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Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice

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Zoological Research 2024年第3期45卷 663-678页

作者： Li-Rong Liang Bing Liu Shu-Hui Cao You-Yi zhao Tian Zeng mei-Ting Zhai Ze Fan Dan-Yi He San-Xin Ma Xiao-Tong Shi Yao Zhang Hui Zhang State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of AnesthesiologySchool of StomatologyAir Force Medical UniversityXi’anShaanxi 710032China Department of Anesthesiology 986th Air Force HospitalAir Force Medical UniversityXi’anShaanxi 710032China

A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive ***,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive ***,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly *** this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal *** neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral *** indicated that ADNP was significantly down-regulated following developmental exposure to *** adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine ***,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane ***-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by *** analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic *** of Wnt signaling was restored in the davunetide-treated ***,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general *** study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal

关键词： Davunetide Sevoflurane Abnormal social behaviors ADNP Neurotoxicity

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Method for detector description conversion from DD4hep to Filmbox

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Nuclear Science and Techniques 2024年第09期 6-17页

作者： zhao-Yang Yuan Tian-Zi Song Yu-Jie Zeng Kai-Xuan Huang Yu-mei Zhang Zheng-Yun You School of Physics Sun Yat-sen University Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen University

DD4hep serves as a generic detector description toolkit recommended for offline software development in next-generation high-energy physics(HEP) experiments. Conversely, Filmbox(FBX) stands out as a widely used 3D modeling file format within the 3D software industry. In this paper, we introduce a novel method that can automatically convert complex HEP detector geometries from DD4hep description into 3D models in the FBX format. The feasibility of this method was demonstrated by its application to the DD4hep description of the Compact Linear Collider detector and several sub-detectors of the super Tau-Charm facility and circular electron-positron collider experiments. The automatic DD4hep–FBX detector conversion interface provides convenience for further development of applications, such as detector design, simulation,visualization, data monitoring, and outreach, in HEP experiments.

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Vaccinia virus viability under different environmental conditions and different disinfectants treatment

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Biosafety and Health 2024年第1期6卷 21-27页

作者： Shan mei Liang Wei Yu Xie Fei zhao Yu Huang Zhangling Fan Yamei Hu Liming Wang Lingwa Wang Ying Wang Fengwen Xu Fei Guo NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen Biology and Center for AIDS ResearchChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBejing 100730China Clinical Laboratory Emergency General HospitalBeijing 100028China

Monkeypox(mpox)outbreak in 2022 has caused more than 91,000 cases,has spread to 115 countries,regions,and territories,and has thus attracted much *** stability of poxvirus particles in the environment is recognized as an important factor in determining their ***,few studies have investigated the persistence of poxviruses on material surfaces under various environmental conditions,and their sensitivity to ***,we systematically measured the stability of vaccinia virus(VACV)under different environmental conditions and sensitivity to inactivation methods via plaque assay,quantitative real‐time polymerase chain reaction(qPCR),and Gaussia luciferase(G‐luciferase)reporter *** results show that VACV is stable on the surface of stainless steel,glass,clothing,plastic,towel,A4 paper,and tissue and persists much longer at 4℃ and?20℃,but is effectively inactivated by ultraviolet(UV)irradiation,heat treatment,and chemical *** study raises the awareness of long persistence of poxviruses in the environment and provides a simple solution to inactivate poxviruses using common disinfectants,which is expected to help the control and prevention of mpox virus and future poxvirus outbreaks.

关键词： Poxvirus Mpox virus Vaccinia virus Persistence Disinfectant

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Experimental and simulation study on shear stress-induced erythrocyte damage based on vortex oscillator

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Biomedical Engineering Communications 2024年第1期3卷 23-30页

作者： Xu mei Li-Pu zhao Lian Hou Ying-Ying Zhong State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Mechanical and Electrical Engineering Silicon Lake Vocational and Technical CollegeSuzhou 215006China College of Education Central China Normal UniversityWuhan 430079China

Background:Shear stress-induced erythrocyte damage,namely hemolysis,is an important problem in the development of blood-contacting medical devices such as mechanical circulatory support *** fluid dynamics simulation combined with hemolysis prediction models have been widely used to predict *** the development of hemolysis prediction models,the new hemolysis prediction model requires more experimental data to *** addition,the difference of in vitro blood-shearing device also affect the accuracy of hemolysis ***:To address these problems,a new in vitro blood-shearing device(vortex oscillator)was used to further verify the accuracy of the hemolysis prediction models,and to guide the optimal design of blood-contacting medical devices such as mechanical circulatory support ***,the flow field information such as wall stress and velocity of the vortex oscillator under different speeds was ***,different hemolysis prediction models were used to calculate hemolysis,and the predicted data was compared with the experimental *** and Conclusion:In this study,the flow field information inside the vortex oscillator at high rotational speeds was systematically investigated,and the prediction of hemolysis was carried *** results showed that the predicted data of hemolysis was significantly different from the experimental data,which indicated that it was urgent to establish a standardized in vitro blood-shearing platform to provide a reference for accurate hemolysis prediction.

关键词： CFD Hemolysis prediction model Vortex oscillator Shear stress

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Gastric cancer liver metastasis will reduce the efficacy of immunotherapy

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2760-2764页

作者： Liang Wang Shan-Shan Liu sheng-mei Zhang Xiao-Qian Chen Tao Huang Rong Tian Ya-Qi zhao Zhou Chen Cai-Rang Xianba Department of Gastrointestinal Oncology Surgery The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Intensive Care Unit The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Ultrasound The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of General Surgery Hainan State People's Hospital of Qinghai ProvinceHainan Tibetan Autonomous Prefecture 813000Qinghai ProvinceChina

Immune checkpoint inhibitors augment the antitumor activity of T cells by inhibiting the negative regulatory pathway of T cells,leading to notable efficacy in patients with non-small cell lung cancer,melanoma,and other malignancies through immunotherapy ***,secondary malignant liver tumors not only lower the liver's sensitivity to immunotherapy but also trigger systemic immune suppression,resulting in reduced overall effectiveness of immune *** receiving immunotherapy for non-small cell lung cancer and melanoma experience reduced response rates,progression-free survival,and overall survival when secondary malignant tumors develop in the *** Liu's retrospective analysis,valuable insights are provided for the future clinical management of these ***,in patients with gastric cancer(GC),the occurrence of liver metastasis might be indicative of reduced efficacy of *** liver immune tolerance mechanisms and their negative impacts allows for the potential benefits of immunotherapy in patients with GC and liver *** Gastric cancer(GC)ranks among the prevalent malignancies affecting the digestive system *** on the latest epidemiological data[1,2],it holds the fifth position for incidence and the fourth position for mortality among all malignant *** cases and fatalities in China make up roughly half of the worldwide *** investigations[3]have demonstrated that the median overall survival(mOS)among advanced GC patients left untreated typically ranges from 3 to 4 *** chemotherapy recipients often experience a mOS of around one year,accompanied by a marked improvement in the quality of life among patients with advanced *** mainstay of treatment for advanced GC patients involves chemotherapeutic medications such as fluoropyrimidines,platinum compounds,and ***,their efficacy in tumor control is constrained by acquired resistance and pr

关键词： Immune checkpoint inhibitors Gastric cancer Gastric cancer with liver metastasis Immunotherapy Liver immune tolerance

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Subgroups of peripheral immune effector cells in cervical cancer patients are more sensitive to radiation therapy than chemotherapy

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Cancer Advances 2024年第3期7卷 1-7页

作者： Ning zhao Dong-mei Han Cai-Hong Wu Hao Jin National Clinical Research Center for Cancer Tianjin Cancer Hospital Airport HospitalTianjin 300308China Center for Precision Cancer Medicine&Translational Research Tianjin Cancer Hospital Airport HospitalTianjin 300308China Oncology Department Tianjin Cancer Hospital Airport HospitalTianjin 300308China.

Background:CD8 positive T lymphocytes and natural killer(NK)cells in the peripheral blood of cervical cancer patients exhibit varying sensitivities to radiotherapy and ***:A total of 50 healthy peoples and 60 cervical cancer patients were *** patients with cervical cancer were separated into two groups:radiation and chemotherapy,and blood sample were collected before and after *** on the proportion of CD8 positive T lymphocytes and NK cells were gathered for analytical ***:Compared to healthy individuals,patients with cervical cancer exhibit a reduced proportion of CD8 positive T cells within their peripheral *** for patients with cervical cancer,radiation therapy has been found to be more effective than chemotherapy in increasing the proportion of CD8 positive T lymphocytes and NK ***:These results suggest that radiation therapy increases the levels of CD8 positive T lymphocytes and NK cells within the peripheral blood of patients with cervical *** study hypothesis that the changes in the percentage of CD8 positive T lymphocytes may serve as a potential indicator for predicting treatment efficacy.

关键词： CD8 positive T lymphocytes flow cytometry natural killer cells radiotherapy uterine cervical neoplasms

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Omadacycline in the treatment of scrub typhus:Three case reports

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World Journal of Clinical Cases 2024年第25期12卷 5832-5838页

作者： Xue-mei Lang Yun Qiu Ya-Juan Jia Hong Sun Su-Min Gao Hong-mei zhao Department of Emergency Medicine The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223000Jiangsu ProvinceChina

BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(***).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical ***,omadacycline application in the treatment of scrub typhus remains *** SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and *** samples were collected before omadacycline was administered,and *** infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug *** tNGS is an effective method for diagnosing scrub *** can be considered an alternative option for antiinfective therapy in patients with *** infections.

关键词： Omadacycline Scrub typhus Orientia tsutsugamushi Targeted nextgeneration sequencing Eschar Case report

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高速变轨距转向架结构优化及动力学性能分析与预测

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吉林大学学报（工学版） 2024年第2期54卷 453-460页

作者：刘玉梅盛佳香庄娇娇陈熔赵大龙吉林大学交通学院长春130022 临沂大学机械与车辆工程学院山东临沂276000 中车长春轨道客车股份有限公司长春130022

提出一种基于小波理论改进三角级数法的轨道不平顺模拟方法,结合建立的7刚体42自由度车辆动力学模型和轮轨接触模型,基于SIMPACK搭建变轨距列车的动力学仿真模型,采用参数试验法对悬挂参数与车轮踏面进行优化设计,对经结构优化的变轨距... 详细信息

提出一种基于小波理论改进三角级数法的轨道不平顺模拟方法,结合建立的7刚体42自由度车辆动力学模型和轮轨接触模型,基于SIMPACK搭建变轨距列车的动力学仿真模型,采用参数试验法对悬挂参数与车轮踏面进行优化设计,对经结构优化的变轨距转向架进行车辆动力学性能预测,车辆的临界速度远高于400 km/h的设计要求,平稳性指标达到标准规定的二级车辆平稳性水平,曲线通过性评价指标均低于安全限值,所开发的变轨距转向架列车具有良好的动力学性能。

关键词：铁路运输变轨距转向架车辆动力学结构优化轨道不平顺小波理论

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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min Liu Hai-Lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying zhao Yun-Xiao Shang Ling Cao Yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao Xiao-Yan Dong Dao-Jiong Lin Hong-mei Xu De-Yu zhao mei Zeng Zhi-Min Chen Li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

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Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

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Current Medical Science 2024年第2期44卷 309-327页

作者： Xiao-jun WANG Jia-ping CHEN Xin-wei QIAO Wang-yang MENG Yang-wei WANG Yun-chong MENG Rong zhao Wei LIN Yong-de LIAO Han XIAO Pei-yuan mei Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival *** suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and ***,a comprehensive analysis of their role in LUSC is *** study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of ***:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO ***,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in *** core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for *** specimens were examined by immunohistochemical analysis to confirm the diagnostic value in ***,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was ***:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for ***10 showed a significant positive correlation with immune cell infiltration and immune checkpoint ***:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

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