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Inhibitory effects of EGFR antisense oligodeoxynucleotide in human colorectal cancer cell line

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World Journal of Gastroenterology 2000年第5期6卷 747-749页

作者： Yong he Jun Zhou Jin sheng wu Ke Feng Dou Department of hepatobiliary Surgery Xijing Hospitalthe Fourth Military Medical UniversityXi’an 710032China Department of Pathology Qindu Hospitalthe Fourth Military Medical UniversityXi’anChina Department of General Surgery Tangdu Hospitalthe Fourth Military Medical UniversityXi’an China

INTRODUCTIONEpidermal-growth-factor receptor(EGFR) is apolypeptide with 1186 amino acids,which binds toEGF family growth *** major naturalligands in the family interact with EGFR:one isEGF,the other is transforming growth factor-α(TGF-α).When EGF or TGF-α,binds to EGFR,tyrosine kinase activity is induced which in turntriggers a series of events regulating the *** importance of EGFR in growthregulating pathways was confirmed by the fact

关键词： colorectal neoplasms oligonucleotides antisense epidermal growth factor receptor gene therapy liposomes flow cytometry

Single-element amorphous metals

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Interdisciplinary Materials 2024年第4期3卷 480-491页

作者： Xiao Han Geng wu Dong sheng he Xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefeiAnhuiChina Core Research Facilities Southern University of Science and TechnologyShenzhenChina

To unveil the nature of amorphous states,single-element amorphous metals have been the perfect research subject due to the simplest ***,the extreme crystal nucleation and growth rate in single-element metal make the synthesis of single-element amorphous metals seemingly impossible in the ***,benefited by several delicate synthetic strategies developed recently,the single-element amorphous metals have been successfully *** review aims to provide a systematic overview of the synthesis of single-element amorphous metals covering the challenges in physics and recent *** addition,current understanding of the atomic and electronic structures of single-element amorphous metal has also been ***,the challenges that worth further investigation are *** identifying the potential avenues for further exploration,this review aims to contribute valuable insights that will propel the cognition of single-element amorphous metals.

关键词： amorphous metal single-element structure synthesis

国际视野下中学与大学数学教育衔接的研究述评

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数学教育学报 2025年第1期34卷 6-12页

作者：李娜吴盛棋张滢李波华中师范大学数学与统计学学院香港大学教育学院

数学家和数学教育者一直以来都高度关注中学数学与大学数学之间的衔接问题．这主要表现在两方面：大学新生如何在教师的帮助下，实现从高中数学思维向大学数学思维的转变；以及中学数学教师，尤其是新手教师，如何将高等数学思维渗透到... 详细信息

数学家和数学教育者一直以来都高度关注中学数学与大学数学之间的衔接问题．这主要表现在两方面：大学新生如何在教师的帮助下，实现从高中数学思维向大学数学思维的转变；以及中学数学教师，尤其是新手教师，如何将高等数学思维渗透到日常教学中．近年来，国内外学者对上述问题进行了深入研究．通过梳理国际上有影响力的文献发现，造成中学数学与大学数学衔接不良的主要原因有：中学与大学数学概念的界定方式存在差异；学生的数学演绎推理能力未达要求；学生缺乏必要的数学语言理解能力；以及新手教师缺乏在中学课堂引入大学数学知识的经验．基于此，中学教师可以采取从更高观点看初等数学，将教师教学专业知识进行概念化，以及在教学中进行教学转换等策略．

关键词：国际视野中学数学大学数学衔接问题研究述评

Development and application of coke oven gas spraying on sinter bed

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Journal of Iron and Steel Research International 2020年第6期27卷 617-623页

作者： he-ping Li sheng-li wu Zhi-bin Hong heng Zhou Ming-yin Kou School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Ironmaking Plant Shanghai Meishan Iron and Steel Co.Ltd.Nanjing210039JiangsuChina

The Shanghai Meishan Iron and Steel Co., Ltd. has a large supply of coke oven gas (COG) and has the potential to develop and apply the spraying of COG on the surface of a sinter bed. The effects of the amount of COG, the spraying time, and the spraying distribution with the process on the quantity and quality indexes of sinter were investigated in the laboratory experi-ments. The results showed that the COG spraying can improve the sinter indexes to a large extent if appropriate parameters were used. It was found that an appropriate amount of COG, a relatively long spraying time, and a decreasing distribution of the COG amount with the spraying process all help to obtain a better performance for sinter quantity and quality indexes. When the COG spraying was applied to the No. 3 sintering machine, the sinter tumbler index increased by 0.45%, the overall finished product rate increased by 0.72%, the solid fuel consumption decreased by 4.06kg/t, the reducibility increased by 3.89%, and the cost of iron decreased by 5.29 CNY/t, and the CO2, SO2 and Nox emissions also decreased, thus proving the feasibility of this technology. Therefore, COG spraying provides a new way to improve sinter and also decrease the energy consumption and pollution.

关键词： Coke oven gas spraying Sinter index Spraying distribution High quality Low energy consumption Low pollution

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我国生物制造底盘菌种现状、问题及对策

中国科学院院刊 2025年第1期40卷 2-13页

作者：陈国强吴赴清郑爽丁军盛君婷清华大学生命科学学院北京100084 清华大学化学工程系北京100084 清华大学合成与系统生物学中心北京100084

生物制造是新质生产力的重要组成部分,是继信息技术之后新一轮科技革命的制高点和产业变革的新引擎,在新能源、新材料、生物医药、绿色食品、环境保护等领域展现出巨大的应用前景。生物制造以底盘菌种为“芯片”,通过菌种设计构建、细... 详细信息

生物制造是新质生产力的重要组成部分,是继信息技术之后新一轮科技革命的制高点和产业变革的新引擎,在新能源、新材料、生物医药、绿色食品、环境保护等领域展现出巨大的应用前景。生物制造以底盘菌种为“芯片”,通过菌种设计构建、细胞规模化培养、产物分离提取等过程,生产各种生物产品。我国生物制造底盘菌种原始创新不足,无法支撑产业健康发展。文章总结了国内外常见底盘菌种类型和新型底盘菌种开发现状,分析了我国底盘菌种开发面临的主要问题和挑战,并针对新型极端微生物底盘菌种开发,从顶层设计、“十五五”布局、平台建设、政策制度、人才培养、审批机制、司法保护、评价体系等方面提出了推进我国自主知识产权底盘菌种开发的若干建议。

关键词：底盘菌种生物制造合成生物新质生产力极端微生物

CO_(2) conversion and decarburization kinetics of CO_(2) gas and liquid Fe-C alloy at 1873 K

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Journal of Iron and Steel Research International 2022年第3期29卷 425-433页

作者： Wen-he wu Rong Zhu Zhi-zheng Li Chun-yang Wang Guang-sheng Wei School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Research Center of Carbon Dioxide Science University of Science and Technology BeijingBeijing100083China

The reactions between CO_(2) gas and liquid Fe-C alloy with different initial carbon concentrations at 1873 K were investigated using experimental results,thermodynamic equilibrium,and kinetic *** average CO_(2) conversion is greater than 80%when the carbon content ranges from 4.0 to 1.0 wt.%.When the carbon content decreases from 0.5 to 0.1 wt.%,the average CO_(2) conversion diminishes from 83.50%to 40.84%.This proves that CO_(2) gas and liquid Fe-C alloy reaction does not reach equilibrium under experimental conditions compared with the calculated thermodynamic *** the kinetic analysis,it is shown that in the medium-to high-carbon liquid Fe-C alloys,the rate-controlling step involves CO_(2) gas mass transfer or mixed rate-controlling of CO_(2) gas mass transfer with adsorption and dissociation of CO_(2) *** contrast,in the low-carbon liquid Fe-C alloy,carbon mass transfer occurs in the molten *** critical carbon content of the rate-controlling step transformation is 0.7937 wt.%.

关键词： CO_(2)utilization CO_(2)conversion Decarburization kinetics Fe-C alloy Rate-controlling step

Self-sensing tribological coating with phosphor particles for wear indicator

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Rare Metals 2023年第7期42卷 2462-2469页

作者： Ling he Xue-Yan wu Wen-sheng Li Mi-Na Zhang Shu-Jie Liu State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Monitoring of coating health was achieved by embedding sensor materials(MAl_(2)O_(4):Eu^(2+),Dy^(3+),M=Sr,Ba)in tribological *** the luminescence disappears under ultraviolet(UV)light,it means that the functional coating is worn out and that recoating is *** this work,four types of alloy(Cu-14Al-X,Cu,Cu-Al,Al)composite coatings were investigated by vacuum pres sure-as sis ted sintering *** composite coatings with different copper-aluminium alloy matrixes were compared by phase composition,microstructure,luminescence properties and tribological *** results indicate that the Cu-14Al-X matrix composite coating shows not only good resistance to wear but also exhibits strong green light emitting under ultraviolet(UV)*** is the best wear-resistant self-sensitive coating which has potential industrial *** the coating wore or broke,the emitting intensity will decrease or disappear.

关键词： Copper-aluminium alloy coatings Luminescent powders Wear indicator Luminescent spectroscopy Tribology

A study of a supersonic capsule/rigid disk-gap-band parachute system using large-eddy simulation

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Applied Mathematics and Mechanics(English Edition) 2021年第4期42卷 485-500页

作者： sheng GONG Chuijie wu School of Aeronautics and Astronautics Dalian University of TechnologyDalian 116024Liaoning ProvinceChina

The aerodynamic performances and flow features of the capsule/rigid disk-gap-band(DGB)parachute system from the Mach number 1.8 to 2.2 are *** use the adaptive mesh refinement(AMR),the hybrid tuned center-difference and weighted essentially non-oscillatory(TCD-WENO)scheme,and the large-eddy simulation(LES)with the stretched-vortex subgrid *** simulations reproduce complex interaction of the flow structures,including turbulent wakes and bow shocks,as well as bow shocks and expansion *** results show that the calculated aerodynamic drag coefficient agrees well with the previou *** the aerodynamic drag coefficient and the aerodynamic drag oscillation of the parachute system decrease with the increase of the initial Mach number of the *** is found that the position and angle of the bow shock ahead of the canopy change as the Mach number increases,which makes the flow inside the canopy and the turbulent wake behind the canopy more complex and unstable.

关键词： compressible flow adaptive mesh refinement(AMR) large-eddy simulation(LES) supersonic flow rigid disk-gap-band(DGB)parachute

Hydrodynamic characteristics and particle tracking of 90° lateral intakes at an inclined river slope

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Water Science and Engineering 2024年第2期17卷 197-208页

作者： Wei he Si-yuan Feng Jian Zhang Hong-wu Tang Yang Xiao sheng Chen Chun-sheng Liu College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Collaborative Innovation Center on Water Safety and Water Science Hohai UniversityNanjing 210098China

Lateral intakes are common in *** pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division *** hydraulic characteristics of lateral withdrawal from inclined river slopes at different intake elevations should be ***,the division width exhibits significant vertical non-uniformity at an inclined river slope,which should be ***,a three-dimensional(3-D)hydrodynamic and particle-tracking model was developed with the Open Source Field Operation and Manipulation(Open FOAM),and the model was validated with physical model tests for 90°lateral withdrawal from an inclined side *** flow fields,withdrawal sources,and division widths were investigated with different intake bottom elevations,withdrawal discharges,and main channel *** study showed that under inclined side bank conditions,water entered the intake at an oblique angle,causing significant 3-D spiral flows in the intake rather than two-dimensional closed recirculation.A lower withdrawal discharge,a lower bottom elevation of the intake,or a higher main channel velocity could further strengthen this *** average division width and turbulent kinetic energy were smaller under inclined side bank conditions than under vertical bank *** a low intake bottom elevation,a low withdrawal discharge,or a high main channel velocity,the sources of lateral withdrawal were in similar ranges near the local inclined bank in the vertical *** inclined slope conditions,sediment deposition near the intake entrance could be reduced,compared to that under vertical slope *** results provide hydrodynamic and sediment references for engineering designs for natural rivers with inclined terrains.

关键词： Lateral withdrawal Hydrodynamic characteristics Particle tracking Inclined river slope Bottom elevation of intake OpenFOAM