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Rapid progressive vaccine-induced immune thrombotic thrombocytopenia with cerebral venous thrombosis after ChAdOx1 nCoV-19(AZD1222)vaccination:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9462-9469页

作者： Shin-Kuang Jiang Wei-Liang Chen Chun Chien Chi-Syuan Pan sheng-ta tsai Department of Neurology China Medical University HospitalTaichung 404332Taiwan Department of Radiology China Medical University HospitalTaichung 404332Taiwan Department of Neurology China Medical University Hsinchu HospitalHsinchu 30272Taiwan Department of Emergency China Medical University HospitalTaichung 404332Taiwan Neuroscience and Brain Disease Center China Medical UniversityTaichung 404332Taiwan

BACKGROUND Vaccine-induced immune thrombotic thrombocytopenia(VITT)is a rare and potentially life-threatening condition after receiving coronavirus disease *** is characterized by symptom onset at 5 to 30 d postvaccination,thrombocytopenia,thrombosis,high D-dimer level,and antiplatelet factor 4(anti-PF4)antibody *** can progress very fast,requiring urgent *** few studies have described its detailed clinical course and imaging *** report a typical VITT case in a patient who underwent regular repeated brain imaging *** SUMMARY A young woman presented with headaches at 7 d after the ChAdOx1 nCoV-19vaccine(AZD1222)*** then showed progressive symptoms of left upper limb *** computed tomography revealed venous infarction at the right parietal lobe with a hyperacute thrombus in the cortical *** hours later,brain magnetic resonance imaging revealed hemorrhage at the same *** resonance venography showed an irregular contour of the right transverse *** examination revealed a high D-dimer level,thrombocytopenia,and a high titer for anti-PF4 *** was treated with anticoagulants,intravenous immunoglobulin,and steroids and analgesic agents were administered for pain *** had a marked improvement on headaches and clumsiness after treatment along with radiological thrombus *** follow-up at the outpatient department,her modified Rankin scale at 90 d was *** Clinicians should be alerted whenever patients present with persistent and progressive headaches or focal motor/sensory deficits postvaccination.

关键词： Vaccine-induced immune thrombotic thrombocytopenia Intracranial Sinus Thrombosis ChAdOx1 nCoV-19 vaccine(AZD1222) Headache Serial brain image Case report

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Predictors of unfavorable outcome at 90 days in basilar artery occlusion patients

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World Journal of Clinical Cases 2022年第12期10卷 3677-3685页

作者： Yu-Chen Chiu Jia-Li Yang Wei-Chun Wang Hung-Yu Huang Wei-Liang Chen Pao-sheng Yen Ying-Lin Tseng Hsiu-Hsueh Chen sheng-ta tsai Department of Neurology An Nan HospitalChina Medical UniversityTainan 709204Taiwan College of Medicine China Medical UniversityTaichung 404332Taiwan Department of Anesthesiology China Medical University HospitalTaichung 404332Taiwan Department of Neurology China Medical University HospitalTaichung 404332Taiwan Department of Radiology China Medical University HospitalTaichung 404332Taiwan Department of Radiology Kuang Tien General HospitalTaichung 404332Taiwan Stroke Center China Medical University HospitalTaichung 404332Taiwan

BACKGROUND In a previous study,basilar artery occlusion(BAO)was shown to lead to death or disability in 80%of the *** treatment for BAO patients in the acute stage includes thrombolysis and intra-arterial thrombectomy,but not all patients benefit from these ***,understanding the predictors of outcome before initiating these treatments is of special *** To determine the predictors related to the 90-d clinical outcome in patients with BAO in an Asian *** We performed a retrospective case review of patients admitted to a tertiary stroke center between 2015 and *** used the international classification of diseases-10 criteria to identify cases of posterior circulation stroke.A neurologist reviewed every case,and patients fulfilling the criteria defined in the Basilar Artery International Cooperation Study were *** then analyzed the patients’characteristics and factors related to the 90-d *** We identified a total of 99 patients as real BAO *** these patients,33(33.3%)had a favorable outcome at 90 d(modified Rankin Scale:0–3).Moreover,72 patients received intra-arterial thrombectomy,while 13 patients received intravenous tissue-type plasminogen activator *** observed a favorable outcome in 33.3%of the cases and an unfavorable outcome in 66.7%of the *** found that the initial National Institutes of Health Stroke Scale(NIHSS)score and several BAO symptoms,including impaired consciousness,tetraparesis,and pupillary abnormalities,were significantly associated with an unfavorable outcome(P<0.05),while cerebellar symptoms were associated with a favorable outcome(P<0.05).In the receiver operating characteristic(ROC)analysis,the areas under the ROC curve of initial NIHSS score,impaired consciousness,tetraparesis,cerebellar symptoms,and pupillary abnormalities were 0.836,0.644,0.727,0.614,and 0.614,*** NIHSS score showed a higher AUROC(0.836)compared to BAO ***

关键词： Basilar artery occlusion National Institutes of Health Stroke Scale Natural course Outcome Asian

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Glutamic acid decarboxylase 65-positive autoimmune encephalitis presenting with gelastic seizure, responsive to steroid: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5325-5331页

作者： Camerdy Yue Yang sheng-ta tsai Department of Neurology China Medical University HospitalTaichung 404332Taiwan

BACKGROUND Anti-glutamic acid decarboxylase(GAD)antibody is known to cause several autoimmune-related *** most known relationship is that it may cause type I *** addition,it was also reported to result in several neurologic syndromes including stiff person syndrome,cerebellar ataxia,and autoimmune *** ago,isolated epilepsy associated with anti-GAD antibody was first ***,the association between temporal lobe epilepsy and anti-GAD antibody has been ***,with improvements in examination technique,many more autoimmune-related disorders can be diagnosed and treated easier than in the *** SUMMARY A 44-year-old female Asian with a history of end-stage renal disease(without diabetes mellitus)under hemodialysis presented with diffuse abdominal *** initial diagnosis was peritonitis complicated with sepsis and paralytic *** peritonitis was treated and she recovered well,but seizure attack was noticed during *** clinical impression was gelastic seizure with the presentation of frequent smiling,head turned to the right side,and eyes staring without focus;the duration was about 5–10 *** lobe epilepsy was recorded through electroencephalogram,and she was later diagnosed with anti-GAD65 antibody positive autoimmune *** seizure was treated initially with several anticonvulsants but with poor ***,she showed excellent response to intravenous methylprednisolone pulse *** consciousness returned to normal,and no more seizures were recorded after 5 d of intravenous methylprednisolone *** In any case presenting with new-onset epilepsy,in addition to performing routine brain imaging to exclude structural lesion and cerebrospinal fluid studies to exclude common etiologies of infection and inflammation,checking the autoimmune profile has to be *** the practice of modern medicine,autoimmune-related disorders are relatively treatab

关键词： Anti-GAD antibody GAD65 antibody Autoimmune encephalitis Gelastic seizure Electroencephalogram Case report

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Propofol pump controls nonconvulsive status epilepticus in a hepatic encephalopathy patient: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2831-2837页

作者： Shao Hor Chih-Yu Chen sheng-ta tsai Department of Anesthesiology China Medical University HospitalTaichung 40447Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal MedicineChina Medical University HospitalTaichung 40447Taiwan Department of Neurology China Medical University HospitalTaichung 40447Taiwan

BACKGROUND Status epilepticus is an emergent and critical condition which needs management without hesitation. Nonconvulsive status epilepticus (NCSE) tends to be less recognized, and its diagnosis is delayed in comparison with overt status epilepticus because of the absence of specific clinical signs. It is often difficult to make a diagnosis, particularly in patients with hepatic encephalopathy. CASE SUMMARY A 38-year-old man with a history of alcoholic liver cirrhosis presented with altered mental status;the initial diagnosis was hepatic encephalopathy. Although optimal treatment for hepatic encephalopathy was administered, the patient's mental status did not improve. A final diagnosis of NCSE was made by continuous electroencephalogram (EEG) monitoring. Treatment with levetiracetam and propofol pump was immediately started. The patient’s consciousness gradually improved after discontinuation of propofol therapy, and no further epileptic discharge was observed by EEG monitoring. After 1 wk, the patient returned to full consciousness, and he was able to walk in the hospital ward without assistance. He was discharged with minimal sequela of bilateral conjunctivitis. CONCLUSION In cases of persistent altered mental status without reasonable diagnosis, NCSE should be considered in hepatic encephalopathy patients with persistently altered levels of consciousness, and EEG monitoring is very important. We also recommend propofol as a safe and efficient therapy for NCSE in liver cirrhosis patients.

关键词： Nonconvulsive status epilepticus Hepatic encephalopathy Electroencephalogram Propofol Multidisciplinary team Case report

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Emerging role of galectin 3 in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： Brian M.Lozinski Khanh ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

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Discussion of the Composition of Jaboticaba in Different Processes

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Food and Nutrition Sciences 2024年第1期15卷 101-112页

作者： Ching-Hu tsai Yi-Chun Lin Chih-ta Liu Yo-Ju Chen Department of Long-Term Care Kang Ning University Taipei Department of Respiratory Therapy En Chu Kong Hospital New Taipei City Department of Thoracic Surgery Division En Chu Kong Hospital New Taipei City

This study discusses the composition analysis and comparison of Jaboticaba under different processing conditions for fermented liquid, jam, fruit powder, and fruit vinegar. The differences and comparison of the contents of total polyphenols, anthocyanins, resveratrol, superoxide dismutase, small molecular peptides and ellagic acid in their products were analyzed. After analysis and comparison of results, the content of total polyphenols was found to be the highest 44.82 ± 0.89 (mg/g) after being fermented directly from fresh fruit. The fresh fruit was dried at low temperature and ground into powder, with a maximum ellagic acid content of 12.799 ± 0.12 (mg/g). Fresh fruit was then made into jam, with the highest anthocyanin content of 57.39 ± 1.20 (mg/g). The fruit vinegar was produced by fermentation. Except for the content of small molecule peptides, which was similar to the content of fermentation broth and fruit powder, they were 20.63 ± 1.61, 23.84 ± 2.51 and 20.52 ± 1.21 (mg/g), and the rest of the composition was not as good as other samples. In the fresh fruit fermentation broth samples, resveratrol was produced and detected, and its content was 2.14 (mg/L), while it was not detected in other samples, and a superoxide dismutase (SOD)-like enzyme was detected in the fresh fruit fermentation broth. The highest activity was 49002.5 units/mL. Jaboticaba is prepared using a fermentation broth processing method with fresh fruit, and its total polyphenol content is higher than that of fruit powder, jam, and fruit vinegar. The commercial value of Jaboticaba and the establishment of composition content data are relatively improved, which is more promising for the future.

关键词： Jaboticaba Total Polyphenols Anthocyanins Resveratrol Small Molecule Peptides

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Exponentially Bounded C-semigroup and the Cauchy Initial Value Problems in Complete Random Normed Modules

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2195-2212页

作者： Son ta CONG Thang Dang HUNG Oanh Le THI Department of Mathematics University of ScienceVietnam National University 334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Natural Sciences Hong Duc University565 Quang TrungDong VeThanh HoaVietnam

In this paper,the notion of C-semigroup of continuous module homomorphisms on a complete random normal(RN)module is introduced and *** existence and uniqueness of solution to the Cauchy problem with respect to exponen... 详细信息

关键词： C-semigroup Cauchy problem random normed modules L^(0)-Lipschitz

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A robust vector tracking loop structure based on potential bias analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 405-420页

作者： Qiongqiong JIA Yiran LUO Bing XU Li-ta HSU Renbiao WU Tianjin Key Lab for Advanced Signal Processing Civil Aviation University of ChinaTianjin 300300China Interdisciplinary Division of Aeronautical and Aviation Engineering The Hong Kong Polytechnic University999077Hong KongChina Department of Geomatics Engineering University of CalgaryCalgary T2N1N4Canada

This paper proposes a robust vector tracking loop structure based on potential bias analysis. The influence of four kinds of biases on the existing two implementations of Vector Tracking Loops(VTLs) is illustrated by theoretical analysis and numerical simulations, and the following findings are obtained. Firstly, the initial user state bias leads to steady navigation solution bias in the relative VTL, while new measurements can eliminate it in the absolute VTL. Secondly, the initial code phase bias is transferred to the following navigation solutions in the relative VTL, while new measurements can eliminate it in the absolute VTL. Thirdly, the user state bias induced by erroneous navigation solution of VTLs can be eliminated by both of the two VTLs. Fourthly,the multipath/NLOS likely affects the two VTLs, and the induced tracking bias in the duration of the multipath/NLOS would decrease the performance of VTLs. Based on the above analysis,a robust VTL structure is proposed, where the absolute VTL is selected for its robustness to the two kinds of initialization biases;meanwhile, the instant bias detection and correction method is used to improve the performance of VTLs in the duration of the multipath/NLOS. Numerical simulations and experimental results verify the effectiveness of the proposed robust VTL structure.

关键词： Global Navigation Satellite System(GNSS) Vector Tracking Loop(VTL) Multipath Non-Line-of-Sight(NLOS) Tracking bias propagation Least Absolute Shrinkage and Selection Operator(LASSO)

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The impact of broad glutamine metabolism inhibition on the tumor microenvironment

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Genes & Diseases 2024年第3期11卷 2-4页

作者： Tianhe Li Yun-ta Chuang Tian-Li Wang Departments of Pathology Oncologyand Gynecology and ObstetricsThe Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21231USA

Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and *** also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox *** cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.

关键词： metabolism tumor microenvironment

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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam ta Zhou Zong-Rui Ma Jia-Bao sheng Victor CWtam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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