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Dialectical study of disulfidptosis and clinical outcome in patients with colorectal cancer

Traditional Medicine Research 2024年第10期9卷 52-63页

作者： Hua-mei Zhu Yu-tao Chen Yang Ye Yue-Feng Hu Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000China The Second School of Medicine Wenzhou Medical UniversityWenzhou 325000China

Background:Colorectal cancer(CRC)is a leading cause of cancer mortality *** study aims to develop a prognostic model based on disulfidptosis-related genes to assess survival outcomes in CRC,highlighting the tumor microenvironment’s ***:The thought of traditional Chinese medicine syndrome differentiation and treatment runs through the whole *** analyzed CRC tissue data from The Cancer Genome Atlas and the Gene Expression Omnibus using single-sample gene set enrichment and weighted gene correlation network analyses to identify prognostic markers and evaluate immune *** also investigated predictive drug ***:We identified seven disulfidptosis-related markers–complement C1q A chain(C1QA),solute carrier family 11 member 1(SLC11A1),cluster of differentiation 36(CD36),cluster of differentiation 6(CD6),interleukin 1 receptor associated kinase 3(IRAK3),S100 calcium binding protein A8(S100A8),and CD8 subunit alpha(CD8A)–that significantly influence *** classified in the low-risk group demonstrated improved overall survival compared to those in the high-risk group across training(P=0.0026)and validation cohorts(P=0.032).Differential gene expression was significant in the high-risk group(P<0.001),and prevalent mutations included APC regulator of WNT signaling pathway(APC),tumor protein P53(TP53),Titin(TTN),and Kirsten rat sarcoma viral oncogene(KRAS).The risk score correlated linearly with tumor microenvironment *** results of drug analysis showed that some traditional drugs may have anticancer effects through the vertical action of ***:Our prognostic model,integrating seven disulfidptosis-related genes,categorizes CRC patients by survival probability and underscores these genes as potential biomarkers linked to the tumor *** findings support their use in refining therapeutic strategies for CRC.

关键词： colorectal cancer tumor microenvironment disulfidptosis WGCNA LASSO regression

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Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

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World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： Jia-Ming Wang Yu-tao Pan Chen-Song Yang Ming-Chong Liu sheng-Chao Ji Ning Han Fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

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Recent Advances in Video Coding for Machines Standard and Technologies

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ZTE Communications 2024年第1期22卷 62-76页

作者： ZHANG Qiang mei Junjun GUAN tao SUN Zhewen ZHANG Zixiang YU Li State Key Laboratory of Mobile Network and Mobile Multimedia Technology Shenzhen 518055China ZTE Corporation Shenzhen 518057China Huazhong University of Science and Technology Wuhan 430074China

To improve the performance of video compression for machine vision analysis tasks,a video coding for machines(VCM)standard working group was established to promote standardization *** this paper,recent advances in video coding for machine standards are presented and comprehensive introductions to the use cases,requirements,evaluation frameworks and corresponding metrics of the VCM standard are *** the existing methods are presented,introducing the existing proposals by category and the research progress of the latest VCM ***,we give conclusions.

关键词： video coding for machines VCM video compression

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Quantum generative adversarial networks based on a readout error mitigation method with fault tolerant mechanism

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Chinese Physics B 2024年第4期33卷 285-295页

作者：赵润盛马鸿洋程涛王爽范兴奎 School of Sciences Qingdao University of TechnologyQingdao 266033China School of Information and Control Engineering Qingdao University of TechnologyQingdao 266033China

Readout errors caused by measurement noise are a significant source of errors in quantum circuits,which severely affect the output results and are an urgent problem to be solved in noisy-intermediate scale quantum(NISQ)*** this paper,we use the bit-flip averaging(BFA)method to mitigate frequent readout errors in quantum generative adversarial networks(QGAN)for image generation,which simplifies the response matrix structure by averaging the qubits for each random bit-flip in advance,successfully solving problems with high cost of measurement for traditional error mitigation *** experiments were simulated in Qiskit using the handwritten digit image recognition dataset under the BFA-based method,the Kullback-Leibler(KL)divergence of the generated images converges to 0.04,0.05,and 0.1 for readout error probabilities of p=0.01,p=0.05,and p=0.1,***,by evaluating the fidelity of the quantum states representing the images,we observe average fidelity values of 0.97,0.96,and 0.95 for the three readout error probabilities,*** results demonstrate the robustness of the model in mitigating readout errors and provide a highly fault tolerant mechanism for image generation models.

关键词： readout errors quantum generative adversarial networks bit-flip averaging method fault tolerant mechanisms

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Magnetic-biased chiral molecules enabling highly oriented photovoltaic perovskites

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National Science Review 2024年第2期11卷 221-230页

作者： Jing Chen Caner Deger Zhen-Huang Su Kai-Li Wang Guang-Peng Zhu Jun-Jie Wu Bing-Chen He Chun-Hao Chen tao Wang Xing-Yu Gao Ilhan Yavuz Yan-Hui Lou Zhao-Kui Wang Liang-sheng Liao Institute of Functional Nano&Soft Materials(FUNSOM) Laboratory of Advanced Negative Carbon TechnologiesSoochow University Department of Physics Marmara University Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of Sciences College of Energy Soochow Institute for Energy and Materials Innovations Soochow University Macao Institute of Materials Science and Engineering Macau University of Science and Technology

The interaction between sites A, B and X with passivation molecules is restricted when the conventional passivation strategy is applied in perovskite（ABX3） photovoltaics. Fortunately, the revolving A-site presents an opportunity to strengthen this interaction by utilizing an external field. Herein, we propose a novel approach to achieving an ordered magnetic dipole moment, which is regulated by a magnetic field via the coupling effect between the chiral passivation molecule and the A-site（formamidine ion） in *** strategy can increase the molecular interaction energy by approximately four times and ensure a well-ordered molecular arrangement. The quality of the deposited perovskite film is significantly optimized with inhibited nonradiative recombination. It manages to reduce the open-circuit voltage loss of photovoltaic devices to 360 mV and increase the power conversion efficiency to 25.22%. This finding provides a new insight into the exploration of A-sites in perovskites and offers a novel route to improving the device performance of perovskite photovoltaics.

关键词： perovskite photovoltaics magnetic moment A-site regulation chiral molecules

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Textured CsPbI_(3)nanorods composite fibers for stable high output piezoelectric energy harvester

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eScience 2024年第5期4卷 150-159页

作者： tao Yang Dengzhou Jia Bing Xu Yongfei Hao Yanglong Hou Kang Wang Enhui Wang Zhentao Du sheng Cao Kuo-Chih Chou Xinmei Hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110000China School of Materials Shenzhen Campus of Sun Yat-Sen UniversityShenzhen 518107China MOE Key Laboratory of New Processing Technology for Non-ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China

The utilization of piezoelectric nanogenerator(PENG)based on halide perovskite materials has demonstrated significant promise for energy harvesting ***,the challenge of synthesizing halide perovskite materials with both high output performance and stability using a straightforward process persists as a substantial ***,we present the fabrication of CsPbI_(3)nanorods(NRs)exhibiting highly uniform orientation within polyvinylidene fluoride(PVDF)fibers through a simple texture engineering approach,marking the instance of enhancing PENG performance in this *** resultant composite fibers showcase a short-circuit current density(I_(sc))of 0.78μAcm^(-2)and an open-circuit voltage(V_(oc))of 81V,representing a 2.5 fold increase compared to the previously reported highest value achieved without the electric poling *** outstanding output performance is ascribed to the orientation of CsPbI_(3)NRs facilitated by texture engineering and dipole poling via the self-polarization ***,the PENG exhibits exceptional thermal and water stability,rendering it suitable for deployment in diverse and challenging environmental *** findings underscore the significant potential of textured CsPbI_(3)NRs composite fibers for powering low-power consumer electronics,including commercial LEDs and electronic watches.

关键词： Texture engineering CsPbI_(3) Piezoelectric nanogenerator Self-polarization Electrospinning

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Sleep quality in middle-aged and elderly hemodialysis patients:Impact of a structured nursing intervention program

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World Journal of Clinical Cases 2024年第25期12卷 5713-5719页

作者： Ling-Ling tao Cai-Hua Zeng Wen-Juan mei Yan-Li Zou Blood Purification Room The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Poor sleep quality is common among hemodialysis patients and can significantly impact their *** study aimed to evaluate the effectiveness of a structured nursing intervention program in improving sleep quality in middleaged and elderly hemodialysis *** To evaluate the impact of nursing intervention on sleep quality in hemodialysis *** This cross-sectional study was conducted in a tertiary hospital,the First Affiliated Hospital of Nanchang University,in *** study included 105 middle-aged and elderly hemodialysis patients aged≥45 years who underwent maintenance hemodialysis for at least 3 mo,utilizing the Pittsburgh Sleep Quality Index(PSQI)to identify poor *** identified underwent a 12-wk nursing intervention program focusing on education,relaxation techniques,and ***-intervention,sleep quality was reassessed using the *** The study found that 68.6%of hemodialysis patients were poor *** the 12-wk nursing intervention program,there was a significant decrease in the mean global PSQI score from 8.9±3.2 to 5.1±2.7(P<0.001),indicating improved sleep *** demonstrated the effectiveness of the structured nursing intervention in enhancing sleep quality for middle-aged and elderly hemodialysis *** The structured nursing intervention program focusing on sleep hygiene education,relaxation techniques,and counseling effectively improved sleep quality among middle-aged and elderly hemodialysis *** significant decrease in the mean global PSQI score post-intervention indicates the positive impact of tailored nursing interventions in addressing poor sleep quality in this patient *** findings emphasize the importance of implementing targeted nursing interventions to enhance the quality of life for hemodialysis patients by addressing the prevalent issue of poor sleep quality.

关键词： Hemodialysis patients Nursing intervention Sleep quality Elderly Pittsburgh Sleep Quality Index Patient wellbeing

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Acute macular neuroretinopathy following COVID-19 infection:Three case reports

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World Journal of Clinical Cases 2024年第25期12卷 5775-5783页

作者： Chao Bi Chun-mei Huang Ye-Qiang Shi Chao Huang tao Yu Department of Ophthalmology Jinan Second People’s HospitalJinan 250021Shandong ProvinceChina Department of Ophthalmology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina School of Pharmaceutical Sciences of Shandong University Jinan 250102Shandong ProvinceChina

BACKGROUND During the Coronavirus disease 2019(COVID-19)pandemic,a notable increase in acute macular neuroretinopathy(AMN)cases was *** study aimed to investigate the potential association between AMN and COVID-19 by examining 3 cases in *** SUMMARY The first case involved a 30-year-old man who presented with progressive vision loss following a COVID-19 *** coherence tomography(OCT)and near-infrared imaging identified hallmark AMN lesions,hyperreflective disruptions within the outer plexiform layer,and hyporeflective anomalies in the ellipsoid zone,leading to an AMN *** partial visual recovery,OCT angiography(OCTA)revealed persistent microvascular changes,specifically a decreased vascular density in the deep capillary *** second case was a 24-year-old woman who experienced blurred vision and exhibited bilateral cottonwool spots on fundus examination *** confirmed the presence of AMN along with paracentral acute middle maculopathy(PAMM).Follow-up OCTA found a progressive reduction in vascular density,indicating ongoing microvascular *** third case was a 28-year-old woman who reported sensations of occlusion in her right eye following a COVID-19 *** confirmed both AMN and PAMM,revealing similar decreases of microvascular density on OCTA despite a significant improvement in visual *** noted that all 3 patients had received the COVID-19 vaccine prior to the appearance of *** The findings highlight the diagnostic utility of advanced ocular imaging in detecting AMN in COVID-19 patients and the importance of comprehensive eye examinations.

关键词： Acute macular neuroretinopathy Paracentral acute middle maculopathy COVID-19 Optical coherence tomography Optical coherence tomography angiography Deep capillary plexus Case report

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Hydraulic properties and drought response of a tropical bamboo (Cephalostachyum pergracile)

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Plant Diversity 2024年第3期46卷 406-415页

作者： Wanwalee Kongjarat Lu Han Amy Ny Aina Aritsara Shu-Bin Zhang Gao-Juan Zhao Yong-Jiang Zhang Phisamai Maenpuen Ying-mei Li Yi-Ke Zou Ming-Yi Li Xue-Nan Li Lian-Bin tao Ya-Jun Chen CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of the Chinese Academy of Sciences Beijing 100049China T-STAR Core Team Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China School of Biology and Ecology University of MaineOronoMEUSA Climate Change Institute University of MaineOronoME 04469USA School of Biological and Chemical Science Pu’er UniversityXueyuan RoadYunnan 665000China Institute of Ecology and Geobotany School of Ecology and Environmental SciencesYunnan UniversityKunmingYunnan 650091China School of Ecology and Environment Southwest Forestry UniversityKunmingYunnan 650224China Yuanjiang Savanna Ecosystem Research Station Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYuanjiangYunnan 653300China

Bamboo plants are an essential component of tropical ecosystems,yet their vulnerability to climate extremes,such as drought,is poorly understood due to limited knowledge of their hydraulic *** pergracile,a commonly used tropical bamboo species,exhibited a substantially higher mortality rate than other co-occurring bamboos during a severe drought event in 2019,but the underlying mechanisms remain *** study investigated the leaf and stem hydraulic traits related to drought responses,including leaf-stem embolism resistance(P50leaf;P50stem) estimated using optical and X-ray microtomography methods,leaf pressure-volume and water-releasing ***,we investigated the seasonal water potentials,native embolism level(PLC) and xylem water source using stable *** found that *** exhibited strong resistance to embolism,showing low P50leaf,P50stem,and turgor loss point,despite its rapid leaf water ***,its leaves displayed greater resistance to embolism than its stem,suggesting a lack of effective hydraulic vulnerability segmentation(HVS) to protect the stem from excessive xylem *** the dry season,approximately 49% of the water was absorbed from the upper 20-cm-deep soil ***,significant diurnal variation in leaf water potentials and an increase in midday PLC from 5.87±2.33% in the wet season to 12.87±4.09%in the dry season were *** summary,this study demonstrated that the rapid leaf water loss,high reliance on surface water,and a lack of effective HVS in *** accelerated water depletion and increased xylem embolism even in the typical dry season,which may explain its high mortality rate during extreme drought events in 2019.

关键词： Climate change Drought Hydraulic safety Hydraulic vulnerability segmentation Stable isotope Tree mortality

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Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2791-2803页

作者： Gang Yang Jinpeng Cao Jian Qin Xinyue mei Shidong Deng Yingjiao Xia Jun Zhao Junxiang Wang tao Luan Daxiang Chen Peiyu Huang Cheng Chen Xi Sun Qi Luo Jie Su Yunhui Zhang Nanshan Zhong Zhongfang Wang The Affiliated Hospital of Kunming University of Science and Technology.Department of Respiratory and Critical Care Medicine The First People’s Hospital of Yunnan provinceKunmingYunnanChina Guangzhou National Laboratory BiolandGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

The immunoprotective components control COVID-19 disease severity,as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity,remain ***,we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by *** found that early and robust SARS-CoV-2-specific CD4^(+)and CD8^(+)T cell responses ameliorate disease progression and shortened hospital stay,while delayed and attenuated virus-specific CD8^(+)T cell responses are prominent severe COVID-19 *** antiviral antibody generation rather than titer level associates with severe ***,initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity,demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate ***,initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection ***,our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.

关键词： severity immunity infection

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