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Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease

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Cellular & Molecular Immunology 2023年第1期20卷 38-50页

作者： Miao-Hsi Hsieh Pei-Chi Chen Han-Yin Hsu Jui-Chang Liu Yu-sheng Ho Yuh Jyh Lin Chin-Wei Kuo Wen-Shuo Kuo Hui-Fang kao Shulhn-Der Wang Zhi-Gang Liu Lawrence Shih-Hsin Wu Jiu-Yao Wang Center for Allergy Immunologyand Microbiome(A.I.M.)China Medical University HospitalTaichungTaiwanChina Graduate Institute of Basic Medical Sciences College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Nursing National Tainan Junior College of NursingTainanTaiwanChina Graduate Institute of Biochemistry and Molecular Biology College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Pediatrics National Cheng Kung University HospitalTainanTaiwanChina Division of Pulmonary Medicine Department of Internal MedicineNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Institute of Clinical Medicine College of MedicineNational Cheng Kung UniversityTainanTaiwanChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjingChina School of post-Baccalaureate Chinese Medicine China Medical UniversityTaichungTaiwanChina Department of Respirology and Allergy Third Affiliated Hospital of Shenzhen UniversityShenzhenChina Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Allergy Immunologyand Rheumatology(AIR)China Medical University Children’s HospitalTaichungTaiwanChina

Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or in patients with chronic obstructive pulmonary disease (COPD) who are also chronically exposed to cigarette smoke (CS). However, the roles and molecular mechanisms of SP-D and FMs in COPD have not yet been determined. In this study, increased levels of SP-D were found in the bronchoalveolar lavage fluid (BALF) and sera of ozone- and CS-exposed mice. Furthermore, SP-D-knockout mice showed increased lipid-laden FMs and airway inflammation caused by ozone and CS exposure, similar to that exhibited by our study cohort of chronic smokers and COPD patients. We also showed that an exogenous recombinant fragment of human SP-D (rfhSP-D) prevented the formation of oxidized low-density lipoprotein (oxLDL)-induced FMs in vitro and reversed the airway inflammation and emphysematous changes caused by oxidative stress and CS exposure in vivo. SP-D upregulated bone marrow-derived macrophage (BMDM) expression of genes involved in countering the oxidative stress and lipid metabolism perturbations induced by CS and oxLDL. Our study demonstrates the crucial roles of SP-D in the lipid homeostasis of dysfunctional alveolar macrophages caused by ozone and CS exposure in experimental mouse emphysema, which may provide a novel opportunity for the clinical application of SP-D in patients with COPD.

关键词： Alveolar macrophages Chronic obstructive pulmonary diseases Surfactant protein D Lipid metabolism Ozone Cigarettes

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安脑丸联合降血压药治疗原发性高血压病的经济学评价:一项基于决策树模型的研究

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中国中药杂志 2024年第6期49卷 1683-1689页

作者：陈子佳崔鑫韩晟乔萌付常宽王志飞谢雁鸣中国中医科学院中医临床基础医学研究所北京100700 北京大学医药管理国际研究中心北京100089

该研究旨在评价中国医疗环境下安脑丸联合降血压药治疗原发性高血压病的经济性。从卫生体系角度出发,运用TreeAge pro 2018构建模型对2种治疗方案进行成本⁃效果分析及敏感性分析。模拟模型干预时间为2周,成本参数源于药智网,效果参数基... 详细信息

该研究旨在评价中国医疗环境下安脑丸联合降血压药治疗原发性高血压病的经济性。从卫生体系角度出发,运用TreeAge pro 2018构建模型对2种治疗方案进行成本⁃效果分析及敏感性分析。模拟模型干预时间为2周,成本参数源于药智网,效果参数基于安脑丸加载随机对照试验(RCT)合并后的Meta分析,安脑丸组干预措施为安脑丸联合降血压药(硝苯地平控释片+氯沙坦钾片),对照组干预措施为降血压药(硝苯地平控释片+氯沙坦钾片)。基础分析显示,2组增量成本⁃效果比(ICER)为2678.67元,ICER小于2022年人均可支配收入的7.26%,即相比于单用降血压药,安脑丸联合降血压药每多治疗1例有效的原发性高血压病患者需多花费2678.67元。敏感性分析验证了基础分析结果的稳健性,概率敏感性分析显示,当患者的个人意愿支付价格高于2650元时,安脑丸组干预措施具有经济性的概率更高,与基础分析结果一致。结果表明,当个人意愿支付价格高于2650元时,原发性高血压病患者选用安脑丸联合降血压药比单用降血压药在改善有效率方面更具有经济性。

关键词：安脑丸原发性高血压病药物经济学成本⁃效果分析

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Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome

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Chinese Journal of Integrative Medicine 2020年第7期26卷 519-526页

作者： Yung-Hsiang Chen Wen-Chi Chen kao-Sung Tsai po-Len Liu Ming-Yen Tsai Tzu-Chun Lin Shih-Chieh Yu Huey-Yi Chen Graduate Institute of Integrated Medicine College of MedicineResearch Center for Chinese Medicine and AcupunctureChinese Medicine Research CenterChina Medical UniversityTaichungTaiwanChina Departments of Medical Research Urologyand Obstetrics and GynecologyChina Medical University HospitalTaichungTaiwanChina Department of Psychology College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Department of Applied Cosmetology Master Program of Cosmetic ScienceHungkuang UniversityTaiwanChina Department of Respiratory Therapy College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Chinese Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiungTaiwanChina Department of Dermatology Chung Shan University HospitalInstitute of MedicineSchool of MedicineChung Shan Medical UniversityTaichungTaiwanChina Department of Neurology Kuang Tien General HospitalTaichungTaiwanChina

Objective:To investigate the efficacy of frankincense and myrrha in the treatment of acute interstitial cystitis/painful bladder syndrome(IC/PBS).Methods:The effects of frankincense and myrrha on the proliferation and migration of primary human urothelial cells(HUCs)were assessed in *** the animal study,48 virgin female rats were randomized into 4 groups(12 in each group):(1)control group(saline-injected control);(2)cyclophosphamide(CYP)group(intraperitoneal injected 150 mg/kg CYP);(3)CYP+pentosan polysulfate sodium group(orally received 50 mg/kg pentosan polysulfate sodium);and(4)CYP+frankincense and myrrha group[orally received frankincense(200 mg/kg)and myrrha(200 mg/kg)].Rats orally received pentosan polysulfate sodium or frankincense and myrrha on day 1,2,and *** experiments were performed on day *** and cystometry assessment behavior test were *** interval values were assessed in rats under ***,immunohistochemistry and Western blot were used to confirm the location and level,respectively,of cell junction-associated protein zonula occludens-2(ZO-2)***:Low dose frankincense and myrrha increased cell proliferation and migration in HUCs compared with control(Ppolysulfate and frankincense+myrrha groups compared with the CYP-induced acute IC/PBS group(P<0.05).Conclusion:frankincense and myrrha modulate urothelial wound healing,which ameliorates typical features of acute IC/PBS in rats.

关键词： frankincense myrrha acute interstitialcystitis painful bladder syndrome cell junction-associated protein

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用于H_(2)po_(4)^(-)检测的比率型荧光探针合成及性能研究

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化学试剂 2024年第6期46卷 33-38页

作者：郭昌晟陈君霞刘忆茹卢钰盛董智云席福贵忻州师范学院化学系山西忻州034000

设计合成了一种基于吖啶-苯并咪唑鎓的大环受体ABIM,可作为H_(2)po_(4)^(-)的荧光比率传感器。借助荧光光谱研究了受体ABIM对H_(2)po_(4)^(-)的选择性识别,在大环受体ABIM的乙腈溶液中加入H_(2)po_(4)^(-)后,在426 nm处荧光发射明显“... 详细信息

设计合成了一种基于吖啶-苯并咪唑鎓的大环受体ABIM,可作为H_(2)po_(4)^(-)的荧光比率传感器。借助荧光光谱研究了受体ABIM对H_(2)po_(4)^(-)的选择性识别,在大环受体ABIM的乙腈溶液中加入H_(2)po_(4)^(-)后,在426 nm处荧光发射明显“关闭”,506 nm处荧光发射明显“打开”,溶液荧光颜色由蓝色变为蓝绿色,新的荧光发射峰可能是由于H_(2)po_(4)^(-)诱导两个受体中的吖啶环之间形成Excimer产生的。ABIM与H_(2)po_(4)^(-)以1∶1的化学计量比结合,结合常数为(7.13±0.48)×10^(6)L/mol,检出限为2.38×10-7 mol/L,最佳响应时间为2 min。回收实验表明,ABIM可应用于样品中H_(2)po_(4)^(-)的检测。

关键词：吖啶苯并咪唑鎓 H 2po-4 大环比率型荧光探针

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Rubus chingii Hu: an overview of botany, traditional uses,phytochemistry, and pharmacology

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Chinese Journal of Natural Medicines 2020年第6期18卷 401-416页

作者： sheng Jia-Yun WANG Si-Qi LIU kao-Hua ZHU Bo ZHANG Qiao-Yan QIN Lu-Ping WU Jian-Jun School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou 310053China

Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits(Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity,and quality control of R. chingii. possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use.

关键词： Rubus chingii Hu Botany Traditional uses Phytochemistry Pharmacology Review

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Hollow cubic MnS-CoS_(2)-NC@NC designed by two kinds of nitrogen-doped carbon strategy for sodium ion batteries with ultraordinary rate and cycling performance

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Nano Research 2022年第4期15卷 3273-3282页

作者： Ruipeng Wei Yutao Dong Yingying Zhang Xiyang Kang Xia sheng Jianmin Zhang College of Science Henan Agricultural UniversityZhengzhou 450002China College of Chemistry Zhengzhou UniversityZhengzhou 450001China

In order to obtain an advanced anode material that exhibits excellent electrochemical performance in sodium ion batteries,a hollow nanocube MnS-CoS_(2)-NC@NC(NC=nitrogen-doped carbon)with two kinds of nitrogen-doped carbon was synthesized by simple one-step *** of the two kinds of nitrogen-doped carbon comes from the organic ligands in the precursor being mixed in the sulfide after calcination,and the other comes from the calcination of the coated polydopamine(PDA)to form a carbon shell wrapped outside the *** characteristic nanostructure with two kinds of nitrogen-doped carbon can not only improve the overall conductivity of the electrode material,which is obviously beneficial to the rapid transmission of sodium ions and thus outstanding rate performance,but also can alleviate volume expansion to maintain battery cycle *** the half-cell,the MnS-CoS_(2)-NC@NC electrode not only provides an ultra-high specific capacity of 608.5 mA·h·g^(-1)at 0.2 A·g^(-1)for 100 cycles,but also shows an outstanding rate performance of 560.5 mA·h·g^(-1)at 5.0 A·g^(-1)for 1,100 *** in a full-cell composed with Na3V2(po4)3 as the positive material,it can still maintain a capacity of 436.7 mA·h·g^(-1)after 900 cycles at 1.0 A·g^(-1).In order to explore its sodium storage mechanism,in-situ and ex-situ X-ray diffraction(XRD)tests were carried out to prove that CoS_(2)and MnS were reduced to produce metallic Co and metallic Mn during the discharging process,respectively,and reversibly returned during the charging process.

关键词： MnS CoS_(2) hollow nanocube nitrogen-doped carbon sodium ion battery

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Refractive Index Engineering as a Novel Strategy toward Highly Transparent and Tough Sustainable polymer Blends

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Chinese Journal of polymer Science 2020年第12期38卷 1335-1344页

作者： Si-Ting Sun Hang Wang Dong Huang Ying-Li Ding Yang Zhang Dong-po Song Kun-Yu Zhang Li Pan Yue-sheng Li Department of polymer Science and Engineering School ofChemical Engineering and TechnologyTianjin UniversityTianin 300350China Department of Chemical Engineering Xiamen UniversityXiamen 361005China Tianjin Key Laboratory ofComposite and Functional Materials School ofMaterials Science and EngineeringTianjin UniversityTlanin 300350 China Cllaborotive lovation Center ofChemical Science and Engineering(injin) Tianjin 300072 China

High transparency and toughness are prerequisites for sustainable polymers if they are to find wide application as alternatives to petroleum-based ***,the utility of sustainable polymers such as commercially available polylactide(PLA)is limited by their inherent brittleness and high ***,toughening PLA-based materials via cost-effective blending strategies without sacrificing transparency remains a ***,we report a novel strategy involving active refractive index matching for creation of highly transparent and tough PLA ***,we engineered the refractive index of a promising renewable poly(epichlorohydrin-co-ethylene oxide)elastomer by introducing polar ionic moieties via a simple chemical method,and we blended the resulting ionomers with *** best blend showed an impact strength of>80 kJ/m2,an elongation at break of 400%,and high transparency(90%).These characteristics are of great importance for potential applications such as *** strategy offers a versatile new way to prepare high-performance sustainable polymer materials with excellent transparency.

关键词： polylactide Blending strategies Refraaive index matching poly(epichlorohydrin-co-ethylene oxide) Ionomers

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清咳平喘颗粒治疗轻中型新型冠状病毒感染的临床研究

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现代药物与临床 2024年第6期39卷 1505-1510页

作者：盛媛姬崔曼曼霍佳慧孙玮邵幼林徐天敏常州市第三人民医院江苏常州213001

目的观察清咳平喘颗粒治疗轻型、中型新冠病毒感染患者的临床有效性及安全性。方法选取2023年4月—2023年6月在常州市第三人民医院就诊的轻型、中型新冠病毒感染(痰热壅肺型)患者93例,按照随机数字表法将患者分为对照组(45例)和治疗组... 详细信息

目的观察清咳平喘颗粒治疗轻型、中型新冠病毒感染患者的临床有效性及安全性。方法选取2023年4月—2023年6月在常州市第三人民医院就诊的轻型、中型新冠病毒感染(痰热壅肺型)患者93例,按照随机数字表法将患者分为对照组(45例)和治疗组(48例)。对照组患者进行基础治疗及抗病毒治疗。治疗组在对照组治疗基础上服用清咳平喘颗粒,1袋/次,3次/d,两组疗程均为7d。观察两组患者临床疗效,比较治疗前后两组患者中医证候评分,简易咳嗽程度评分表(CET),主要临床症状消失率及C反应尿蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)等炎症指标。结果治疗后,治疗组总有效率(97.92%)显著高于对照组(86.67%)(P<0.05)。治疗后,两组中医证候评分、咳嗽程度评分显著降低(P<0.05),且治疗组在第7天的治疗作用显著强于对照组(P<0.05)。治疗后,相比对照组,治疗组能够显著促进咳嗽症状消失(P<0.05)。治疗后,两组患者炎症指标IL-6、CRP水平显著降低(P<0.05),且治疗组显著低于对照组(P<0.05)。结论清咳平喘颗粒联合西医常规治疗能够显著提高新冠病毒感染治疗的临床有效率,降低中医证候评分,改善患者咳嗽程度,促进咳嗽症状的缓解与消失,降低炎症水平,安全性良好,具有临床推广价值。

关键词：清咳平喘颗粒轻型新冠病毒感染中型新冠病毒感染痰热壅肺证简易咳嗽程度评分表降钙素原

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电动汽车充电站规划研究综述

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中国公路学报 2022年第12期35卷 230-252页

作者：王震坡张瑾刘鹏张照生北京理工大学电动车辆国家工程研究中心北京100081 北京理工大学电动车辆协同创新中心北京100081 北京理工大学重庆创新中心重庆401120

新能源汽车尤其是电动汽车已在全球范围内得到广泛推广应用,从而带来了巨大的充电需求。同时,部分充电站规划不合理导致充电站空间布局和服务容量与实际充电需求不匹配,充电站利用率低和用户充电不便并存的现象已经成为了电动汽车产业... 详细信息

新能源汽车尤其是电动汽车已在全球范围内得到广泛推广应用,从而带来了巨大的充电需求。同时,部分充电站规划不合理导致充电站空间布局和服务容量与实际充电需求不匹配,充电站利用率低和用户充电不便并存的现象已经成为了电动汽车产业痛点。充电站的合理布局规划是优化电动汽车使用体验和充电体验、降低用户“里程焦虑”、提高充电桩利用率、优化城市电动汽车交通网络和电力网络的关键,也成为当前电动汽车及智能交通领域急需解决的问题。为提供该领域较为全面的综述视角,首先概述电动汽车充电站的发展情况、设施类型、相关标准,总结从“车端”、“站端”出发的电动汽车充电需求估计方法,然后从选址、定容、求解算法维度分析充电站规划模型,列举国内外在多优化目标、多约束条件、多阶段规划的覆盖模型、截流模型等规划模型中的研究成果,以及在各经典模拟网络和实际城市环境中的测试、应用情况,最后对目前充电站规划领域存在的充电需求估计准确性、充电站与未来需求的匹配度等问题进行总结,对“车-桩-路-网”互联时代下充分利用电动汽车的分布式储能、灵活充放电的特征进行有序充电引导、新能源消纳、电网削峰填谷的协同规划发展应用前景进行展望。

关键词：汽车工程电动汽车综述充电站选址定容规划方法

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粉煤灰资源利用:无机矿物改良剂对CFA源蛋白石/沙粒团聚体形成的影响

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Journal of Central South University 2024年第4期31卷 1248-1264页

作者：李为轮王一霖朱锋周秋生刘桂华彭志宏齐天贵申雷霆李小斌 School of Metallurgy and Environment Central South UniversityChangsha 410083China

粉煤灰碱法提铝的副产物-蛋白石(SiO_(2)·nH_(2)O,非晶质二氧化硅)具有很强的吸附性,是土壤中的次生/黏土矿物。将蛋白石与沙粒复配形成团聚体应用于沙漠化土壤修复,是一种前景广阔的大规模生态化处置方式。然而,由于无机矿物质的缺乏... 详细信息

粉煤灰碱法提铝的副产物-蛋白石(SiO_(2)·nH_(2)O,非晶质二氧化硅)具有很强的吸附性,是土壤中的次生/黏土矿物。将蛋白石与沙粒复配形成团聚体应用于沙漠化土壤修复,是一种前景广阔的大规模生态化处置方式。然而,由于无机矿物质的缺乏,该团聚体与自然土壤团聚体仍有差距。本文通过短期土培实验,研究了石灰石(CaCO_(3))、脱硫石膏(CaSO_(4)·2H_(2)O)、磷酸钙(Ca_(3)(po_(4))_(2))、赤铁矿(Fe_(2)O_(3))、三水铝石(Al(OH)_(3))等无机矿物改良剂对团聚体形成、稳定以及孔隙特征的影响,并阐述了其内在的吸附机理。结果表明,五种改良剂中,只有石膏可有效降低团聚体的pH,且石膏对提升团聚体的保水效果最为显著,但石膏会增大电导率。改良剂均能促进团聚体的形成,提高机械稳定性,石膏、CaCO_(3)、Fe_(2)O_(3)有利于提高团聚体的水稳性。XRD/SEM/FT-IR/XPS等分析表明,无机矿物与沙子/蛋白石发生吸附作用,团聚体表面形成了有利于团聚体生成的无机矿物界面层。与CK相比,改良后的大团聚体(>0.25 mm)以孔径po_(4))_(2)和Al(OH)_(3)增加了>15 nm介孔的数量。总之,作为土壤“骨架”的无机矿物有效改善了蛋白石/沙粒团聚体的物理结构,加速了团聚体的形成。因此,脱硫石膏优化了大聚集体的形成和稳定性。经脱硫石膏改良的团聚体可作为类土壤基质,加速退化的沙漠化土壤的生态重建。

关键词：无机矿物改良剂蛋白石/沙粒团聚体脱硫石膏团聚体稳定性孔隙特征沙漠化土壤修复

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