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Effect of Ink Molecular Weights and Annealing Conditions on Molecular Transfer Printing

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Chinese Journal of Polymer Science 2018年第6期36卷 697-702页

作者： Yuan-Yuan Pang sheng-xiang ji Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100049China

The molecular transfer printing（MTP） technique has been invented to fabricate chemical patterns with high fidelity using homopolymer inks. In this work, we systematically studied the effects of the molecular weights of homopolymer inks and transfer conditions on the MTP process. We explored a large range of molecular weights（~3.5-56 kg·mol^（-1）） of hydroxyl-terminated polystyrene（PS-OH） and hydroxyl-terminated poly（methyl methacrylate）（PMMA-OH） in the MTP process, and found that the resulting chemical patterns on replicas from all five blends were functional and able to direct the assembly of films of the same blends. The transfer temperature and the film annealing sequences had an impact on the MTP process. MTP was sensitive to the transfer temperature and could only be performed within a certain temperature range, i.e. higher than the glass transition temperature（T_g） of copolymers and lower than the rearrangement temperature of the assembled domains. Pre-organization of the blend films was also necessary for MTP since the preferential wetting of PMMA domains at the replica surface might result in the formation of a PMMA wetting layer to prevent the presentation of underlying chemical patterns to the replica surface.

关键词： Block copolymer Molecular transfer printing Thermal annealing Chemical pattern Directed self-assembly

Engineering Antibacterial Activities and Biocompatibility of Hyperbranched Lysine-based Random Copolymers

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Chinese Journal of Polymer Science 2023年第3期41卷 345-355,I0006页

作者： Hui Liu Xiao Liu Yuan-Qiao Cao Ming Liu Miao-Miao Han sheng-xiang ji Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China

Antimicrobial peptides(AMPs)have been considered as an alternative to small molecule antibiotics since they are difficult to develop antimicrobial *** polylysine(HPL),an AMP mimics,has gained attention due to its broad-spectrum antibacterial activities,but it also suffers from high *** we report a facile strategy to engineer the toxicity of HPL by copolymerizing lysine(K)with a hydrophobic amino acid,e.g.,alanine(A),tryptophan(W)or phenylalanine(F),to afford hyperbranched random *** copolymers have comparable antibacterial activities to HPL while their cytotoxicities and in vivo toxicities are lowered when the type and content of hydrophobic amino acid and the size of copolymers are *** *** infection model demonstrates that the copolymers are effective against the *** infection in *** copolymers kill the bacteria through the disruption of cell membranes and the bacteria do not develop resistance to the copolymers.

关键词： Hyperbranched random copolymers Lysine Hydrophobic amino acid Antibacterial activity High selectivity

Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films

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Chinese Journal of Polymer Science 2021年第8期39卷 1020-1028,I0007页

作者： Xiao Liu jian-Wei Guo Ya-Dong Liu Ming Liu Hui Liu Miao-Miao Han sheng-xiang ji Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein, we prepare an antibacterial composite(TPU-x) through blending medical grade thermoplastic polyurethane(TPU) and the complex(PL-DOSS) of ε-polylysine(ε-PL) and docusate sodium(DOSS). >99% reduction of colony forming unit(CFU) can be obtained in TPU-x composite films even at relatively low content of PL-DOSS, e.g. 0.13% for Methicillin resistant S. aureus(MRSA) and 0.5% for E. coli. The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ~100 nm. TPU-x composite films exhibit long-term stability in saline and good biocompatibility, and retain mechanical properties of TPU.

关键词： Nosocomial infections Antibacterial composite Solution blending Thermoplastic polyurethane Polylysine

黄淮海夏播玉米产区生产要素替代关系实证研究

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现代农业科技 2020年第18期 12-15页

作者：盛积祥刘哲青岛农业大学管理学院山东青岛266109

基于玉米生产成本的上涨,建立超越对数成本函数模型,利用1999—2018年20年的面板数据探究玉米生产要素之间的替代关系。结果表明,种子对土地的替代关系呈现先上升后平稳的态势;机械要素对土地的替代呈现出略有下滑、基本平稳的趋势;化... 详细信息

基于玉米生产成本的上涨,建立超越对数成本函数模型,利用1999—2018年20年的面板数据探究玉米生产要素之间的替代关系。结果表明,种子对土地的替代关系呈现先上升后平稳的态势;机械要素对土地的替代呈现出略有下滑、基本平稳的趋势;化肥对土地的替代关系呈现波浪形趋势,但始终维持在较高的替代水平。机械对劳动力的替代关系基本呈现平稳态势,但从其他各类要素对劳动力替代效应的程度来看,机械对劳动力的替代效果更加显著。

关键词：生产要素超越对数成本函数要素替代黄淮海玉米产区

Construction of a genetic linkage map and mapping of a female-specific DNA marker in half-smooth tongue sole（Cynoglossus semilaevis）

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Construction of a genetic linkage map and mapping of a femal...

2009年中国水产学会学术年会

作者： LIAO Xiao-Lin,MA Hong-Yu,XU Gen-Bo,SHAO Chang-Wei,TIAN Yong-sheng, ji xiang-Shan,YANG jing-Feng,CHEN Song-Lin Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao 266071,China

＜正＞The half-smooth tongue sole（Cynoglossus semilaevis,hereafter,‘tongue sole’） is a marine flatfish with great commercial importance for fisheries and aquaculture in *** has also been a promising model for the study of sex determination mechanisms in ***,we report the construction of a genetic linkage map for the tongue sole,based on 137 markers including 103 AFLP markers,33 microsatellite markers,and one female-specific DNA ***-six linkage groups（LGs） were found. The total map length was 934.6 cM（Kosambi）,with an average spacing of 8.4 cM,covering 64.4%of the estimated genome ***,a female-specific SCAR marker,CseF-382,was mapped on *** study represents the first genetic linkage map in the tongue *** map has great potential in the identification of quantitative traits loci and sex-related genes and marker-assisted selection in the tongue sole. Meanwhile,the new set of polymorphic microsatellite markers developed in this study is not only useful for genetic mapping but also of critical importance for studies on genetic diversity and broodstock management in tongue sole.

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牙鲆的胚胎发育

水产学报 2004年第6期28卷 609-615页

作者：田永胜陈松林严安生季相山中国水产科学研究院黄海水产研究所农业部海洋渔业资源可持续利用重点实验室华中农业大学水产学院中国水产科学研究院黄海水产研究所农业部海洋渔业资源可持续利用重点实验室山东青岛　266071 湖北武汉　430070

在牙鲆胚胎玻璃化冷冻中,为了准确选择胚胎的冷冻时期,掌握胚胎发育进程,同时为牙鲆苗种培育提供一定的依据,对海水工厂化养殖牙鲆的胚胎发育进行了研究。牙鲆受精卵培养在14～16℃、盐度29.9的海水中,利用Olympus显微镜对牙鲆胚胎发育... 详细信息

在牙鲆胚胎玻璃化冷冻中,为了准确选择胚胎的冷冻时期,掌握胚胎发育进程,同时为牙鲆苗种培育提供一定的依据,对海水工厂化养殖牙鲆的胚胎发育进行了研究。牙鲆受精卵培养在14～16℃、盐度29.9的海水中,利用Olympus显微镜对牙鲆胚胎发育过程连续观察,对各个胚胎时期的发育时间进行了记录,并对每一时期的特征用Olympus照像机进行了拍摄。实验记录了从受精卵到出膜后5d的29个具体发育时期的特征和发育时间,拍摄了30张具有代表性的胚胎和鱼苗图片,将牙鲆胚胎发育划分为卵裂期、囊胚期、原肠期、神经胚期、肌节期、尾芽期、心跳期、胚体转动期、出膜前期、出膜期10个连续的典型时期。在此培养条件下牙鲆胚胎历时93h完成整个胚胎发育,孵化出膜,再经96h的胚后发育卵黄囊完全吸收,之后进入变态期,向成鱼转化。

关键词：牙鲆胚胎发育

Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye Jun-ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

冻伤灵膏治疗冻伤的多中心双盲试验和动物实验

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新药与临床 1987年第6期 327-329页

作者：崔极贵王浴生向继德马德强张晋陈远征向青成都军区总医院四川华西医科大学四川军区门诊部四川军区门诊部成都 610083

本文报告外用冻伤灵膏治疗冻伤的双盲临床研究及动物实验研究。冻伤灵膏组(治疗组)共收治457例Ⅰ-Ⅱ度冻伤患者;冻疮膏组(对照组)共收治61例也属Ⅰ-Ⅱ度冻伤患者。2组均为局部用药。结果在1wk左右治疗组治愈412例(90.2％),对照组治愈26... 详细信息

本文报告外用冻伤灵膏治疗冻伤的双盲临床研究及动物实验研究。冻伤灵膏组(治疗组)共收治457例Ⅰ-Ⅱ度冻伤患者;冻疮膏组(对照组)共收治61例也属Ⅰ-Ⅱ度冻伤患者。2组均为局部用药。结果在1wk左右治疗组治愈412例(90.2％),对照组治愈26例(43％),疗效差异显著(p<0.01)。表明冻伤灵膏的疗效明显优于冻疮膏。动物实验研究表明,冻伤灵膏具有预防冻伤并在-70℃超低温下,对实验动物有良好保护作用。

关键词：冻伤山莨菪碱微循环