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miR-146a-3p targeted RELB to regulate cytokine secretion in endothelial cells of atherosclerotic mice

Journal of Hainan Medical University 2020年第10期26卷 21-27页

作者： Zhong-Wei Wu sheng-ji zhao Chun-Fu Li Chao-Quan Liu Department of Cardiology Hainan West Central HospitalDanzhou CityHainan ProvinceHainan Danzhou 571700

Objective:To explore how miR-146a-3p can regulate the cytokine secretion of endothelial cells in atherosclerotic mice through the nuclear factorκB subunit(RELB).Methods:Apolipoprotein knockout(ApoE-/-)mouse atherosclerosis model was established by feeding program of high-fat diet formula and vascular endothelial cells were performed on primary *** difference in expression levels of miR-146a-3p in endothelial tissues of atherosclerotic mice and control mice was detected by real-time fluorescence quantitative *** match between mir-146a-3p and RelB was analyzed by *** whether miR-146a-3p targeted RELB was checked by luciferase reporter *** the case of miR-146a-3p mimics overexpression or miR-146a-3p inhibitor knockdown,the granulocyte colony stimulating factor(GCSF),the levels of granulocyte macrophage colony stimulating factor(GM-CSF),interleukin 2(IL-2),interleukin 3(IL-3),interleukin 4(IL-4),interleukin 5(IL-5),interleukin 6(IL-6),interleukin 9(IL-9),interleukin 10(IL-10),interleukin 12 p40(IL-12 p40),interleukin 12 p70(IL-12 p70),interleukin 13(IL-13),interleukin 17(IL-17),interferon gamma(IFN-γ),monocyte chemotactic protein 1(MCP-1),monocyte chemoattractant protein 5(MCP-5),small inducible cytokine A5(RANTES),and tumor necrosis factor-α(TNFα)were detected by enzyme-linked immunosorbent ***:Compared with the control group,the expression of miR-146a-3p in vascular endothelial tissue of atherosclerotic mice was reduced(P<0.05);MiR-146a-3p targeted the 3'UTR of RELB;After overexpression of miR-520a-3p,the expression level of RELB was decreased,and the levels of GCSF,GM-CSF,IL-2,IL-3,IL-4,IL-5,IL-6,IL-9,IL-10,IL-12 p40,IL-12 p70,IL-13,IL-17,IFN-γ,MCP-1,MCP-5,RANTES,and TNFαcytokines secreted by endothelial cells in atherosclerotic mice were decreased(P<0.05);After knocking down miR-520a-3p,the expression level of RELB was increased,and the levels of GCSF,GM-CSF,IL-2,IL-3,IL-4,IL-5,IL-6,IL-9,IL-10,IL-12 p40,IL-12 p70,IL-13,IL

关键词： miR-146a-3p RELB Atherosclerosis Cytokines Vascular endothelial cells

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Single-dose daclizumab induction therapy in patients with liver transplantation

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World Journal of Gastroenterology 2003年第8期9卷 1881-1883页

作者： Lu-Nan Yan Wei Wang Bo Li Shi-Chun Lu Tian-Fu Wen Qi-Yuan Lin Yong Zeng Nan-sheng Cheng ji-Chun zhao Yue-Meng Dai, Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China Liver Transplantation Center West China Hospital Sichuan University Chengdu 610041 Sichuan Province China. yanlunan@***

AIM: To investigate the efficacy and safety of a singledose daclizumab induction therapy in orthotopic liver transplantation (OLTx).METHODS: A retrospective study was made for 54 cases of OLTx in recent three years. The daclizumab group consisted of 23 cases of OLTx who received single-dose of 2 mg/kg intravenously after postoperative 24 hours. The control group consisted of the remaining 31 patients. Additional immunosuppressors included steroids, mycomphenolate mofetil, facrolimus or microemulsion cyclosporine used in all patients. Meta-statistical analysis was made for general data,incidence of acute rejection and infection, postoperative clinical course, complications and prognosis between two ***: Pretransplant demographies were not significantly different between two groups. In the induction group there were significantly less acute rejection episodes (5 of 23, 21.74 %) than those in the control group (12 of 31, 38.71%), which were proved by pathologic diagnosis (P＜0.05). The incidence of infection at the early stage was not significantly different between two ***: Induction therapy with single-dose of daclizumab is safe and effective and appears to be able to reduce the incidence of acute rejection.

关键词：肝移植术急性排斥反应感应疗法 daclizumab 临床疗效

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基于模糊邻域粗糙集的信息系统不确定性度量方法

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南京大学学报（自然科学版） 2017年第5期53卷 926-936页

作者：徐风姚晟纪霞赵鹏汪杰安徽大学计算机科学与技术学院合肥230601 安徽大学计算智能与信号处理教育部重点实验室合肥230601

邻域粗糙集和模糊粗糙集是粗糙集理论中处理数值型数据的两种重要模型.在数值型信息系统中融合两者在不确定性度量方面的优越性,首先引入了模糊邻域粗糙集模型,并在该模型上定义了模糊邻域粗糙度的概念.模糊邻域粗糙度是通过粗糙集的边... 详细信息

邻域粗糙集和模糊粗糙集是粗糙集理论中处理数值型数据的两种重要模型.在数值型信息系统中融合两者在不确定性度量方面的优越性,首先引入了模糊邻域粗糙集模型,并在该模型上定义了模糊邻域粗糙度的概念.模糊邻域粗糙度是通过粗糙集的边界域来度量信息系统的不确定性,为了达到更为全面的度量效果,在模糊邻域粗糙集模型中定义了模糊邻域粒结构,并基于该粒结构提出了模糊邻域粒度的概念,模糊邻域粒度是对信息系统分类能力的一种度量.最后,通过将两种度量方法进行结合,提出了一种基于模糊邻域粗糙集的混合不确定性度量方法,并从理论上证明其有效性.实验结果表明,所提出的混合度量方法综合了两种单独度量方法的优点,在数值型信息系统中具有更好的度量效果,因此所提出的不确定性度量方法更具有一定的优越性.

关键词：不确定性度量模糊邻域近似粗糙度模糊邻域粒度混合度量

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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CoTCPP integrates with BiOBr microspheres for improved solar-driven CO_(2)reduction performance

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Green Energy & Environment 2025年第1期10卷 193-202页

作者： Lina Li Yi Zhang Gaopeng Liu Tiange Wei Junze zhao Bin Wang Mengxia ji Yuanbin She jiexiang Xia Huaming Li School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu University301 Xuefu RoadZhenjiang212013China State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

CO_(2) photoreduction into carbon-based chemicals has been considered as an appropriate way to alleviate the energy issue and greenhouse ***,the 5,10,15,20-tetra(4-carboxyphenyl)porphyrin cobalt(II)(CoTCPP)has been integrated with BiOBr microspheres and formed the CoTCPP/BiOBr *** as-prepared CoTCPP/BiOBr-2 composite shows optimized photocatalytic performance for CO_(2) conversion into CO and CH_(4) upon irradiation with 300 W Xe lamp,which is 2.03 and 2.58 times compared to that of BiOBr,*** introduced CoTCPP significantly enhanced light absorption properties,promoted rapid separation of photogenerated carriers and boosted the chemisorption of CO_(2) *** metal Co^(2+) at the center of the porphyrin molecules also acts as adsorption center for CO_(2) molecules,accelerating the CO_(2) conversion into CO and *** possible mechanism of CO_(2) photoreduction was explored by in-situ FT-IR *** work offers a new possibility for the preparation of advanced photocatalysts.

关键词： BiOBr CoTCPP CO_(2)photoreduction Carriers transfer CO_(2)adsorption-activation

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A self-adaptive inorganic in-situ separator by particle crosslinking for nonflammable lithium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 469-480页

作者： jiarui Yang jiuzhou Liu Wenrui Cai Ziyu zhao Shan Wang Lu He Shanshan Lv Zhiwei Zhu Zhongfeng ji Guojiang Wen Hua Li Yuanming Zhai Xuewei Fu Wei Yang Yu Wang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University

All-safe liquid-state lithium-ion batteries(ASLS-LIBs) is of great interest as they can potentially combine the safety of all-solid-state batteries with the high performance and low manufacturing cost of traditional liquid-state LIBs. However, the practical success of ASLS-LIBs is bottlenecked by the lack of advanced separator technology that can simultaneously realize high performances in puncturing-tolerability,fire-resistance, and importantly, wetting-capability with non-flammable liquid-electrolytes. Here, we propose a concept of inorganic in-situ separator(IISS) by hybrid-sol physical crosslinking directly onto the electrode surface to address the above challenges. Particularly, the hybrid-sol is designed with silica nanoparticles as the building block and poly(vinylidene difluoride) nanoparticles as the crosslinking agent. The critical factors for controlling the IISS microstructures and properties have been systematically investigated. The advantages of the IISS have been confirmed by its fast wetting with various fireresistant liquid-electrolytes, customizable thickness and porous structures, robust interface with planar or three-dimensional(3D)-structured electrodes, and importantly, unexpected self-adaptability against puncturing. Enabled by the above merits, a fire-resistant ASLS-LIB is successfully assembled and demonstrated with stable electrochemical performance. This sol-crosslinked IISS may open an avenue for the studies on the next-generation separator technology, cell assembling, solid electrolyte processing as well as non-flammable secondary batteries.

关键词： Silica nanoparticles

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泄漏检测与修复技术管理体系研究及评估建议

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现代化工 2017年第10期37卷 10-14页

作者：彭茵吉晟赵子玮郑幸成陈璐黄浩云天津市大气污染防治重点实验室天津300191 天津环科瞻云科技发展有限公司天津300191 天津工业大学天津300191 天津市环境保护科学研究院天津300191

泄漏检测与修复技术(LDAR)是治理石化化工企业生产装置设备组件无组织泄漏的有效技术,国内正在广泛推广,但目前缺少对LDAR实施效果的评估考核标准。借鉴美国、欧盟、台湾地区泄漏检测管控体系,结合天津市在石化化工装置LDAR评估工作中... 详细信息

泄漏检测与修复技术(LDAR)是治理石化化工企业生产装置设备组件无组织泄漏的有效技术,国内正在广泛推广,但目前缺少对LDAR实施效果的评估考核标准。借鉴美国、欧盟、台湾地区泄漏检测管控体系,结合天津市在石化化工装置LDAR评估工作中发现的问题,建议LDAR实施效果核查和评估技术重点应侧重加强检测机构的认证和规范管理、实施VOCs减排量核算、发展环境定量改善情况的审查和评估、推广LDAR技术现场核查、完善LDAR经济惩罚措施等。

关键词：挥发性有机物泄漏检测与修复环境管理体系评估

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng zhao Wen-Bo Deng ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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基于C/S架构的电厂建设管理系统

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指挥技术学院学报 2001年第5期12卷 43-45页

作者：王盛军赵继广装备指挥技术学院试验工程系

在电厂建设过程中利用计算机技术进行辅助管理 ,可提高工作效率 ,合理利用资源。为此提出了一种电厂建设管理系统的设计方案 ,根据电厂建设的实际情况划分了各子系统的主要功能 ,避免各子系统的数据冗余和错误。提出了一种二维的数据库... 详细信息

在电厂建设过程中利用计算机技术进行辅助管理 ,可提高工作效率 ,合理利用资源。为此提出了一种电厂建设管理系统的设计方案 ,根据电厂建设的实际情况划分了各子系统的主要功能 ,避免各子系统的数据冗余和错误。提出了一种二维的数据库系统结构 ,同时提供了与其它数据库系统的接口 ,实现了不同系统间的信息资源共享。

关键词：管理信息系统网络数据库

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坛紫菜种质材料DNA指纹图谱的构建

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水产学报 2010年第6期34卷 913-920页

作者：谢潮添陈昌生纪德华赵国瑞徐燕史修周集美大学水产学院

采用20对简单重复序列(SSR)引物对福建省坛紫菜种质资源库中保存的44个坛紫菜种质材料进行了遗传分析,共检测到了81个多态性位点,每对引物检测到的等位基因介于2～6个之间,平均为4.05个,引物的PIC值介于0.15～0.79之间,平均为0.57。然... 详细信息

采用20对简单重复序列(SSR)引物对福建省坛紫菜种质资源库中保存的44个坛紫菜种质材料进行了遗传分析,共检测到了81个多态性位点,每对引物检测到的等位基因介于2～6个之间,平均为4.05个,引物的PIC值介于0.15～0.79之间,平均为0.57。然后根据3对引物(Phes08,Phes03和PC13)扩增出的16个多态性位点构建了44个坛紫菜种质材料的指纹图谱库,使得每一种质材料均具有其特异的DNA指纹图谱。并根据指纹图谱中各扩增位点条带的有无,将指纹图谱转化成了计算机可以识别的数码指纹,开发了相应的数码指纹识别软件,为坛紫菜种质的自动化鉴定及坛紫菜种质资源库的信息化管理奠定了基础。

关键词：坛紫菜种质材料简单重复序列指纹图谱库

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