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Enhanced invasion in vitro and the distribution patterns in vivo of CD133＋ glioma stem cells

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Chinese Medical Journal 2011年第17期124卷 2599-2604页

作者： YU sheng-ping yang xue-jun ZHANG Bin MING Hao-lang CHEN Cong REN Bing-cheng LIU Zhi-feng LIU Bin Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Background Recent studies have suggested that cancer stem cells cause tumor recurrence based on their resistance to radiotherapy and chemotherapy. Although the highly invasive nature of glioblastoma cells is also implicated in the failure of current therapies, it is not clear whether cancer stem cells are involved in invasiveness. This study aimed to assess invasive ability of glioma stem cells （GSCs） derived from C6 glioma cell line and the distribution patterns of GSCs in Sprague-Dawley （SD） rat brain tumor. Methods Serum-free medium culture and magnetic isolation were used to gain purely CD133＋ GSCs. The invasive ability of CD133＋ and CD133- C6 cells were determined using matrigel invasion assay. Immunohistochemical staining for stem cell markers and luxol fast blue staining for white matter tracts were performed to show the distribution patterns of GSCs in brain tumor of rats and the relationship among GSCs, vessels, and white matter tracts. The results of matrigel invasion assay were estimated using the Student＇s t test and the analysis of Western blotting was performed using the one-way analysis of variance （ANOVA） test. Results CD133＋ GSCs （number： 85.3±4.0） were significantly more invasive in vitro than matched CD133- cells （number： 25.9=~3.1）（t=14.5, P 〈0.005）. GSCs invaded into the brain diffusely and located in perivascular niche of tumor-brain interface or resided within perivascular niche next to white fiber tracts. The polarity of glioma cells containing GSCs was parallel to the white matter tracts. Conclusions Our data suggest that CD133＋ GSCs exhibit more aggressive invasion in vitro and GSCs in vivo probably disseminate along the long axis of blood vessels and transit through the white matter tracts. The therapies targeting GSCs invasion combined with traditional glioblastoma multiforme therapeutic paradigms might be a new approach for avoiding mali qnant glioma recurrence.

关键词： glioma glioma stem cell invasion white matter tracts

Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China Earth Sciences 2025年第1期68卷 74-93页

作者： Ye yang Steven A.BINNIE sheng XU Cong-Qiang LIU Tibor J.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

关键词： 10Be-derived denudation rate Climate change Tectonic uplift Topographic gradient Asian mountains

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing yang Lilingxuan Yao Xinyue Xu yang Li Junhui xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Non-contact and Automatic Measurement of 2D Size with CCD Matrix and Computer System

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Semiconductor Photonics and Technology 2003年第3期9卷 189-192页

作者： ZHANG Ye, WANG Wen-sheng, GUO yang-xue, SONG Hui-ying (College of Photoelectr.Eng.,Changchun University of Science and Technology,Changchun 130022,CHN) College of Photoelectr. Eng. Changchun University of Science and Technology Changchun 130022

A measurement system with the CCD matrix and computer system is designed to test the 2D size of any shape workpieces automatically. In addition, the system adopts the method of the relative measurement which increases the precision and the *** importantly,the precision cant be changed with the conditions of the temperature and air *** experiments show that the relative precision of 0.002 9 and the absolute precision of 2.97 μm are obtained. The instrument may be used in the product line and make the testing on line possible.

关键词： CCD matrix photographic objective computer

Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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Energy Engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei xue HaoQiu Ning yang Yuwen Zhang Chaoyu Wang Edwin E.Nyakilla Department of New Energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind Energy and Solar Energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： Electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

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基于空间聚类分析的南海主要航线提取方法

交通运输工程学报 2016年第6期16卷 91-98页

作者：王加胜刘永学杨昆李满春孙超云南师范大学信息学院云南昆明650500 云南师范大学西部资源环境地理信息技术教育部工程研究中心云南昆明650500 南京大学中国南海研究协同创新中心江苏南京210093

提出了一种基于空间聚类分析的南海主要航线提取方法,利用2001-2014年VOSClim舰船数据,通过航线生成、航线聚类、聚类中心线提取得到了南海主要航线提取与分级结果,将提取结果与美国中央情报局所得航线进行对比,对南海主要航线分布特征... 详细信息

提出了一种基于空间聚类分析的南海主要航线提取方法,利用2001-2014年VOSClim舰船数据,通过航线生成、航线聚类、聚类中心线提取得到了南海主要航线提取与分级结果,将提取结果与美国中央情报局所得航线进行对比,对南海主要航线分布特征进行分析。分析结果表明：提取出21条南海主要航线,一-三级航线分别有5、6、10条;在21条南海主要航线中,经过南沙群岛周边海域的航线多达14条;在5条一级航线中,分布在南海北部、西部和南部的航线分别有1、2、2条;重要性指数由高到低的前5条航线依次为新加坡—香港、香港—台湾海峡、新加坡—巴拉巴克海峡、新加坡—巴士海峡、新加坡—高雄航线;南海主要航线以西南—东北向为主,新加坡、香港为南海最重要的2个交通枢纽。

关键词：航线空间聚类 VOSClim 中心线分级南海

Nd-Fe-B永磁体化学镀Ni-Cu-P工艺研究

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稀土 2002年第2期23卷 71-72页

作者：于升学杨雪梅杨洪生燕山大学材料化工学院化学工程系河北秦皇岛066004 唐山水泥机械厂河北唐山063000

本文研究了烧结型 Nd- Fe- B永磁体化学镀 Ni- Cu- P的工艺过程 ,Nd- Fe- B永磁体经除油、封孔、出光后直接化学镀 Ni- Cu- P合金 ,可以获得与基体结合良好、耐蚀性高的镀层。

关键词：钕铁磁永磁体化学镀镍铜磷合金

Substrate bias effects in p-channel GaN-on-Si transistors

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Science China(Information Sciences) 2025年第1期68卷 404-405页

作者： Mengyao ZHAO Jie MA Lanlan yang Chuanqi PAN Denggui WANG Jianjun ZHOU sheng LI Jiaxing WEI Long ZHANG Siyang LIU Weifeng SUN National ASIC System Engineering Research Center School of Integrated Circuits Southeast University National Center of Technology Innovation for Electronic Design Automation Southeast University National Key Laboratory of Solid-State Microwave Devices and Circuits

The drain current （ID） of the n-channel GaN field-effecttransistor （n-FET） is influenced by the substrate-to-source bias voltage (VBS)（substrate bias effect）[1].Actually,nonzero VBSis also likely to occur in p-FET in real application,because the source electrode of p-FET is usually connected to high *** study reports the dependency between IDand VBSin p-FET for the first time,and analyzes the underlying mechanisms from the perspective of vertical electric field （EF） distribution.

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary