene oligoglycoside aspacochioside C.

Two New Furostanol Glycosides from Asparagus cochinchinensis

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Chinese Chemical Letters 2002年第12期13卷 1185-1188页

作者： Yong Chun yang sheng yang huang Jian Gong SHI Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

Two new furostanol oligoglycosides named as aspacochioside A (1) and B (2) were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Their structures were elucidated to be 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glucopyranosyl}]-26-O-[b-D-glucopy- ranosyl]-(25S)-5b-furostane-3b,22a,26-triol 1 and 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glu- copyranosyl}]-26-O-[b-D-glucopyranosyl]-22a-methoxy-(25S)-5b-furostane-3b,26-diol 2 on the basis of spectroscopic techniques and chemical methods.

关键词： Asparagus cochinchinensis (Lour.) Merr Liliaceae, furostanol glycoside aspaco- chiosides A, B.

Primary jejunoileal neoplasmas:a review of 60 cases

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World Journal of Gastroenterology 2003年第4期9卷 862-864页

作者： Yun-sheng yang Qi-yang huang Wei-Feng Wang Gang Sun Li-Hua Peng Department of Gastroenterology,China PLA General Hospital,Beijing 100853,China Department of Gastroenterology China PLA General Hospital Beijing 100853 China. yangys@***

AIM: Primary neoplasmas of the jejunum and ileum are infrequent and lack specific manifestations and inaccessibility of conventional endoscopy, so the diagnosis of these tumors are usually delayed. So far the data of primary jejunoileal neoplasmas is still scarce, especially in Chinese medical literature in English. There may be some differences among the Chinese and the westerners in jejunoileal ***: A retrospective analysis was made on clinical findings and pathological ***: Of the 60 patients with jejunal or ileal neoplasmas, the most frequent symptom was abdominal pain (57%), followed by tarry stool (43%) and hematochezia (10%). Abdominal mass (40%) was the most common finding on physical examination, followed by anemia and weight loss (35%). 67% of the jejunoileal neoplasms were located in the jejunum. Among the malignant neoplasmas (68%), malignant stroma (47%) was most common, while the benign stromoma (20%) was the most common benign neoplasmas. Preoperatively, 40 patients (67%) were diagnosed as small bowel neoplasmas, of which 34 were found by enteroclysis. Abdominal mass was shown by CT in 18 cases and by ultrasonography in 13. The mean duration of symptoms before diagnosis was 7 months. In 41 patients with malignant tumors, the duration of symptoms before diagnosis exceeded 12 months in 21 cases, lymphatic or distant metastases were found in 26 (63%)cases during operation. An emergency laparotomy was performed in 4patients (7%) owing to intestinal obstruction or ***: Primary jejunoileal neoplasmas in Chinese present some difference from Westerners on clinical features and histopathologic types. Enteroclysis remains the major relevant diagnostic procedure in this study, the misdiagnotic rate is high preoperatively due to failure of detection by conventional imaging procedures such as CT and inaccessibility of routine endoscopy. For the suspected patients, combined application of aforementioned procedures may fac

关键词：原发性空回肠肿瘤临床症状病理特点诊断外科治疗

Challenges in the management of visual and tactile hallucinations in elderly people

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World Journal of Psychiatry 2025年第1期15卷 185-188页

作者： Si-sheng huang Division of Geriatric Psychiatry Department of PsychiatryChanghua Christian HospitalChanghua 500Taiwan Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402Taiwan

This letter provides a concise review of the pertinent literature on visual and tactile hallucinations in elderly *** discussion addresses differential diagnoses and potential underlying mechanisms,as well as the psychopathology associated with tactile hallucinations,and emphasizes the necessity for invest-igation into the possibility of coexisting delusional infestation(parasitosis).These symptoms frequently manifest in patients with primary psychotic disorders,organic mental disorders,and substance use *** proposed pathophy-siological mechanisms may involve dopaminergic imbalances and dysfunction of the striatal dopamine transporter.

关键词： Delusional infestation Dementia Haptic hallucination Scratching behavior Tactile hallucination Visual hallucination Alzheimer’s disease

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang Yu-Wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

卟啉环上的亲核取代:2.溶剂对2-NO_2-TPPCu(Ⅱ)与苯酚钠反应的影响

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武汉大学学报（自然科学版） 2000年第2期46卷 145-149页

作者：欧阳艳陈彰评陈阳生黄齐茂李湛武汉大学化学与环境科学学院武汉430072

研究了溶剂对 2 - NO2 - 5 ,10 ,15 ,2 0 -四苯基卟啉铜 (2 - NO2 - TPPCu( ) ) 1与苯酚钠反应的影响 ,发现反应速度、产物分布与所用溶剂有很大关系 .在苯酚中反应 ,主要产物为碳碳键相连的产物 2 - (2 -羟基苯基 ) - TPPCu( ) 2 (5 0 ... 详细信息

研究了溶剂对 2 - NO2 - 5 ,10 ,15 ,2 0 -四苯基卟啉铜 (2 - NO2 - TPPCu( ) ) 1与苯酚钠反应的影响 ,发现反应速度、产物分布与所用溶剂有很大关系 .在苯酚中反应 ,主要产物为碳碳键相连的产物 2 - (2 -羟基苯基 ) - TPPCu( ) 2 (5 0 % )和 2 - (4-羟基苯基 ) - TPPCu( ) 3(2 8% ) ,在非质子极性溶剂中反应 ,主要得到碳氧键相连的产物 2 -苯氧基 - TPPCu( ) 4 .在苯甲腈、DMSO、DMF和吡啶中反应 ,4的产率分别为 5 5 %、 5 2 %、47%和 11.7% .实验结果说明 ,在反应中存在 SRN1和 SNAr的竞争 ,质子性溶剂有利于 SRN1反应 ,并主要生成碳碳键产物 2、3,非质子极性溶剂能加速 SNAr反应 ,生成醚键产物 4.

关键词：亲核取代溶剂效应四苯基卟啉铜卟啉环苯酚钠

Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-yang Nong Yong-Yi Cen Shan-Jin Lu Rui-Sui huang Qiong Chen Li-Feng huang Jian-Ning huang Xue Wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

巨大芽孢杆菌青霉素G酰化酶基因在枯草杆菌中的高表达

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生物化学与生物物理学报 1999年第5期31卷 601-603页

作者：杨晟黄艳红黄晓冬李士云袁中一中国科学院上海生物化学研究所!上海200031

用ＰＣＲ方法从巨大芽孢杆菌的基因组ＤＮＡ中扩增到青霉素Ｇ酰化酶基因，并装载到枯草杆菌表达质粒ｐＰＺＷ１０３中，将其转化到枯草杆菌ＤＢ１０４中进行了分泌表达。重组菌株产酶无需苯乙酸诱导。在３７ ℃培养... 详细信息

用ＰＣＲ方法从巨大芽孢杆菌的基因组ＤＮＡ中扩增到青霉素Ｇ酰化酶基因，并装载到枯草杆菌表达质粒ｐＰＺＷ１０３中，将其转化到枯草杆菌ＤＢ１０４中进行了分泌表达。重组菌株产酶无需苯乙酸诱导。在３７ ℃培养２４ｈ，菌液中酶活力可达６ｕ／ｍｌ。１０天的连续传代实验表明重组菌株的稳定性很高。发酵液上清中的青霉素Ｇ酰化酶经Ａｌ２Ｏ３层析，再经ｐｈｅｎｙｌ ＳｅｐｈａｒｏｓｅＣＬ４Ｂ疏水层析，将其浓缩百倍以上，两步总得率为７９％，可直接用来固定化作酶制剂

关键词：巨大芽孢杆菌青霉素G酰化酶枯草芽孢杆菌基因表达

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最佳的分类器链局部检测与挖掘算法

计算机工程与设计 2017年第11期38卷 3056-3060,3079页

作者：李哲周油胜龙洋黄益华国网重庆市电力公司电力科学研究院重庆401123 重庆邮电大学计算机科学与技术学院重庆400065 重庆电力高等专科学校电力工程学院重庆400084

为在先验信息不足以及数据动态变化时,从大数据中检测各种概念并提取有用的信息,提出一种局部检测与挖掘算法,构建最佳分类器链。采用多臂赌博机对分类器进行学习,构建的分类器在运行时不需要通过分布式局部分类器中央单元进行任何信息... 详细信息

为在先验信息不足以及数据动态变化时,从大数据中检测各种概念并提取有用的信息,提出一种局部检测与挖掘算法,构建最佳分类器链。采用多臂赌博机对分类器进行学习,构建的分类器在运行时不需要通过分布式局部分类器中央单元进行任何信息的交换,只需反馈有限的挖掘效果,确保最佳分类器链的学习;无需任何先验信息,学习的后悔值随分类函数个数的增加呈线性增长。数值模拟实验结果表明,与经典相关方法相比,该方法在分类器数量增加时性能更优,收敛速度更快。

关键词：分类器链检测与挖掘赌博机问题后悔值局部学习算法