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World Journal of Experimental Medicine 2024年第2期14卷 103-113页

作者： Ming Zhou tao-sheng li Hiroshi Abe Hideo Akashi Ryoji Suzuki Yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Sendai Old Age Refresh Station A Long-term Care Health FacilitySendai 981-1105Japan

BACKGROUND ATP sensitive K+(K_(ATP))channels are ubiquitously distributed in various of cells and tissues,including the *** play a role in the pathogenesis of myocardial and liver *** To evaluate the radiation-induced changes in the expression of K_(ATP)channel subunits in the mouse liver to understand the potential role of K_(ATP)channels in radiation *** Adult C57BL/6 mice were randomly exposed toγ-rays at 0 Gy(control,n=2),0.2 Gy(n=6),1 Gy(n=6),or 5 Gy(n=6).The livers were removed 3 and 24 h after radiation *** and eosin staining was used for morphological observation;immunohistochemical staining was applied to determine the expression of K_(ATP)channel subunits in the liver *** Compared with the control group,the livers exposed to 0.2 Gyγ-ray showed an initial increase in the expression of Kir6.1 at 3 h,followed by recovery at 24 h after *** to a high dose of 5.0 Gy resulted in decreased expression of Kir6.1 and increased expression of SUR2B at 24 ***,the expression of Kir6.2,SUR1,or SUR2A had no remarkable changes at 3 and 24 h after exposure to any of these *** The expression levels of Kir6.1 and SUR2B in mouse liver changed differently in response to different radiation doses,suggesting a potential role for them in radiation-induced liver injury.

关键词： Radiation exposure ATP-sensitive K^(+)channel Mouse liver

THE CALCULATION OF THE PROFILE-liNEAR AVERAGE VELOCITY IN THE TRANSITION REGION FOR ULTRASONIC HEAT METER BASED ON THE METHOD OF LES

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Journal of Hydrodynamics 2011年第1期23卷 89-94页

作者： liU Yong-hui DU Guang-sheng tao li-li SHEN Fang School of Energy and Power Engineering Shandong University Jinan 250061 China

The measurement accuracy of an ultrasonic heat meter depends on the relationship of the profile-linear average *** are various methods for the calculation of the laminar and turbulence flow regions,but few methods for the transition *** present,the traditional method to deal with the transition region is to adopt the relationship for the turbulent flow *** this article,a simplified model of the pipe is used to study the characteristics of the transition flow with specific Reynolds *** k-εmodel and the Large Eddy Simulation（LES）model are,respectively,used to calculate the flow field of the transition region,and a comparison with the experiment results shows that the LES model is more effective than the k-εmodel,it is also shown that there will be a large error if the relationship based on the turbulence flow is used to calculate the profile-linear average velocity relationship of the transition *** profile-linear average velocity for the Reynolds number ranging from 5 300 to 10 000 are calculated,and the relationship curve is *** results of this article can be used to improve the measurement accuracy of ultrasonic heat meter and provide a theoretical basis for the research of the whole transition flow.

关键词： ultrasonic heat meter Large Eddy Simulation(LES) model profile average velocity linear average velocity pipe

Performance evaluation of ultra-long lithium heat pipe using an improved lumped parameter model

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Nuclear Science and Techniques 2021年第12期32卷 89-102页

作者： Chong-Ju Hu Da-li Yu Mei-sheng He Hua-Ping Mei Jie Yu tao-sheng li Institute of Nuclear Energy Safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Suzhou University Suzhou 234000China

lithium heat pipes have broad applications in heat pipe cooling reactors and hypersonic vehicles owing to their ultra-high working *** particular,when the length of the lithium heat pipe is ultra-long,the flow and heat transfer characteristics are more *** this study,an improved lumped parameter model that considers the Marangoni effect,bending effect,and different vapor flow patterns and Mach numbers was ***after,the proposed model was verified using the University of New Mexico’s Heat Pipe and HTPIPE ***,the verified model was applied to simulate the steady-state operation of an ultra-long lithium heat pipe in a Heat PipeSegmented Thermoelectric Module Converters space *** on the results:(1)Vapor thermal resistance was dominant at low heating power and decreased with increasing heating *** vapor flow inside the heat pipe developed from the laminar to the turbulent phase,whereas the liquid phase in the heat pipe was always laminar.(2)The vapor pressure drop caused by bending was approximately 22–23%of the total,and the bending effect on the liquid pressure drop could be ignored.(3)The Marangoni effect reduced the capillary limit by hindering the liquid reflux,especially at low vapor *** considering the Marangoni effect,the capillary limit of the lithium heat pipe was overestimated by 9%when the vapor temperature was 1400 K.(4)The total thermal resistance of the heat pipe significantly increased with increasing adiabatic length when the vapor temperature was ***,the wick dryness increased with increasing adiabatic length at any vapor *** findings improve on current knowledge for the optimal design and safety analysis of a heat pipe reactor,which adopts ultra-long lithium heat pipes.

关键词： lithium heat pipe Bending effect Marangoni effect Capillary limit Heat Pipe-Segmented Thermoelectric Module Converters(HP-STMC)

Metastable magnetic behavior in La_(0.9)Tb_(0.1)MnO_3

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Rare Metals 2017年第7期36卷 596-600页

作者： Wei-Bin liu Ying-Tang Zhang Zi-Yu Chen li-Zhu liu sheng-tao li tao-tao Ai Department of Physics Beijing University of Aeronautics and Astronautics School of Material Science and Engineering Institute of Functional MaterialShaanxi University of Technology Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and Technology State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong University

The linear and nonlinear magnetizations of La0.9Tb0.1MnO3 at low temperatures were reported in de- tail. The temperature dependence of magnetization shows peaks at 50, 100 and 150 K, respectively. When LaMnO3 is Tb-doped, its magnetic structure exhibits a canted an- tiparallel spin order. This is different from classical antiferromagnetic （AFM） in which the relaxation behavior takes place at about 150 K. At 50 K, Tb-doped LaMnO3 exhibits canonical spin glass behavior, arising from the competition of exchange and super-exchange between spins. The peak at 100 K shows neither spin glass behavior nor canted AFM behavior. Its peak value increases with frequency increasing, and the transition temperature of the peak shifts to higher temperatures with frequency increasing. The study of aging behavior at 100 K shows a periodical variable metastability, which is ascribed to the competition between ferromagnetic （FM）-, AFM- and sinusoidal-order interactions. This work should shed a light on understanding the complex magnetic structure of the perovskite oxides.

关键词： La0.9Tb0.1MnO3 Relaxation behavior Metastability

TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator

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Nuclear Science and Techniques 2023年第4期34卷 69-78页

作者： Hui-Hui Xiao ling-ling liu Wen-Yi li Bing-Bing li Xiang-li Cui Jie li tao-sheng li Zong-tao Hu School of Basic Medical Sciences Anhui Medical UniversityHefei 230000China Hefei Cancer Hospital Chinese Academy of SciencesHefei 230000China Institute of Health and Medical Technology Hefei Institute of Materials ScienceChinese Academy of SciencesHefei 230000China University of Science and Technology of China Hefei 230000China Hefei Institute of Materials Science Chinese Academy of SciencesHefei 230000China

The application of a thermoluminescent detector(TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury(RILD) in mice were to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360° arc volumetric rotational intensity-modulated radiotherapy(VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume(PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6 J mice were randomly divided into control and 25-Gy radiation groups and were examined daily for changes in body weight. They were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase(ALT), aspartate aminotransferase(AST), and alkaline phosphatase(ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within ± 3% of the Dmean value of the evaluation parameter in the TPS system. The mice in the 25-Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from-1.5 to 6%;construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible.

关键词： Thermoluminescent detector Radiation-induced liver injury linear accelerator Volumetric rotational intensity-modulated radiotherapy

Numerical simulation of tritium behavior under a postulated accident condition for CFETR TEP system

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Nuclear Science and Techniques 2023年第7期34卷 206-218页

作者： Hai-Xia Wang Xue-Wei Fu Wei-Ping liu tao-sheng li Jie Yu Institute of Nuclear Energy Safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

China Fusion Engineering Test Reactor(CFETR)is China's self-designed and ongoing next-generation fusion reactor *** confinement systems in CFETR guarantee that the radiation level remains below the safety limit during tritium handling and operation in the fuel cycle *** tritium technology team is responsible for studying tritium transport behavior in the CFETR tritium safety confinement systems of the National Key R&D Program of China launched in 2017,and we are conducting CFETR tritium plant safety analysis by using CFD *** this paper,the tritium migration and removal behavior were studied under a postulated accident condition for the Tokamak Exhaust Processing system of *** quantitative results of the transport behavior of tritium in the process room and glove box during the whole accident sequence(e.g.,tritium release,alarm,isolation,and tritium removal)have been *** results support the detailed design and engineering demonstration-related research of CFETR tritium plant.

关键词： China Fusion Engineering Test Reactor(CFETR) Tokamak Exhaust Processing(TEP)system Numerical simulation Tritium transport behavior Tritium confinement system Accident condition

Neutronics analysis of a stacked structure for a subcritical system with LEU solution driven by a D-T neutron source for~(99)Mo production

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Nuclear Science and Techniques 2021年第11期32卷 52-62页

作者： Lei Ren Yun-Cheng Han Jia-Chen Zhang Xiao-Yu Wang tao-sheng li Jie Yu Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

The utilization of neutrons markedly affects the medical isotope yield of a subcritical system driven by an external D-T neutron *** general methods to improve the utilization of neutrons include moderating multiplying,and reflecting neutrons,which ignores the use of neutrons that backscatter to the source *** this study,a stacked structure was formed by assembling the multiplier and the low-enriched uranium solution to enable the full use of neutrons that backscatter to the source direction and further improve the utilization of neutrons.A model based on SuperMC was used to evaluate the neutronics and safety behavior of the subcritical system,such as the neutron effective multiplication factor,neutron energy spectrum,medical isotope yield,and heat *** on the calculation results,when the intensity of the neutron source was 59×10^(13)n/s,the optimized design with a stacked structure could increase the yield of ^(99)Mo to182 Ci/day,which is approximately 16% higher than that obtained with a single-layer *** inlet H_(2)O coolant velocity of 1.0 m/s and initial temperature of 20℃ were also found to be sufficient to prevent boiling of the fuel solution.

关键词： Neutronics analysis Stacked structure ~(99)Mo yield Subcritical system D-T neutron source

Approaches towards the core pentasaccharide in N-linked glycans

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Chinese Chemical Letters 2018年第1期29卷 35-39页

作者： Ning Wang sheng-tao li Tian-Tian Lu Hideki Nakanishi Xiao-Dong Gao Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of Biotechnology Jiangnan University

All eukaryotic cells share a common core pentasaccharide, Man3GlcNAc2 （M3）, which is found in both dolichol-linked oligosaccharides （DLOs） and N-linked glycoproteins. A pentasaccharide M3 can be elongated and elaborated by various glycosyltransferases and is thus considered as the key intermediate in the in vitro synthetic pathway of N-glycans. In this review, we describe the progresses in the preparation of M3 by chemical and chemoenzymatic methods. We first draw a brief schematic view of the typical N-glycan biological pathway and then focus on the requirements and challenges in obtaining core pentasaccharides. Representative methods and recent reported findings, especially research progress in chemoenzymatic synthesis, are highlighted. In addition, the opportunities in exploiting novel methods for constructing N-glycans, as well as their applications, are discussed.

关键词： N-GlycanPentasaccharideChemoenzymatic synthesisAlg proteinsMannosyltransferase

Landsat Image-Based Spatiotemporal Variation Analysis of Erosion and Deposition off the Qingshuigou of the Yellow River Delta from 1984 to 2021

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Journal of Ocean University of China 2024年第5期23卷 1173-1184页

作者： DONG sheng li Songda tao Shanshan College of Engineering Ocean University of ChinaQingdao 266404China

Owing to climate change and human activity,the Qingshuigou of the Yellow River Delta(YRD)has undergone dynamic changes in erosion and ***,studying these changes is important to ensure ecological protection and sustainable *** this study,the trend of erosion-deposition evolution in the Qingshuigou was investigated based on 38 coastline phases extracted from Landsat series images of the YRD at one-year intervals from 1984 to *** periodicity of the scouring and deposition evolution was also analyzed using wavelet *** showed that the total area of the Qingshuigou was affected by deposition and erosion and that the fluctuation first increased and then *** total area reached a maximum in *** depositional area first increased and then decreased,whereas the overall erosion area *** and erosion areas showed periodic changes to some extent;however,the periodic signal intensity ***,factors including channel morphological evolution and variations in water and sediment discharge affect the spatiotemporal dynamics of erosion and deposition *** application of nonconsistency tests finally revealed that deposition area and flushing magnitude exhibited non-stationarities,which are potentially attributed to impacts from climatic change drivers.

关键词： Yellow River Delta coastline erosion and deposition remote sensing wavelet analysis

Systematic review and meta-analysis on phosphodiesterase 5 inhibitors and α-adrenoceptor antagonists used alone or combined for treatment of LUTS due to BPH

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Asian Journal of Andrology 2015年第6期17卷 1022-1032,I0012页

作者： Xing-Huan Wang Xiao Wang Ming-Jun Shi sheng li tao liu Xin-Hua Zhang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China.

The aim of this systematic review is to determine the comparative effectiveness and safety of phosphodiesterase 5 inhibitors （PDE5-1s） and （x-blockers used alone or combined for the treatment of lower urinary tract symptoms （LUTS） due to benign prostatic hyperplasia （BPH）. An electronic search of PubMed, Cochrane library and Embase up to January 2014 was performed to identify randomized controlled trials comparing the efficacy and safety of PDE5-Is and （x-blockers for treatment of lower urinary tract symptoms due to benign prostatic hyperplasia, which assessed IPSS score, maximum flow rate, postvoided residual urine, quality of life and Erectile Function （IIEF） score as outcomes. Data were analyzed by fixed or random effect models using Cochrane Collaboration review manager software. A total of 12 studies were included, Our novel data demonstrated that there was a trend that （x-blockers were more efficacious than PDE5-Is on decreasing IPSS score and increasing maximum flow rate. （x-blockers were significantly more effective than PDE5-Is on reduction of postvoided residual urine with a mean difference of 3.67 （95% CI 1.56 to 5.77, P = 0.0006） and PDE5-Is showed greater effect than （x-blockers on increasing IIEF score with a mean difference of 9.82 （95% CI 3.80 to 15.85, P = 0.001）. In conclusion, our novel data demonstrated that PDE5-Is plus ABs ranked the highest on the improvement of LUTS/BPH. PDE5-Is monotherapy was also effective in this kind of disorder except less reduction of PVR than ABs, In addition, both combined- or mono-therapy were safe.

关键词： benign prostatic hyperplasia lower urinary tract symptoms meta-analysis phosphodiesterase 5 inhibitors -adrenoceptorantagonists