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Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2194-2209页

作者： Zhilin Li Qianfeng Zhang Zhiqian Li Long Ren Dayi Pan Qiyong gong Zhongwei Gu hao Cai Kui Luo Department of Radiology Huaxi MR Research Center(HMRRC)Clinical Research Center for BreastDepartment of Breast SurgeryDepartment of Thoracic Surgery and Institute of Thoracic OncologyFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China Hospital Sichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Key Laboratory of Research and Development for Natural ProductsSchool of PharmacyYunnan UniversityKunming 650500China

Despite the great potential of anti-PD-L1 antibodies for immunotherapy,their low response rate due to an immunosuppressive tumor microenvironment has hampered their *** address this issue,we constructed a cell membrane-coated nanosystem(mB4S)to reverse an immunosuppressive microenvironment to an immuno-supportive one for strengthening the anti-tumor *** this system,Epirubicin(EPI)as an immunogenic cell death(ICD)inducer was coupled to a branched glycopolymer via hydrazone bonds and diABZI as a stimulator of interferon genes(STING)agonist was encapsulated into *** internalization of mB4S,EPI was acidic-responsively released to induce ICD,which was characterized by an increased level of calreticulin(CRT)exposure and enhanced ATP ***,diABZI effectively activated the STING *** with mB4S in combination with an anti-PD-L1 antibody elicited potent immune responses by increasing the ratio of matured dendritic cells(DCs)and CD8+T cells,promoting cytokines secretion,up-regulating M1-like tumor-associated macrophages(TAMs)and down-regulating immunosuppressive myeloid-derived suppressor cells(MDSCs).Therefore,this nanosystem for co-delivery of an ICD inducer and a STING agonist achieved promotion of DCs maturation and CD8+T cells infiltration,creating an immuno-supportive microenvironment,thus potentiating the therapy effect of the anti-PD-L1 antibody in both 4T1 breast and CT26 colon tumor mice.

关键词： Glycopolymer Polymer prodrug Immunogenic cell death Nanoassembly Epirubicin STING pathway Immuno-supportive microenvironment Immunotherapy

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Engineering of oxygen vacancy and bismuth cluster assisted ultrathin Bi_(12)O_(17)Cl_(2)nanosheets with efficient and selective photoreduction of CO_(2)to CO

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Carbon Energy 2024年第4期6卷 1-11页

作者： Meili Guan Ni Lu Xuan Zhang Qiuwan Wang Jian Bao Guiye Chen hao Yu Huaming Li Jiexiang Xia Xuezhong gong College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdaoShandongChina Institute for Energy Research Jiangsu UniversityZhenjiangJiangsuChina National Center of International Joint Research for Hybrid Materials Technology Institute of Hybrid MaterialsCollege of Materials Science andEngineeringNational Base of International Science and Technology Cooperation on Hybrid MaterialsQingdao UniversityQingdaoShandongChina

The photocatalytic conversion of CO_(2)into solar‐powered fuels is viewed as a forward‐looking strategy to address energy scarcity and global *** work demonstrated the selective photoreduction of CO_(2)to CO using ultrathin Bi_(12)O_(17)Cl_(2)nanosheets decorated with hydrothermally synthesized bismuth clusters and oxygen vacancies(OVs).The characterizations revealed that the coexistences of OVs and Bi clusters generated in situ contributed to the high efficiency of CO_(2)–CO conversion(64.3μmol g^(−1)h^(−1))and perfect *** OVs on the facet(001)of the ultrathin Bi_(12)O_(17)Cl_(2)nanosheets serve as sites for CO_(2)adsorption and activation sites,capturing photoexcited electrons and prolonging light absorption due to defect *** addition,the Bi‐cluster generated in situ offers the ability to trap holes and the surface plasmonic resonance *** study offers great potential for the construction of semiconductor hybrids as multiphotocatalysts,capable of being used for the elimination and conversion of CO_(2)in terms of energy and environment.

关键词： Bi cluster Bi_(12)O_(17)Cl_(2)nanosheet oxygen vacancy photocatalytic CO_(2)reduction

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Single-atom Rh catalysts for efficiently degrading Rhodamine B with high concentration

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Rare Metals 2024年第5期43卷 2331-2338页

作者： Shou-Yao Hu Jian-Ping Guan Run-Ze Ma Yu Tao Dong-hao Liu Jia-Xin gong Yu Xiong Department of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

Highly concentrated dye wastewater has a serious effect on the quality of natural waters;thus,developing novel catalysts to degrade dyes rapidly and efficiently is of great *** the first time,this study reports an Rh single atom loaded on a nitrogen-doped carbon(SA-Rh/CN)*** catalyst exhibits an excellent processing capacity for high concentrations of Rhodamine B(Rh B),high catalytic activity(95.7% degradation of Rh B in60 min)and excellent stability(93.5% degradation efficiency after 10 stable runs).

关键词： catalyst. catalysts loaded

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Multifunctional cellular carbon foams derived from chitosan toward self-cleaning, thermal insulation, and highly efficient microwave absorption properties

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Nano Research 2024年第3期17卷 927-938页

作者： Beibei Zhan Yanling hao Xiaosi Qi Yunpeng Qu Junfei Ding Jing-liang Yang Xiu gong Yanli Chen Qiong Peng Wei Zhong College of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China Minzu Normal University of Xingyi Xingyi 562400China National Laboratory of Solid State Microstructures and Jiangsu Provincial Laboratory for NanoTechnology Nanjing UniversityNanjing 210093China

To adapt the practical demand,designing and constructing the multifunctional microwave absorbers(MAs)is the key future direction of research and ***,effective integrating the multiple functions into a single material remains a huge ***,cellular carbon foams(CCFs)with different porous structures were elaborately designed and fabricated in high efficiency through a facile continuous freeze-drying and carbonization processes using a sustainable biomass chitosan as the *** obtained results revealed that the thermal treated temperature and g-C_(3)N_(4) amount played a great impact on the carbonization degrees,pore sizes,and morphologies of CCFs,which led to their tunable electromagnetic(EM)parameters,improved conduction loss,and polarization loss *** to the special cellular structure,the designed CCFs samples simultaneously displayed the strong absorption capabilities,broad absorption bandwidths,and thin matching ***,the as-prepared CCFs exhibited the strong hydrophobicity and good thermal insulation,endowing its attractive functions of self-cleaning and thermal ***,our findings not only presented a facile approach to produce different porous structures of CCFs,but also provided an effective strategy to develop multifunctional high-performance MAs on basis of three-dimensional CCFs.

关键词： multifunctional microwave absorbers carbon foams cellular structure self-cleaning thermal insulation

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Efficient production of ligand-free microscintillators at gram-scale for high-resolution X-ray luminescence imaging

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Chinese Chemical Letters 2024年第3期35卷 554-558页

作者： hao Jiang Qihao Chen Hongyu Wang Tingting Wu Jianwei gong Zhenzhen Zhang Qiushui Chen Huanghao Yang Lili Xie New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhou 350108China School of Public Health Fujian Medical UniversityFuzhou 350108China Joint School of National University of Singapore and Tianjin University Fuzhou International Campus of Tianjin UniversityFuzhou 350207China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The efficient production of high-quality scintillators with long radioluminescence afterglow is crucial for high-performance X-ray luminescence extension ***,scaling-up the synthesis of ligand-free scintillators to fabricate large-area X-ray imaging screens for industrial applications remains a *** this study,we report an efficient method to synthesize ligand-free,lanthanide-doped microscintillators by a one-pot reaction via the concentrated hydrothermal *** as-synthesized microscintillators exhibit prolonged persistent radioluminescence for up to 30 days after X-ray exposure and remain high stability in air or water for more than 18 months without *** Carlo simulations indicate that the size effect is responsible for the excellent afterglow performance of the *** employ these high-quality lanthanide-doped microscintillators to fabricate a large-area X-ray imaging detector using a blade-coating method,a spatial resolution of 24.9 lp/mm for X-ray *** study offers a solution for scaling-up the synthesis of low-cost microscintillators for practical applications.

关键词： Microscintillators NaLuF_(4):Tb^(3+) Afterglow X-ray detector X-ray luminescence imaging

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New material of Coniopteris simplex from the Middle Jurassic of the Ordos Basin,Inner Mongolia,China and implications on its spatio-temporal distribution and paleogeography

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Journal of Palaeogeography 2024年第2期13卷 199-211页

作者： Yun-Feng Li Chang-Lu Zhang Fei Liang Xiao Tan Fan-hao gong Chun-Lin Sun Tao Li Yu-Ling Na Research Center of Paleontology and Stratigraphy Jilin UniversityChangchun 130026Jilin ProvinceChina College of Earth Sciences Jilin UniversityChangchun 130061Jilin ProvinceChina College of Paleontology Shenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Key Lab of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Shenyang Center of Geological Survey China Geological SurveyShenyang 110034Liaoning ProvinceChina

Coniopteris simplex is a common component in many Jurassic ***,due to morphological variations in sterile fronds and incomplete preservation of reproductive organs,its classification has been controversial for a long ***,we present new material collected from the Middle Jurassic Yan’an Formation in the Ordos Basin,Inner *** new material reveals important morphological characters,including hemi-dimorphic fronds,two forms of sterile pinnae,short-stalked sori and sporangia on fertile fronds,annulus of sporangium composed of about 30 cells,in situ rounded triangular spores with protruded suture,and the lips of trilete laesura encircled by one or two rows of small *** on these observations,we emended the diagnosis of this common *** spatio-temporal distribution of Coniopteris simplex shows that the iconic species was restricted to the paleolatitudes ranging from 19.5°N to 48.9°N in the Northern Hemisphere during the Early—Late Jurassic,mainly distributed in the tropical to paratropical zones,and the paleolongitude ranging from 9.6°E to 129.3°E,which may be limited by the opening of the Viking Corridor and the splitting of the Central Atlantic Ocean.

关键词： Coniopteris simplex Yan'an Formation Middle Jurassic Inner Mongolia Paleogeography

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Magmatic-tectonic response of the South China Craton to the Paleo-Pacific subduction during the Triassic:a new viewpoint based on Well NK-1

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Journal of Oceanology and Limnology 2024年第1期42卷 58-89页

作者： Chan WANG hao LIU Gang LI Zhen SUN Tingting gong Li MIAO Xiaowei ZHU Yunying ZHANG Weihai XU Wen YAN Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Key Laboratory of Tectonic Controlled Mineralization and Oil Reservoir of Ministry of Natural Resources Chengdu University of TechnologyChengdu 610059China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China College of Earth Science Chengdu University of TechnologyChengdu 610059China University of Chinese Academy of Sciences Beijing 100049China

The Nansha Block(NB)is one of the blocks separated from the southern margin of the South China Craton(SCC)by the western Pacific subduction,which contains rich information of geodynamic and tectonic *** reveal the essence of western Paleo-Pacific subduction during the Triassic period,Well NK-1 in this block was selected for petrographic study,and published research data from other cooperative teams were compared.A double-cycle pattern of basic to neutral magmatic volcanism was established,and 36 lithological rhythmic layers and representative cryptoexplosive breccia facies and welded tuff bands were *** with a reanalysis of published geochronological data,geochemical elements,and isotope geochemistry,we found that the rock assemblages could be divided into an intermediate-acid dacite(DA)series(SiO_(2)>65%)and basaltic(BA)series(Co<40μg/g),which was formed during the early Late Triassic((218.6±3.2)–(217.9±3.5)Ma).BA exhibits obvious calc-alkaline island-arc magmatic properties:(^(87)Sr/^(86)Sr)_i ratio ranging 0.70377–0.71118(average:0.70645),^(147)Sm/^(144)Nd ratio ranging 0.119–0.193(average:0.168),and chondrite-normalized rare earth element(REE)curves being flat,while DA exhibits remarkable characteristics of subducted island-arc andesitic magma:(^(87)Sr/^(86)Sr)_i ratio(0.70939–0.71129;average:0.71035),εNd(t)value(-6.2–-4.8;average:-5.6)andε_(Hf)(t)value(-2.9–-1.7,average:-2.2)show obvious crust-mantle mixing *** and DA reveal typical characteristics of island-arc magma systems and typeⅡenriched mantle(EM-Ⅱ)*** magma was likely resulted from the process whereby the continental crust frontal accretionary wedge was driven by the Paleo-Pacific slab subduction into the deep and began to melt,resulting in a large amount of melt(fluid)joined the asthenosphere on the side of the continental *** contrast,DA magma was likely resulted from the process whereby the plate front was forced to bend with increasing subducti

关键词： Paleo-Pacific tectonic domain tectonic evolution rift volcanic rock Nansha Block South China Craton

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An early scoring system to predict mechanical ventilation for botulism: a single-center-based study

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World Journal of Emergency Medicine 2024年第5期15卷 365-371页

作者： Yaqing An Tuokang Zheng Yanling Dong Yang Wu Yu gong Yu Ma hao Xiao Hengbo Gao Yingping Tian Dongqi Yao Emergency Department the Second Hospital of Hebei Medical UniversityShijiazhuang 050051China

BACKGROUND: Early identification of patients requiring ventilator support will be beneficial for the outcomes of botulism. The present study aimed to establish a new scoring system to predict mechanical ventilation(MV) for botulism ***: A single-center retrospective study was conducted to identify risk factors associated with MV in botulism patients from 2007 to 2022. Univariate analysis and multivariate logistic regression analysis were used to screen out risk factors for constructing a prognostic scoring system. The area under the receiver operating characteristic(ROC) curve was ***: A total of 153 patients with botulism(66 males and 87 females, with an average age of 43 years) were included. Of these, 49 patients(32.0%) required MV, including 21(13.7%) with invasive ventilation and 28(18.3%) with non-invasive ventilation. Multivariate analysis revealed that botulinum toxin type, pneumonia, incubation period, degree of hypoxia, and severity of muscle involvement were independent risk factors for MV. These risk factors were incorporated into a multivariate logistic regression analysis to establish a prognostic scoring system. Each risk factor was scored by allocating a weight based on its regression coefficient and rounded to whole numbers for practical utilization([botulinum toxin type A: 1], [pneumonia: 2], [incubation period ≤1 day: 2], [hypoxia <90%: 2], [severity of muscle involvement: grade Ⅱ, 3;gradeⅢ, 7;grade IV, 11]). The scoring system achieved an area under the ROC curve of 0.82(95% CI 0.75–0.89, P<0.001). At the optimal threshold of 9, the scoring system achieved a sensitivity of 83.7% and a specificity of 70.2%.CONCLUSION: Our study identified botulinum toxin type, pneumonia, incubation period, degree of hypoxia, and severity of muscle involvement as independent risk factors for MV in botulism patients. A score ≥9 in our scoring system is associated with a higher likelihood of requiring MV in botulism patients. This scoring

关键词： Botulism Scoring system Botulinum toxin type Incubation period Hypoxia Pneumonia Severity of muscle involvement

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Minimally invasive reconstruction of extensive mid-lower ureteral strictures using a bilateral Boari flap

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Asian Journal of Urology 2024年第3期11卷 377-383页

作者： Shuaishuai Chai hao Zhang gong Cheng Jiawei Chen Xincheng Gao Yuancheng Zhou Xingyuan Xiao Bing Li Department of Urology Zhongnan Hospital of Wuhan UniversityWuhanChina Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Objective:To describe and evaluate the technique using bilateral Boari flap ureteroneocystostomy(BBFUNC)for bilateral mid-lower ureteral ***:We retrospectively reviewed five patients who underwent minimally invasive BBFUNC in our institution(Union Hospital,Wuhan,China)between July 2019 and December *** bilateral ureters were mobilized and transected above the stenotic *** bladder was isolated and incised longitudinally from the middle of the anterior ***,an inverted U-shaped bladder flap was created on both sides,fixed onto the psoas tendon,and anastomosed to the ipsilateral distal normal *** double-J stenting,the Boari flaps were tubularized,and the bladder was closed with continuous *** patients’perioperative data and follow-up outcomes were collected,and a descriptive statistical analysis was ***:No case converted to open surgery,and no intraoperative complication *** median surgical time was 230(range 203-294)*** median length of the bladder flaps was 6.2(range 4.3-10.0)cm on the left and 5.5(range 4.7-10.5)cm on the right *** patients had not developed recurrent ureteral stenosis during the median follow-up time of 17(range 16-45)months and had a normal maximum flow rate after *** median post-void residual was 7(range 0-19)*** maximal bladder capacity was decreased in one(20%)***:The present study demonstrates that minimally invasive BBFUNC is feasible and safe in treating is limited.

关键词： Reconstructive surgery Boariflap Ureteral stricture Ureteron-eocystostomy Minimallyinvasive

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玄武岩纤维/树脂基复合混凝土的力学性能和抗冻性能研究

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功能材料 2024年第2期55卷 2148-2154页

作者：龚皓中南大学土木工程学院长沙410000

以环氧树脂E51为基体材料,丙酮为稀释剂,通过添加玄武岩纤维,制备出了玄武岩纤维/树脂基复合混凝土,探究了玄武岩纤维掺杂量对复合混凝土的力学性能和抗冻性能的影响。结果表明,掺入适量玄武岩纤维后,复合混凝土宏观裂纹数量减少,玄武... 详细信息

以环氧树脂E51为基体材料,丙酮为稀释剂,通过添加玄武岩纤维,制备出了玄武岩纤维/树脂基复合混凝土,探究了玄武岩纤维掺杂量对复合混凝土的力学性能和抗冻性能的影响。结果表明,掺入适量玄武岩纤维后,复合混凝土宏观裂纹数量减少,玄武岩纤维在混凝土中横纵交错分布,与凝胶和骨料结合紧密,混凝土的力学性能得到了显著提高。随着玄武岩纤维掺杂量的增多,复合混凝土的抗压强度、抗折强度和相对动弹性模量均先升高后轻微降低,质量损失率先减小后增大。当玄武岩纤维掺杂量为0.60%(体积分数)时,复合混凝土的抗压强度和抗折强度均达到最大值,分别为41.63和8.90 MPa,在冻融循环100次时,相对动弹性模量最大为59.54%,质量损失率最低为1.02%,其力学性能和抗冻性能最佳。通过对质量损失率和相对动弹性模量进行曲线拟合分析可知,相对动弹性模量对于冻融循环的敏感程度更高,更适合用于评估混凝土的使用寿命,测试出玄武岩纤维的掺杂量为0.60%(质量分数)的混凝土的预估寿命可达9.84年,较未掺杂的试样提高了51.38%。综合可知,玄武岩纤维的最佳掺杂量为0.60%(体积分数)。

关键词：玄武岩纤维环氧树脂混凝土力学性能抗冻性能使用寿命

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