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Identification of the activity source of CO2 electroreduction by strategic catalytic site distribution in stable supramolecular structure system

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National Science Review 2021年第3期8卷 78-87页

作者： sheng-nan sun Ning Li Jiang Liu Wen-Xin Ji Long-Zhang Dong Yi-Rong Wang Ya-Qian Lan Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BatteriesSchool of Chemistry and Materials Science Nanjing Normal University School of Chemistry and Chemical Engineering Yangzhou University State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering Ningxia University

Identification of the real catalytic site in CO;2;reduction reaction（CO;2;RR） is critical for the rational design of catalysts and the understanding of reactive *** this study,the catalytic activity of pyridine-containing materials was for the first time structurally demonstrated in CO;2;RR by crystalline supramolecular coordination compounds model *** system consists of three stable supramolecular coordination compounds（Ni-TPYP,Ni-TPYP-1 and Ni-TPP） with different numbers（4,2 and 0） of active pyridine groups（*** pyridine nitrogen atoms）.The electrocatalytic test results show that with the decrease of the number of active pyridine groups,the CO;2;RR performance is gradually reduced,mainly showing the reduction of highest FE;CO;（99.8%,83.7% and 25.6%,respectively）.The crystallographic,experimental and theoretical evidences prove that the CO;2;RR activity is more likely derived from uncoordinated pyridine nitrogen than the electrocatalytic inert metal nickel in porphyrin *** work serves as an important case study for the identification of electrocatalytic activity of pyridine-containing materials in CO;2;RR by simple supramolecular model system.

关键词： strategic catalytic site distribution supramolecular structure system active source CO2 electroreduction

Green synthesis of bifunctional phthalocyanine-porphyrin COFs in water for efficient electrocatalytic CO2 reduction coupled with methanol oxidation

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National Science Review 2023年第11期10卷 160-170页

作者： Mi Zhang Jia-Peng Liao Run-Han Li sheng-nan sun Meng Lu Long-Zhang Dong Pei Huang Shun-Li Li Yue-Peng Cai Ya-Qian Lan South China Normal University School of Chemistry

Electrocatalytic CO2reduction(ECR) coupled with organic oxidation is a promising strategy to produce high value-added chemicals and improve energy efficiency. However, achieving the efficient redox coupling reaction is still challenging due to the lack of suitable electrocatalysts. Herein, we designed two bifunctional polyimides-linked covalent organic frameworks(PI-COFs) through assembling phthalocyanine(Pc) and porphyrin(Por) by non-toxic hydrothermal methods in pure water to realize the above catalytic *** to the high conductivity and well-defined active sites with different chemical environments, Ni Pc-Ni Por COF performs efficient ECR coupled with methanol oxidation reaction(MOR)(Faradaic efficiency of CO(FECO) = 98.12%, partial current densities of CO(j CO) = 6.14 m A cm-2for ECR, FEHCOOH = 93.75%,j HCOOH = 5.81 m A cm-2for MOR at low cell voltage(2.1 V) and remarkable long-term stability).Furthermore, experimental evidences and density functional theory(DFT) calculations demonstrate that the ECR process mainly conducts on Ni Pc unit with the assistance of Ni Por, meanwhile, the MOR prefers Ni Por conjugating with Ni Pc. The two units of Ni Pc-Ni Por COF collaboratively promote the coupled oxidation-reduction reaction. For the first time, this work achieves the rational design of bifunctional COFs for coupled heterogeneous catalysis, which opens a new area for crystalline material catalysts.

关键词： hydrothermal synthesis phthalocyanine-porphyrin COFs bifunctional electrocatalysts electrocatalytic CO2 reduction methanol oxidation reaction

A Nomogram Model for Predicting Type-2 Myocardial Infarction Induced by Acute Upper Gastrointestinal Bleeding

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Current Medical Science 2022年第2期42卷 317-326页

作者： Gui-jun JIANG Ru-kai GAO Min WANG Tu-xiu XIE Li-ying ZHAN Jie WEI sheng-nan sun Pei-yu JI Ding-yu TAN Jing-jun LYU Emergency Department Renmin Hospital of Wuhan UniversityWuhan430060China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan430060China Wuhan Britain-China School Wuhan430022China Medical College of Wuhan University of Science and Technology Wuhan430065China Department of General Practice Renmin Hospital of Wuhan UniversityWuhan430060China Emergency Department Qilu Hospital of Shandong University(Qingdao)Qingdao266000China Emergency Department Clinical Medical College of Yangzhou UniversityNorthern Jiangsu People’s HospitalYangzhou225001China

Objective To examine the independent risk factors of type-2 myocardial infarction(T2MI)elicited by acute upper gastrointestinal bleeding(AUGIB),and to establish a nomogram model for the prediction of AUGIB-induced *** A nomogram model was established on the basis of a retrospective study that involved 533 patients who suffered from AUGIB in the Department of Critical Care Medicine(CCM)or Emergency Intensive Care Unit(EICU)of Renmin Hospital of Wuhan University,Wuhan,China,from January 2017 to December *** predictive accuracy and discriminative power of the nomogram were initially evaluated by internal validation,which involved drawing the receiver operating characteristic(ROC)curve,calculating the area under the curve(AUC),plotting the calibration curve derived from 1000 resampled bootstrap data sets,and computing the root mean square error(RMSE).The predictive ability of the nomogram was further validated through the prospective and multicenter study conducted by the investigators,which enrolled 240 AUGIB patients[including 88 cases from Renmin Hospital of Wuhan University,73 cases from Qilu Hospital of Shandong University(Qingdao),and 79 cases from Northern Jiangsu People’s Hospital)],who were admitted to the Department of CCM or EICU,from February 2021 to July *** Among the 533 patients in the training cohort,78(14.6%)patients were assigned to the T2MI group and 455(85.4%)patients were assigned to the non-T2MI *** multivariate analysis revealed that age>65,hemorrhagic shock,cerebral stroke,heart failure,chronic kidney disease,increased blood urea nitrogen,decreased hematocrit,and elevated D-Dimer were independent risk factors for AUGIB-induced *** these factors were incorporated into the nomogram *** AUC for the nomogram for predicting T2MI was 0.829(95%CI,0.783-0.875)in the internal validation cohort and 0.848(95%CI,0.794-0.902)in the external validation *** calibration curve for the risk of T2MI exhibited good cons

关键词： acute upper gastrointestinal bleeding type-2 myocardial infarction nomogram prediction risk factors prognosis

乙二醇氧化在不同电位区间下的电极负载量的优化

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电化学 2022年第2期28卷 127-135页

作者：孙圣男徐梽川新加坡南洋理工大学材料科学与工程学院新加坡639798 新加坡科技研究局材料研究与工程研究院新加坡138634 北京大学工程科学与新兴技术高精尖创新中心磁电功能材料与器件北京市重点实验室北京大学材料科学与工程学院北京大学工学院北京100871 新加坡-希伯来大学联合研究院 CREATE卓越研究和科技企业园区新加坡138602 新加坡南洋理工大学能源研究所交叉研究生院新加坡639798

由于近年来在电化学能源转化、存储及高附加值化学品电合成上的兴趣,设计与制备电催化剂受到越来越多的关注。活性是电催化剂关键参数之一,但观测到的活性会受到催化剂负载量的影响。本工作中,我们采用Co_(3)O_(4)/石墨纸(Co_(3)O_(4)/G... 详细信息

由于近年来在电化学能源转化、存储及高附加值化学品电合成上的兴趣,设计与制备电催化剂受到越来越多的关注。活性是电催化剂关键参数之一,但观测到的活性会受到催化剂负载量的影响。本工作中,我们采用Co_(3)O_(4)/石墨纸(Co_(3)O_(4)/GPE)电极作为电极模型,通过循环伏安法和计时电位法展示Co_(3)O_(4)的负载量是如何影响乙二醇在碱性溶液(KOH)中氧化的。基于对氧化还原峰和双电层电容的分析可以得出增加催化剂负载量可以增加电化学活性位点数,也可以在低的氧化电位下促进乙二醇氧化,但在高的电位下并没有明显的促进作用。这个结果提供了对有机小分子电催化剂负载量优化的一些思考。

关键词：负载量氧化还原双电层电容氧化钴乙二醇氧化

Mitochondrial Autophagy and NLRP3 Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation

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Chinese Medical Journal 2018年第10期131卷 1174-1184页

作者： Jing-Jun Lyu Jawahar L Mehta Yi Li Lu Ye sheng-nan sun Hong-Shuang sun Jia-Chang Li Dong-Mei Zhang Jie Wei Department of Emergency Renmin Hospital o1 Wuhan University Wuhan Hubei 430060 China Department of Medicine Central Arkansas Veterans Healthcare System University of Arkansas for Medical Sciences Little Rock AR 72205 USA Department of Emergency Peking Union Medical College Hospital Beijing 100032 China

Background：The incidence of cancer,diabetes,and autoimmune diseases has been ***,there are more and more patients with solid organ *** survival rate of these immunocompromised individuals is extremely low when they are severely *** this study,we established cardiac arrest cardiopulmonary resuscitation （CPR） model in severe combined immunodeficient （SCID） mice,analyzed the expression and activation of mitochondrial autophagy and NLRP3 inflammasome/caspase-1,and explored mitochondrial repair and inflammatory injury in immunodeficiency individual during systemic ischemia-reperfusion ***：A potassium chloride-induced cardiac arrest model was established in C57BL/6 and nonobese diabetic/SCID （NOD/SCID） *** hundred male C57BL/6 mice and 100 male NOD/SCID mice were randomly divided into five groups （control,2 h post-CPR,12 h post-CPR,24 h post-CPR,and 48 h post-CPR）.A temporal dynamic view of alveolar epithelial cells,macrophages,and neutrophils from bronchoalveolar lavage fluid （BALF） was obtained using Giemsa *** characterization ofphenotypic analysis of macrophages in the lung interstitial tissue was analyzed by flow *** morphological changes ofmitochondria 48 h after CPR were studied by transmission electron microscopy and quantified according to the Flameng grading *** blotting analysis was used to detect the expression and activation of the markers of mitochondrial autophagy,NLRP3 inflammasome,and ***：（1） In NOD/SCID mice,macrophages were disintegrated in BALF,and many alveolar epithelial cells were shed at 48 h after *** with C57BL/6 mice,the ratio of macrophages/total cells peaked at 12 h and was significantly higher in NOD/SCID mice （31.17 ± 4.13 vs.49.69 ± 2.43,t =14.46,P =0.001）.After 24 h,the results showed a downward ***,a large number of macrophages were disintegrated in the BALF.（2） Mitochondrial autophagy was present in both C

关键词： Autophagy Cardiopulmonary Resuscitation Immunodeficiency Macrophage Mitochondria NLRP3 Inftammasome

Combination immunotherapy of glioblastoma with dendritic cell cancer vaccines,anti-PD-1 and poly I:C

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Journal of Pharmaceutical Analysis 2023年第6期13卷 616-624页

作者： Ping Zhu Shi-You Li Jin Ding Zhou Fei sheng-nan sun Zhao-Hui Zheng Ding Wei Jun Jiang Jin-Lin Miao San-Zhong Li Xing Luo Kui Zhang Bin Wang Kun Zhang Su Pu Qian-Ting Wang Xin-Yue Zhang Gao-Liu Wen Jun OLiu John Thomas August Huijie Bian Zhi-nan Chen You-Wen He Department of Clinical Immunology Xijing HospitalDepartment of Cell BiologyNational Translational Science Center for Molecular MedicineFourth Military Medical UniversityXi'an710032China Beijing Tricision Biotherapeutics Inc. Beijing100176China Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi'an710032China Zhuhai Tricision Biotherapuetics Inc. ZhuhaiGuangdong519040China Department of Pharmacology and Molecular Sciences Johns Hopkins University School of MedicineBaltimoreMD21205USA

Glioblastoma(GBM)is a lethal cancer with limited therapeutic *** cell(DC)-based cancer vaccines provide a promising approach for GBM *** studies suggest that other immunotherapeutic agents may be combined with DC vaccines to further enhance antitumor ***,we report a GBM case with combination immunotherapy consisting of DC vaccines,anti-programmed death-1(anti-PD-1)and poly I:C as well as the chemotherapeutic agent cyclophosphamide that was integrated with standard chemoradiation therapy,and the patient remained disease-free for 69 *** patient received DC vaccines loaded with multiple forms of tumor antigens,including mRNA-tumor associated antigens(TAA),mRNA-neoantigens,and hypochlorous acid(HOCl)-oxidized tumor ***,mRNA-TAAs were modified with a novel TriVac technology that fuses TAAs with a destabilization domain and inserts TAAs into full-length lysosomal associated membrane protein-1 to enhance major histocompatibility complex(MHC)class I and II antigen *** treatment consisted of 42 DC cancer vaccine infusions,26 anti-PD-1 antibody nivolumab administrations and 126 poly I:C injections for DC *** patient also received 28 doses of cyclophosphamide for depletion of regulatory T *** immunotherapy-related adverse events were observed during the *** antitumor CD4t and CD8t T-cell responses were *** patient remains free of disease *** is the first case report on the combination of the above three agents to treat glioblastoma *** results suggest that integrated combination immunotherapy is safe and feasible for long-term treatment in this patient.A large-scale trial to validate these findings is warranted.

关键词： Glioblastoma multiforme DC vaccine Tumor-associated antigens Neoantigens

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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机场道面管理的评价模型

同济大学学报（自然科学版） 2004年第6期32卷 731-735页

作者：暨育雄阚胜男冯奇孙立军同济大学道路与交通工程教育部重点实验室上海200092

根据我国机场道面的实际状况 ,构建了适用于水泥混凝土道面管理的 4个评价模型———损坏状况评价、结构强度评价、平整度评价和抗滑评价模型 .通过这 4个评价模型 ,可以对机场道面的调查检测数据进行评价分析 ,了解机场道面的整个使用... 详细信息

根据我国机场道面的实际状况 ,构建了适用于水泥混凝土道面管理的 4个评价模型———损坏状况评价、结构强度评价、平整度评价和抗滑评价模型 .通过这 4个评价模型 ,可以对机场道面的调查检测数据进行评价分析 ,了解机场道面的整个使用状况 ,为确定养护措施。

关键词：机场道面水泥混凝土道面评价模型惰性点理论道面管理系统

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin nan Wang Huiqi sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics